{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:50:53Z","timestamp":1791247853557,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["BJCH2024GG02"],"award-info":[{"award-number":["BJCH2024GG02"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["Z230007"],"award-info":[{"award-number":["Z230007"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370684"],"award-info":[{"award-number":["32370684"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFC3410200"],"award-info":[{"award-number":["2025YFC3410200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016126","name":"Beijing Hospital Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016126","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jhepr.2026.101978","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:41:18Z","timestamp":1786549278000},"page":"101978","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome-scale CRISPR screening uncovers SRSF6 as a target to sensitize hepatocellular carcinoma to radiotherapy"],"prefix":"10.1016","volume":"8","author":[{"given":"Wenyi","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezuo","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueting","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minqi","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoran","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajing","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4969-398X","authenticated-orcid":false,"given":"Weihu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2026.101978_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jhepr.2026.101978_bib2","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0140-6736(25)01042-6","article-title":"The Lancet Commission on addressing the global hepatocellular carcinoma burden: comprehensive strategies from prevention to treatment","volume":"406","author":"Chan","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.jhepr.2026.101978_bib3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ejca.2021.11.023","article-title":"Global, regional and national burden of primary liver cancer by subtype","volume":"161","author":"Rumgay","year":"2022","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jhepr.2026.101978_bib4","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1001\/jamasurg.2022.4702","article-title":"Phase 2 evaluation of neoadjuvant intensity-modulated radiotherapy in centrally located hepatocellular carcinoma: a nonrandomized controlled trial","volume":"157","author":"Wu","year":"2022","journal-title":"JAMA Surg"},{"key":"10.1016\/j.jhepr.2026.101978_bib5","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1002\/hep.31993","article-title":"Phase 2 study of adjuvant radiotherapy following narrow-margin hepatectomy in patients with HCC","volume":"74","author":"Chen","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101978_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2022.109462","article-title":"Survival benefit of radiotherapy following narrow-margin hepatectomy in patients with hepatocellular carcinoma: a propensity score-matched analysis based on phase II study","volume":"180","author":"Long","year":"2023","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.jhepr.2026.101978_bib7","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1200\/JCO.2017.75.3228","article-title":"Radiofrequency ablation versus stereotactic body radiotherapy for localized hepatocellular carcinoma in nonsurgically managed patients: analysis of the National Cancer Database","volume":"36","author":"Rajyaguru","year":"2018","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jhepr.2026.101978_bib8","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1200\/JCO.2015.61.4925","article-title":"Outcomes after stereotactic body radiotherapy or radiofrequency ablation for hepatocellular carcinoma","volume":"34","author":"Wahl","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jhepr.2026.101978_bib9","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1200\/JCO.18.02184","article-title":"Neoadjuvant three-dimensional conformal radiotherapy for resectable hepatocellular carcinoma with portal vein tumor thrombus: a randomized, open-label, multicenter controlled study","volume":"37","author":"Wei","year":"2019","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jhepr.2026.101978_bib10","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12943-023-01801-2","article-title":"Molecular mechanisms of tumor resistance to radiotherapy","volume":"22","author":"Wu","year":"2023","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jhepr.2026.101978_bib11","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/s41392-025-02458-7","article-title":"KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma","volume":"10","author":"Wu","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jhepr.2026.101978_bib12","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1002\/hep.32615","article-title":"Methyltransferase 1 is required for nonhomologous end-joining repair and renders hepatocellular carcinoma resistant to radiotherapy","volume":"77","author":"Liao","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101978_bib13","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41418-024-01411-5","article-title":"Integrin \u03b26\/Annexin A2 axis triggers autophagy to orchestrate hepatocellular carcinoma radioresistance","volume":"32","author":"Gao","year":"2025","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jhepr.2026.101978_bib14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12943-024-02049-0","article-title":"Tumor cell-intrinsic MELK enhanced CCL2-dependent immunosuppression to exacerbate hepatocarcinogenesis and confer resistance of HCC to radiotherapy","volume":"23","author":"Tang","year":"2024","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jhepr.2026.101978_bib15","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.jhep.2022.01.009","article-title":"COMMD10 inhibits HIF1\u03b1\/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma","volume":"76","author":"Yang","year":"2022","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.101978_bib16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41418-022-01051-7","article-title":"SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma","volume":"30","author":"Chen","year":"2023","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jhepr.2026.101978_bib17","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1002\/hep.32177","article-title":"Integration of glucose and cardiolipin anabolism confers radiation resistance of HCC","volume":"75","author":"Fang","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.101978_bib18","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.cell.2015.02.038","article-title":"Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis","volume":"160","author":"Chen","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jhepr.2026.101978_bib19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1247005","article-title":"Genome-scale CRISPR-Cas9 knockout screening in human cells","volume":"343","author":"Shalem","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.jhepr.2026.101978_bib20","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nrg3899","article-title":"High-throughput functional genomics using CRISPR-Cas9","volume":"16","author":"Shalem","year":"2015","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jhepr.2026.101978_bib21","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41586-020-2099-x","article-title":"CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities","volume":"580","author":"Han","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jhepr.2026.101978_bib22","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/s41586-020-2246-4","article-title":"CRISPR screen in regulatory T cells reveals modulators of Foxp3","volume":"582","author":"Cortez","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jhepr.2026.101978_bib23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41586-025-08795-5","article-title":"Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3","volume":"642","author":"Chen","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.jhepr.2026.101978_bib24","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nbt.3536","article-title":"CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes","volume":"34","author":"Evers","year":"2016","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jhepr.2026.101978_bib25","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nbt.3599","article-title":"Comparing CRISPR and RNAi-based screening technologies","volume":"34","author":"Housden","year":"2016","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jhepr.2026.101978_bib26","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1038\/s41467-019-12606-7","article-title":"Genome-wide CRISPR\/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC","volume":"10","author":"Wei","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2026.101978_bib27","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1080\/15548627.2022.2117893","article-title":"Genome-scale CRISPR screen identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinoma","volume":"19","author":"Pan","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.jhepr.2026.101978_bib28","doi-asserted-by":"crossref","first-page":"eadw7181","DOI":"10.1126\/sciadv.adw7181","article-title":"Genome-wide CRISPR screen identifies splicing factor SF3B4 in driving hepatocellular carcinoma","volume":"11","author":"Guo","year":"2025","journal-title":"Sci Adv"},{"key":"10.1016\/j.jhepr.2026.101978_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2025.101502","article-title":"Genome-wide CRISPR screening identifies NF\u03baB and c-MET as druggable targets to sensitize lenvatinib treatment in hepatocellular carcinoma","volume":"19","author":"Wan","year":"2025","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.101978_bib30","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1007\/s11427-021-2067-7","article-title":"CRISPR-Cas9-based genome-wide screening identified novel targets for treating sorafenib-resistant hepatocellular carcinoma: a cross-talk between FGF21 and the NRF2 pathway","volume":"65","author":"Chen","year":"2022","journal-title":"Sci China Life Sci"},{"key":"10.1016\/j.jhepr.2026.101978_bib31","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1136\/gutjnl-2024-332902","article-title":"Nuclear translocation of plasma membrane protein ADCY7 potentiates T cell-mediated antitumour immunity in HCC","volume":"74","author":"Chen","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2026.101978_bib32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12943-025-02319-5","article-title":"BIRC2 blockade facilitates immunotherapy of hepatocellular carcinoma","volume":"24","author":"Fu","year":"2025","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jhepr.2026.101978_bib33","doi-asserted-by":"crossref","first-page":"eadg3358","DOI":"10.1126\/scitranslmed.adg3358","article-title":"Pharmaco-proteogenomic characterization of liver cancer organoids for precision oncology","volume":"15","author":"Ji","year":"2023","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jhepr.2026.101978_bib34","unstructured":"https:\/\/portal.gdc.cancer.gov\/ (accessed December 2024)."},{"key":"10.1016\/j.jhepr.2026.101978_bib35","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nmeth.3047","article-title":"Improved vectors and genome-wide libraries for CRISPR screening","volume":"11","author":"Sanjana","year":"2014","journal-title":"Nat Methods"},{"key":"10.1016\/j.jhepr.2026.101978_bib36","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nrm2178","article-title":"RNA-binding proteins: modular design for efficient function","volume":"8","author":"Lunde","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jhepr.2026.101978_bib37","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrm760","article-title":"Messenger-RNA-binding proteins and the messages they carry","volume":"3","author":"Dreyfuss","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jhepr.2026.101978_bib38","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1074\/jbc.M310030200","article-title":"Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy","volume":"279","author":"Taneja","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhepr.2026.101978_bib39","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12943-024-02055-2","article-title":"NSUN6-mediated 5-methylcytosine modification of NDRG1 mRNA promotes radioresistance in cervical cancer","volume":"23","author":"Yu","year":"2024","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jhepr.2026.101978_bib40","doi-asserted-by":"crossref","first-page":"7051","DOI":"10.1038\/s41388-020-01482-x","article-title":"Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA","volume":"39","author":"Xu","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.jhepr.2026.101978_bib41","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1136\/gutjnl-2017-314983","article-title":"SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer","volume":"68","author":"Wan","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2026.101978_bib42","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/s12964-023-01340-9","article-title":"Indacaterol inhibits collective cell migration and IGDQ-mediated single cell migration in metastatic breast cancer MDA-MB-231 cells","volume":"21","author":"Ayama-Canden","year":"2023","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.jhepr.2026.101978_bib43","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.ccell.2024.03.004","article-title":"Pharmacogenomic profiling of intra-tumor heterogeneity using a large organoid biobank of liver cancer","volume":"42","author":"Yang","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jhepr.2026.101978_bib44","doi-asserted-by":"crossref","first-page":"8088","DOI":"10.1038\/ncomms9088","article-title":"Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)","volume":"6","author":"Altmeyer","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2026.101978_bib45","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.cell.2015.07.047","article-title":"A liquid-to-solid phase transition of the ALS protein FUS accelerated by disease mutation","volume":"162","author":"Patel","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jhepr.2026.101978_bib46","doi-asserted-by":"crossref","first-page":"24731","DOI":"10.1074\/jbc.M113.497974","article-title":"The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage","volume":"288","author":"Mastrocola","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhepr.2026.101978_bib47","doi-asserted-by":"crossref","first-page":"10287","DOI":"10.1093\/nar\/gks798","article-title":"PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks","volume":"40","author":"Krietsch","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhepr.2026.101978_bib48","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1093\/nar\/gku601","article-title":"DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal","volume":"42","author":"Britton","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhepr.2026.101978_bib49","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ncb2426","article-title":"A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response","volume":"14","author":"Adamson","year":"2012","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jhepr.2026.101978_bib50","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.molcel.2011.12.035","article-title":"Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair","volume":"45","author":"Polo","year":"2012","journal-title":"Mol Cell"},{"key":"10.1016\/j.jhepr.2026.101978_bib51","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nsmb.2756","article-title":"Splicing factor SRSF6 promotes hyperplasia of sensitized skin","volume":"21","author":"Jensen","year":"2014","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.jhepr.2026.101978_bib52","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202000825","article-title":"The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic \u03b2-cells","volume":"4","author":"Alvelos","year":"2021","journal-title":"Life Sci Alliance"},{"key":"10.1016\/j.jhepr.2026.101978_bib53","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1093\/nar\/gkac1225","article-title":"Poison cassette exon splicing of SRSF6 regulates nuclear speckle dispersal and the response to hypoxia","volume":"51","author":"de Oliveira Freitas Machado","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhepr.2026.101978_bib54","article-title":"Multi-omics analysis reveals translational landscapes and regulations in mouse and human oocyte aging","volume":"10","author":"Huang","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.jhepr.2026.101978_bib55","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202403156R","article-title":"Angiogenic factor AGGF1 is a general splicing factor regulating angiogenesis and vascular development by alternative splicing of SRSF6","volume":"39","author":"Lv","year":"2025","journal-title":"FASEB J"},{"key":"10.1016\/j.jhepr.2026.101978_bib56","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.cmet.2021.09.008","article-title":"DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing","volume":"33","author":"Li","year":"2021","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhepr.2026.101978_bib57","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1038\/s41467-024-47178-8","article-title":"Genetic associations of protein-coding variants in venous thromboembolism","volume":"15","author":"He","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2026.101978_bib58","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/bpa.12387","article-title":"MAP2 splicing is altered in Huntington's disease","volume":"27","author":"Cabrera","year":"2017","journal-title":"Brain Pathol"},{"key":"10.1016\/j.jhepr.2026.101978_bib59","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1093\/brain\/awaa150","article-title":"Pathogenic SREK1 decrease in Huntington's disease lowers TAF1 mimicking X-linked dystonia parkinsonism","volume":"143","author":"Hern\u00e1ndez","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.jhepr.2026.101978_bib60","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1038\/s41467-018-06281-3","article-title":"Regulatory mechanisms of incomplete huntingtin mRNA splicing","volume":"9","author":"Neueder","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2026.101978_bib61","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13046-021-01882-1","article-title":"Oncogenic lncRNA ZNF561-AS1 is essential for colorectal cancer proliferation and survival through regulation of miR-26a-3p\/miR-128-5p-SRSF6 axis","volume":"40","author":"Si","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.jhepr.2026.101978_bib62","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/jgh.16152","article-title":"Genetic compensation response could exist in colorectal cancer: UPF3A upregulates the oncogenic homologue gene SRSF3 expression corresponding to SRSF6 to promote colorectal cancer metastasis","volume":"38","author":"Xu","year":"2023","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.101978_bib63","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.canlet.2016.07.015","article-title":"Long non-coding RNA LINC01133 inhibits epithelial-mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6","volume":"380","author":"Kong","year":"2016","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jhepr.2026.101978_bib64","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/path.4129","article-title":"The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers","volume":"229","author":"Cohen-Eliav","year":"2013","journal-title":"J Pathol"},{"key":"10.1016\/j.jhepr.2026.101978_bib65","doi-asserted-by":"crossref","first-page":"eado8231","DOI":"10.1126\/sciadv.ado8231","article-title":"SRSF6 modulates histone-chaperone HIRA splicing to orchestrate AR and E2F activity in prostate cancer","volume":"10","author":"Montero-Hidalgo","year":"2024","journal-title":"Sci Adv"},{"key":"10.1016\/j.jhepr.2026.101978_bib66","first-page":"1851","article-title":"SRSF6 regulates alternative splicing of genes involved in DNA damage response and DNA repair in HeLa cells","volume":"44","author":"Yang","year":"2020","journal-title":"Oncol Rep"},{"key":"10.1016\/j.jhepr.2026.101978_bib67","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.gene.2008.05.008","article-title":"Splicing and splice factor SRp55 participate in the response to DNA damage by changing isoform ratios of target genes","volume":"420","author":"Filippov","year":"2008","journal-title":"Gene"},{"key":"10.1016\/j.jhepr.2026.101978_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001124","article-title":"The SR protein B52\/SRp55 is required for DNA topoisomerase I recruitment to chromatin, mRNA release and transcription shutdown","volume":"6","author":"Juge","year":"2010","journal-title":"PLoS Genet"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926002491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926002491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:53:07Z","timestamp":1791244387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555926002491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":68,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2589555926002491"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101978","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-scale CRISPR screening uncovers SRSF6 as a target to sensitize hepatocellular carcinoma to radiotherapy","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.101978","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"101978"}}