{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:50:48Z","timestamp":1791247848373,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017618","name":"National Institute of Diabetes and Digestive and Kidney Diseases Division of Diabetes Endocrinology and Metabolic Diseases","doi-asserted-by":"publisher","award":["U-01 58369"],"award-info":[{"award-number":["U-01 58369"]}],"id":[{"id":"10.13039\/100017618","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jhepr.2026.101962","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:26:19Z","timestamp":1785885979000},"page":"101962","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum receptor-interacting protein kinase 3 (RIPK3) is associated with transplant-free survival in acute liver failure"],"prefix":"10.1016","volume":"8","author":[{"given":"Gautam","family":"Mehta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugo","family":"Soffientini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime L.","family":"Speiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bahnassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Dara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Durkalski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine J.","family":"Karvellas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2026.101962_bib1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/0140-6736(93)91736-6","article-title":"Classification of acute liver failure","volume":"342","author":"O'Grady","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.jhepr.2026.101962_bib2","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1136\/bmj.313.7070.1417","article-title":"Reducing paracetamol overdoses","volume":"313","author":"Fagan","year":"1996","journal-title":"BMJ"},{"key":"10.1016\/j.jhepr.2026.101962_bib3","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/hep.20948","article-title":"Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study","volume":"42","author":"Larson","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101962_bib4","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0016-5085(89)90081-4","article-title":"Early indicators of prognosis in fulminant hepatic failure","volume":"97","author":"O'Grady","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2026.101962_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122929","article-title":"Predicting outcome on admission and post-admission for acetaminophen-induced acute liver failure using classification and regression tree models","volume":"10","author":"Speiser","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jhepr.2026.101962_bib6","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1053\/jhep.2002.35069","article-title":"Serum phosphate is an early predictor of outcome in severe acetaminophen-induced hepatotoxicity","volume":"36","author":"Schmidt","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101962_bib7","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/hep.21503","article-title":"MELD score as a predictor of liver failure and death in patients with acetaminophen-induced liver injury","volume":"45","author":"Schmidt","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101962_bib8","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0140-6736(02)07743-7","article-title":"Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study","volume":"359","author":"Bernal","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jhepr.2026.101962_bib9","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.cgh.2016.03.046","article-title":"Development of a model to predict transplant-free survival of patients with acute liver failure","volume":"14","author":"Koch","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.101962_bib10","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1478-3231.2010.02243.x","article-title":"Medical and psychiatric outcomes for patients transplanted for acetaminophen-induced acute liver failure: a case-control study","volume":"30","author":"Karvellas","year":"2010","journal-title":"Liver Int"},{"key":"10.1016\/j.jhepr.2026.101962_bib11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0140-6736(10)60274-7","article-title":"Acute liver failure","volume":"376","author":"Bernal","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jhepr.2026.101962_bib12","first-page":"246A","article-title":"Liver transplantation for acute liver failure: results from the NIH acute liver failure study group","volume":"56","author":"Reddy","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101962_bib13","first-page":"163","article-title":"Acute liver failure: clinical features, outcome analysis, and applicability of prognostic criteria","volume":"6","author":"Shakil","year":"2000","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jhepr.2026.101962_bib14","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/hep.24027","article-title":"Necrosis versus apoptosis in acetaminophen-induced hepatotoxicity","volume":"53","author":"Schulze-Osthoff","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101962_bib15","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/s41575-018-0065-y","article-title":"Apoptosis and necroptosis in the liver: a matter of life and death","volume":"15","author":"Schwabe","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.101962_bib16","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1007\/s00018-016-2203-4","article-title":"Necroptosis-independent signaling by the RIP kinases in inflammation","volume":"73","author":"Moriwaki","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jhepr.2026.101962_bib17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jhep.2012.10.002","article-title":"ARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis","volume":"58","author":"An","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101962_bib18","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/hep.26547","article-title":"Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice","volume":"58","author":"Ramachandran","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101962_bib19","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.4049\/jimmunol.1600690","article-title":"Knockdown of RIPK1 markedly exacerbates murine immune-mediated liver injury through massive apoptosis of hepatocytes, independent of necroptosis and inhibition of NF-kappaB","volume":"197","author":"Suda","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.jhepr.2026.101962_bib20","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1002\/hep.27939","article-title":"Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis","volume":"62","author":"Dara","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101962_bib21","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1172\/JCI87545","article-title":"The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis","volume":"126","author":"Gunther","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhepr.2026.101962_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/706156","article-title":"Protective effects of necrostatin-1 against concanavalin A-induced acute hepatic injury in mice","volume":"2013","author":"Zhou","year":"2013","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jhepr.2026.101962_bib23","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.celrep.2013.08.045","article-title":"Protective roles for caspase-8 and cFLIP in adult homeostasis","volume":"5","author":"Weinlich","year":"2013","journal-title":"Cell Rep"},{"key":"10.1016\/j.jhepr.2026.101962_bib24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jhepr.2026.101962_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14128","article-title":"Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic\/pyroptotic cell death","volume":"8","author":"Rogers","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2026.101962_bib26","doi-asserted-by":"crossref","first-page":"6527","DOI":"10.3748\/wjg.v25.i44.6527","article-title":"Gasdermin D-mediated hepatocyte pyroptosis expands inflammatory responses that aggravate acute liver failure by upregulating monocyte chemotactic protein 1\/CC chemokine receptor-2 to recruit macrophages","volume":"25","author":"Li","year":"2019","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhepr.2026.101962_bib27","first-page":"1148","article-title":"Gasdermin D inhibitor necrosulfonamide alleviates lipopolysaccharide\/D-galactosamine-induced acute liver failure in mice","volume":"10","author":"Wu","year":"2022","journal-title":"J Clin Transl Hepatol"},{"key":"10.1016\/j.jhepr.2026.101962_bib28","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.3748\/wjg.v30.i11.1588","article-title":"Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53\/glutathione peroxidase 4\/gasdermin D axis","volume":"30","author":"Zhou","year":"2024","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhepr.2026.101962_bib29","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3892\/mmr.2024.13185","article-title":"NLRP3 deficiency protects against acetaminophen-induced liver injury by inhibiting hepatocyte pyroptosis","volume":"29","author":"Yuan","year":"2024","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jhepr.2026.101962_bib30","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/s41418-024-01343-0","article-title":"GSDME promotes MASLD by regulating pyroptosis, Drp1 citrullination-dependent mitochondrial dynamic, and energy balance in intestine and liver","volume":"31","author":"Zhu","year":"2024","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jhepr.2026.101962_bib31","doi-asserted-by":"crossref","first-page":"724","DOI":"10.7326\/M15-2211","article-title":"Outcomes in adults with acute liver failure between 1998 and 2013: an observational cohort study","volume":"164","author":"Reuben","year":"2016","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jhepr.2026.101962_bib32","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/bmj.39335.541782.AD","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"335","author":"von","year":"2007","journal-title":"BMJ"},{"key":"10.1016\/j.jhepr.2026.101962_bib33","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1053\/jhep.2001.22172","article-title":"A model to predict survival in patients with end-stage liver disease","volume":"33","author":"Kamath","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101962_bib34","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.jhepr.2026.101962_bib35","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.3390\/biomedicines10102386","article-title":"Plasma mitochondrial DNA and necroptosis as prognostic indicators in critically ill patients with sepsis","volume":"10","author":"Choi","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.jhepr.2026.101962_bib36","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1165\/rcmb.2017-0393OC","article-title":"Microparticulate caspase 1 regulates gasdermin D and pulmonary vascular endothelial cell injury","volume":"59","author":"Mitra","year":"2018","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jhepr.2026.101962_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-41425-6","article-title":"Potential of circulating receptor-interacting protein kinase 3 levels as a marker of acute liver injury","volume":"13","author":"Kondo","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhepr.2026.101962_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.126","article-title":"Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury","volume":"6","author":"Deutsch","year":"2015","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jhepr.2026.101962_bib39","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/imr.12536","article-title":"RIPK3 in cell death and inflammation: the good, the bad, and the ugly","volume":"277","author":"Orozco","year":"2017","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jhepr.2026.101962_bib40","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/cdd.2016.46","article-title":"RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury","volume":"23","author":"Newton","year":"2016","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jhepr.2026.101962_bib41","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1055\/s-0038-1629924","article-title":"The receptor interacting protein kinases in the liver","volume":"38","author":"Dara","year":"2018","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhepr.2026.101962_bib42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molcel.2014.03.003","article-title":"Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3","volume":"54","author":"Wang","year":"2014","journal-title":"Mol Cell"},{"key":"10.1016\/j.jhepr.2026.101962_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.668459","article-title":"The lipopolysaccharide-sensing caspase(s)-4\/11 are activated in cirrhosis and are causally associated with progression to multi-organ injury","volume":"9","author":"Soffientini","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jhepr.2026.101962_bib44","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1002\/hep.29645","article-title":"Pyroptosis by caspase11\/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients","volume":"67","author":"Khanova","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101962_bib45","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jhep.2025.07.034","article-title":"Identification and validation of RIPK3 as a novel biomarker to predict outcomes in patients with acute decompensation of cirrhosis","volume":"84","author":"Verma","year":"2026","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101962_bib46","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/HEP.0000000000000868","article-title":"NK-cell-elicited gasdermin-D-dependent hepatocyte pyroptosis induces neutrophil extracellular traps that facilitate HBV-related acute-on-chronic liver failure","volume":"81","author":"Zhao","year":"2025","journal-title":"Hepatology"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926002338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926002338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:52:41Z","timestamp":1791244361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555926002338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2589555926002338"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101962","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum receptor-interacting protein kinase 3 (RIPK3) is associated with transplant-free survival in acute liver failure","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101962","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"101962"}}