{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:14:48Z","timestamp":1783635288303,"version":"3.55.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023771","name":"Manufacturer Vilhelm Pedersen and Wife Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jhepr.2026.101822","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:12:03Z","timestamp":1773335523000},"page":"101822","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of novel assays of non-ceruloplasmin copper to monitor chelation treatment in patients with Wilson disease"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-1983","authenticated-orcid":false,"given":"Peter","family":"Ott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9807-6852","authenticated-orcid":false,"given":"Thomas","family":"Sandahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6257-3160","authenticated-orcid":false,"given":"Aftab","family":"Ala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cassiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Couchonnal-Bedoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6305-3327","authenticated-orcid":false,"given":"Rubens Gisbert","family":"Cury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Czlonkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Denk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"D\u2019Inca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8957-5796","authenticated-orcid":false,"given":"Francisco","family":"de Assis Aquino Gondim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9559-3552","authenticated-orcid":false,"given":"Joanna","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5640-7534","authenticated-orcid":false,"given":"Aurelia","family":"Poujois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alexandre","family":"Twardowschy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6336-9935","authenticated-orcid":false,"given":"Karl Heinz","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Zuin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4872-3860","authenticated-orcid":false,"given":"C. Omar F.","family":"Kamlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9043-0554","authenticated-orcid":false,"given":"Michael L.","family":"Schilsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2026.101822_bib1","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/hep.32805","article-title":"A multidisciplinary approach to the diagnosis and management of Wilson disease: executive summary of the 2022 practice guidance on Wilson disease from the American association for the study of liver diseases","volume":"77","author":"Schilsky","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101822_bib2","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.jhep.2024.11.007","article-title":"EASL-ERN clinical practice guidelines on Wilson's disease","volume":"82","year":"2025","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101822_bib3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.aca.2019.11.033","article-title":"Biomedical copper speciation in relation to Wilson's disease using strong anion exchange chromatography coupled to triple quadrupole inductively coupled plasma mass spectrometry","volume":"1098","author":"Solovyev","year":"2020","journal-title":"Anal Chim Acta"},{"key":"10.1016\/j.jhepr.2026.101822_bib4","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1515\/cclm-2024-0213","article-title":"Accurate non-ceruloplasmin bound copper: a new biomarker for the assessment and monitoring of Wilson disease patients using HPLC coupled to ICP-MS\/MS","volume":"63","author":"Harrington","year":"2024","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.jhepr.2026.101822_bib5","first-page":"13","article-title":"A fit-for-purpose copper speciation method for the determination of exchangeable copper relevant to Wilson's disease","volume":"414","author":"Del Castillo Busto","year":"2021","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.jhepr.2026.101822_bib6","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/s00216-009-2809-6","article-title":"Determination of ultrafiltrable and exchangeable copper in plasma: stability and reference values in healthy subjects","volume":"394","author":"El Balkhi","year":"2009","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.jhepr.2026.101822_bib7","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/S2468-1253(22)00270-9","article-title":"Trientine tetrahydrochloride versus penicillamine for maintenance therapy in Wilson disease (CHELATE): a randomised, open-label, non-inferiority, phase 3 trial","volume":"7","author":"Schilsky","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.101822_bib8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/hep.32074","article-title":"Designing clinical trials in Wilson's disease","volume":"74","author":"Ott","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101822_bib9","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S2468-1253(22)00284-9","article-title":"Monitoring and treatment of Wilson disease: progress and challenges","volume":"7","author":"Medici","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.101822_bib10","article-title":"Non-ceruloplasmin copper and urinary copper in clinically stable Wilson disease: alignment with recommended targets","volume":"6","author":"Ott","year":"2024","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhepr.2026.101822_bib11","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/j.cca.2011.08.019","article-title":"Relative exchangeable copper: a new highly sensitive and highly specific biomarker for Wilson's disease diagnosis","volume":"412","author":"El Balkhi","year":"2011","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jhepr.2026.101822_bib12","first-page":"11997B","article-title":"Exchangeable serum copper: adult and pediatric reference intervals and vitro stability in a Nordic cohort","volume":"565","author":"Christensen","year":"2025","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jhepr.2026.101822_bib13","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1097\/HEP.0000000000000708","article-title":"Effects of trientine and penicillamine on intestinal copper uptake: a mechanistic 64 Cu PET\/CT study in healthy humans","volume":"79","author":"Kirk","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101822_bib14","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S2468-1253(17)30293-5","article-title":"Bis-choline tetrathiomolybdate in patients with Wilson's disease: an open-label, multicentre, phase 2 study","volume":"2","author":"Weiss","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.101822_bib15","series-title":"Encyclopedia of inorganic and bioorganic chemistry","article-title":"Ceruloplasmin","author":"Lindley","year":"2011"},{"key":"10.1016\/j.jhepr.2026.101822_bib16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13023-025-03545-2","article-title":"A comparative analysis in monitoring 24-hour urinary copper in Wilson disease: sampling on or off treatment?","volume":"20","author":"Mohr","year":"2025","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jhepr.2026.101822_bib17","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/jimd.12046","article-title":"Long-term evaluation of urinary copper excretion and non-caeruloplasmin associated copper in Wilson disease patients under medical treatment","volume":"42","author":"Pfeiffenberger","year":"2019","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jhepr.2026.101822_bib18","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/jimd.12430","article-title":"Adherence to treatment, a challenge even in treatable metabolic rare diseases: a cross sectional study of Wilson's disease","volume":"44","author":"Jacquelet","year":"2021","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jhepr.2026.101822_bib19","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/ene.12320","article-title":"Compliant treatment with anti-copper agents prevents clinically overt Wilson's disease in pre-symptomatic patients","volume":"21","author":"Dziezyc","year":"2014","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.jhepr.2026.101822_bib20","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/brain\/71.4.410","article-title":"The copper and iron content of brain and liver in the normal and in hepato-lenticular degeneration","volume":"71","author":"Cumings","year":"1948","journal-title":"Brain"},{"key":"10.1016\/j.jhepr.2026.101822_bib21","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s13023-025-03821-1","article-title":"Predictive value of liver enzymes in long-term prognosis of hepatic Wilson disease: results from the Wilson AEEH registry","volume":"20","author":"Berenguer","year":"2025","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jhepr.2026.101822_bib22","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1097\/MPG.0000000000003531","article-title":"Long-term urinary copper excretion and exchangeable copper in children with Wilson disease under chelation therapy","volume":"75","author":"Ngwanou","year":"2022","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jhepr.2026.101822_bib23","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/mds.28333","article-title":"Plasma neurofilament light as a biomarker of neurological involvement in Wilson's disease","volume":"36","author":"Shribman","year":"2021","journal-title":"Mov Disord"},{"key":"10.1016\/j.jhepr.2026.101822_bib24","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1002\/mds.29229","article-title":"Brain atrophy is substantially accelerated in neurological Wilson's disease: a longitudinal study","volume":"37","author":"Smolinski","year":"2022","journal-title":"Mov Disord"},{"key":"10.1016\/j.jhepr.2026.101822_bib25","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s13760-022-02091-z","article-title":"Serum neurofilament light chain and initial severity of neurological disease predict the early neurological deterioration in Wilson's disease","volume":"123","author":"Ziemssen","year":"2022","journal-title":"Acta Neurol Belg"},{"key":"10.1016\/j.jhepr.2026.101822_bib26","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/ene.13171","article-title":"Exchangeable copper: a reflection of the neurological severity in Wilson's disease","volume":"24","author":"Poujois","year":"2017","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.jhepr.2026.101822_bib27","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.pjnns.2014.05.002","article-title":"Symptomatic copper deficiency in three Wilson's disease patients treated with zinc sulphate","volume":"48","author":"Dziezyc","year":"2014","journal-title":"Neurol Neurochir Pol"},{"key":"10.1016\/j.jhepr.2026.101822_bib28","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/mdc3.13813","article-title":"Can patients with Wilson's disease develop copper deficiency?","volume":"10","author":"Chevalier","year":"2023","journal-title":"Mov Disord Clin Pract"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926000935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926000935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:25:36Z","timestamp":1783632336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555926000935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2589555926000935"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101822","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of novel assays of non-ceruloplasmin copper to monitor chelation treatment in patients with Wilson disease","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101822","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"101822"}}