{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T02:27:10Z","timestamp":1779416830756,"version":"3.53.1"},"reference-count":15,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","award":["CM23\/00068"],"award-info":[{"award-number":["CM23\/00068"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/00131"],"award-info":[{"award-number":["PI21\/00131"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI23\/01102"],"award-info":[{"award-number":["PI23\/01102"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PI23\/00997"],"award-info":[{"award-number":["FIS PI23\/00997"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI25\/00914"],"award-info":[{"award-number":["PI25\/00914"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["CM24\/00083"],"award-info":[{"award-number":["CM24\/00083"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["CIBEREHD CB06 04 0026"],"award-info":[{"award-number":["CIBEREHD CB06 04 0026"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["EJP_RD (RiTA) AC23_2\/00015"],"award-info":[{"award-number":["EJP_RD (RiTA) AC23_2\/00015"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jhepr.2026.101772","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:26:32Z","timestamp":1770337592000},"page":"101772","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic value of factor VIII, D-dimer and high molecular risk variants assessing re-thrombosis risk in non-cirrhotic portal vein thrombosis"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6963-9203","authenticated-orcid":false,"given":"Anna","family":"Baiges","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Procopet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"T\u00e9llez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elba","family":"Llop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7741-2439","authenticated-orcid":false,"given":"Anna","family":"Darnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3536-4288","authenticated-orcid":false,"given":"\u00c1ngeles","family":"Garc\u00eda-Criado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Turon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4468-2053","authenticated-orcid":false,"given":"Oana","family":"Nicoara-Farcau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3216-7692","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Larrue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5997-9511","authenticated-orcid":false,"given":"Valeria","family":"Perez-Campuzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meritxell","family":"Nomdedeu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1274-4782","authenticated-orcid":false,"given":"Joan Carles","family":"Reverter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"\u00c1lvarez-Larr\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7486-8484","authenticated-orcid":false,"given":"Dolors","family":"Colomer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8571-1466","authenticated-orcid":false,"given":"Marta","family":"Garrote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"L\u00f3pez-Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6076-5136","authenticated-orcid":false,"given":"Sonia","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8700-6282","authenticated-orcid":false,"given":"Sarah","family":"Shalaby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0371-990X","authenticated-orcid":false,"given":"Asunci\u00f3n","family":"Ojeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3070-0310","authenticated-orcid":false,"given":"Lara","family":"Orts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Requejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Calleja Panero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-9278","authenticated-orcid":false,"given":"Christophe","family":"Bureau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9131-2592","authenticated-orcid":false,"given":"Agust\u00edn","family":"Albillos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Hern\u00e1ndez-Gea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9032-4954","authenticated-orcid":false,"given":"Juan Carlos","family":"Garc\u00eda-Pag\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2026.101772_bib1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jhep.2022.08.023","article-title":"Incidence and factors predictive of recurrent thrombosis in people with non-cirrhotic portal vein thrombosis","volume":"78","author":"Baiges","year":"2023","journal-title":"J Hepatol"},{"issue":"12","key":"10.1016\/j.jhepr.2026.101772_bib2","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2200104","article-title":"Rivaroxaban prophylaxis in non cirrhotic portal vein thrombosis","volume":"1","author":"Plessier","year":"2022","journal-title":"NEJM Evid"},{"key":"10.1016\/j.jhepr.2026.101772_bib3","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jhep.2024.04.016","article-title":"Recurrent splanchnic and extrasplanchnic thrombotic events in patients with non-cirrhotic portal vein thrombosis associated with local factors","volume":"81","author":"Ollivier-Hourmand","year":"2024","journal-title":"J Hepatol [Internet]"},{"key":"10.1016\/j.jhepr.2026.101772_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1053\/j.seminhematol.2004.09.009","article-title":"von Willebrand factor and factor VIII as risk factors for arterial and venous thrombosis","volume":"42","author":"Martinelli","year":"2005","journal-title":"Semin Hematol [Internet]"},{"key":"10.1016\/j.jhepr.2026.101772_bib5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jhep.2020.06.045","article-title":"Next-generation sequencing in the diagnosis of non-cirrhotic splanchnic vein thrombosis","volume":"74","author":"Magaz","year":"2021","journal-title":"J Hepatol [Internet]"},{"key":"10.1016\/j.jhepr.2026.101772_bib6","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00277-023-05610-x","article-title":"Genomic classification and outcomes of Young patients with polycythemia vera and essential thrombocythemia according to the presence of splanchnic vein thrombosis and its chronology","volume":"103","author":"Garrote","year":"2024","journal-title":"Ann Hematol"},{"key":"10.1016\/j.jhepr.2026.101772_bib7","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jhep.2014.08.032","article-title":"Role of calreticulin mutations in the aetiological diagnosis of splanchnic vein thrombosis","volume":"62","author":"Turon","year":"2015","journal-title":"J Hepatol [Internet]"},{"key":"10.1016\/j.jhepr.2026.101772_bib8","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1007\/s00277-019-03766-z","article-title":"Genomic characterization in triple-negative primary myelofibrosis and other myeloid neoplasms with bone marrow fibrosis","volume":"98","author":"Alvarez-Larr\u00e1n","year":"2019","journal-title":"Ann Hematol [Internet]"},{"key":"10.1016\/j.jhepr.2026.101772_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/blood-2015-03-631747","article-title":"Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes","volume":"126","author":"Steensma","year":"2015","journal-title":"Blood [Internet]"},{"key":"10.1016\/j.jhepr.2026.101772_bib10","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S2468-1253(24)00155-9","article-title":"Portal vein thrombosis: diagnosis, management, and endpoints for future clinical studies","volume":"9","author":"Elkrief","year":"2024","journal-title":"Lancet Gastroenterol Hepatol [Internet]"},{"issue":"7","key":"10.1016\/j.jhepr.2026.101772_bib11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/MBC.0000000000001385","article-title":"Factor VIII beyond haemophilia: a hidden regulator of venous thrombosis and endothelial dysfunction","volume":"36","author":"Prasannan","year":"2025","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"6","key":"10.1016\/j.jhepr.2026.101772_bib12","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1365-2141.2012.09134.x","article-title":"Elevated factor VIII levels and risk of venous thrombosis","volume":"157","author":"Jenkins","year":"2012","journal-title":"Br J Haematol"},{"issue":"1","key":"10.1016\/j.jhepr.2026.101772_bib13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/jth.14343","article-title":"High levels of coagulation factors and venous thrombosis risk: strongest association for factor VIII and von Willebrand factor","volume":"17","author":"Rietveld","year":"2019","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jhepr.2026.101772_bib14","doi-asserted-by":"crossref","DOI":"10.1007\/s11239-025-03161-8","article-title":"Association between elevated plasma levels of factor VIII and risk of recurrent venous thromboembolism: a systematic review and meta-analysis","author":"Teymoori","year":"2025","journal-title":"J Thromb Thrombolysis"},{"issue":"8","key":"10.1016\/j.jhepr.2026.101772_bib15","doi-asserted-by":"crossref","first-page":"523","DOI":"10.7326\/0003-4819-153-8-201010190-00009","article-title":"Patient-level meta-analysis: effect of measurement timing, threshold, and patient age on ability of D-dimer testing to assess recurrence risk after unprovoked venous thromboembolism","volume":"153","author":"Douketis","year":"2010","journal-title":"Ann Intern Med"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926000431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926000431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T01:50:25Z","timestamp":1779414625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555926000431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2589555926000431"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101772","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic value of factor VIII, D-dimer and high molecular risk variants assessing re-thrombosis risk in non-cirrhotic portal vein thrombosis","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101772","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"101772"}}