{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:32:48Z","timestamp":1793151168413,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024370","name":"Ministero dell'Istruzione dell'Universita e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["CUP B53C22006120001"],"award-info":[{"award-number":["CUP B53C22006120001"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["CUP B93D21010860004"],"award-info":[{"award-number":["CUP B93D21010860004"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jhepr.2026.101903","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:55:09Z","timestamp":1779926109000},"page":"101903","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Spatial proteomics and cell-cell crosstalk analysis reveal PD-L1 and IL-6 interaction in human primary sclerosing cholangitis"],"prefix":"10.1016","volume":"8","author":[{"given":"Giulia","family":"Orlandi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3561-8903","authenticated-orcid":false,"given":"Diletta","family":"Overi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Di Tinco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7818-0003","authenticated-orcid":false,"given":"Alessandra","family":"Pisciotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Bertani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"De Biasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6339-6397","authenticated-orcid":false,"given":"Stefano","family":"Leone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Cardinale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Franchitto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selenia","family":"Miglietta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-8494","authenticated-orcid":false,"given":"Ludovica","family":"Ceci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7195-3760","authenticated-orcid":false,"given":"Paolo","family":"Onori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savino","family":"Paradiso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Franchitto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Alvaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8570-2519","authenticated-orcid":false,"given":"Guido","family":"Carpino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Gaudio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Carnevale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2026.101903_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41572-025-00600-x","article-title":"Primary sclerosing cholangitis","volume":"11","author":"Manns","year":"2025","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jhepr.2026.101903_bib2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/hep.30210","article-title":"Neoplastic transformation of the peribiliary stem cell niche in Cholangiocarcinoma arisen in primary Sclerosing Cholangitis","volume":"69","author":"Carpino","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101903_bib3","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.jhep.2015.06.018","article-title":"Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis","volume":"63","author":"Carpino","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101903_bib4","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/hep.30871","article-title":"Peribiliary gland niche participates in biliary tree regeneration in mouse and in human primary Sclerosing Cholangitis","volume":"71","author":"Carpino","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101903_bib5","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.bbadis.2017.06.017","article-title":"Mechanisms of cholangiocyte responses to injury","volume":"1864","author":"Sato","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jhepr.2026.101903_bib6","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/hep.28831","article-title":"Forkhead box A2 regulates biliary heterogeneity and senescence during cholestatic liver injury in micedouble dagger","volume":"65","author":"McDaniel","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101903_bib7","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jhep.2014.11.027","article-title":"Autophagy and senescence in fibrosing cholangiopathies","volume":"62","author":"Nakanuma","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101903_bib8","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1002\/hep.31110","article-title":"Genomic characterization of cholangiocarcinoma in primary sclerosing cholangitis reveals therapeutic opportunities","volume":"72","author":"Goeppert","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101903_bib9","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41575-019-0125-y","article-title":"Cholangiocyte pathobiology","volume":"16","author":"Banales","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.101903_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb3107","article-title":"A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells","volume":"13","author":"Zimmer","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jhepr.2026.101903_bib11","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.bbadis.2017.08.020","article-title":"Cholangiocytes in the pathogenesis of primary sclerosing cholangitis and development of cholangiocarcinoma","volume":"1864","author":"Chung","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jhepr.2026.101903_bib12","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.jhep.2014.06.016","article-title":"The Fas\/Fas ligand apoptosis pathway underlies immunomodulatory properties of human biliary tree stem\/progenitor cells","volume":"61","author":"Riccio","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101903_bib13","doi-asserted-by":"crossref","first-page":"30352","DOI":"10.1074\/jbc.M111.269464","article-title":"Cholangiocyte N-Ras protein mediates lipopolysaccharide-induced interleukin 6 secretion and proliferation","volume":"286","author":"O'Hara","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhepr.2026.101903_bib14","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1056\/NEJMra1506330","article-title":"Primary Sclerosing Cholangitis","volume":"375","author":"Lazaridis","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhepr.2026.101903_bib15","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1016\/j.ymthe.2024.09.026","article-title":"PD-L1: from cancer immunotherapy to therapeutic implications in multiple disorders","volume":"32","author":"Lee","year":"2024","journal-title":"Mol Ther"},{"key":"10.1016\/j.jhepr.2026.101903_bib16","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/HEP.0000000000001425","article-title":"Refinement of histologic subtypes and identification of biomarkers linked to unfavorable prognosis in cholangiocarcinoma: the ENSCCA registries\u2019 framework for digital twin advancement","volume":"83","author":"Carpino","year":"2026","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101903_bib17","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1186\/s13287-021-02664-4","article-title":"Role of PD-L1 in licensing immunoregulatory function of dental pulp mesenchymal stem cells","volume":"12","author":"Di Tinco","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jhepr.2026.101903_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13287-023-03254-2","article-title":"Flow-dependent shear stress affects the biological properties of pericyte-like cells isolated from human dental pulp","volume":"14","author":"Bertani","year":"2023","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jhepr.2026.101903_bib19","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/s41467-022-28803-w","article-title":"Fully-automated and ultra-fast cell-type identification using specific marker combinations from single-cell transcriptomic data","volume":"13","author":"Ianevski","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2026.101903_bib20","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.immuni.2021.01.012","article-title":"Chemokines and the immune response to cancer","volume":"54","author":"Ozga","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.jhepr.2026.101903_bib21","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41577-023-00856-y","article-title":"Targeting IL-6 trans-signalling: past, present and future prospects","volume":"23","author":"Rose-John","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jhepr.2026.101903_bib22","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s13238-013-2084-3","article-title":"NF-kappaB and STAT3 signaling pathways collaboratively link inflammation to cancer","volume":"4","author":"Fan","year":"2013","journal-title":"Protein Cell"},{"key":"10.1016\/j.jhepr.2026.101903_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/cr.2010.183","article-title":"NF-kappaB and STAT3 - key players in liver inflammation and cancer","volume":"21","author":"He","year":"2011","journal-title":"Cell Res"},{"key":"10.1016\/j.jhepr.2026.101903_bib24","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.jhep.2014.02.006","article-title":"Characterization of animal models for primary sclerosing cholangitis (PSC)","volume":"60","author":"Fickert","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101903_bib25","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.jhep.2023.12.023","article-title":"Single-cell, single-nucleus, and spatial transcriptomics characterization of the immunological landscape in the healthy and PSC human liver","volume":"80","author":"Andrews","year":"2024","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101903_bib26","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1097\/HEP.0000000000001432","article-title":"Multimodal transcriptomics identifies metallothionein as a novel pathway in primary sclerosing cholangitis","volume":"83","author":"Chung","year":"2026","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101903_bib27","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ctrv.2017.11.007","article-title":"CXCL9, CXCL10, CXCL11\/CXCR3 axis for immune activation - a target for novel cancer therapy","volume":"63","author":"Tokunaga","year":"2018","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.jhepr.2026.101903_bib28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1600-065X.2010.00923.x","article-title":"The PD-1 pathway in tolerance and autoimmunity","volume":"236","author":"Francisco","year":"2010","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jhepr.2026.101903_bib29","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1084\/jem.20142237","article-title":"Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells","volume":"212","author":"Odorizzi","year":"2015","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhepr.2026.101903_bib30","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1089\/scd.2018.0033","article-title":"Immunosuppression of human adipose-derived stem cells on T cell subsets via the reduction of NF-kappaB activation mediated by PD-L1\/PD-1 and Gal-9\/TIM-3 pathways","volume":"27","author":"Zhou","year":"2018","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.jhepr.2026.101903_bib31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41577-025-01221-x","article-title":"Regulators of CD8(+) T cell exhaustion","volume":"26","author":"Sun","year":"2026","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jhepr.2026.101903_bib32","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.celrep.2017.04.031","article-title":"Interferon receptor signaling pathways regulating PD-L1 and PD-L2 expression","volume":"19","author":"Garcia-Diaz","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.jhepr.2026.101903_bib33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41577-019-0218-4","article-title":"Tumour-intrinsic resistance to immune checkpoint blockade","volume":"20","author":"Kalbasi","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jhepr.2026.101903_bib34","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000603","article-title":"IL-6-Dependent STAT3 activation and induction of proinflammatory cytokines in primary Sclerosing cholangitis","volume":"14","author":"Dold","year":"2023","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.jhepr.2026.101903_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.1248","article-title":"STAT activation in regulatory CD4(+) T cells of patients with primary sclerosing cholangitis","volume":"12","author":"Dold","year":"2024","journal-title":"Immun Inflamm Dis"},{"key":"10.1016\/j.jhepr.2026.101903_bib36","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1172\/JCI126022","article-title":"IL-6\/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion","volume":"129","author":"Chan","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhepr.2026.101903_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2026.1713704","article-title":"Immunomodulatory properties of human dental pulp stromal cells: the role of IL-6\/JAK\/STAT3 pathway and PD-L1","volume":"17","author":"Di Tinco","year":"2026","journal-title":"Front Immunol"},{"key":"10.1016\/j.jhepr.2026.101903_bib38","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/ng.3528","article-title":"Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci","volume":"48","author":"Ellinghaus","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.jhepr.2026.101903_bib39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cytogfr.2009.11.005","article-title":"Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer","volume":"21","author":"Grivennikov","year":"2010","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jhepr.2026.101903_bib40","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1126\/science.1062374","article-title":"Duration of nuclear NF-kappaB action regulated by reversible acetylation","volume":"293","author":"Chen","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.jhepr.2026.101903_bib41","doi-asserted-by":"crossref","first-page":"6539","DOI":"10.1093\/emboj\/cdf660","article-title":"Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB","volume":"21","author":"Chen","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.jhepr.2026.101903_bib42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41575-025-01153-w","article-title":"Cholangiocarcinoma 2026: status quo, unmet needs and priorities","volume":"23","author":"Banales","year":"2026","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.101903_bib43","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1158\/1078-0432.CCR-25-1834","article-title":"Clinicogenomic characterization of primary Sclerosing Cholangitis-associated biliary tract cancers","volume":"32","author":"Wang","year":"2026","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jhepr.2026.101903_bib44","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1038\/s41467-021-21928-4","article-title":"Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy","volume":"12","author":"De Biasi","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2026.101903_bib45","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jhep.2017.05.009","article-title":"norUrsodeoxycholic acid improves cholestasis in primary sclerosing cholangitis","volume":"67","author":"Fickert","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101903_bib46","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1136\/gutjnl-2024-333297","article-title":"24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting T(H)17 pathogenicity and transdifferentiation","volume":"74","author":"Zhu","year":"2025","journal-title":"Gut"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926001746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926001746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:41:11Z","timestamp":1793148071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555926001746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2589555926001746"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101903","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatial proteomics and cell-cell crosstalk analysis reveal PD-L1 and IL-6 interaction in human primary sclerosing cholangitis","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101903","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"101903"}}