{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:52:36Z","timestamp":1791503556447,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"Fondazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"AIRC Foundation for Cancer Research","doi-asserted-by":"publisher","award":["IG 2020-ID, 24858"],"award-info":[{"award-number":["IG 2020-ID, 24858"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jhepr.2026.102017","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T23:18:59Z","timestamp":1788045539000},"page":"102017","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["First decompensation outweighs portal vein thrombosis in cACLD: Molecular profiling and derivation of the VAIL score"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6388-7022","authenticated-orcid":false,"given":"Erica","family":"Villa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2313-2642","authenticated-orcid":false,"given":"Rosina Maria","family":"Critelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9140-673X","authenticated-orcid":false,"given":"Rossella","family":"Donghia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endrit","family":"Shahini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Milosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4702-7975","authenticated-orcid":false,"given":"Filippo","family":"Scian\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Dituri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5140-8060","authenticated-orcid":false,"given":"Gianluigi","family":"Giannelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2026.102017_bib1","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.4254\/wjh.v7.i27.2774","article-title":"Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: a meta-analysis","volume":"7","author":"Stine","year":"2015","journal-title":"World J Hepatol"},{"key":"10.1016\/j.jhepr.2026.102017_bib2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jhep.2021.04.029","article-title":"Current knowledge and management of portal vein thrombosis in cirrhosis","volume":"75","author":"Senzolo","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.102017_bib3","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/hep.27546","article-title":"Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: results of a longitudinal study","volume":"61","author":"Nery","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102017_bib4","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000025439","article-title":"Effect of portal vein thrombosis on the prognosis of patients with cirrhosis without a liver transplant: a systematic review and meta-analysis","volume":"100","author":"Xian","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jhepr.2026.102017_bib5","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3390\/jcm11030800","article-title":"The pathophysiology of portal vein thrombosis in cirrhosis: getting deeper into Virchow's triad","volume":"11","author":"Anton","year":"2022","journal-title":"J Clin Med"},{"issue":"Suppl. 1","key":"10.1016\/j.jhepr.2026.102017_bib6","article-title":"Pathophysiology of decompensated cirrhosis: portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction","volume":"75","author":"Engelmann","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.102017_bib7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jhep.2005.10.013","article-title":"Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies","volume":"44","author":"D\u2019Amico","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.102017_bib8","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jhep.2017.10.020","article-title":"Clinical states of cirrhosis and competing risks","volume":"68","author":"D\u2019Amico","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.102017_bib9","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jhep.2015.05.022","article-title":"Expanding consensus in portal hypertension: report of the Baveno VI Consensus Workshop: stratifying risk and individualizing care for portal hypertension","volume":"63","author":"De Franchis","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.102017_bib10","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/bjs.1800600817","article-title":"Transection of the oesophagus for bleeding oesophageal varices","volume":"60","author":"Pugh","year":"1973","journal-title":"Br J Surg"},{"key":"10.1016\/j.jhepr.2026.102017_bib11","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1053\/jhep.2001.22172","article-title":"A model to predict survival in patients with end-stage liver disease","volume":"33","author":"Kamath","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102017_bib12","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/liv.15161","article-title":"Early prediction of decompensation (EPOD) score: non-invasive determination of cirrhosis decompensation risk","volume":"42","author":"Schneider","year":"2022","journal-title":"Liver Int"},{"key":"10.1016\/j.jhepr.2026.102017_bib13","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1053\/jhep.2003.50346","article-title":"A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C","volume":"38","author":"Wai","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102017_bib14","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1200\/JCO.2014.57.9151","article-title":"Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach\u2014the ALBI grade","volume":"33","author":"Johnson","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jhepr.2026.102017_bib15","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/hep.21178","article-title":"Development of a simple noninvasive index to predict significant fibrosis in patients with HIV\/HCV coinfection","volume":"43","author":"Sterling","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102017_bib16","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00535-019-01656-9","article-title":"The von Willebrand factor antigen to platelet ratio (VITRO) score predicts hepatic decompensation and mortality in cirrhosis","volume":"55","author":"Schwarzer","year":"2020","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jhepr.2026.102017_bib17","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/jgh.15819","article-title":"CHESS-ALARM score to stratify decompensation risk in compensated advanced chronic liver disease patients: an international multicenter study","volume":"37","author":"Wong","year":"2022","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.102017_bib18","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"EASL Clinical Practice Guidelines: management of hepatocellular carcinoma","volume":"69","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.102017_bib19","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/hep.27875","article-title":"Portal vein thrombosis and chronic liver disease progression: the closer you look the more you see","volume":"63","author":"Giannini","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102017_bib20","article-title":"The impact of portal vein thrombosis on the prognosis of patients with cirrhosis: a retrospective propensity-score matched study","volume":"8","author":"Chen","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jhepr.2026.102017_bib21","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/liv.14121","article-title":"Incidence, predictive factors and clinical significance of development of portal vein thrombosis in cirrhosis: a prospective study","volume":"39","author":"Noronha Ferreira","year":"2019","journal-title":"Liver Int"},{"key":"10.1016\/j.jhepr.2026.102017_bib22","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/ueg2.12496","article-title":"Predicting de-novo portal vein thrombosis after HCV eradication: a long-term competing risk analysis in the ongoing PITER cohort","volume":"12","author":"Kondili","year":"2024","journal-title":"United Eur Gastroenterol J"},{"key":"10.1016\/j.jhepr.2026.102017_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071262","article-title":"Baseline MELD score predicts hepatic decompensation during antiviral therapy in patients with chronic hepatitis C and advanced cirrhosis","volume":"8","author":"Dultz","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jhepr.2026.102017_bib24","article-title":"Risk of further decompensation\/mortality in patients with cirrhosis and ascites as the first single decompensation event","volume":"4","author":"Balcar","year":"2022","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhepr.2026.102017_bib25","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgast-2024-001430","article-title":"Systematic review and meta-analysis of biomarkers predicting decompensation in patients with compensated cirrhosis","volume":"11","author":"Gananandan","year":"2024","journal-title":"BMJ Open Gastroenterol"},{"key":"10.1016\/j.jhepr.2026.102017_bib26","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/hep.27387","article-title":"Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces","volume":"61","author":"Simonetto","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102017_bib27","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.jhep.2020.11.019","article-title":"PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis","volume":"74","author":"Trebicka","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.102017_bib28","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/hep.25806","article-title":"von Willebrand factor as new noninvasive predictor of portal hypertension, decompensation and mortality in patients with liver cirrhosis","volume":"56","author":"Ferlitsch","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102017_bib29","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/apt.14522","article-title":"Von Willebrand factor indicates bacterial translocation, inflammation, and procoagulant imbalance and predicts complications independently of portal hypertension severity","volume":"47","author":"Mandorfer","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhepr.2026.102017_bib30","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1007\/s12072-023-10577-y","article-title":"Von Willebrand factor processing in patients with advanced chronic liver disease and its relation to portal hypertension and clinical outcome","volume":"17","author":"Simbrunner","year":"2023","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jhepr.2026.102017_bib31","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1136\/gutjnl-2023-330584","article-title":"Recent advances in the prevention and treatment of decompensated cirrhosis and acute-on-chronic liver failure (ACLF) and the role of biomarkers","volume":"73","author":"Trebicka","year":"2024","journal-title":"Gut"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926002880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926002880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:27:11Z","timestamp":1791502031000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555926002880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S2589555926002880"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.102017","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"First decompensation outweighs portal vein thrombosis in cACLD: Molecular profiling and derivation of the VAIL score","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.102017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"102017"}}