{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:26:06Z","timestamp":1793719566968,"version":"4.6.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["AAPEAC2022. LCC \/VM"],"award-info":[{"award-number":["AAPEAC2022. LCC \/VM"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["INCa_1602 PlBio21-268"],"award-info":[{"award-number":["INCa_1602 PlBio21-268"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["PLBIO 24-107"],"award-info":[{"award-number":["PLBIO 24-107"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["PlBio 21-268"],"award-info":[{"award-number":["PlBio 21-268"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["INCa_1602"],"award-info":[{"award-number":["INCa_1602"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["PlBio 24-107"],"award-info":[{"award-number":["PlBio 24-107"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003990","name":"R\u00e9gion \u00cele-de-France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006678","name":"French Association of Liver Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006678","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jhepr.2026.102040","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:52:40Z","timestamp":1789746760000},"page":"102040","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel 3D models for \u03b2-catenin-driven liver cancers"],"prefix":"10.1016","volume":"8","author":[{"given":"Vanessa","family":"Bou Malham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"L\u00e9andre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akila","family":"Hamimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9291-2207","authenticated-orcid":false,"given":"Isabelle","family":"Lagoutte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Bouchet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Archambault-Marsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9my","family":"Augustin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7464-9804","authenticated-orcid":false,"given":"Ang\u00e9lique","family":"Gougelet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3949-9107","authenticated-orcid":false,"given":"Sabine","family":"Colnot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0772-1711","authenticated-orcid":false,"given":"Christ\u00e8le","family":"Desbois-Mouthon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2026.102040_bib1","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0140-6736(22)01200-4","article-title":"Hepatocellular carcinoma","volume":"400","author":"Vogel","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.jhepr.2026.102040_bib2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.17998\/jlc.2022.02.24","article-title":"Recent updates on the classification of hepatoblastoma according to the International Pediatric liver Tumors Consensus","volume":"22","author":"Jeong","year":"2022","journal-title":"J Liver Cancer"},{"key":"10.1016\/j.jhepr.2026.102040_bib3","doi-asserted-by":"crossref","DOI":"10.1172\/JCI154515","article-title":"beta-Catenin signaling in hepatocellular carcinoma","volume":"132","author":"Xu","year":"2022","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhepr.2026.102040_bib4","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41575-025-01127-y","article-title":"WNT-beta-catenin signalling in hepatocellular carcinoma: from bench to clinical trials","volume":"23","author":"Lehrich","year":"2026","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2026.102040_bib5","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1158\/1078-0432.CCR-18-2293","article-title":"Prospective genotyping of hepatocellular carcinoma: clinical implications of next-generation sequencing for Matching patients to targeted and immune therapies","volume":"25","author":"Harding","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jhepr.2026.102040_bib6","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1158\/1078-0432.CCR-18-1942","article-title":"WNT\/beta-catenin pathway activation Correlates with immune exclusion across human cancers","volume":"25","author":"Luke","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jhepr.2026.102040_bib7","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1158\/1078-0432.CCR-18-3778","article-title":"Immune exclusion-Wnt\/CTNNB1 Class Predicts resistance to Immunotherapies in HCC","volume":"25","author":"Pinyol","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jhepr.2026.102040_bib8","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1158\/2159-8290.CD-19-0074","article-title":"Beta-catenin activation promotes immune Escape and resistance to Anti-PD-1 Therapy in hepatocellular carcinoma","volume":"9","author":"Ruiz de Galarreta","year":"2019","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jhepr.2026.102040_bib9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/hep.29672","article-title":"New insights into diagnosis and therapeutic options for proliferative hepatoblastoma","volume":"68","author":"Hooks","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102040_bib10","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ccr.2008.11.002","article-title":"Hepatic stem-like phenotype and interplay of Wnt\/beta-catenin and Myc signaling in aggressive childhood liver cancer","volume":"14","author":"Cairo","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jhepr.2026.102040_bib11","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1158\/2159-8290.CD-20-1809","article-title":"Integrated Genomic analysis identifies driver genes and cisplatin-Resistant Progenitor phenotype in Pediatric liver cancer","volume":"11","author":"Hirsch","year":"2021","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jhepr.2026.102040_bib12","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1038\/s41467-021-25430-9","article-title":"Genetic and epigenetic basis of hepatoblastoma diversity","volume":"12","author":"Nagae","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2026.102040_bib13","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/hep.28888","article-title":"Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups","volume":"65","author":"Sumazin","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102040_bib14","doi-asserted-by":"crossref","DOI":"10.1136\/wjps-2020-000220","article-title":"Advances in the conventional clinical treatment for hepatoblastoma and therapeutic innovation","volume":"4","author":"Chen","year":"2021","journal-title":"World J Pediatr Surg"},{"key":"10.1016\/j.jhepr.2026.102040_bib15","doi-asserted-by":"crossref","first-page":"17216","DOI":"10.1073\/pnas.0404761101","article-title":"Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas","volume":"101","author":"Colnot","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhepr.2026.102040_bib16","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jhep.2022.02.023","article-title":"Deleting the beta-catenin degradation domain in mouse hepatocytes drives hepatocellular carcinoma or hepatoblastoma-like tumor growth","volume":"77","author":"Loesch","year":"2022","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.102040_bib17","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.ymthe.2024.01.036","article-title":"DLK1\/DIO3 locus upregulation by a beta-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis","volume":"32","author":"Sanceau","year":"2024","journal-title":"Mol Ther"},{"key":"10.1016\/j.jhepr.2026.102040_bib18","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1053\/j.gastro.2019.05.069","article-title":"Hepatocellular carcinomas with mutational activation of beta-catenin Require choline and can Be detected by Positron Emission Tomography","volume":"157","author":"Gougelet","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2026.102040_bib19","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gutjnl-2014-308969","article-title":"Antitumour activity of an inhibitor of miR-34a in liver cancer with beta-catenin-mutations","volume":"65","author":"Gougelet","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2026.102040_bib20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3892\/ijmm.2025.5626","article-title":"Insights on the differences between two- and three-dimensional culture systems in tumor models","volume":"56","author":"Zhang","year":"2025","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jhepr.2026.102040_bib21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12929-024-00994-y","article-title":"Scaffold-based 3D cell culture models in cancer research","volume":"31","author":"Abuwatfa","year":"2024","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.jhepr.2026.102040_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241512046","article-title":"Three-Dimensional cell cultures: the bridge between in vitro and in vivo models","volume":"24","author":"Urzi","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhepr.2026.102040_bib23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.slasd.2023.03.006","article-title":"In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models","volume":"28","author":"Lee","year":"2023","journal-title":"SLAS Discov"},{"key":"10.1016\/j.jhepr.2026.102040_bib24","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/nm.4438","article-title":"Human primary liver cancer-derived organoid cultures for disease modeling and drug screening","volume":"23","author":"Broutier","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.jhepr.2026.102040_bib25","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.celrep.2018.07.001","article-title":"Organoid models of human liver cancers derived from tumor Needle Biopsies","volume":"24","author":"Nuciforo","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.jhepr.2026.102040_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12092668","article-title":"A human organoid model of aggressive hepatoblastoma for disease modeling and drug testing","volume":"12","author":"Saltsman","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jhepr.2026.102040_bib27","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1038\/s41467-022-32473-z","article-title":"Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids","volume":"13","author":"Song","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2026.102040_bib28","article-title":"A developmental biliary lineage program cooperates with Wnt activation to promote cell proliferation in hepatoblastoma","volume":"15","author":"Wu","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2026.102040_bib29","article-title":"Single-cell transcriptomic mapping of patient-derived primary liver cancer organoids reveals molecular subtypes and guides precision drug targeting","volume":"49","author":"Dai","year":"2026","journal-title":"Cel Oncol (Dordr)"},{"key":"10.1016\/j.jhepr.2026.102040_bib30","article-title":"A patient-derived HCC spheroid system to model the tumor microenvironment and treatment response","volume":"7","author":"Crouchet","year":"2025","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhepr.2026.102040_bib31","article-title":"Metabolic Reprogramming and the recovery of physiological Functionality in 3D cultures in Micro-bioreactors","volume":"5","author":"Wrzesinski","year":"2018","journal-title":"Bioengineering (Basel)"},{"key":"10.1016\/j.jhepr.2026.102040_bib32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13072-022-00470-7","article-title":"Investigation of reversible histone acetylation and dynamics in gene expression regulation using 3D liver spheroid model","volume":"15","author":"Stransky","year":"2022","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.jhepr.2026.102040_bib33","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.toxlet.2024.10.004","article-title":"Time-course characterization of whole-transcriptome dynamics of HepG2\/C3A spheroids and its toxicological implications","volume":"401","author":"Kim","year":"2024","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.jhepr.2026.102040_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143255","article-title":"Hepatocellular carcinoma (HepG2\/C3A) cell-based 3D model for genotoxicity testing of chemicals","volume":"755","author":"Stampar","year":"2021","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jhepr.2026.102040_bib35","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1002\/hep.26924","article-title":"T-cell factor 4 and beta-catenin chromatin occupancies pattern zonal liver metabolism in mice","volume":"59","author":"Gougelet","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102040_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhepr.2026.102040_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21062027","article-title":"Recent Advances in practical methods for liver cell biology: a Short Overview","volume":"21","author":"Torres","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhepr.2026.102040_bib38","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1136\/gutjnl-2017-315448","article-title":"beta-catenin-activated hepatocellular carcinomas are addicted to fatty acids","volume":"68","author":"Senni","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2026.102040_bib39","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1172\/JCI43937","article-title":"Oncogenic beta-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice","volume":"122","author":"Anson","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhepr.2026.102040_bib40","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/hep.21467","article-title":"Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets","volume":"45","author":"Boyault","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2026.102040_bib41","doi-asserted-by":"crossref","first-page":"6779","DOI":"10.1158\/0008-5472.CAN-08-0742","article-title":"Focal gains of VEGFA and molecular classification of hepatocellular carcinoma","volume":"68","author":"Chiang","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhepr.2026.102040_bib42","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1158\/1078-0432.CCR-11-2322","article-title":"Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib","volume":"18","author":"Lachenmayer","year":"2012","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jhepr.2026.102040_bib43","article-title":"Development of mutated beta-catenin gene signature to identify CTNNB1 mutations from whole and spatial transcriptomic data in patients with HCC","volume":"6","author":"Lehrich","year":"2024","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhepr.2026.102040_bib44","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jhep.2020.03.025","article-title":"Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications","volume":"73","author":"Carrillo-Reixach","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2026.102040_bib45","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/s43018-023-00609-9","article-title":"WNTinib is a multi-kinase inhibitor with specificity against beta-catenin mutant hepatocellular carcinoma","volume":"4","author":"Rialdi","year":"2023","journal-title":"Nat Cancer"},{"key":"10.1016\/j.jhepr.2026.102040_bib46","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/1878-0261.70168","article-title":"Effective therapeutic targeting of CTNNB1-mutant hepatoblastoma with WNTinib","volume":"20","author":"Balaseviciute","year":"2026","journal-title":"Mol Oncol"},{"key":"10.1016\/j.jhepr.2026.102040_bib47","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1056\/NEJMoa0708857","article-title":"Sorafenib in advanced hepatocellular carcinoma","volume":"359","author":"Llovet","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhepr.2026.102040_bib48","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1053\/j.gastro.2012.05.033","article-title":"Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells","volume":"143","author":"Buurman","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2026.102040_bib49","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1038\/s44319-025-00619-x","article-title":"Increased reproducibility of brain organoids through controlled fluid dynamics","volume":"26","author":"Aiello","year":"2025","journal-title":"EMBO Rep"},{"key":"10.1016\/j.jhepr.2026.102040_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2025.103923","article-title":"Protocol for the establishment and characterization of lung tumoroids from surgical resection without the use of Matrigel","volume":"6","author":"Dona","year":"2025","journal-title":"STAR Protoc"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926003113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555926003113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T14:26:36Z","timestamp":1793715996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555926003113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S2589555926003113"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.102040","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel 3D models for \u03b2-catenin-driven liver cancers","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2026.102040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"102040"}}