{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T19:46:39Z","timestamp":1773603999557,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hospital Infection"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.jhin.2007.05.014","type":"journal-article","created":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T08:57:35Z","timestamp":1185958655000},"page":"67-71","source":"Crossref","is-referenced-by-count":31,"title":["Brief exposure of 0.05% chlorhexidine does not impair non-osteoarthritic human cartilage metabolism"],"prefix":"10.1016","volume":"67","author":[{"given":"A.J.","family":"Best","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.F.","family":"Nixon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.J.S.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhin.2007.05.014_bib1","first-page":"348","article-title":"Chondrolyse a la chlorhexidine, un cas controle histologiquement","volume":"70","author":"Tricoit","year":"1984","journal-title":"Rev\u00a0De\u00a0Chir Orthopedique"},{"key":"10.1016\/j.jhin.2007.05.014_bib2","first-page":"685","article-title":"De bon usage des solutions de rincage en chirurgie orthopaedique: a poops d'un cos de chondrolyse a la chlorhexidine","volume":"52","author":"Rombouts","year":"1986","journal-title":"Acta Orthop Belg"},{"key":"10.1016\/j.jhin.2007.05.014_bib3","first-page":"112","article-title":"Chondrolyse a la chlorhexidine","volume":"53","author":"Bellen","year":"1987","journal-title":"Acta Orthop Belg"},{"key":"10.1016\/j.jhin.2007.05.014_bib4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1302\/0301-620X.80B3.8519","article-title":"Clinical and pathological changes in the knee after accidental chlorhexidine irrigation during arthroscopy","volume":"80-B","author":"Douw","year":"1998","journal-title":"J Bone Joint Surg [Br]"},{"key":"10.1016\/j.jhin.2007.05.014_bib5","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1302\/0301-620X.81B6.9719","article-title":"Chlorhexidine and chondrolysis in the knee","volume":"81-B","author":"Van Huyssteen","year":"1999","journal-title":"J Bone and Joint Surg [Br]"},{"key":"10.1016\/j.jhin.2007.05.014_bib6","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/jor.1100180513","article-title":"A quantitative assessment of the effect of chlorhexidine 0.05% on rat articular cartilage metabolism in vitro and in vivo","volume":"18","author":"Reading","year":"2000","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jhin.2007.05.014_bib7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0195-6701(84)90122-1","article-title":"An experimental evaluation of antiseptic wound irrigation","volume":"5","author":"Platt","year":"1984","journal-title":"J Hosp Infect"},{"issue":"Suppl. 1","key":"10.1016\/j.jhin.2007.05.014_bib8","article-title":"Surgical wound decontamination with chlorhexidine jet lavage","volume":"81-B","author":"Taylor","year":"1999","journal-title":"J Bone Joint Surg [Br]"},{"key":"10.1016\/j.jhin.2007.05.014_bib9","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1532-950X.1994.tb00505.x","article-title":"Effects of 0.05% chlorhexidine lavage on the tarsocrural joints of horses","volume":"23","author":"Wilson","year":"1994","journal-title":"Vet Surg"},{"key":"10.1016\/j.jhin.2007.05.014_bib10","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1302\/0301-620X.75B5.8376427","article-title":"Effect of antiseptics, UV light and lavage on airborne bacteria in a wound model","volume":"75-B","author":"Taylor","year":"1993","journal-title":"J Bone and Joint Surg [Br]"},{"key":"10.1016\/j.jhin.2007.05.014_bib11","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1302\/0301-620X.76B3.8175856","article-title":"The effects in vitro of irrigating solutions on intact rat articular cartilage","volume":"76-B","author":"Bulstra","year":"1994","journal-title":"J Bone and Joint Surg [Br]"},{"key":"10.1016\/j.jhin.2007.05.014_bib12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF00541171","article-title":"The mouse patella assay: an easy method of quantitating articular cartilage chondrocyte function in vivo and in vitro","volume":"1","author":"Van den Berg","year":"1982","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.jhin.2007.05.014_bib13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0749-8063(95)90001-2","article-title":"Influence of various irrigation fluids on articular cartilage","volume":"11","author":"Gradinger","year":"1995","journal-title":"Arthroscopy"},{"key":"10.1016\/j.jhin.2007.05.014_bib14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/BF02615102","article-title":"Organ culture of human articular cartilage: studies on sulphated glycosaminoglycan synthesis","volume":"13","author":"McKenzie","year":"1977","journal-title":"In Vitro"},{"key":"10.1016\/j.jhin.2007.05.014_bib15","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00541319","article-title":"Quantification of glycosaminoglycan metabolism in anatomically intact cartilage of the mouse patella: in vitro and in\u00a0vivo studies with 35S-sulfate, 3H-glucosamine and 3H-acetate","volume":"6","author":"de Vries","year":"1986","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.jhin.2007.05.014_bib16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1574-6968.1992.tb14042.x","article-title":"The mechanism of action of chlorhexidine","volume":"79","author":"Kuyyakanond","year":"1992","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.jhin.2007.05.014_bib17","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1574-6968.1997.tb12657.x","article-title":"Flow cytometric analysis of chlorhexidine action","volume":"154","author":"Sheppard","year":"1997","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.jhin.2007.05.014_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1600-051X.1977.tb00053.x","article-title":"Safety of Hibitane. II. Human experience","volume":"4","author":"Rushton","year":"1977","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jhin.2007.05.014_bib19","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-0765.1976.tb00064.x","article-title":"Two years oral use of chlorhexidine in man. IV. Effect on various medical parameters","volume":"11","author":"Rindom Schiott","year":"1976","journal-title":"J Periodont Res"},{"key":"10.1016\/j.jhin.2007.05.014_bib20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0195-6701(91)90231-V","article-title":"Non toxic\u00a0antiseptic irrigation with chlorhexidine in experimental revascularisation in the rat","volume":"17","author":"Severyns","year":"1991","journal-title":"J Hosp Infect"},{"key":"10.1016\/j.jhin.2007.05.014_bib21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1600-051X.1977.tb00052.x","article-title":"Safety of Hibitane. I. Laboratory experiments","volume":"4","author":"Case","year":"1977","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.jhin.2007.05.014_bib22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1532-950X.1988.tb01019.x","article-title":"Effects of chlorhexidine diacetate and povidone iodine on wound healing in dogs","volume":"17","author":"Sanchez","year":"1988","journal-title":"Vet Surg"},{"key":"10.1016\/j.jhin.2007.05.014_bib23","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0195-6701(86)90122-2","article-title":"Antiseptic toxicity in wounds healing by secondary intention","volume":"8","author":"Brennan","year":"1986","journal-title":"J Hosp Infect"},{"key":"10.1016\/j.jhin.2007.05.014_bib24","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1001\/archderm.125.1.50","article-title":"Anaphylactic symptoms due to chlorhexidine gluconate","volume":"125","author":"Okano","year":"1989","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jhin.2007.05.014_bib25","first-page":"1784","article-title":"Effects of intraarticular chlorhexidine diacetate on the stifle of healthy dogs","volume":"54","author":"Anderson","year":"1993","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.jhin.2007.05.014_bib26","first-page":"1385","article-title":"The use of chlorhexidine in the treatment of bone and joint infections","volume":"18","author":"Gerard","year":"1979","journal-title":"Ann Med Nancy"},{"key":"10.1016\/j.jhin.2007.05.014_bib27","first-page":"9","article-title":"Treatment of septic knee by pressure irrigation through the arthroscope","volume":"98","author":"Halperin","year":"1980","journal-title":"J Ir Med Assoc"},{"key":"10.1016\/j.jhin.2007.05.014_bib28","doi-asserted-by":"crossref","first-page":"600","DOI":"10.2106\/00004623-199704000-00021","article-title":"Articular cartilage I and II","volume":"79-A","author":"Buckwalter","year":"1997","journal-title":"J\u00a0Bone Joint Surg [A]"},{"key":"10.1016\/j.jhin.2007.05.014_bib29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1136\/ard.21.1.45","article-title":"Cell counts of normal and osteoarthritic articular cartilage in relation to the uptake of sulphate in vitro","volume":"21","author":"Meachim","year":"1962","journal-title":"Ann Rheum Dis"}],"container-title":["Journal of Hospital Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019567010700179X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019567010700179X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T12:57:10Z","timestamp":1556715430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019567010700179X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S019567010700179X"],"URL":"https:\/\/doi.org\/10.1016\/j.jhin.2007.05.014","relation":{},"ISSN":["0195-6701"],"issn-type":[{"value":"0195-6701","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}