{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:03:54Z","timestamp":1790114634312,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Independent Research Fund Denmark","doi-asserted-by":"publisher","award":["DFF-6110-00536"],"award-info":[{"award-number":["DFF-6110-00536"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011722","name":"Higher Education Funding Council for England","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NFF19OC0055039"],"award-info":[{"award-number":["NFF19OC0055039"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jhepr.2026.101922","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:20:30Z","timestamp":1780986030000},"page":"101922","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alpha 2A adrenergic receptor antagonism reduces fibrosis, inflammation and portal hypertension in models of chronic liver disease"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8118-4643","authenticated-orcid":false,"given":"Karen Louise","family":"Thomsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7882-1816","authenticated-orcid":false,"given":"Anne Catrine","family":"Daugaard Mikkelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1625-9204","authenticated-orcid":false,"given":"Nathan","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeba","family":"Habtesion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7469-9995","authenticated-orcid":false,"given":"Sara Ellegaard","family":"Paaske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1211-9298","authenticated-orcid":false,"given":"Jane","family":"Macnaughtan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8421-8814","authenticated-orcid":false,"given":"Maria Castanho","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Gallego-Dur\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8494-8947","authenticated-orcid":false,"given":"Manuel","family":"Romero-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Hamilton-Dutoit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9440-0571","authenticated-orcid":false,"given":"Krista","family":"Rombouts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7747-4015","authenticated-orcid":false,"given":"Rajiv","family":"Jalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6275-9384","authenticated-orcid":false,"given":"Rajeshwar Prosad","family":"Mookerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jhepr.2026.101922_bib1","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jhep.2014.05.047","article-title":"Vascular pathobiology in chronic liver disease and cirrhosis - current status and future directions","volume":"61","author":"Iwakiri","year":"2014","journal-title":"J Hepatol"},{"issue":"11","key":"10.1016\/j.jhepr.2026.101922_bib2","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1136\/gutjnl-2012-304038","article-title":"Carvedilol for primary prophylaxis of variceal bleeding in cirrhotic patients with haemodynamic non-response to propranolol","volume":"62","author":"Reiberger","year":"2013","journal-title":"Gut"},{"issue":"12","key":"10.1016\/j.jhepr.2026.101922_bib3","first-page":"1449","article-title":"Noncirrhotic human nonalcoholic fatty liver disease induces portal hypertension in relation to the histological degree of steatosis","volume":"22","author":"Francque","year":"2010","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.jhepr.2026.101922_bib4","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/hep.27368","article-title":"Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up","volume":"61","author":"Ekstedt","year":"2015","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.jhepr.2026.101922_bib5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41575-018-0097-3","article-title":"Hepatic microcirculation and mechanisms of portal hypertension","volume":"16","author":"Gracia-Sancho","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.jhepr.2026.101922_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004414","article-title":"Upregulation of phagocyte-derived catecholamines augments the acute inflammatory response","volume":"4","author":"Flierl","year":"2009","journal-title":"PloS one"},{"issue":"1","key":"10.1016\/j.jhepr.2026.101922_bib7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1053\/j.gastro.2007.10.055","article-title":"Relationship between activation of the sympathetic nervous system and renal blood flow autoregulation in cirrhosis","volume":"134","author":"Stadlbauer","year":"2008","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.jhepr.2026.101922_bib8","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/liv.12559","article-title":"Systemic inflammation is associated with increased intrahepatic resistance and mortality in alcohol-related acute-on-chronic liver failure","volume":"35","author":"Mehta","year":"2015","journal-title":"Liver Int"},{"issue":"8","key":"10.1016\/j.jhepr.2026.101922_bib9","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1136\/gutjnl-2022-328708","article-title":"Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET)","volume":"72","author":"Weiss","year":"2023","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.jhepr.2026.101922_bib10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0925-4439(01)00055-2","article-title":"The role of Kupffer cell alpha(2)-adrenoceptors in norepinephrine-induced TNF-alpha production","volume":"1537","author":"Zhou","year":"2001","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"10.1016\/j.jhepr.2026.101922_bib11","doi-asserted-by":"crossref","first-page":"G1274","DOI":"10.1152\/ajpgi.2000.279.6.G1274","article-title":"Gut-derived norepinephrine plays a critical role in producing hepatocellular dysfunction during early sepsis","volume":"279","author":"Yang","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"4","key":"10.1016\/j.jhepr.2026.101922_bib12","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1002\/hep.26429","article-title":"Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice","volume":"58","author":"Pradere","year":"2013","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.jhepr.2026.101922_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005504","article-title":"Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis","volume":"4","author":"Miksa","year":"2009","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.jhepr.2026.101922_bib14","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1124\/jpet.105.085944","article-title":"Two \"knockout\" mouse models demonstrate that aortic vasodilatation is mediated via alpha2a-adrenoceptors located on the endothelium","volume":"314","author":"Shafaroudi","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"10.1016\/j.jhepr.2026.101922_bib15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0306-3623(00)00051-3","article-title":"Role of the postsynaptic alpha(2)-adrenergic receptor subtypes in catecholamine-induced vasoconstriction","volume":"34","author":"Duka","year":"2000","journal-title":"Gen Pharmacol"},{"issue":"4","key":"10.1016\/j.jhepr.2026.101922_bib16","doi-asserted-by":"crossref","first-page":"G1014","DOI":"10.1152\/ajpgi.2001.281.4.G1014","article-title":"Norepinephrine-induced hepatocellular dysfunction in early sepsis is mediated by activation of alpha2-adrenoceptors","volume":"281","author":"Yang","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"3","key":"10.1016\/j.jhepr.2026.101922_bib17","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1136\/gut.2003.026658","article-title":"Hepatic fibrogenesis requires sympathetic neurotransmitters","volume":"53","author":"Oben","year":"2004","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.jhepr.2026.101922_bib18","doi-asserted-by":"crossref","first-page":"454","DOI":"10.2174\/1874467214666210412144416","article-title":"Thioacetamide-induced norepinephrine production by hepatocytes is associated with hepatic stellate cell activation and liver fibrosis","volume":"15","author":"Tang","year":"2022","journal-title":"Curr Mol Pharmacol"},{"issue":"9","key":"10.1016\/j.jhepr.2026.101922_bib19","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1017\/S1461145709991088","article-title":"Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism","volume":"13","author":"Dwyer","year":"2010","journal-title":"Int J Neuropsychopharmacol"},{"issue":"257","key":"10.1016\/j.jhepr.2026.101922_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009934","article-title":"Genotype-based treatment of type 2 diabetes with an alpha2A-adrenergic receptor antagonist","volume":"6","author":"Tang","year":"2014","journal-title":"Sci translational Med"},{"issue":"1","key":"10.1016\/j.jhepr.2026.101922_bib21","first-page":"15","article-title":"[Chronology of portal hypertension, decreased sodium excretion, and activation of the renin-angiotensin system in experimental biliary cirrhosis]","volume":"49","author":"Poo","year":"1997","journal-title":"Rev Invest Clin"},{"issue":"3","key":"10.1016\/j.jhepr.2026.101922_bib22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00109-009-0555-z","article-title":"Antagonism of alpha2A-adrenoceptor: a novel approach to inhibit inflammatory responses in sepsis","volume":"88","author":"Zhang","year":"2010","journal-title":"J Mol Med (Berlin, Germany)"},{"issue":"5","key":"10.1016\/j.jhepr.2026.101922_bib23","article-title":"Yohimbine promotes cardiac NE release and prevents LPS-induced cardiac dysfunction via blockade of presynaptic alpha2A-adrenergic receptor","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS ONE"},{"issue":"3","key":"10.1016\/j.jhepr.2026.101922_bib24","doi-asserted-by":"crossref","first-page":"G295","DOI":"10.1152\/ajpgi.00036.2014","article-title":"Experimental nonalcoholic steatohepatitis compromises ureagenesis, an essential hepatic metabolic function","volume":"307","author":"Thomsen","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"6","key":"10.1016\/j.jhepr.2026.101922_bib25","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.jhep.2024.01.032","article-title":"Exploring the impact of the PNPLA3 I148M variant on primary human hepatic stellate cells using 3D extracellular matrix models","volume":"80","author":"Caon","year":"2024","journal-title":"J Hepatol"},{"issue":"2","key":"10.1016\/j.jhepr.2026.101922_bib26","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nprot.2015.017","article-title":"High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers","volume":"10","author":"Mederacke","year":"2015","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jhepr.2026.101922_bib27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-1-4939-3170-5_17","article-title":"Determination and characterization of tetraspanin-associated phosphoinositide-4 kinases in primary and neoplastic liver cells","volume":"1376","author":"Rombouts","year":"2016","journal-title":"Methods Mol Biol"},{"issue":"6","key":"10.1016\/j.jhepr.2026.101922_bib28","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.jhepr.2026.101922_bib29","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.jhep.2015.11.019","article-title":"Ammonia produces pathological changes in human hepatic stellate cells and is a target for therapy of portal hypertension","volume":"64","author":"Jalan","year":"2016","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.jhepr.2026.101922_bib30","article-title":"Post-transcriptional regulation of hepatic DDAH1 with TNF blockade leads to improved eNOS function and reduced portal pressure in cirrhotic rats","volume":"7","author":"Balasubramanian","year":"2017","journal-title":"Scientific Rep"},{"issue":"4","key":"10.1016\/j.jhepr.2026.101922_bib31","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.jhep.2011.01.034","article-title":"Beta-blockers cause paracentesis-induced circulatory dysfunction in patients with cirrhosis and refractory ascites: a cross-over study","volume":"55","author":"Serste","year":"2011","journal-title":"J Hepatol"},{"issue":"10","key":"10.1016\/j.jhepr.2026.101922_bib32","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1136\/gut.25.10.1034","article-title":"Splanchnic and renal elimination and release of catecholamines in cirrhosis. Evidence of enhanced sympathetic nervous activity in patients with decompensated cirrhosis","volume":"25","author":"Henriksen","year":"1984","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.jhepr.2026.101922_bib33","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0168-8278(88)80053-9","article-title":"Plasma catecholamine level and portal venous pressure as guides to prognosis in patients with cirrhosis","volume":"6","author":"Tage-Jensen","year":"1988","journal-title":"J Hepatol"},{"issue":"2","key":"10.1016\/j.jhepr.2026.101922_bib34","first-page":"170","article-title":"Acute-on-chronic liver failure: the liver and portal haemodynamics","volume":"17","author":"Mookerjee","year":"2011","journal-title":"Curr Opin Crit Care"},{"issue":"3","key":"10.1016\/j.jhepr.2026.101922_bib35","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.cld.2006.08.017","article-title":"Hepatic fibrosis, stellate cells, and portal hypertension","volume":"10","author":"Rockey","year":"2006","journal-title":"Clin Liver Dis"},{"issue":"3","key":"10.1016\/j.jhepr.2026.101922_bib36","doi-asserted-by":"crossref","first-page":"G652","DOI":"10.1152\/ajpgi.00143.2003","article-title":"Influence of caveolin on constitutively activated recombinant eNOS: insights into eNOS dysfunction in BDL rat liver","volume":"285","author":"Hendrickson","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"10.1016\/j.jhepr.2026.101922_bib37","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/hep.21491","article-title":"Increasing dimethylarginine levels are associated with adverse clinical outcome in severe alcoholic hepatitis","volume":"45","author":"Mookerjee","year":"2007","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.jhepr.2026.101922_bib38","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1136\/gut.52.8.1182","article-title":"Tumour necrosis factor alpha is an important mediator of portal and systemic haemodynamic derangements in alcoholic hepatitis","volume":"52","author":"Mookerjee","year":"2003","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.jhepr.2026.101922_bib39","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/lt.21053","article-title":"Inflammation is an important determinant of levels of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) in acute liver failure","volume":"13","author":"Mookerjee","year":"2007","journal-title":"Liver Transpl"},{"issue":"Suppl 1","key":"10.1016\/j.jhepr.2026.101922_bib40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12072-017-9826-x","article-title":"Biology of portal hypertension","volume":"12","author":"McConnell","year":"2018","journal-title":"Hepatol Int"},{"issue":"6","key":"10.1016\/j.jhepr.2026.101922_bib41","doi-asserted-by":"crossref","first-page":"400","DOI":"10.21037\/atm.2020.02.184","article-title":"The cellular pathways of liver fibrosis in non-alcoholic steatohepatitis","volume":"8","author":"Mendez-Sanchez","year":"2020","journal-title":"Ann Transl Med"},{"issue":"6","key":"10.1016\/j.jhepr.2026.101922_bib42","first-page":"344","article-title":"Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology","volume":"3","author":"Weiskirchen","year":"2014","journal-title":"Hepatobiliary Surg Nutr"},{"issue":"11","key":"10.1016\/j.jhepr.2026.101922_bib43","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/aps.2014.84","article-title":"Selective alpha1B- and alpha1D-adrenoceptor antagonists suppress noradrenaline-induced activation, proliferation and ECM secretion of rat hepatic stellate cells in vitro","volume":"35","author":"Liu","year":"2014","journal-title":"Acta Pharmacol Sin"},{"issue":"2","key":"10.1016\/j.jhepr.2026.101922_bib44","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1053\/jhep.2002.31166","article-title":"Inhibition of rat liver fibrogenesis through noradrenergic antagonism","volume":"35","author":"Dubuisson","year":"2002","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.jhepr.2026.101922_bib45","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1139\/Y10-013","article-title":"Functional linkage as a direction for studies in oxidative stress: alpha-adrenergic receptors","volume":"88","author":"Ziolkowski","year":"2010","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.jhepr.2026.101922_bib46","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3389\/fnins.2017.00243","article-title":"Effects of alpha2A adrenoceptors on norepinephrine secretion from the locus coeruleus during chronic stress-induced depression","volume":"11","author":"Wang","year":"2017","journal-title":"Front Neurosci"},{"issue":"6","key":"10.1016\/j.jhepr.2026.101922_bib47","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jhep.2017.02.026","article-title":"Targeting hepatic macrophages to treat liver diseases","volume":"66","author":"Tacke","year":"2017","journal-title":"J Hepatol"},{"issue":"5","key":"10.1016\/j.jhepr.2026.101922_bib48","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.jhep.2011.02.021","article-title":"The role of liver biopsy in the diagnosis and prognosis of patients with acute deterioration of alcoholic cirrhosis","volume":"55","author":"Mookerjee","year":"2011","journal-title":"J Hepatol"},{"issue":"6","key":"10.1016\/j.jhepr.2026.101922_bib49","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/hep.510300613","article-title":"Autonomic dysfunction and hyperdynamic circulation in cirrhosis with ascites","volume":"30","author":"Trevisani","year":"1999","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.jhepr.2026.101922_bib50","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.drudis.2017.06.007","article-title":"Mouse models of nonalcoholic steatohepatitis in preclinical drug development","volume":"22","author":"Hansen","year":"2017","journal-title":"Drug Discov Today"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258955592600193X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258955592600193X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:20:37Z","timestamp":1790112037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S258955592600193X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S258955592600193X"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101922","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alpha 2A adrenergic receptor antagonism reduces fibrosis, inflammation and portal hypertension in models of chronic liver disease","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101922","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"101922"}}