{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:04:15Z","timestamp":1790114655738,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jhepr.2026.101932","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T15:55:25Z","timestamp":1781884525000},"page":"101932","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Alcohol intake reprograms hepatic immune-metabolic circuits to exacerbate murine atherosclerosis and human cardiovascular risk"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1842-5069","authenticated-orcid":false,"given":"Constanze","family":"Hoebinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0411-166X","authenticated-orcid":false,"given":"Georg","family":"Semmler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr","family":"Petrenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-8878","authenticated-orcid":false,"given":"Dragana","family":"Rajcic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1290-8310","authenticated-orcid":false,"given":"Dorothea Katharina","family":"Hoffelner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"Duckova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9248-4097","authenticated-orcid":false,"given":"Taras","family":"Baranovskyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Goederle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"My Phung","family":"Khuu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Paeslack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0696-2636","authenticated-orcid":false,"given":"Christoph","family":"Reinhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7344-302X","authenticated-orcid":false,"given":"Petra","family":"Pjevac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"S\u00e9neca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2996-5861","authenticated-orcid":false,"given":"Kamil","family":"Mieczkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Burger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3356-4115","authenticated-orcid":false,"given":"Ina","family":"Bergheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Gensluckner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"V\u00f6lkerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Reiberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Scheiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar","family":"Aigner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Wernly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7838-4532","authenticated-orcid":false,"given":"Christian","family":"Datz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph J.","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3381-2107","authenticated-orcid":false,"given":"Tim","family":"Hendrikx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2026.101932_bib1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(24)01811-7","article-title":"Steatotic liver disease","volume":"404","author":"Israelsen","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jhepr.2026.101932_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2025.09.008","article-title":"Prevalence of fibrosis and applicability of lab-based noninvasive tests from primary to tertiary care","author":"Semmler","year":"2025","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.101932_bib3","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101932_bib4","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S2468-1253(23)00443-0","article-title":"Validation of the new nomenclature of steatotic liver disease in patients with a history of excessive alcohol intake: an analysis of data from a prospective cohort study","volume":"9","author":"Israelsen","year":"2024","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.101932_bib5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00508-025-02617-4","article-title":"Austrian multisociety consensus on metabolic dysfunction-associated steatotic liver disease : Austrian Society of Gastroenterology and Hepatology (\u00d6GGH), Austrian Society of Diabetology (\u00d6DG), Austrian Society of Obesity (\u00d6AG)","volume":"137","author":"Mandorfer","year":"2025","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.jhepr.2026.101932_bib6","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.cgh.2018.11.033","article-title":"Effects of alcohol consumption and metabolic syndrome on mortality in patients with nonalcoholic and alcohol-related fatty liver disease","volume":"17","author":"Younossi","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.101932_bib7","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.jhep.2024.06.036","article-title":"Low-to-moderate alcohol consumption is associated with increased fibrosis in individuals with metabolic dysfunction-associated steatotic liver disease","volume":"81","author":"Marti-Aguado","year":"2024","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101932_bib8","series-title":"One in twelve adults in the EU consumes alcohol every day","year":"2021"},{"key":"10.1016\/j.jhepr.2026.101932_bib9","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3350\/cmh.2022.0239","article-title":"Forecasted 2040 global prevalence of nonalcoholic fatty liver disease using hierarchical bayesian approach","volume":"28","author":"Le","year":"2022","journal-title":"Clin Mol Hepatol"},{"key":"10.1016\/j.jhepr.2026.101932_bib10","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jhep.2024.11.028","article-title":"Metabolic dysfunction and alcohol-related liver disease (MetALD): position statement by an expert panel on alcohol-related liver disease","volume":"82","author":"Arab","year":"2025","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101932_bib11","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.3849","article-title":"Association of habitual alcohol intake with risk of cardiovascular disease","volume":"5","author":"Biddinger","year":"2022","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jhepr.2026.101932_bib12","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1136\/gutjnl-2023-330595","article-title":"MASLD: a systemic metabolic disorder with cardiovascular and malignant complications","volume":"73","author":"Targher","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2026.101932_bib13","doi-asserted-by":"crossref","first-page":"116","DOI":"10.14348\/molcells.2021.2147","article-title":"Increased hepatic lipogenesis elevates liver cholesterol content","volume":"44","author":"Berger","year":"2021","journal-title":"Mol Cells"},{"key":"10.1016\/j.jhepr.2026.101932_bib14","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1089\/met.2019.0115","article-title":"High-risk atherosclerosis and metabolic phenotype: the roles of ectopic adiposity, atherogenic dyslipidemia, and inflammation","volume":"18","author":"Lechner","year":"2020","journal-title":"Metab Syndr Relat Disord"},{"key":"10.1016\/j.jhepr.2026.101932_bib15","article-title":"Comprehensive lipidomics reveals phenotypic differences in hepatic lipid turnover in ALD and NAFLD during alcohol intoxication","volume":"3","author":"Israelsen","year":"2021","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhepr.2026.101932_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1148827","article-title":"Chronic-binge ethanol feeding aggravates systemic dyslipidemia in Ldlr(-\/-) mice, thereby accelerating hepatic fibrosis","volume":"14","author":"Hoebinger","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jhepr.2026.101932_bib17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11883-022-00992-1","article-title":"Alcohol consumption and cardiovascular disease risk: placing new data in context","volume":"24","author":"Hoek","year":"2022","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.jhepr.2026.101932_bib18","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1136\/gutjnl-2023-331003","article-title":"Metabolic dysfunction-associated steatotic liver disease and risk of cardiovascular disease","volume":"73","author":"Lee","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2026.101932_bib19","article-title":"Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice","author":"Hendrikx","year":"2023721959","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2026.101932_bib20","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12872-017-0507-4","article-title":"Monocyte\/lymphocyte ratio predicts the severity of coronary artery disease: a syntax score assessment","volume":"17","author":"Ji","year":"2017","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.jhepr.2026.101932_bib21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrcardio.2016.183","article-title":"Role of gut microbiota in atherosclerosis","volume":"14","author":"Jonsson","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jhepr.2026.101932_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpg.2024.101923","article-title":"The microbiome-driven impact of western diet in the development of noncommunicable chronic disorders","volume":"72","author":"Severino","year":"2024","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.jhepr.2026.101932_bib23","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.jhep.2019.08.005","article-title":"Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development","volume":"71","author":"Mouries","year":"2019","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101932_bib24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41575-018-0099-1","article-title":"Alcohol, liver disease and the gut microbiota","volume":"16","author":"Bajaj","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.101932_bib25","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41579-023-00904-3","article-title":"The gut-liver axis and gut microbiota in health and liver disease","volume":"21","author":"Hsu","year":"2023","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jhepr.2026.101932_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1927633","article-title":"Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis","volume":"13","author":"Rao","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jhepr.2026.101932_bib27","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1161\/CIRCULATIONAHA.115.019645","article-title":"Akkermansia muciniphila protects against atherosclerosis by preventing metabolic endotoxemia-induced inflammation in Apoe-\/- mice","volume":"133","author":"Li","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jhepr.2026.101932_bib28","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1136\/ard.2010.129429","article-title":"Serum urate and its relationship with alcoholic beverage intake in men and women: findings from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort","volume":"69","author":"Gaffo","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jhepr.2026.101932_bib29","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.jhep.2015.11.022","article-title":"Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism","volume":"64","author":"Wan","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101932_bib30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijcard.2018.03.045","article-title":"Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: a five-year cohort study in Japan","volume":"261","author":"Kuwabara","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jhepr.2026.101932_bib31","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1161\/ATVBAHA.119.313224","article-title":"Soluble uric acid promotes atherosclerosis via AMPK (AMP-Activated protein kinase)-mediated inflammation","volume":"40","author":"Kimura","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jhepr.2026.101932_bib32","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1161\/CIRCULATIONAHA.124.070535","article-title":"Cardiovascular-liver-metabolic health: recommendations in screening, diagnosis, and management of metabolic dysfunction-associated steatotic liver disease in cardiovascular disease via modified delphi approach","volume":"151","author":"Chew","year":"2025","journal-title":"Circulation"},{"key":"10.1016\/j.jhepr.2026.101932_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.102292","article-title":"Metabolic dysfunction-associated steatotic liver disease increases the risk of incident cardiovascular disease: a nationwide cohort study","volume":"65","author":"Moon","year":"2023","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.jhepr.2026.101932_bib34","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s42255-024-01043-6","article-title":"An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)","volume":"6","author":"Vacca","year":"2024","journal-title":"Nat Metab"},{"key":"10.1016\/j.jhepr.2026.101932_bib35","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000450","article-title":"A novel experimental model of MetALD in male mice recapitulates key features of severe alcohol-associated hepatitis","volume":"8","author":"Babuta","year":"2024","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhepr.2026.101932_bib36","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1161\/CIRCRESAHA.122.320263","article-title":"Animal models of atherosclerosis-supportive notes and tricks of the trade","volume":"130","author":"Gister\u00e5","year":"2022","journal-title":"Circ Res"},{"key":"10.1016\/j.jhepr.2026.101932_bib37","doi-asserted-by":"crossref","first-page":"908","DOI":"10.5551\/jat.32672","article-title":"Analysis of gut microbiota in coronary artery disease patients: a possible link between gut microbiota and coronary artery disease","volume":"23","author":"Emoto","year":"2016","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.jhepr.2026.101932_bib38","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41577-021-00584-1","article-title":"How the immune system shapes atherosclerosis: roles of innate and adaptive immunity","volume":"22","author":"Roy","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jhepr.2026.101932_bib39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrcardio.2009.228","article-title":"Monocytes in atherosclerosis: subsets and functions","volume":"7","author":"Woollard","year":"2010","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jhepr.2026.101932_bib40","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.pharmthera.2016.12.004","article-title":"Allopurinol as a therapeutic option in cardiovascular disease","volume":"172","author":"Okafor","year":"2017","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jhepr.2026.101932_bib41","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/eurjpc\/zwab154","article-title":"2021 ESC Guidelines on cardiovascular disease prevention in clinical practice","volume":"29","author":"Visseren","year":"2022","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jhepr.2026.101932_bib42","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1093\/eurheartj\/ehab309","article-title":"SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe","volume":"42","author":"collaboration","year":"2021","journal-title":"Eur Heart J"}],"updated-by":[{"DOI":"10.1016\/j.jhepr.2026.102001","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000}}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258955592600203X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258955592600203X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:17:56Z","timestamp":1790111876000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S258955592600203X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S258955592600203X"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101932","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alcohol intake reprograms hepatic immune-metabolic circuits to exacerbate murine atherosclerosis and human cardiovascular risk","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101932","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"101932"}}