{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T03:52:24Z","timestamp":1776138744374,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100019624","name":"University Hospital Hradec Kralove","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofhospitalinfection.com","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hospital Infection"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jhin.2024.08.012","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T22:19:50Z","timestamp":1726179590000},"page":"73-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The role of colonization with resistant Gram-negative bacteria in the treatment of febrile neutropenia after stem cell transplantation"],"prefix":"10.1016","volume":"153","author":[{"given":"T.","family":"Sokolov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Paterov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zav\u0159elov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"V\u00ed\u0161ek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"\u017d\u00e1k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Radocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhin.2024.08.012_bib1","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1002\/cncr.21847","article-title":"Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients","volume":"106","author":"Kuderer","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.jhin.2024.08.012_bib2","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1002\/cncr.20983","article-title":"Incidence, cost, and mortality of neutropenia hospitalization associated with chemotherapy","volume":"103","author":"Caggiano","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.jhin.2024.08.012_bib3","doi-asserted-by":"crossref","first-page":"557","DOI":"10.6004\/jnccn.2005.0031","article-title":"Guidelines of the National Comprehensive Cancer Network on the use of myeloid growth factors with cancer chemotherapy: a review of the evidence","volume":"3","author":"Lyman","year":"2005","journal-title":"J\u00a0Natl Compr Cancer Netw"},{"key":"10.1016\/j.jhin.2024.08.012_bib4","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1002\/cncr.25332","article-title":"Risk of mortality in patients with cancer who experience febrile neutropenia","volume":"116","author":"Lyman","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.jhin.2024.08.012_bib5","series-title":"StatPearls [internet]. Treasure island, FL","article-title":"Febrile neutropenia","author":"Punnapuzha","year":"2023"},{"key":"10.1016\/j.jhin.2024.08.012_bib6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/cncr.11882","article-title":"Chemotherapy-induced neutropenia: risks, consequences, and new directions for its management","volume":"100","author":"Crawford","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.jhin.2024.08.012_bib7","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/bjh.13113","article-title":"Mucosal barrier injury, fever and infection in neutropenic patients with cancer: introducing the paradigm febrile mucositis","volume":"167","author":"van der Velden","year":"2014","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jhin.2024.08.012_bib8","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/apt.13302","article-title":"Chemotherapy-driven dysbiosis in the intestinal microbiome","volume":"42","author":"Montassier","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhin.2024.08.012_bib9","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/jac\/31.6.813","article-title":"Selective decontamination of the digestive tract and its role in antimicrobial prophylaxis","volume":"31","author":"Donnelly","year":"1993","journal-title":"J\u00a0Antimicrob Chemother"},{"issue":"9 Suppl","key":"10.1016\/j.jhin.2024.08.012_bib10","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1002\/cncr.20162","article-title":"Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients","volume":"100","author":"Sonis","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.jhin.2024.08.012_bib11","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/sj.bmt.1702447","article-title":"Mucosal barrier injury: biology, pathology, clinical counterparts and consequences of intensive treatment for haematological malignancy: an overview","volume":"25","author":"Blijlevens","year":"2000","journal-title":"Bone Marrow Transplant"},{"issue":"9296","key":"10.1016\/j.jhin.2024.08.012_bib12","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/S0140-6736(01)06884-2","article-title":"Clinical picture: bacterial translocation in neutropenic sepsis","volume":"358","author":"Cornely","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jhin.2024.08.012_bib13","series-title":"CDC invests in microbial ecology research [Internet]","year":"2022"},{"key":"10.1016\/j.jhin.2024.08.012_bib14","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/21505594.2016.1156821","article-title":"Bloodstream infections in neutropenic cancer patients: a practical update","volume":"7","author":"Gustinetti","year":"2016","journal-title":"Virulence"},{"key":"10.1016\/j.jhin.2024.08.012_bib15","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/bmt.2010.286","article-title":"Impact of bloodstream infections on outcome and the influence of prophylactic oral antibiotic regimens in allogeneic hematopoietic SCT recipients","volume":"46","author":"Liu","year":"2011","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jhin.2024.08.012_bib16","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00277-019-03622-0","article-title":"Management of sepsis in neutropenic cancer patients: 2018 guidelines from the Infectious Diseases Working Party (AGIHO) and Intensive Care Working Party (iCHOP) of the German Society of Hematology and Medical Oncology (DGHO)","volume":"98","author":"Kochanek","year":"2019","journal-title":"Ann Hematol"},{"key":"10.1016\/j.jhin.2024.08.012_bib17","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1200\/JCO.2012.47.2365","article-title":"Outcomes of critically ill patients with hematologic malignancies: prospective multicenter data from France and Belgium \u2013 a groupe de recherche respiratoire en r\u00e9animation onco-h\u00e9matologique study","volume":"31","author":"Azoulay","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jhin.2024.08.012_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/CCM.0b013e3181c0349e","article-title":"Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter study","volume":"38","author":"Soares","year":"2010","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jhin.2024.08.012_bib19","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1200\/JCO.2006.05.7869","article-title":"Prognosis of critically ill patients with cancer and acute renal dysfunction","volume":"24","author":"Soares","year":"2006","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jhin.2024.08.012_bib20","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1378\/chest.08-0359","article-title":"Short- and long-term outcomes of critically ill patients with cancer and prolonged ICU length of stay","volume":"134","author":"Soares","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.jhin.2024.08.012_bib21","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s00134-012-2791-x","article-title":"Long-term outcomes and quality of life in critically ill patients with hematological or solid malignancies: a single center study","volume":"39","author":"Oeyen","year":"2013","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jhin.2024.08.012_bib22","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1097\/CCM.0000000000000989","article-title":"Effect of early intervention on long-term outcomes of critically ill cancer patients admitted to ICUs","volume":"43","author":"Lee","year":"2015","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jhin.2024.08.012_bib23","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1093\/cid\/cir073","article-title":"Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the Infectious Diseases Society of America","volume":"52","author":"Freifeld","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jhin.2024.08.012_bib24","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0188-4409(00)00080-1","article-title":"Microbiological findings in febrile neutropenia","volume":"31","author":"Gayt\u00e1n-Mart\u00ednez","year":"2000","journal-title":"Arch Med Res"},{"key":"10.1016\/j.jhin.2024.08.012_bib25","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.ijantimicag.2006.12.012","article-title":"Pandrug-resistant Gram-negative bacteria: the dawn of the post-antibiotic era?","volume":"29","author":"Falagas","year":"2007","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jhin.2024.08.012_bib26","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jhin.2024.08.012_bib27","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/jac\/dkq494","article-title":"Bacteraemia due to multidrug-resistant Gram-negative bacilli in cancer patients: risk factors, antibiotic therapy and outcomes","volume":"66","author":"Gudiol","year":"2011","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jhin.2024.08.012_bib28","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/jac\/dkm514","article-title":"Recent changes in bacterial epidemiology and the emergence of fluoroquinolone-resistant Escherichia coli among patients with haematological malignancies: results of a prospective study on 823 patients at a single institution","volume":"61","author":"Cattaneo","year":"2008","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jhin.2024.08.012_bib29","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1086\/521260","article-title":"Screening for extended-spectrum beta-lactamase-producing Enterobacteriaceae among high-risk patients and rates of subsequent bacteremia","volume":"45","author":"Reddy","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jhin.2024.08.012_bib30","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.ijantimicag.2016.08.021","article-title":"Colonisation with extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae and risk for infection among patients with solid or haematological malignancy: a systematic review and meta-analysis","volume":"48","author":"Alevizakos","year":"2016","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jhin.2024.08.012_bib31","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.3324\/haematol.2013.091025","article-title":"European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the era of growing resistance: summary of the 2011 4th European Conference on Infections in Leukemia","volume":"98","author":"Averbuch","year":"2013","journal-title":"Haematologica"},{"key":"10.1016\/j.jhin.2024.08.012_bib32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1055\/s-0034-1398387","article-title":"Clinical management of infections caused by En-terobacteriaceae that express extended-spectrum \u03b2-lactamase and AmpC enzymes","volume":"36","author":"Harris","year":"2015","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.jhin.2024.08.012_bib33","first-page":"299","article-title":"Incidence and clinical impact of extended-spectrum-beta-lactamase (ESBL) production and fluoroquinolone resistance in bloodstream infections caused by Escherichia coli in\u00a0patients with hematological malignancies","volume":"58","author":"Trecarichi","year":"2009","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.jhin.2024.08.012_bib34","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/jac\/dkp411","article-title":"Bacteraemia due to extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) in cancer patients: clinical features, risk factors, molecular epidemiology and outcome","volume":"65","author":"Gudiol","year":"2010","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jhin.2024.08.012_bib35","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/jac\/dkn514","article-title":"Analysis of 4758 Escherichia coli bacteraemia episodes: predictive factors for isolation of an antibiotic-resistant strain and their impact on the outcome","volume":"63","author":"Ortega","year":"2009","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jhin.2024.08.012_bib36","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1128\/AAC.50.2.498-504.2006","article-title":"Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome","volume":"50","author":"Tumbarello","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jhin.2024.08.012_bib37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1201-9712(00)90061-4","article-title":"Ceftazidime-resistant Klebsiella pneumoniae bloodstream infection in children with febrile neutropenia","volume":"4","author":"Ariffin","year":"2000","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.jhin.2024.08.012_bib38","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.3324\/haematol.2010.036640","article-title":"Multidrug resistant Pseudomonas aeruginosa bloodstream infection in adult patients with hematologic malignancies","volume":"96","author":"Trecarichi","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.jhin.2024.08.012_bib39","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S1473-3099(22)00811-8","article-title":"Incidence of infection with multidrug-resistant Gram-negative bacteria and vancomycin-resistant enterococci in carriers: a systematic review and meta-regression analysis","volume":"23","author":"Willems","year":"2023","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jhin.2024.08.012_bib40","article-title":"Febrile neutropenia in cancer patient: epidemiology, microbiology, pathophysiology and management","volume":"5","author":"Rasmy","year":"2016","journal-title":"J\u00a0Cancer Prev Curr Res"},{"issue":"Suppl 1","key":"10.1016\/j.jhin.2024.08.012_bib41","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1086\/383048","article-title":"Changes in the etiology of bacteremia in febrile neutropenic patients and the susceptibilities of the currently isolated pathogens","volume":"39","author":"Ramphal","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jhin.2024.08.012_bib42","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1086\/598620","article-title":"Changing epidemiology of infections in patients with neutropenia and cancer: emphasis on Gram-positive and resistant bacteria","volume":"29","author":"Zinner","year":"1999","journal-title":"Clin Infect Dis"},{"issue":"Suppl 1","key":"10.1016\/j.jhin.2024.08.012_bib43","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/j.ijantimicag.2007.06.012","article-title":"Bacteraemia in febrile neutropenic cancer patients","volume":"30","author":"Klastersky","year":"2007","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jhin.2024.08.012_bib44","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3109\/00365548.2012.735372","article-title":"Bacteremia in Swedish hematological patients with febrile neutropenia: bacterial spectrum and antimicrobial resistance patterns","volume":"45","author":"Aust","year":"2013","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.jhin.2024.08.012_bib45","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.ijantimicag.2018.08.007","article-title":"Assessing antimicrobial stewardship initiatives: clinical evaluation of cefepime or piperacillin\/tazobactam in patients with bloodstream infections secondary to AmpC-producing organisms","volume":"52","author":"McKamey","year":"2018","journal-title":"Int J Antimicrob Agents"}],"container-title":["Journal of Hospital Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195670124002949?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195670124002949?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:50:12Z","timestamp":1739494212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0195670124002949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":45,"alternative-id":["S0195670124002949"],"URL":"https:\/\/doi.org\/10.1016\/j.jhin.2024.08.012","relation":{},"ISSN":["0195-6701"],"issn-type":[{"value":"0195-6701","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of colonization with resistant Gram-negative bacteria in the treatment of febrile neutropenia after stem cell transplantation","name":"articletitle","label":"Article Title"},{"value":"Journal of Hospital Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhin.2024.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Healthcare Infection Society. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}