{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:48:44Z","timestamp":1786992524368,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jhltopen.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHLT Open"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jhlto.2025.100335","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T11:23:48Z","timestamp":1751973828000},"page":"100335","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Thrombotic Microangiopathy After Lung Transplantation: A Retrospective Observational Multicenter Cohort Study"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1653-7405","authenticated-orcid":false,"given":"Pierre","family":"Gazengel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5080-6331","authenticated-orcid":false,"given":"Vincent","family":"Bunel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9188-833X","authenticated-orcid":false,"given":"Kinan","family":"El-Husseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Zaidan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Lefevre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5798-5715","authenticated-orcid":false,"given":"Romain","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0045-2018","authenticated-orcid":false,"given":"Xavier","family":"Demant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Falque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Eschapasse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1947-3401","authenticated-orcid":false,"given":"Thomas","family":"Villeneuve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaelle","family":"Dauriat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4043-4666","authenticated-orcid":false,"given":"Pauline","family":"Prad\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4760-6267","authenticated-orcid":false,"given":"Olaf","family":"Mercier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Fadel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2243-0736","authenticated-orcid":false,"given":"Cl\u00e9ment","family":"Picard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4426-9645","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Le Pavec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jhlto.2025.100335_bib1","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1053\/j.ajkd.2010.06.006","article-title":"The role of endothelial cell injury in thrombotic microangiopathy","volume":"56","author":"Goldberg","year":"2010","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"10.1016\/j.jhlto.2025.100335_bib2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jtct.2022.11.015","volume":"29","author":"Schoettler","year":"2023","journal-title":"Transplant Cell Ther"},{"issue":"7","key":"10.1016\/j.jhlto.2025.100335_bib3","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1056\/NEJMra1312353","article-title":"Syndromes of thrombotic microangiopathy","volume":"371","author":"George","year":"2014","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jhlto.2025.100335_bib4","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2215\/CJN.00620117","article-title":"Thrombotic microangiopathy and the kidney","volume":"13","author":"Brocklebank","year":"2018","journal-title":"CJASN"},{"issue":"1","key":"10.1016\/j.jhlto.2025.100335_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/01.tp.0000188140.50673.63","article-title":"Thrombotic microangiopathy after lung transplantation","volume":"81","author":"Hachem","year":"2006","journal-title":"Transplantation"},{"issue":"2","key":"10.1016\/j.jhlto.2025.100335_bib6","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0041-1345(03)00015-0","article-title":"Tacrolimus-induced hemolytic uremic syndrome case presentation in a lung transplant recipient","volume":"35","author":"Shitrit","year":"2003","journal-title":"Transplant Proc"},{"issue":"4","key":"10.1016\/j.jhlto.2025.100335_bib7","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/S0041-1345(98)00338-8","article-title":"Cyclosporine A-associated thrombotic thrombocytopenic purpura following lung transplantation","volume":"30","author":"Roberts","year":"1998","journal-title":"Transplant Proc"},{"key":"10.1016\/j.jhlto.2025.100335_bib8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1749-8090-5-70","article-title":"Dangerous drug interactions leading to hemolytic uremic syndrome following lung transplantation","volume":"5","author":"Parissis","year":"2010","journal-title":"J Cardiothorac Surg"},{"issue":"10","key":"10.1016\/j.jhlto.2025.100335_bib9","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/S1053-2498(99)00056-X","article-title":"Successful use of cyclosporine in a lung transplant recipient with tacrolimus-associated hemolytic uremic syndrome","volume":"18","author":"Myers","year":"1999","journal-title":"J Heart Lung Transplant"},{"issue":"1","key":"10.1016\/j.jhlto.2025.100335_bib10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00007890-199207000-00028","article-title":"Successful renal transplantation after cyclosporine-associated hemolytic-uremic syndrome following bilateral lung transplantation","volume":"54","author":"Butkus","year":"1992","journal-title":"Transplantation"},{"issue":"7","key":"10.1016\/j.jhlto.2025.100335_bib11","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/SMJ.0b013e3181792687","article-title":"The spectrum of thrombotic thrombocytopenic purpura: a clinicopathologic demonstration of tacrolimus-induced thrombotic thrombocytopenic purpura in a lung transplant patient","volume":"101","author":"Go","year":"2008","journal-title":"South Med J"},{"issue":"7","key":"10.1016\/j.jhlto.2025.100335_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.15373","article-title":"Outcomes of early thrombotic microangiopathy in renal transplantation","volume":"38","author":"Mour","year":"2024","journal-title":"Clin Transplant"},{"issue":"3","key":"10.1016\/j.jhlto.2025.100335_bib13","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/j.1600-6143.2011.03841.x","article-title":"Thrombotic microangiopathy after living-donor liver transplantation","volume":"12","author":"Shindoh","year":"2012","journal-title":"Am J Transplant"},{"issue":"12","key":"10.1016\/j.jhlto.2025.100335_bib14","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1097\/01.tp.0000226066.82066.fa","article-title":"Thrombotic microangiopathy with acquired deficiency in ADAMTS 13 activity in lung transplant recipients","volume":"81","author":"Mal","year":"2006","journal-title":"Transplantation"},{"issue":"3","key":"10.1016\/j.jhlto.2025.100335_bib15","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1600-6143.2010.03016.x","article-title":"A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study)","volume":"10","author":"Durrbach","year":"2010","journal-title":"Am J Transplant"},{"issue":"3","key":"10.1016\/j.jhlto.2025.100335_bib16","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1600-6143.2009.03005.x","article-title":"A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study)","volume":"10","author":"Vincenti","year":"2010","journal-title":"Am J Transplant"},{"issue":"12","key":"10.1016\/j.jhlto.2025.100335_bib17","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.1681\/ASN.2021050628","article-title":"Conversion from calcineurin inhibitor- to belatacept-based maintenance immunosuppression in renal transplant recipients: a randomized phase 3b trial","volume":"32","author":"Budde","year":"2021","journal-title":"J Am Soc Nephrol"},{"issue":"7","key":"10.1016\/j.jhlto.2025.100335_bib18","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1111\/ajt.13698","article-title":"Effect of an early switch to belatacept among calcineurin inhibitor-intolerant graft recipients of kidneys from extended-criteria donors","volume":"16","author":"Le Meur","year":"2016","journal-title":"Am J Transplant"},{"key":"10.1016\/j.jhlto.2025.100335_bib19","unstructured":"Belatacept rescue therapy of CNI-induced nephrotoxicity, meta-analysis - PubMed. Accessed January 8, 2025. \u3008https:\/\/pubmed-ncbi-nlm-nih-gov.proxy.insermbiblio.inist.fr\/34597943\/\u3009."},{"issue":"3","key":"10.1016\/j.jhlto.2025.100335_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0281492","article-title":"Conversion to belatacept after lung transplantation: report of 10 cases","volume":"18","author":"Brugi\u00e8re","year":"2023","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jhlto.2025.100335_bib21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/TP.0000000000001873","article-title":"Maintenance belatacept-based immunosuppression in lung transplantation recipients who failed calcineurin inhibitors","volume":"102","author":"Iasella","year":"2018","journal-title":"Transplantation"},{"issue":"3","key":"10.1016\/j.jhlto.2025.100335_bib22","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/TP.0000000000004841","article-title":"A pilot randomized controlled trial of De Novo Belatacept-based immunosuppression after lung transplantation","volume":"108","author":"Huang","year":"2024","journal-title":"Transplantation"},{"issue":"4","key":"10.1016\/j.jhlto.2025.100335_bib23","doi-asserted-by":"crossref","first-page":"A6452","DOI":"10.1016\/j.chest.2023.07.4160","article-title":"Balancing the benefits and risks: managing opportunistic infections with belatacept in lung transplant recipients","volume":"164","author":"Moin","year":"2023","journal-title":"Chest"},{"issue":"10","key":"10.1016\/j.jhlto.2025.100335_bib24","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.healun.2017.07.021","article-title":"Report of the ISHLT Working Group on Primary Lung Graft Dysfunction, part I: definition and grading-A 2016 Consensus Group statement of the International Society for Heart and Lung Transplantation","volume":"36","author":"Snell","year":"2017","journal-title":"J Heart Lung Transplant"},{"issue":"2","key":"10.1016\/j.jhlto.2025.100335_bib25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.healun.2013.10.022","article-title":"A new classification system for chronic lung allograft dysfunction","volume":"33","author":"Verleden","year":"2014","journal-title":"J Heart Lung Transplant"},{"issue":"2","key":"10.1016\/j.jhlto.2025.100335_bib26","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1053\/ajkd.2003.50058","article-title":"De novo thrombotic microangiopathy in renal transplant recipients: a comparison of hemolytic uremic syndrome with localized renal thrombotic microangiopathy","volume":"41","author":"Schwimmer","year":"2003","journal-title":"Am J Kidney Dis"},{"issue":"7","key":"10.1016\/j.jhlto.2025.100335_bib27","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1056\/NEJMra1312353","article-title":"Syndromes of thrombotic microangiopathy","volume":"371","author":"George","year":"2014","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.jhlto.2025.100335_bib28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/01.tp.0000188140.50673.63","article-title":"Thrombotic microangiopathy after lung transplantation","volume":"81","author":"Hachem","year":"2006","journal-title":"Transplantation"},{"issue":"2","key":"10.1016\/j.jhlto.2025.100335_bib29","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2215\/CJN.00620117","article-title":"Thrombotic microangiopathy and the kidney","volume":"13","author":"Brocklebank","year":"2018","journal-title":"CJASN"},{"issue":"4","key":"10.1016\/j.jhlto.2025.100335_bib30","article-title":"Thrombotic microangiopathy: a devastating complication after lung transplantation","volume":"11","author":"Rosseels","year":"2025","journal-title":"Transplant Direct"},{"issue":"1","key":"10.1016\/j.jhlto.2025.100335_bib31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00007890-199207000-00028","article-title":"Successful renal transplantation after cyclosporine-associated hemolytic-uremic syndrome following bilateral lung transplantation","volume":"54","author":"Butkus","year":"1992","journal-title":"Transplantation"},{"issue":"10","key":"10.1016\/j.jhlto.2025.100335_bib32","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/S1053-2498(99)00056-X","article-title":"Successful use of cyclosporine in a lung transplant recipient with tacrolimus-associated hemolytic uremic syndrome","volume":"18","author":"Myers","year":"1999","journal-title":"J Heart Lung Transplant"},{"issue":"2","key":"10.1016\/j.jhlto.2025.100335_bib33","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0041-1345(03)00015-0","article-title":"Tacrolimus-induced hemolytic uremic syndrome case presentation in a lung transplant recipient","volume":"35","author":"Shitrit","year":"2003","journal-title":"Transplant Proc"},{"issue":"7","key":"10.1016\/j.jhlto.2025.100335_bib34","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/SMJ.0b013e3181792687","article-title":"The spectrum of thrombotic thrombocytopenic purpura: a clinicopathologic demonstration of tacrolimus-induced thrombotic thrombocytopenic purpura in a lung transplant patient","volume":"101","author":"Go","year":"2008","journal-title":"South Med J"},{"key":"10.1016\/j.jhlto.2025.100335_bib35","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1749-8090-5-70","article-title":"Dangerous drug interactions leading to hemolytic uremic syndrome following lung transplantation","volume":"5","author":"Parissis","year":"2010","journal-title":"J Cardiothorac Surg"},{"issue":"4","key":"10.1016\/j.jhlto.2025.100335_bib36","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/S0041-1345(98)00338-8","article-title":"Cyclosporine A-associated thrombotic thrombocytopenic purpura following lung transplantation","volume":"30","author":"Roberts","year":"1998","journal-title":"Transplant Proc"},{"issue":"2","key":"10.1016\/j.jhlto.2025.100335_bib37","first-page":"95","article-title":"Tacrolimus (FK506) associated thrombotic thrombocytopenic purpura\/hemolytic uremic syndrome in lung transplant salvage with a plasmapheresis and cyclosporin","volume":"13","author":"Boctor","year":"2006","journal-title":"Egypt J Immunol"},{"issue":"12","key":"10.1016\/j.jhlto.2025.100335_bib38","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1592\/phco.26.12.1730","article-title":"Factors influencing the magnitude and clinical significance of drug interactions between azole antifungals and select immunosuppressants","volume":"26","author":"Saad","year":"2006","journal-title":"Pharmacotherapy"},{"issue":"6","key":"10.1016\/j.jhlto.2025.100335_bib39","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.blre.2014.09.001","article-title":"De novo thrombotic microangiopathy after non-renal solid organ transplantation","volume":"28","author":"Verbiest","year":"2014","journal-title":"Blood Rev"},{"key":"10.1016\/j.jhlto.2025.100335_bib40","doi-asserted-by":"crossref","first-page":"755","DOI":"10.12659\/AOT.900915","article-title":"Increased incidence of thrombotic microangiopathy after ABO-incompatible living donor liver transplantation","volume":"21","author":"Kishida","year":"2016","journal-title":"Ann Transplant"},{"issue":"2","key":"10.1016\/j.jhlto.2025.100335_bib41","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/jhbp.1032","article-title":"The outcomes of thrombotic microangiopathy after liver transplantation: A nationwide survey in Japan","volume":"29","author":"Takatsuki","year":"2022","journal-title":"J Hepato-Biliary-Pancreatic Sci"},{"issue":"3","key":"10.1016\/j.jhlto.2025.100335_bib42","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/MOT.0000000000000753","article-title":"Survival in adult lung transplantation: where are we in 2020?","volume":"25","author":"Bos","year":"2020","journal-title":"Curr Opin Organ Transplant"},{"issue":"2","key":"10.1016\/j.jhlto.2025.100335_bib43","doi-asserted-by":"crossref","first-page":"430","DOI":"10.2215\/CJN.05840710","article-title":"Switching from calcineurin inhibitor-based regimens to a belatacept-based regimen in renal transplant recipients: a randomized phase II study","volume":"6","author":"Rostaing","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"issue":"4","key":"10.1016\/j.jhlto.2025.100335_bib44","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1056\/NEJMoa1506027","article-title":"Belatacept and long-term outcomes in kidney transplantation","volume":"374","author":"Vincenti","year":"2016","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.jhlto.2025.100335_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.trre.2021.100653","article-title":"Belatacept rescue therapy of CNI-induced nephrotoxicity, meta-analysis","volume":"35","author":"El hennawy","year":"2021","journal-title":"Transplant Rev"},{"key":"10.1016\/j.jhlto.2025.100335_bib46","doi-asserted-by":"crossref","first-page":"205","DOI":"10.5935\/0101-2800.20170035","article-title":"Belatacept in kidney transplantation - past and future perspectives","volume":"39","author":"Siddiqui","year":"2017","journal-title":"Braz J Nephrol"},{"issue":"3","key":"10.1016\/j.jhlto.2025.100335_bib47","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/TP.0000000000004841","article-title":"A pilot randomized controlled trial of De Novo Belatacept-based immunosuppression after lung transplantation","volume":"108","author":"Huang","year":"2024","journal-title":"Transplantation"}],"container-title":["JHLT Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950133425001302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950133425001302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T07:30:24Z","timestamp":1758785424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950133425001302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":47,"alternative-id":["S2950133425001302"],"URL":"https:\/\/doi.org\/10.1016\/j.jhlto.2025.100335","relation":{},"ISSN":["2950-1334"],"issn-type":[{"value":"2950-1334","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thrombotic Microangiopathy After Lung Transplantation: A Retrospective Observational Multicenter Cohort Study","name":"articletitle","label":"Article Title"},{"value":"JHLT Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhlto.2025.100335","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of International Society for Heart and Lung Transplantation.","name":"copyright","label":"Copyright"}],"article-number":"100335"}}