{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:04:06Z","timestamp":1791461046989,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008856","name":"Zhejiang Provincial Health Commission","doi-asserted-by":"publisher","award":["WK-ZJ-2425"],"award-info":[{"award-number":["WK-ZJ-2425"]}],"id":[{"id":"10.13039\/501100008856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2604300"],"award-info":[{"award-number":["2023YFC2604300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010896","name":"International Cooperation and Exchange Programme","doi-asserted-by":"publisher","award":["W2412017"],"award-info":[{"award-number":["W2412017"]}],"id":[{"id":"10.13039\/501100010896","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010896","name":"International Cooperation and Exchange Programme","doi-asserted-by":"publisher","award":["2024VTJP1003"],"award-info":[{"award-number":["2024VTJP1003"]}],"id":[{"id":"10.13039\/501100010896","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92369107"],"award-info":[{"award-number":["92369107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872935"],"award-info":[{"award-number":["81872935"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017577","name":"Basic Public Welfare Research Program of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017577","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LD22H190003"],"award-info":[{"award-number":["LD22H190003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jhepr.2026.101780","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:22:11Z","timestamp":1770826931000},"page":"101780","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Glycodeoxycholic acid inhibits hepatocellular carcinoma by driving M1 polarization of macrophages via the S1PR2\u2013NF-\u03baB\u2013NLRP3 pathway"],"prefix":"10.1016","volume":"8","author":[{"given":"Mingxia","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyao","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lushun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaibing","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keer","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqing","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9126-476X","authenticated-orcid":false,"given":"Yan","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1016\/j.jhepr.2026.101780_bib1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/hep.31288","article-title":"Epidemiology of hepatocellular carcinoma","volume":"73","author":"McGlynn","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101780_bib2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s13045-019-0806-6","article-title":"Tumorigenesis, diagnosis, and therapeutic potential of exosomes in liver cancer","volume":"12","author":"Wang","year":"2019","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.jhepr.2026.101780_bib3","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(18)30010-2","article-title":"Hepatocellular carcinoma","volume":"391","author":"Forner","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jhepr.2026.101780_bib4","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1016\/S0140-6736(17)31046-2","article-title":"Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1\/2 dose escalation and expansion trial","volume":"389","author":"El-Khoueiry","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jhepr.2026.101780_bib5","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/S1470-2045(18)30351-6","article-title":"Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial","volume":"19","author":"Zhu","year":"2018","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jhepr.2026.101780_bib6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.canlet.2016.01.043","article-title":"Tumor microenvironment and therapeutic response","volume":"387","author":"Wu","year":"2017","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jhepr.2026.101780_bib7","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12943-019-1047-6","article-title":"Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities","volume":"18","author":"Lu","year":"2019","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jhepr.2026.101780_bib8","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-009993","article-title":"Disruption of tumor-intrinsic PGAM5 increases anti-PD-1 efficacy through the CCL2 signaling pathway","volume":"13","author":"Wei","year":"2025","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.jhepr.2026.101780_bib9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13046-020-01808-3","article-title":"Promotion of epithelial-mesenchymal transformation by hepatocellular carcinoma-educated macrophages through Wnt2b\/\u03b2-catenin\/c-Myc signaling and reprogramming glycolysis","volume":"40","author":"Jiang","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.jhepr.2026.101780_bib10","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nrd.2016.111","article-title":"Immuno-oncologists eye up macrophage targets","volume":"15","author":"Morrison","year":"2016","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jhepr.2026.101780_bib11","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.cell.2018.05.060","article-title":"Single-cell map of diverse immune phenotypes in the breast tumor microenvironment","volume":"174","author":"Azizi","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jhepr.2026.101780_bib12","doi-asserted-by":"crossref","first-page":"5801","DOI":"10.3390\/ijms22115801","article-title":"Tumor immune microenvironment and immunosuppressive therapy in hepatocellular carcinoma: a review","volume":"22","author":"Oura","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhepr.2026.101780_bib13","first-page":"1551","article-title":"Astragaloside IV inhibits the progression of liver cancer by modulating macrophage polarization through the TLR4\/NF-\u03baB\/STAT3 signaling pathway","volume":"14","author":"Min","year":"2022","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.jhepr.2026.101780_bib14","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3390\/ijms17030320","article-title":"CD86+\/CD206+, diametrically polarized tumor-associated macrophages, predict hepatocellular carcinoma patient prognosis","volume":"17","author":"Dong","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhepr.2026.101780_bib15","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1158\/0008-5472.CAN-20-2990","article-title":"Macrophage-based approaches for cancer immunotherapy","volume":"81","author":"Anderson","year":"2021","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhepr.2026.101780_bib16","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1158\/2159-8290.CD-15-1032","article-title":"IFN\u03b3 and CCL2 cooperate to redirect tumor-infiltrating monocytes to degrade fibrosis and enhance chemotherapy efficacy in pancreatic carcinoma","volume":"6","author":"Long","year":"2016","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jhepr.2026.101780_bib17","article-title":"Anti-CD47 treatment stimulates phagocytosis of glioblastoma by M1 and M2 polarized macrophages and promotes M1 polarized macrophages in vivo","volume":"11","author":"Zhang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jhepr.2026.101780_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102463","article-title":"Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing","volume":"56","author":"Hao","year":"2022","journal-title":"Redox Biol"},{"key":"10.1016\/j.jhepr.2026.101780_bib19","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-004297","article-title":"Bufalin stimulates antitumor immune response by driving tumor-infiltrating macrophage toward M1 phenotype in hepatocellular carcinoma","volume":"10","author":"Yu","year":"2022","journal-title":"J Immunother Cancer"},{"issue":"Suppl 2","key":"10.1016\/j.jhepr.2026.101780_bib20","doi-asserted-by":"crossref","first-page":"S237","DOI":"10.2337\/dc09-S355","article-title":"Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration","volume":"32","author":"Staels","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jhepr.2026.101780_bib21","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1126\/science.adl4100","article-title":"Bile acid synthesis impedes tumor-specific T cell responses during liver cancer","volume":"387","author":"Varanasi","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.jhepr.2026.101780_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan5931","article-title":"Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells","volume":"360","author":"Ma","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jhepr.2026.101780_bib23","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jhep.2022.02.030","article-title":"Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis","volume":"77","author":"Sun","year":"2022","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101780_bib24","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1021\/pr500920q","article-title":"Profiling of serum bile acids in a healthy Chinese population using UPLC-MS\/MS","volume":"14","author":"Xie","year":"2015","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jhepr.2026.101780_bib25","doi-asserted-by":"crossref","first-page":"W509","DOI":"10.1093\/nar\/gkaa407","article-title":"TIMER2.0 for analysis of tumor-infiltrating immune cells","volume":"48","author":"Li","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhepr.2026.101780_bib26","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.bbadis.2018.05.011","article-title":"Animal models to study bile acid metabolism","volume":"1865","author":"Li","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jhepr.2026.101780_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202207074","article-title":"Effects of 3-HAA on HCC by regulating the heterogeneous macrophages-a scRNA-seq analysis","volume":"10","author":"Xue","year":"2023","journal-title":"Adv Sci"},{"key":"10.1016\/j.jhepr.2026.101780_bib28","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/s42255-022-00559-z","article-title":"Metabolic messengers: bile acids","volume":"4","author":"Perino","year":"2022","journal-title":"Nat Metab"},{"key":"10.1016\/j.jhepr.2026.101780_bib29","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.apsb.2014.12.009","article-title":"Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism","volume":"5","author":"Kwong","year":"2015","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.jhepr.2026.101780_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2481418","article-title":"Deoxycholic acid-mediated sphingosine-1-phosphate receptor 2 signaling exacerbates DSS-induced colitis through promoting cathepsin B release","volume":"2018","author":"Zhao","year":"2018","journal-title":"J Immunol Res"},{"key":"10.1016\/j.jhepr.2026.101780_bib31","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrd2619","article-title":"Targeting bile-acid signalling for metabolic diseases","volume":"7","author":"Thomas","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jhepr.2026.101780_bib32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrgastro.2017.119","article-title":"Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis","volume":"15","author":"Jia","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.101780_bib33","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.canlet.2019.04.009","article-title":"Glycochenodeoxycholate promotes hepatocellular carcinoma invasion and migration by AMPK\/mTOR dependent autophagy activation","volume":"454","author":"Gao","year":"2019","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jhepr.2026.101780_bib34","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000217","article-title":"Bile acids promote the development of HCC by activating inflammasome","volume":"7","author":"Chen","year":"2023","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhepr.2026.101780_bib35","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/s11671-018-2653-8","article-title":"The apoptosis effect on liver cancer cells of gold nanoparticles modified with lithocholic acid","volume":"13","author":"Zhao","year":"2018","journal-title":"Nanoscale Res Lett"},{"key":"10.1016\/j.jhepr.2026.101780_bib36","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.biomaterials.2016.11.040","article-title":"Combination therapy with doxorubicin-loaded galactosylated poly(ethyleneglycol)-lithocholic acid to suppress the tumor growth in an orthotopic mouse model of liver cancer","volume":"116","author":"Singh","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.jhepr.2026.101780_bib37","first-page":"1739","article-title":"Ursodeoxycholic acid-induced inhibition of DLC1 protein degradation leads to suppression of hepatocellular carcinoma cell growth","volume":"25","author":"Chung","year":"2011","journal-title":"Oncol Rep"},{"key":"10.1016\/j.jhepr.2026.101780_bib38","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.4254\/wjh.v14.i9.1730","article-title":"Bile acids as drivers and biomarkers of hepatocellular carcinoma","volume":"14","author":"Colosimo","year":"2022","journal-title":"World J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101780_bib39","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1210\/clinem\/dgac659","article-title":"Circulating bile acids as biomarkers for disease diagnosis and prevention","volume":"108","author":"Qi","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jhepr.2026.101780_bib40","article-title":"Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma","volume":"10","author":"Chen","year":"2011","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.jhepr.2026.101780_bib41","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1021\/acs.jproteome.0c00852","article-title":"Bile acid profiles are distinct among patients with different etiologies of chronic liver disease","volume":"20","author":"Sang","year":"2021","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jhepr.2026.101780_bib42","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s10620-020-06112-w","article-title":"Diet and the human gut microbiome: an international review","volume":"65","author":"Wilson","year":"2020","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jhepr.2026.101780_bib43","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.tjnut.2024.12.035","article-title":"Secondary bile acid derivatives are contributors to the fecal bile acid pool and associated with bile acid-modulating nutrients","volume":"155","author":"Wolf","year":"2025","journal-title":"J Nutr"},{"key":"10.1016\/j.jhepr.2026.101780_bib44","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3390\/nu16020250","article-title":"Gender-specific bile acid profiles in non-alcoholic fatty liver disease","volume":"16","author":"Fitzinger","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.jhepr.2026.101780_bib45","article-title":"Gender-divergent profile of bile acid homeostasis during aging of mice","volume":"7","author":"Fu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jhepr.2026.101780_bib46","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s12072-022-10299-7","article-title":"Abnormal bile acid-microbiota crosstalk promotes the development of hepatocellular carcinoma","volume":"16","author":"Shen","year":"2022","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jhepr.2026.101780_bib47","doi-asserted-by":"crossref","first-page":"6995","DOI":"10.3390\/ijms22136995","article-title":"Macrophage polarization states in the tumor microenvironment","volume":"22","author":"Boutilier","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhepr.2026.101780_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2020.1819155","article-title":"Gut microbial bile acid metabolite skews macrophage polarization and contributes to high-fat diet-induced colonic inflammation","volume":"12","author":"Wang","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jhepr.2026.101780_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102452","article-title":"Chenodeoxycholic acid suppresses AML progression through promoting lipid peroxidation via ROS\/p38 MAPK\/DGAT1 pathway and inhibiting M2 macrophage polarization","volume":"56","author":"Liu","year":"2022","journal-title":"Redox Biol"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926000510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926000510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T01:50:33Z","timestamp":1779414633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555926000510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2589555926000510"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101780","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glycodeoxycholic acid inhibits hepatocellular carcinoma by driving M1 polarization of macrophages via the S1PR2\u2013NF-\u03baB\u2013NLRP3 pathway","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101780","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"101780"}}