{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:15:05Z","timestamp":1783635305543,"version":"3.55.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["411345524"],"award-info":[{"award-number":["411345524"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2151 \\u2013 390873048"],"award-info":[{"award-number":["EXC 2151 \\u2013 390873048"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["432325352"],"award-info":[{"award-number":["432325352"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["410853455"],"award-info":[{"award-number":["410853455"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jhepr.2026.101826","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T08:02:14Z","timestamp":1774425734000},"page":"101826","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["AI-guided additive scoring model for differential diagnosis of primary liver cancer"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1032-4848","authenticated-orcid":false,"given":"Rebekka J.S.","family":"Salzmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7785-6403","authenticated-orcid":false,"given":"Tudor","family":"Mocan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9998-6735","authenticated-orcid":false,"given":"Arnulf G.","family":"Willms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2972-3777","authenticated-orcid":false,"given":"Emil","family":"Mois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0652-0424","authenticated-orcid":false,"given":"Cristiana","family":"Grapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4957-4390","authenticated-orcid":false,"given":"Lavinia Patricia","family":"Mocan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5872-8630","authenticated-orcid":false,"given":"Rares","family":"Craciun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeno","family":"Sparchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo G.H.","family":"Schmidt-Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2074-0930","authenticated-orcid":false,"given":"Jan","family":"Best","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut H.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0113-0777","authenticated-orcid":false,"given":"Marcin","family":"Krawczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon C.","family":"Robson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Lukacs-Kornek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1682-1765","authenticated-orcid":false,"given":"Miroslaw T.","family":"Kornek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2026.101826_bib1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/ijc.33588","article-title":"Cancer statistics for the year 2020: an overview","volume":"149","author":"Ferlay","year":"2021","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jhepr.2026.101826_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.18","article-title":"Hepatocellular carcinoma","volume":"2","author":"Llovet","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jhepr.2026.101826_bib3","article-title":"Cancer statistics, 2026","volume":"76","author":"Siegel","year":"2026","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jhepr.2026.101826_bib4","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0140-6736(11)61347-0","article-title":"Hepatocellular carcinoma","volume":"379","author":"Forner","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jhepr.2026.101826_bib5","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.3748\/wjg.15.1301","article-title":"Diagnosis of hepatocellular carcinoma","volume":"15","author":"Gomaa","year":"2009","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhepr.2026.101826_bib6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/cld.324","article-title":"Clinical diagnosis and management of intrahepatic cholangiocarcinoma","volume":"3","author":"Patel","year":"2014","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.jhepr.2026.101826_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001624","article-title":"Early detection, curative treatment, and survival rates for hepatocellular carcinoma surveillance in patients with cirrhosis: a meta-analysis","volume":"11","author":"Singal","year":"2014","journal-title":"Plos Med"},{"key":"10.1016\/j.jhepr.2026.101826_bib8","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.jhep.2014.01.021","article-title":"Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma","volume":"60","author":"Bridgewater","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101826_bib9","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1055\/s-2004-815564","article-title":"Progenitor cells in diseased human liver","volume":"23","author":"Roskams","year":"2003","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhepr.2026.101826_bib10","first-page":"5239","article-title":"Hepatic biliary epithelial cells acquire epithelial integrity but lose plasticity to differentiate into hepatocytes in vitro during development","volume":"126","author":"Tanimizu","year":"2013","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jhepr.2026.101826_bib11","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jhepr.2026.101826_bib12","series-title":"WHO classification of tumours of the digestive system","year":"2010"},{"key":"10.1016\/j.jhepr.2026.101826_bib13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/cld.1075","article-title":"Diagnostic criteria and LI-RADS for hepatocellular carcinoma","volume":"17","author":"Lee","year":"2021","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.jhepr.2026.101826_bib14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1365-2141.1967.tb08741.x","article-title":"The nature and significance of platelet products in human plasma","volume":"13","author":"Wolf","year":"1967","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jhepr.2026.101826_bib15","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/ncb1800","article-title":"Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers","volume":"10","author":"Skog","year":"2008","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jhepr.2026.101826_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12144","article-title":"A brief history of nearly EV-erything - the rise and rise of extracellular vesicles","volume":"10","author":"Couch","year":"2021","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.jhepr.2026.101826_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","article-title":"Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication","volume":"21","author":"Mathieu","year":"2019","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jhepr.2026.101826_bib18","doi-asserted-by":"crossref","first-page":"27066","DOI":"10.3402\/jev.v4.27066","article-title":"Biological properties of extracellular vesicles and their physiological functions","volume":"4","author":"Y\u00e1\u00f1ez-M\u00f3","year":"2015","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.jhepr.2026.101826_bib19","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fimmu.2020.00074","article-title":"Extracellular vesicles as mediators of cellular crosstalk between immune system and kidney graft","volume":"11","author":"Quaglia","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jhepr.2026.101826_bib20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4161\/psb.2.1.3596","article-title":"Do plant cells secrete exosomes derived from multivesicular bodies?","volume":"2","author":"An","year":"2007","journal-title":"Plant Signaling Behav"},{"key":"10.1016\/j.jhepr.2026.101826_bib21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/jcp.1041470105","article-title":"Exosome formation during maturation of mammalian and avian reticulocytes: evidence that exosome release is a major route for externalization of obsolete membrane proteins","volume":"147","author":"Johnstone","year":"1991","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jhepr.2026.101826_bib22","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.4049\/jimmunol.170.6.3037","article-title":"Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo","volume":"170","author":"Skokos","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jhepr.2026.101826_bib23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jhepr.2026.101826_bib24","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1089\/ten.teb.2020.0222","article-title":"The emerging potential of extracellular vesicles in cell-free tissue engineering and regenerative medicine","volume":"27","author":"Alqurashi","year":"2021","journal-title":"Tissue Eng B Rev"},{"key":"10.1016\/j.jhepr.2026.101826_bib25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.21037\/atm.2017.01.53","article-title":"Extracellular vesicles: small bricks for tissue repair\/regeneration","volume":"5","author":"Taverna","year":"2017","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.jhepr.2026.101826_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13045-015-0181-x","article-title":"Exosomes in cancer: small particle, big player","volume":"8","author":"Zhang","year":"2015","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.jhepr.2026.101826_bib27","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.jhep.2017.02.024","article-title":"Cancer-associated circulating large extracellular vesicles in cholangiocarcinoma and hepatocellular carcinoma","volume":"67","author":"Julich-Haertel","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101826_bib28","article-title":"What we missed then, AI sees now: revisiting legacy large extracellular vesicle data to reveal synergistic biomarkers for liver cancer screening","volume":"7","author":"Willms","year":"2025","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhepr.2026.101826_bib29","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1111\/liv.14585","article-title":"Synergistic effects of extracellular vesicle phenotyping and AFP in hepatobiliary cancer differentiation","volume":"40","author":"Urban","year":"2020","journal-title":"Liver Int"},{"key":"10.1016\/j.jhepr.2026.101826_bib30","article-title":"Liquid biopsy in organ damage: small extracellular vesicle chip-based assessment of polytrauma","volume":"14","author":"Wang","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.jhepr.2026.101826_bib31","article-title":"Monocyte derived large extracellular vesicles in polytrauma","volume":"3","author":"Wohler","year":"2024","journal-title":"J Extracell Biol"},{"key":"10.1016\/j.jhepr.2026.101826_bib32","first-page":"4697","article-title":"3-Deazaneplanocin A may directly target putative cancer stem cells in biliary tract cancer","volume":"35","author":"Mayr","year":"2015","journal-title":"Anticancer Res"},{"key":"10.1016\/j.jhepr.2026.101826_bib33","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Thery","year":"2018","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.jhepr.2026.101826_bib34","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v3.26913","article-title":"Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles","volume":"3","author":"Lotvall","year":"2014","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.jhepr.2026.101826_bib35","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1097\/HEP.0000000000000466","article-title":"AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma","volume":"78","author":"Singal","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101826_bib36","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1038\/s41591-025-03953-8","article-title":"The STARD-AI reporting guideline for diagnostic accuracy studies using artificial intelligence","volume":"31","author":"Sounderajah","year":"2025","journal-title":"Nat Med"},{"key":"10.1016\/j.jhepr.2026.101826_bib37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40644-018-0149-5","article-title":"LI-RADS v2017 for liver nodules: how we read and report","volume":"18","author":"Schima","year":"2018","journal-title":"Cancer Imaging"},{"key":"10.1016\/j.jhepr.2026.101826_bib38","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cct.2013.09.009","article-title":"Bayesian two-step Lasso strategy for biomarker selection in personalized medicine development for time-to-event endpoints","volume":"36","author":"Gu","year":"2013","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.jhepr.2026.101826_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1010357","article-title":"Ten quick tips for biomarker discovery and validation analyses using machine learning","volume":"18","author":"Diaz-Uriarte","year":"2022","journal-title":"Plos Comput Biol"},{"key":"10.1016\/j.jhepr.2026.101826_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0066714","article-title":"Principal component analysis based feature extraction approach to identify circulating microRNA biomarkers","volume":"8","author":"Taguchi","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jhepr.2026.101826_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151069","article-title":"Diagnostic performance of alpha-fetoprotein, protein induced by vitamin K absence, osteopontin, Dickkopf-1 and its combinations for hepatocellular carcinoma","volume":"11","author":"Jang","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jhepr.2026.101826_bib42","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.cgh.2022.01.047","article-title":"The performance of AFP, AFP-3, DCP as biomarkers for detection of hepatocellular carcinoma (HCC): a Phase 3 biomarker study in the United States","volume":"21","author":"Tayob","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.101826_bib43","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1055\/s-0042-119529","article-title":"The GALAD scoring algorithm based on AFP, AFP-L3, and DCP significantly improves detection of BCLC early stage hepatocellular carcinoma","volume":"54","author":"Best","year":"2016","journal-title":"Z Gastroenterol"},{"key":"10.1016\/j.jhepr.2026.101826_bib44","doi-asserted-by":"crossref","DOI":"10.1177\/17562848241276334","article-title":"Modernizing metabolic dysfunction-associated steatotic liver disease diagnostics: the progressive shift from liver biopsy to noninvasive techniques","volume":"17","author":"Hudson","year":"2024","journal-title":"Therap Adv Gastroenterol"},{"key":"10.1016\/j.jhepr.2026.101826_bib45","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/cld.740","article-title":"Con: liver biopsy remains the gold standard to evaluate fibrosis in patients with nonalcoholic fatty liver disease","volume":"13","author":"Berger","year":"2019","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.jhepr.2026.101826_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2020.109404","article-title":"Diagnostic performance of LI-RADS for MRI and CT detection of HCC: a systematic review and diagnostic meta-analysis","volume":"134","author":"Liang","year":"2021","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.jhepr.2026.101826_bib47","article-title":"Diagnostic performance of LI-RADS version 2018 for primary liver cancer in patients with liver cirrhosis on enhanced MRI","volume":"12","author":"Liu","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.jhepr.2026.101826_bib48","doi-asserted-by":"crossref","first-page":"949","DOI":"10.3390\/jcm12030949","article-title":"The performance of GALAD score for diagnosing hepatocellular carcinoma in patients with chronic liver diseases: a systematic review and meta-analysis","volume":"12","author":"Guan","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.jhepr.2026.101826_bib49","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-07765-1","article-title":"The role of GALAD score in the surveillance of hepatocellular carcinoma","volume":"15","author":"Istemihan","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhepr.2026.101826_bib50","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ymthe.2016.10.009","article-title":"Disruption of circulating extracellular vesicles as a novel therapeutic strategy against cancer metastasis","volume":"25","author":"Nishida-Aoki","year":"2017","journal-title":"Mol Ther"},{"key":"10.1016\/j.jhepr.2026.101826_bib51","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1091\/mbc.e12-09-0642","article-title":"CD81 regulates cell migration through its association with Rac GTPase","volume":"24","author":"Tejera","year":"2013","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jhepr.2026.101826_bib52","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41392-024-01735-1","article-title":"Extracellular vesicles as tools and targets in therapy for diseases","volume":"9","author":"Kumar","year":"2024","journal-title":"Signal Transduction Targeted Ther"},{"key":"10.1016\/j.jhepr.2026.101826_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116043","article-title":"Improving cancer immunotherapy by preventing cancer stem cell and immune cell linking in the tumor microenvironment","volume":"170","author":"Li","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jhepr.2026.101826_bib54","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1002\/hep.30289","article-title":"Intrahepatic cholangiocarcinoma: continuing challenges and translational advances","volume":"69","author":"Sirica","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101826_bib55","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1002\/hep.32007","article-title":"Comparison of clinical features and outcomes between intrahepatic cholangiocarcinoma and hepatocellular carcinoma in the United States","volume":"74","author":"Lee","year":"2021","journal-title":"Hepatology"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926000972?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926000972?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:24:48Z","timestamp":1783632288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555926000972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2589555926000972"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101826","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AI-guided additive scoring model for differential diagnosis of primary liver cancer","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101826","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"101826"}}