{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:15:20Z","timestamp":1783584920351,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2024B03J1231"],"award-info":[{"award-number":["2024B03J1231"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016691","name":"Guangdong Provincial Pearl River Talents Program","doi-asserted-by":"publisher","award":["2023QN10Y328"],"award-info":[{"award-number":["2023QN10Y328"]}],"id":[{"id":"10.13039\/100016691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016691","name":"Guangdong Provincial Pearl River Talents Program","doi-asserted-by":"publisher","award":["2022YFA1105403"],"award-info":[{"award-number":["2022YFA1105403"]}],"id":[{"id":"10.13039\/100016691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016691","name":"Guangdong Provincial Pearl River Talents Program","doi-asserted-by":"publisher","award":["U23A20172"],"award-info":[{"award-number":["U23A20172"]}],"id":[{"id":"10.13039\/100016691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470891"],"award-info":[{"award-number":["32470891"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515012439"],"award-info":[{"award-number":["2024A1515012439"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3404305"],"award-info":[{"award-number":["2023YFC3404305"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFF0710601"],"award-info":[{"award-number":["2022YFF0710601"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["STS-HP-202204"],"award-info":[{"award-number":["STS-HP-202204"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jhepr.2026.101864","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T15:30:57Z","timestamp":1776526257000},"page":"101864","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of liver failure utilizing multi-cell lineage liver microtissue"],"prefix":"10.1016","volume":"8","author":[{"given":"Mengqi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafeng","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar Deep","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8446-8193","authenticated-orcid":false,"given":"Qinggong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangxue","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangqi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4517-5572","authenticated-orcid":false,"given":"Zhen","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2026.101864_bib1","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1056\/NEJMra1208937","article-title":"Acute liver failure","volume":"369","author":"Bernal","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhepr.2026.101864_bib2","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jhep.2019.12.002","article-title":"Alginate microencapsulated human hepatocytes for the treatment of acute liver failure in children","volume":"72","author":"Dhawan","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101864_bib3","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.stem.2024.02.005","article-title":"Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure","volume":"31","author":"Yuan","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jhepr.2026.101864_bib4","article-title":"Rapid self-assembly mini-livers protect mice against severe hepatectomy-induced liver failure","volume":"11","author":"Luo","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.jhepr.2026.101864_bib5","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1136\/gutjnl-2019-319960","article-title":"Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure","volume":"70","author":"Yang","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2026.101864_bib6","doi-asserted-by":"crossref","first-page":"eado1550","DOI":"10.1126\/sciadv.ado1550","article-title":"Revitalizing liver function in mice with liver failure through transplantation of 3D-bioprinted liver with expanded primary hepatocytes","volume":"10","author":"Deng","year":"2024","journal-title":"Sci Adv"},{"key":"10.1016\/j.jhepr.2026.101864_bib7","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1136\/gutjnl-2024-333885","article-title":"Bioprinting functional hepatocyte organoids derived from human chemically induced pluripotent stem cells to treat liver failure","volume":"74","author":"Li","year":"2025","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2026.101864_bib8","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/s41586-025-08677-w","article-title":"Hepatic stellate cells control liver zonation, size and functions via R-spondin 3","volume":"640","author":"Sugimoto","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.jhepr.2026.101864_bib9","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/s41586-025-08778-6","article-title":"Macrophages harness hepatocyte glutamate to boost liver regeneration","volume":"641","author":"Rigual","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.jhepr.2026.101864_bib10","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1126\/science.1244880","article-title":"Endothelial cell-derived angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat","volume":"343","author":"Hu","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.jhepr.2026.101864_bib11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00204-012-0968-2","article-title":"Multi-cell type human liver microtissues for hepatotoxicity testing","volume":"87","author":"Messner","year":"2013","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jhepr.2026.101864_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040964","article-title":"Human liver spheroids as a model to study aetiology and treatment of hepatic fibrosis","volume":"9","author":"Hurrell","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jhepr.2026.101864_bib13","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.3727\/096368909X474258","article-title":"E-cadherin protects primary hepatocyte spheroids from cell death by a caspase-independent mechanism","volume":"18","author":"Luebke-Wheeler","year":"2009","journal-title":"Cell Transpl"},{"key":"10.1016\/j.jhepr.2026.101864_bib14","doi-asserted-by":"crossref","first-page":"eado9880","DOI":"10.1126\/sciadv.ado9880","article-title":"Designer cellular spheroids with DNA origami for drug screening","volume":"10","author":"Wei","year":"2024","journal-title":"Sci Adv"},{"key":"10.1016\/j.jhepr.2026.101864_bib15","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1136\/gutjnl-2019-318812","article-title":"Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells","volume":"69","author":"Dai","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2026.101864_bib16","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1097\/HEP.0000000000000900","article-title":"Vascular damage and excessive proliferation compromise liver function after extended hepatectomy in mice","volume":"81","author":"De Rudder","year":"2025","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101864_bib17","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nnano.2011.187","article-title":"Challenges and opportunities for structural DNA nanotechnology","volume":"6","author":"Pinheiro","year":"2011","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.jhepr.2026.101864_bib18","doi-asserted-by":"crossref","first-page":"12080","DOI":"10.1021\/acs.nanolett.4c02695","article-title":"Recycling materials for sustainable DNA origami manufacturing","volume":"24","author":"Neuhoff","year":"2024","journal-title":"Nano Lett"},{"key":"10.1016\/j.jhepr.2026.101864_bib19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.yexcr.2016.01.012","article-title":"Vitamin A and insulin are required for the maintenance of hepatic stellate cell quiescence","volume":"341","author":"Yoneda","year":"2016","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jhepr.2026.101864_bib20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1476-5926-7-4","article-title":"The influence of oxygen tension on the structure and function of isolated liver sinusoidal endothelial cells","volume":"7","author":"Martinez","year":"2008","journal-title":"Comp Hepatol"},{"key":"10.1016\/j.jhepr.2026.101864_bib21","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/hep.23085","article-title":"Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro","volume":"50","author":"March","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101864_bib22","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/hep.23354","article-title":"Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells","volume":"51","author":"Si-Tayeb","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101864_bib23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.stem.2018.05.027","article-title":"Generation of hepatic stellate cells from human pluripotent stem cells enables in vitro modeling of liver fibrosis","volume":"23","author":"Coll","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jhepr.2026.101864_bib24","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.biomaterials.2018.11.016","article-title":"Generation of mature kupffer cells from human induced pluripotent stem cells","volume":"192","author":"Tasnim","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.jhepr.2026.101864_bib25","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.stem.2020.06.007","article-title":"Generation of functional liver sinusoidal endothelial cells from human pluripotent stem-cell-derived venous angioblasts","volume":"27","author":"Gage","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jhepr.2026.101864_bib26","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/lt.20073","article-title":"Porcine partial liver transplantation: a novel model of the \"small-for-size\" liver graft","volume":"10","author":"Kelly","year":"2004","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jhepr.2026.101864_bib27","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1097\/00000478-200608000-00009","article-title":"Pathophysiologic observations and histopathologic recognition of the portal hyperperfusion or small-for-size syndrome","volume":"30","author":"Demetris","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jhepr.2026.101864_bib28","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ajt.2022.10.003","article-title":"Normalization of lipid oxidation defects arising from hypoxia early posthepatectomy prevents liver failure in mouse","volume":"23","author":"Birrer","year":"2023","journal-title":"Am J Transpl"},{"key":"10.1016\/j.jhepr.2026.101864_bib29","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1111\/j.1600-6143.2010.03150.x","article-title":"Deceleration of regenerative response improves the outcome of rat with massive hepatectomy","volume":"10","author":"Ninomiya","year":"2010","journal-title":"Am J Transpl"},{"key":"10.1016\/j.jhepr.2026.101864_bib30","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1172\/JCI66369","article-title":"Hepatic stellate cells in liver development, regeneration, and cancer","volume":"123","author":"Yin","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhepr.2026.101864_bib31","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.7150\/ijbs.12118","article-title":"Defective initiation of liver regeneration in osteopontin-deficient mice after partial hepatectomy due to insufficient activation of IL-6\/Stat3 pathway","volume":"11","author":"Wen","year":"2015","journal-title":"Int J Biol Sci"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926001357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926001357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T07:28:56Z","timestamp":1783582136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555926001357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2589555926001357"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101864","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment of liver failure utilizing multi-cell lineage liver microtissue","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101864","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"101864"}}