{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:10:11Z","timestamp":1789593011272,"version":"build-2803163510"},"reference-count":156,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MFE-187806"],"award-info":[{"award-number":["MFE-187806"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jhepr.2026.102030","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:07:41Z","timestamp":1789502861000},"page":"102030","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intravital Imaging as a Tool to Uncover Roles of Immune Cells in Chronic Liver Diseases"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3785-2122","authenticated-orcid":false,"given":"Mahamud ur","family":"Rashid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4702-8540","authenticated-orcid":false,"given":"Woo-Yong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kubes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2026.102030_bib1","doi-asserted-by":"crossref","unstructured":"Racanelli V, Rehermann B. The liver as an immunological organ. Hepatology (Baltimore, Md. 2006;43.","DOI":"10.1002\/hep.21060"},{"key":"10.1016\/j.jhepr.2026.102030_bib2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1152\/physrev.00004.2023","article-title":"The liver as a central \u201chub\u201d of the immune system: pathophysiological implications","volume":"105","author":"Ronca","year":"2025","journal-title":"Physiological reviews"},{"key":"10.1016\/j.jhepr.2026.102030_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-immunol-051116-052415","article-title":"Immune responses in the liver","volume":"36","author":"Kubes","year":"2018","journal-title":"Annual review of immunology"},{"key":"10.1016\/j.jhepr.2026.102030_bib4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jaut.2015.08.020","article-title":"Immunity, tolerance and autoimmunity in the liver: A comprehensive review","volume":"66","author":"Doherty","year":"2016","journal-title":"Journal of autoimmunity"},{"key":"10.1016\/j.jhepr.2026.102030_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2009.08.008","article-title":"Immune tolerance: what is unique about the liver","volume":"34","author":"Tiegs","year":"2010","journal-title":"Journal of autoimmunity"},{"key":"10.1016\/j.jhepr.2026.102030_bib6","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.3748\/wjg.v19.i12.1877","article-title":"Role of T cell death in maintaining immune tolerance during persistent viral hepatitis","volume":"19","author":"Larrubia","year":"2013","journal-title":"World Journal of Gastroenterology: WJG"},{"key":"10.1016\/j.jhepr.2026.102030_bib7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/cmi.2015.112","article-title":"Modulation of liver tolerance by conventional and nonconventional antigen-presenting cells and regulatory immune cells","volume":"13","author":"Horst","year":"2016","journal-title":"Cellular & molecular immunology"},{"key":"10.1016\/j.jhepr.2026.102030_bib8","article-title":"Immunotherapy in liver cancer: overcoming the tolerogenic liver microenvironment","volume":"15","author":"Liu","year":"2024","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.jhepr.2026.102030_bib9","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.3389\/fimmu.2019.02525","article-title":"Liver-mediated adaptive immune tolerance","volume":"10","author":"Zheng","year":"2019","journal-title":"Frontiers in immunology"},{"key":"10.1016\/j.jhepr.2026.102030_bib10","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-014-0145-y","article-title":"Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis","volume":"12","author":"Mokdad","year":"2014","journal-title":"BMC Med"},{"key":"10.1016\/j.jhepr.2026.102030_bib11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"Journal of hepatology"},{"key":"10.1016\/j.jhepr.2026.102030_bib12","first-page":"380","article-title":"Global elimination of chronic hepatitis","author":"Thomas","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhepr.2026.102030_bib13","unstructured":"WHO. Global hepatitis report 2024: action for access in low-and middle-income countries: World Health Organization; 2024 2024."},{"key":"10.1016\/j.jhepr.2026.102030_bib14","unstructured":"Grant LM PM. Viral Hepatitis. In: StatPearls [Internet] Treasure Island (FL): 2025 Jan. StatPearls Publishing2024."},{"key":"10.1016\/j.jhepr.2026.102030_bib15","first-page":"95","article-title":"Progressive familial intrahepatic cholestasis: diagnosis, management, and treatment","volume":"10","author":"Gunaydin","year":"2018","journal-title":"Hepat Med"},{"key":"10.1016\/j.jhepr.2026.102030_bib16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.cld.2018.03.008","article-title":"Liver Biopsy in Primary Biliary Cholangitis: Indications and Interpretation","volume":"22","author":"Tan","year":"2018","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.jhepr.2026.102030_bib17","doi-asserted-by":"crossref","first-page":"170","DOI":"10.32074\/1591-951X-245","article-title":"Autoimmune biliary diseases: primary biliary cholangitis and primary sclerosing cholangitis","volume":"113","author":"Sarcognato","year":"2021","journal-title":"Pathologica"},{"key":"10.1016\/j.jhepr.2026.102030_bib18","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.jhep.2017.07.022","article-title":"Primary sclerosing cholangitis - a comprehensive review","volume":"67","author":"Karlsen","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.102030_bib19","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1016\/j.cgh.2019.07.060","article-title":"Contemporary epidemiology of chronic liver disease and cirrhosis","volume":"18","author":"Moon","year":"2020","journal-title":"Clinical gastroenterology and hepatology"},{"key":"10.1016\/j.jhepr.2026.102030_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/jgh.70037","article-title":"Unraveling Liver Cirrhosis: Bridging Pathophysiology to Innovative Therapeutics","author":"Hegazy","year":"2025","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.jhepr.2026.102030_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100511","article-title":"Comprehensive analysis of liver macrophage composition by flow cytometry and immunofluorescence in murine NASH","volume":"2","author":"Daemen","year":"2021","journal-title":"STAR protocols"},{"key":"10.1016\/j.jhepr.2026.102030_bib22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cld.2019.09.004","article-title":"Liver histology: diagnostic and prognostic features","volume":"24","author":"Gasmi","year":"2020","journal-title":"Clinics in liver disease"},{"key":"10.1016\/j.jhepr.2026.102030_bib23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/jcp.2008.058248","article-title":"Histological patterns in drug-induced liver disease","volume":"62","author":"Ramachandran","year":"2009","journal-title":"Journal of clinical pathology"},{"key":"10.1016\/j.jhepr.2026.102030_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1567916","article-title":"Challenges of in vitro modelling of liver fibrosis","volume":"13","author":"Ros-Tarraga","year":"2025","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"10.1016\/j.jhepr.2026.102030_bib25","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.jcmgh.2022.11.008","article-title":"In vitro models for the study of liver biology and diseases: advances and limitations","volume":"15","author":"Kaur","year":"2023","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"},{"key":"10.1016\/j.jhepr.2026.102030_bib26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1254\/jphs.12R03CP","article-title":"Recent advances in intravital imaging of dynamic biological systems","volume":"119","author":"Kikuta","year":"2012","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jhepr.2026.102030_bib27","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.cell.2011.11.004","article-title":"Intravital imaging","volume":"147","author":"Pittet","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jhepr.2026.102030_bib28","article-title":"Intravital Imaging of Inflammatory Response in Liver Disease","volume":"10","author":"Wang","year":"2022","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"10.1016\/j.jhepr.2026.102030_bib29","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/icb.2017.25","article-title":"Intravital microscopy in historic and contemporary immunology","volume":"95","author":"Secklehner","year":"2017","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.jhepr.2026.102030_bib30","doi-asserted-by":"crossref","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr Biol"},{"key":"10.1016\/j.jhepr.2026.102030_bib31","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/j.2040-4603.2013.tb00495.x","article-title":"Physiology of cholangiocytes","volume":"3","author":"Tabibian","year":"2013","journal-title":"Compr Physiol"},{"key":"10.1016\/j.jhepr.2026.102030_bib32","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0163-7258(92)90055-5","article-title":"Metabolic zonation of the liver: regulation and implications for liver function","volume":"53","author":"Gebhardt","year":"1992","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jhepr.2026.102030_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2024.1521811","article-title":"Cellular and immune landscape of chronic liver diseases: insights from immunophenotyping","volume":"11","author":"Soleimani","year":"2025","journal-title":"Frontiers in Molecular Biosciences"},{"key":"10.1016\/j.jhepr.2026.102030_bib34","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1002\/j.2040-4603.2015.tb00660.x","article-title":"Liver sinusoidal endothelial cells","volume":"5","author":"S\u00f8rensen","year":"2015","journal-title":"Compr Physiol"},{"key":"10.1016\/j.jhepr.2026.102030_bib35","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.cell.2015.03.005","article-title":"Immunosurveillance of the liver by intravascular effector CD8(+) T cells","volume":"161","author":"Guidotti","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jhepr.2026.102030_bib36","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/hep.510300607","article-title":"Microanatomy of the human liver-exploring the hidden interfaces","volume":"30","author":"Saxena","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102030_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3008618","article-title":"The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota","volume":"6","author":"Balmer","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jhepr.2026.102030_bib38","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/0016-5085(89)91571-0","article-title":"Clearance of gut-derived endotoxins by the liver: Release and modification of 3H, 14C-lipopolysaccharide by isolated rat Kupffer cells","volume":"96","author":"Fox","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2026.102030_bib39","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-beta signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.jhepr.2026.102030_bib40","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/hep.23739","article-title":"Endothelial cell toll-like receptor 4 regulates fibrosis-associated angiogenesis in the liver","volume":"52","author":"Jagavelu","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102030_bib41","first-page":"1","article-title":"Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells","author":"Kostallari","year":"2025","journal-title":"Cellular & Molecular Immunology"},{"key":"10.1016\/j.jhepr.2026.102030_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002281","article-title":"Rapid and efficient clearance of blood-borne virus by liver sinusoidal endothelium","volume":"7","author":"Ganesan","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jhepr.2026.102030_bib43","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/hep.28285","article-title":"Bidirectional transendothelial migration of monocytes across hepatic sinusoidal endothelium shapes monocyte differentiation and regulates the balance between immunity and tolerance in liver","volume":"63","author":"Zimmermann","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102030_bib44","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1084\/jem.20160334","article-title":"Identification and treatment of the Staphylococcus aureus reservoir in vivo","volume":"213","author":"Surewaard","year":"2016","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhepr.2026.102030_bib45","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.chom.2016.06.002","article-title":"CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria","volume":"20","author":"Zeng","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jhepr.2026.102030_bib46","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41586-020-2977-2","article-title":"Commensal-driven immune zonation of the liver promotes host defence","volume":"589","author":"Gola","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jhepr.2026.102030_bib47","doi-asserted-by":"crossref","first-page":"eadq9704","DOI":"10.1126\/sciimmunol.adq9704","article-title":"Kupffer cell reverse migration into the liver sinusoids mitigates neonatal sepsis and meningitis","volume":"9","author":"David","year":"2024","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jhepr.2026.102030_bib48","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1146\/annurev-pathmechdis-070323-124158","article-title":"Dynamic Multiplex tissue imaging in inflammation research","volume":"19","author":"Uderhardt","year":"2024","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jhepr.2026.102030_bib49","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1136\/gutjnl-2023-331739","article-title":"Intravital imaging: dynamic insights into liver immunity in health and disease","volume":"73","author":"Wang","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2026.102030_bib50","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.jhep.2015.05.027","article-title":"Understanding liver immunology using intravital microscopy","volume":"63","author":"Marques","year":"2015","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.jhepr.2026.102030_bib51","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ird3.7","article-title":"Advances in intravital imaging of liver immunity using optical microscopy and labeling methods","volume":"1","author":"Yuan","year":"2023","journal-title":"iRADIOLOGY"},{"key":"10.1016\/j.jhepr.2026.102030_bib52","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.immuni.2019.09.002","article-title":"Liver\u2010derived signals sequentially reprogram myeloid enhancers to initiate and maintain Kupffer cell identity","volume":"51","author":"Sakai","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jhepr.2026.102030_bib53","article-title":"Live imaging of innate and adaptive immune responses in the liver","volume":"11","author":"Li","year":"2020","journal-title":"Frontiers in immunology"},{"key":"10.1016\/j.jhepr.2026.102030_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013693","article-title":"Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice","volume":"5","author":"Saederup","year":"2010","journal-title":"PloS one"},{"key":"10.1016\/j.jhepr.2026.102030_bib55","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.cell.2019.08.009","article-title":"Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells","volume":"178","author":"Liu","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jhepr.2026.102030_bib56","first-page":"719","article-title":"Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages","volume":"96","author":"Faust","year":"2000","journal-title":"Blood, the Journal of the American Society of Hematology"},{"key":"10.1016\/j.jhepr.2026.102030_bib57","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nmeth.3322","article-title":"Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes","volume":"12","author":"Hasenberg","year":"2015","journal-title":"Nature methods"},{"key":"10.1016\/j.jhepr.2026.102030_bib58","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1126\/science.1195491","article-title":"Intravascular danger signals guide neutrophils to sites of sterile inflammation","volume":"330","author":"McDonald","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jhepr.2026.102030_bib59","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"Clausen","year":"1999","journal-title":"Transgenic research"},{"key":"10.1016\/j.jhepr.2026.102030_bib60","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/ni1139","article-title":"Visualizing dendritic cell networks in vivo","volume":"5","author":"Lindquist","year":"2004","journal-title":"Nature immunology"},{"key":"10.1016\/j.jhepr.2026.102030_bib61","first-page":"354","article-title":"Isolation and phenotyping of normal mouse liver dendritic cells by an improved method","volume":"14","author":"Mosayebi","year":"2011","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"10.1016\/j.jhepr.2026.102030_bib62","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2026271118","article-title":"Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis","volume":"118","author":"Ducimeti\u00e8re","year":"2021","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.jhepr.2026.102030_bib63","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1084\/jem.20051474","article-title":"Natural killer cell behavior in lymph nodes revealed by static and real-time imaging","volume":"203","author":"Baj\u00e9noff","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhepr.2026.102030_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1002919","article-title":"High-dimensional intravital microscopy reveals major changes in splenic immune system during postnatal development","volume":"13","author":"Porto-Pedrosa","year":"2022","journal-title":"Frontiers in immunology"},{"key":"10.1016\/j.jhepr.2026.102030_bib65","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.7150\/thno.51369","article-title":"Intravital imaging of interactions between iNKT and kupffer cells to clear free lipids during steatohepatitis","volume":"11","author":"Wang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.jhepr.2026.102030_bib66","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1016\/j.celrep.2016.07.052","article-title":"iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation","volume":"16","author":"Thanabalasuriar","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.jhepr.2026.102030_bib67","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.4049\/jimmunol.0903661","article-title":"Notch2 signaling is required for potent antitumor immunity in vivo","volume":"184","author":"Sugimoto","year":"2010","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.jhepr.2026.102030_bib68","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1016\/j.immuni.2021.08.029","article-title":"A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells","volume":"54","author":"Andrews","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.jhepr.2026.102030_bib69","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/08916934.2019.1657098","article-title":"Impacts of GFP-FoxP3+ regulatory T cells on lupus hallmarks differ by genetic background and type of GFP knock-in","volume":"52","author":"Chang","year":"2019","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jhepr.2026.102030_bib70","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/ni.1993","article-title":"Fate mapping of IL-17-producing T cells in inflammatory responses","volume":"12","author":"Hirota","year":"2011","journal-title":"Nature immunology"},{"key":"10.1016\/j.jhepr.2026.102030_bib71","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.4049\/jimmunol.178.5.2961","article-title":"Regulatory T cells dynamically control the primary immune response to foreign antigen","volume":"178","author":"Haribhai","year":"2007","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.jhepr.2026.102030_bib72","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.immuni.2012.06.003","article-title":"Development of interleukin-17-producing \u03b3\u03b4 T cells is restricted to a functional embryonic wave","volume":"37","author":"Haas","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jhepr.2026.102030_bib73","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/nar\/25.6.1317","article-title":"B lymphocyte-specific, Cre-mediated mutagenesis in mice","volume":"25","author":"Rickert","year":"1997","journal-title":"Nucleic acids research"},{"key":"10.1016\/j.jhepr.2026.102030_bib74","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nature communications"},{"key":"10.1016\/j.jhepr.2026.102030_bib75","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1002\/dvdy.20982","article-title":"VE\u2010cadherin\u2010CreERT2 transgenic mouse: a model for inducible recombination in the endothelium","volume":"235","author":"Monvoisin","year":"2006","journal-title":"Developmental dynamics: an official publication of the American Association of Anatomists"},{"key":"10.1016\/j.jhepr.2026.102030_bib76","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.cell.2016.03.009","article-title":"A reservoir of mature cavity macrophages that can rapidly invade visceral organs to affect tissue repair","volume":"165","author":"Wang","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jhepr.2026.102030_bib77","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00204-019-02582-8","article-title":"The pyrrolizidine alkaloid senecionine induces CYP-dependent destruction of sinusoidal endothelial cells and cholestasis in mice","volume":"94","author":"Hessel-Pras","year":"2020","journal-title":"Archives of Toxicology"},{"key":"10.1016\/j.jhepr.2026.102030_bib78","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/dvg.20568","article-title":"Cre activity in fetal albCre mouse hepatocytes: Utility for developmental studies","volume":"47","author":"Weisend","year":"2009","journal-title":"genesis"},{"key":"10.1016\/j.jhepr.2026.102030_bib79","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.3389\/fimmu.2019.02988","article-title":"Optimization of In vivo Imaging Provides a First Look at Mouse Model of Non-Alcoholic Fatty Liver Disease (NAFLD) Using Intravital Microscopy","volume":"10","author":"Davis","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jhepr.2026.102030_bib80","article-title":"Intravital microscopy imaging of the liver following leishmania infection: an assessment of hepatic hemodynamics","volume":"101","author":"Dasari","year":"2015","journal-title":"J Vis Exp"},{"key":"10.1016\/j.jhepr.2026.102030_bib81","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099615","article-title":"Label-free determination of hemodynamic parameters in the microcirculaton with third harmonic generation microscopy","volume":"9","author":"Dietzel","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jhepr.2026.102030_bib82","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1053\/j.gastro.2018.06.048","article-title":"Dysregulated bile transporters and impaired tight junctions during chronic liver injury in mice","volume":"155","author":"Pradhan-Sundd","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2026.102030_bib83","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s42003-020-1006-1","article-title":"Multidimensional imaging of liver injury repair in mice reveals fundamental role of the ductular reaction","volume":"3","author":"Kamimoto","year":"2020","journal-title":"Commun Biol"},{"key":"10.1016\/j.jhepr.2026.102030_bib84","doi-asserted-by":"crossref","DOI":"10.1117\/1.3041159","article-title":"Nonlinear optical microscopy: use of second harmonic generation and two-photon microscopy for automated quantitative liver fibrosis studies","volume":"13","author":"Sun","year":"2008","journal-title":"J Biomed Opt"},{"key":"10.1016\/j.jhepr.2026.102030_bib85","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ni.1855","article-title":"An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells","volume":"11","author":"Lee","year":"2010","journal-title":"Nature Immunology"},{"key":"10.1016\/j.jhepr.2026.102030_bib86","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0030113","article-title":"Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids","volume":"3","author":"Geissmann","year":"2005","journal-title":"PLoS Biol"},{"key":"10.1016\/j.jhepr.2026.102030_bib87","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190723","article-title":"Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets","volume":"217","author":"Deppermann","year":"2020","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhepr.2026.102030_bib88","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1128\/MCB.20.11.4106-4114.2000","article-title":"Analysis of fractalkine receptor CX3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion","volume":"20","author":"Jung","year":"2000","journal-title":"Molecular and cellular biology"},{"key":"10.1016\/j.jhepr.2026.102030_bib89","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2012.12.001","article-title":"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis","volume":"38","author":"Yona","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jhepr.2026.102030_bib90","article-title":"Automatic Detection of LLM-generated Code: A Case Study of Claude 3 Haiku","author":"Rahman","year":"2024","journal-title":"arXiv"},{"key":"10.1016\/j.jhepr.2026.102030_bib91","first-page":"10","article-title":"Intravital imaging of intraepithelial lymphocytes in murine small intestine","volume":"148","author":"Jia","year":"2019","journal-title":"Journal of visualized experiments: JoVE"},{"key":"10.1016\/j.jhepr.2026.102030_bib92","doi-asserted-by":"crossref","unstructured":"Blundell R, Azzopardi JI. Chronic liver diseases. Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases: Academic Press; 2021. p. 129\u2013139.","DOI":"10.1016\/B978-0-12-816488-4.00005-X"},{"key":"10.1016\/j.jhepr.2026.102030_bib93","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S2468-1253(16)30181-9","article-title":"Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study","volume":"2","author":"Blach","year":"2017","journal-title":"The lancet Gastroenterology & hepatology"},{"key":"10.1016\/j.jhepr.2026.102030_bib94","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/S0140-6736(16)31018-2","article-title":"The global burden of viral hepatitis: better estimates to guide hepatitis elimination efforts","volume":"388","author":"Wiktor","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jhepr.2026.102030_bib95","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1084\/jem.194.12.1755","article-title":"Blocking chemokine responsive to gamma-2\/interferon (IFN)-gamma inducible protein and monokine induced by IFNgamma activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes","volume":"194","author":"Kakimi","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhepr.2026.102030_bib96","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1084\/jem.20030239","article-title":"Memory CD81 T cells are required for protection from persistent hepatitis C virus infection","volume":"197","author":"Shoukry","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhepr.2026.102030_bib97","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1126\/science.284.5415.825","article-title":"Viral clearance without destruction of infected cells duringacute HBV infection","volume":"284","author":"Guidotti","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jhepr.2026.102030_bib98","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.immuni.2005.05.005","article-title":"Oscillating CD8(+) T cell effector functions after antigen recognition in the liver","volume":"23","author":"Isogawa","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.jhepr.2026.102030_bib99","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1053\/j.gastro.2008.12.034","article-title":"Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model","volume":"136","author":"Jo","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2026.102030_bib100","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insights into T cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nature reviews immunology"},{"key":"10.1016\/j.jhepr.2026.102030_bib101","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/hep.26668","article-title":"Kupffer cell-derived IL-10 plays a key role in maintaining humoral immune tolerance in hepatitis B virus- persistent mice","volume":"59","author":"Xu","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102030_bib102","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.4049\/jimmunol.1500139","article-title":"Hepatic stellate cells inhibit T cells through active TGF-b1 from a cell surfacebound latent TGF-b1\/GARP complex","volume":"195","author":"Li","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.jhepr.2026.102030_bib103","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nature04444","article-title":"Restoring function in exhausted CD8 T cells during chronic viral infection","volume":"439","author":"Barber","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jhepr.2026.102030_bib104","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41586-019-1620-6","article-title":"Dynamics and genomic landscape of CD8(+) T cells undergoing hepatic priming","volume":"574","author":"B\u00e9n\u00e9chet","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jhepr.2026.102030_bib105","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrgastro.2015.200","article-title":"Immunology in the liver-from homeostasis to disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.102030_bib106","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.4049\/jimmunol.1500846","article-title":"NK cells help induce anti-hepatitis B virus CD8+ T cell immunity in mice","volume":"196","author":"Zheng","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.jhepr.2026.102030_bib107","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1084\/jem.20121172","article-title":"Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion","volume":"210","author":"Peppa","year":"2013","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhepr.2026.102030_bib108","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1136\/gutjnl-2017-314098","article-title":"Regulatory NK cells mediated between immunosuppressive monocytes and dysfunctional T cells in chronic HBV infection","volume":"67","author":"Li","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2026.102030_bib109","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1038\/s41590-025-02199-3","article-title":"CD4(+) T cells license Kupffer cells to reverse CD8(+) T cell dysfunction induced by hepatocellular priming","volume":"26","author":"Venzin","year":"2025","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jhepr.2026.102030_bib110","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/ni.2573","article-title":"Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection","volume":"14","author":"Huang","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jhepr.2026.102030_bib111","first-page":"167","article-title":"Pathogenesis and prevention of hepatic steatosis","volume":"11","author":"Nassir","year":"2015","journal-title":"Gastroenterology & hepatology"},{"key":"10.1016\/j.jhepr.2026.102030_bib112","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2026.102030_bib113","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3389\/fmed.2020.00448","article-title":"Nonalcoholic fatty liver disease and alcohol-related liver disease: two intertwined entities","volume":"7","author":"Idalsoaga","year":"2020","journal-title":"Front Med (Lausanne"},{"key":"10.1016\/j.jhepr.2026.102030_bib114","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1002\/hep.26200","article-title":"Absence of receptor interacting protein kinase 3 prevents ethanolinduced liver injury","volume":"57","author":"Roychowdhury","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102030_bib115","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.15252\/emmm.201403856","article-title":"A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis","volume":"6","author":"Gautheron","year":"2014","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jhepr.2026.102030_bib116","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jhep.2017.11.040","article-title":"Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice","volume":"68","author":"Xu","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.102030_bib117","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1002\/hep.29645","article-title":"Gasdermin-D pathway in alcoholic hepatitis in mice and patients","volume":"67","author":"Khanova","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102030_bib118","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41419-019-1678-y","article-title":"Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis","volume":"10","author":"Tsurusaki","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jhepr.2026.102030_bib119","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0016-5085(03)00907-7","article-title":"Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis","volume":"125","author":"Feldstein","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2026.102030_bib120","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jhep.2020.04.001","article-title":"Lytic cell death in metabolic liver disease","volume":"73","author":"Gautheron","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.102030_bib121","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1073\/pnas.1222738110","article-title":"Conservation and divergence in the transcriptional programs of the human and mouse immune systems","volume":"110","author":"Shay","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhepr.2026.102030_bib122","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/imm.12469","article-title":"Human spleen microanatomy: why mice do not suffice","volume":"145","author":"Steiniger","year":"2015","journal-title":"Immunology"},{"key":"10.1016\/j.jhepr.2026.102030_bib123","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1126\/sciimmunol.aau6085","article-title":"Structure and function of the immune system in the spleen","volume":"4","author":"Lewis","year":"2019","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jhepr.2026.102030_bib124","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.livres.2018.02.002","article-title":"The role of adipose tissue in fatty liver diseases","volume":"2","author":"Parker","year":"2018","journal-title":"Liver Research"},{"key":"10.1016\/j.jhepr.2026.102030_bib125","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasomemediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Henao-Mejia","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jhepr.2026.102030_bib126","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.cmet.2019.10.010","article-title":"The crosstalk between hepatocytes, hepatic macrophages, and hepatic stellate cells facilitates alcoholic liver disease","volume":"30","author":"Kisseleva","year":"2019","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhepr.2026.102030_bib127","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1152\/ajpgi.00098.2002","article-title":"Role of ICAM-1 in chronic ethanol consumption-enhanced liver injury after gut ischemia-reperfusion in rats","volume":"283","author":"Horie","year":"2002","journal-title":"American Journal of Physiology-Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.jhepr.2026.102030_bib128","doi-asserted-by":"crossref","first-page":"240311","DOI":"10.29026\/oea.2025.240311","article-title":"Multiphoton intravital microscopy in small animals of long-term mitochondrial dynamics based on super\u2010resolution radial fluctuations","volume":"8","author":"Darian","year":"2025","journal-title":"Opto-Electronic Advances"},{"key":"10.1016\/j.jhepr.2026.102030_bib129","doi-asserted-by":"crossref","first-page":"eabq5202","DOI":"10.1126\/science.abq5202","article-title":"Kupffer cell-like syncytia replenish resident macrophage function in the fibrotic liver","volume":"381","author":"Peiseler","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.jhepr.2026.102030_bib130","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/hep.31644","article-title":"Programmed Death Ligand 1 Is Overexpressed in Liver Macrophages in Chronic Liver Diseases, and Its Blockade Improves the Antibacterial Activity Against Infections","volume":"74","author":"Pose","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102030_bib131","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"The Lancet"},{"key":"10.1016\/j.jhepr.2026.102030_bib132","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0002-9343(79)90740-X","article-title":"Fatty liver hepatitis and cirrhosis in obese patients","volume":"67","author":"Adler","year":"1979","journal-title":"Am J Med"},{"key":"10.1016\/j.jhepr.2026.102030_bib133","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.jhepr.2026.102030_bib134","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.cmet.2013.11.001","article-title":"Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation","volume":"18","author":"Xu","year":"2013","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhepr.2026.102030_bib135","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1126\/science.aaw2586","article-title":"A lipase-independent pathway of lipid release and immune modulation by adipocytes","volume":"363","author":"Flaherty","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.jhepr.2026.102030_bib136","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.clinbiochem.2015.06.023","article-title":"Gut-liver axis, nutrition, and non-alcoholic fatty liver disease","volume":"48","author":"Kirpich","year":"2015","journal-title":"Clin Biochem"},{"key":"10.1016\/j.jhepr.2026.102030_bib137","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.jceh.2022.01.006","article-title":"Demonstration of gut-barrier dysfunction in early stages of nonalcoholic fatty liver disease: a proof-of-concept study","volume":"12","author":"Kaushal","year":"2022","journal-title":"J Clin Exp Hepatol"},{"key":"10.1016\/j.jhepr.2026.102030_bib138","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.ccell.2016.10.007","article-title":"Circadian homeostasis of liver metabolism suppresses hepatocarcinogenesis","volume":"30","author":"Kettner","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jhepr.2026.102030_bib139","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/hep.27131","article-title":"Epigenetics in liver disease","volume":"60","author":"Mann","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102030_bib140","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.immuni.2020.04.001","article-title":"Niche-specific reprogramming of epigenetic landscapes drives myeloid cell diversity in nonalcoholic steatohepatitis","volume":"52","author":"Seidman","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jhepr.2026.102030_bib141","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.immuni.2020.08.004","article-title":"Osteopontin expression identifies a subset of recruited macrophages distinct from Kupffer cells in the fatty liver","volume":"53","author":"Remmerie","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jhepr.2026.102030_bib142","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.immuni.2020.06.003","article-title":"Impaired Kupffer cell self-renewal alters the liver response to lipid overload during non-alcoholic steatohepatitis","volume":"53","author":"Tran","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jhepr.2026.102030_bib143","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1365-2613.2008.00608.x","article-title":"An intravital microscopic study of the hepatic microcirculation in cirrhotic mice models: relationship between fibrosis and angiogenesis","volume":"89","author":"Vanheule","year":"2008","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.jhepr.2026.102030_bib144","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108626","article-title":"Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH","volume":"34","author":"Daemen","year":"2021","journal-title":"Cell Rep"},{"key":"10.1016\/j.jhepr.2026.102030_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhepr.2020.100117","article-title":"Imaging and immunometabolic phenotyping uncover changes in the hepatic immune response in the early phases of NAFLD","volume":"2","author":"Diniz","year":"2020","journal-title":"JHEP Reports"},{"key":"10.1016\/j.jhepr.2026.102030_bib146","doi-asserted-by":"crossref","first-page":"5132","DOI":"10.1364\/BOE.395890","article-title":"Intravital longitudinal imaging of hepatic lipid droplet accumulation in a murine model for nonalcoholic fatty liver disease","volume":"11","author":"Moon","year":"2020","journal-title":"Biomedical Optics Express"},{"key":"10.1016\/j.jhepr.2026.102030_bib147","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41591-019-0379-5","article-title":"Platelet GPIb\u03b1 is a mediator and potential interventional target for NASH and subsequent liver cancer","volume":"25","author":"Malehmir","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.jhepr.2026.102030_bib148","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jhep.2023.05.045","article-title":"Ductular reaction-associated neutrophils promote biliary epithelium proliferation in chronic liver disease","volume":"79","author":"Ari\u00f1o","year":"2023","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.102030_bib149","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1136\/gutjnl-2011-301400","article-title":"NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis","volume":"61","author":"Gur","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2026.102030_bib150","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/hep.27793","article-title":"Liver inflammation abrogates immunological tolerance induced by Kupffer cells","volume":"62","author":"Heymann","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102030_bib151","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2025-335745","article-title":"Intestinal blood vessel-associated macrophages and gut-vascular barrier dysfunction in cirrhosis","author":"Smets","year":"2025","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2026.102030_bib152","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1359451","article-title":"Organ-on-a-chip for studying immune cell adhesion to liver sinusoidal endothelial cells: the potential for testing immunotherapies and cell therapy trafficking","volume":"12","author":"Kennedy","year":"2024","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jhepr.2026.102030_bib153","article-title":"Liver Organoids: Recent Developments, Limitations and Potential","volume":"8","author":"Harrison","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jhepr.2026.102030_bib154","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s42255-024-01043-6","article-title":"An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)","volume":"6","author":"Vacca","year":"2024","journal-title":"Nature Metabolism"},{"key":"10.1016\/j.jhepr.2026.102030_bib155","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/livers6030045","article-title":"Experimental Rodent Models of Metabolic Dysfunction-Associated Fatty Liver Disease: Present Status and Future Perspective","volume":"6","author":"Bhopale","year":"2026","journal-title":"Livers"},{"key":"10.1016\/j.jhepr.2026.102030_bib156","doi-asserted-by":"crossref","first-page":"33","DOI":"10.21037\/tgh-24-140","article-title":"Overlap syndromes in autoimmune liver disease: a review","volume":"10","author":"Sohal","year":"2025","journal-title":"Transl Gastroenterol Hepatol"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926003010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926003010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:41:02Z","timestamp":1789591262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555926003010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":156,"alternative-id":["S2589555926003010"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.102030","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intravital Imaging as a Tool to Uncover Roles of Immune Cells in Chronic Liver Diseases","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.102030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"102030"}}