{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:34:21Z","timestamp":1776980061047,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltopen.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHLT Open"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jhlto.2025.100445","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T17:12:14Z","timestamp":1764004334000},"page":"100445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Prognostic impact of restrictive ventilatory defects in chronic lung allograft dysfunction without restrictive allograft syndrome-like opacities: Stratification of emerging undefined and unclassified phenotypes"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9173-738X","authenticated-orcid":false,"given":"Taiki","family":"Fukuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusei","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Chi","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Staci M.","family":"Gagne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Johkoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Christiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Ojiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynette","family":"Sholl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuki","family":"Nishino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Hatabu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhlto.2025.100445_bib1","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.healun.2016.09.001","article-title":"The Registry of the International Society for Heart and Lung Transplantation: Thirty-third Adult Lung and Heart-Lung Transplant Report-2016; Focus Theme: primary diagnostic indications for transplant","volume":"35","author":"Yusen","year":"2016","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jhlto.2025.100445_bib2","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/S2213-2600(22)00001-7","article-title":"Pulmonary graft-versus-host disease and chronic lung allograft dysfunction: two sides of the same coin?","volume":"10","author":"Bos","year":"2022","journal-title":"Lancet Respir\u00a0Med"},{"key":"10.1016\/j.jhlto.2025.100445_bib3","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.healun.2019.03.009","article-title":"Chronic lung allograft dysfunction:\u00a0definition, diagnostic criteria, and approaches to treatment-a consensus report from the Pulmonary Council of the ISHLT","volume":"38","author":"Verleden","year":"2019","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jhlto.2025.100445_bib4","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.healun.2020.04.012","article-title":"Risk assessment of chronic lung allograft dysfunction phenotypes: validation and proposed refinement of the 2019 International Society for Heart and Lung Transplantation classification system","volume":"39","author":"Levy","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jhlto.2025.100445_bib5","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.healun.2011.01.712","article-title":"Restrictive allograft syndrome (RAS): a novel form of chronic lung allograft dysfunction","volume":"30","author":"Sato","year":"2011","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jhlto.2025.100445_bib6","first-page":"627","article-title":"Validation and refinement of chronic lung allograft dysfunction phenotypes in bilateral and single lung recipients","volume":"13","author":"DerHovanessian","year":"2016","journal-title":"Ann\u00a0Am\u00a0Thorac\u00a0Soc"},{"key":"10.1016\/j.jhlto.2025.100445_bib7","first-page":"159","article-title":"Impact of forced vital capacity loss on survival after the onset of chronic lung allograft dysfunction","volume":"189","author":"Todd","year":"2014","journal-title":"Am\u00a0J\u00a0Respir\u00a0Crit\u00a0Care Med"},{"key":"10.1016\/j.jhlto.2025.100445_bib8","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1111\/tri.14157","article-title":"Significance of phenotype change after chronic lung allograft dysfunction onset","volume":"34","author":"Fuchs","year":"2021","journal-title":"Transpl Int"},{"key":"10.1016\/j.jhlto.2025.100445_bib9","first-page":"317","article-title":"Restrictive allograft dysfunction rather than bronchiolitis obliterans syndrome had a major impact on the overall survival after living-donor lobar lung transplantation","volume":"54","author":"Matsubara","year":"2024","journal-title":"Surg\u00a0Today"},{"key":"10.1016\/j.jhlto.2025.100445_bib10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/MOT.0000000000000962","article-title":"Chronic lung allograft dysfunction and restrictive allograft syndrome: are phenotypes robust and helpful?","volume":"27","author":"Verleden","year":"2022","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1016\/j.jhlto.2025.100445_bib11","doi-asserted-by":"crossref","first-page":"E51","DOI":"10.1148\/rg.322115127","article-title":"Imaging of the diaphragm: anatomy and function","volume":"32","author":"Nason","year":"2012","journal-title":"Radiographics: a Review publication of the Radiological Society of North America, Inc"},{"key":"10.1016\/j.jhlto.2025.100445_bib12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1177\/1479972317702142","article-title":"Restrictive lung disease: Low EPAP - good ventilation. Is it real?","volume":"14","author":"Fiorentino","year":"2017","journal-title":"Chron Respir Dis"},{"key":"10.1016\/j.jhlto.2025.100445_bib13","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.healun.2019.03.008","article-title":"Chronic lung allograft dysfunction: definition and update of restrictive allograft syndrome-A consensus report from the Pulmonary Council of the ISHLT","volume":"38","author":"Glanville","year":"2019","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jhlto.2025.100445_bib14","first-page":"209","article-title":"Longitudinal forced vital capacity monitoring as a prognostic adjunct after lung transplantation","volume":"192","author":"Belloli","year":"2015","journal-title":"Am\u00a0J\u00a0Respir\u00a0Crit\u00a0Care Med"},{"key":"10.1016\/j.jhlto.2025.100445_bib15","first-page":"e70","article-title":"Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement","volume":"200","author":"Graham","year":"2019","journal-title":"Am\u00a0J\u00a0Respir\u00a0Crit\u00a0Care Med"},{"key":"10.1016\/j.jhlto.2025.100445_bib16","article-title":"Diaphragm dysfunction: diagnostic approaches and management strategies","volume":"5","author":"Dube","year":"2016","journal-title":"J\u00a0Clin\u00a0Med"},{"key":"10.1016\/j.jhlto.2025.100445_bib17","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/tri.13812","article-title":"2021 #1587}: Impact of unilateral diaphragm elevation on postoperative outcomes in bilateral lung transplantation - a retrospective single-center study","volume":"34","author":"Draeger","year":"2021","journal-title":"Transpl Int"},{"key":"10.1016\/j.jhlto.2025.100445_bib18","first-page":"59","article-title":"Recognition of pleural effusion on supine radiographs: how much fluid is required?","volume":"142","author":"Woodring","year":"1984","journal-title":"Am\u00a0J\u00a0Roentgenol"},{"key":"10.1016\/j.jhlto.2025.100445_bib19","first-page":"3346","article-title":"Lung transplantation in elderly patients","volume":"9","author":"Courtwright","year":"2017","journal-title":"J\u00a0Thorac\u00a0Dis"},{"key":"10.1016\/j.jhlto.2025.100445_bib20","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0132-2019","article-title":"Developments in lung transplantation over the past decade","volume":"29","author":"van der Mark","year":"2020","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.jhlto.2025.100445_bib21","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1177\/0013164418817803","article-title":"Evaluation of variance inflation factors in regression models using latent variable modeling methods","volume":"79","author":"Marcoulides","year":"2019","journal-title":"Educ Psychol Meas"},{"key":"10.1016\/j.jhlto.2025.100445_bib22","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1136\/bmj.304.6840.1491","article-title":"Statistical methods for assessing observer variability in clinical measures","volume":"304","author":"Brennan","year":"1992","journal-title":"BMJ"},{"key":"10.1016\/j.jhlto.2025.100445_bib23","first-page":"343","article-title":"A note on quantifying follow-up in studies of failure time","volume":"17","author":"Schemper","year":"1996","journal-title":"Control\u00a0Clin\u00a0Trials"},{"key":"10.1016\/j.jhlto.2025.100445_bib24","doi-asserted-by":"crossref","DOI":"10.1097\/TXD.0000000000001669","article-title":"Baseline lung allograft dysfunction after bilateral lung transplantation is associated with an increased risk of death: results from a multicenter cohort study","volume":"10","author":"Keller","year":"2024","journal-title":"Transplant Direct"},{"key":"10.1016\/j.jhlto.2025.100445_bib25","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.healun.2022.12.026","article-title":"Airway oscillometry parameters in baseline lung allograft dysfunction: associations from a multicenter study","volume":"42","author":"Darley","year":"2023","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jhlto.2025.100445_bib26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.pulmoe.2018.10.008","article-title":"Diaphragmatic dysfunction","volume":"25","author":"Ricoy","year":"2019","journal-title":"Pulmonology"},{"key":"10.1016\/j.jhlto.2025.100445_bib27","first-page":"407","article-title":"Natural history of pleural complications after lung transplantation","volume":"111","author":"Tang","year":"2021","journal-title":"Ann\u00a0Thorac\u00a0Surg"},{"key":"10.1016\/j.jhlto.2025.100445_bib28","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.03387-2020","article-title":"The accuracy of forced vital capacity for diagnosing restrictive allograft syndrome and mixed phenotype of chronic lung allograft dysfunction","volume":"58","author":"Levy","year":"2021","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jhlto.2025.100445_bib29","first-page":"507","article-title":"Impact of immediate primary lung allograft dysfunction on bronchiolitis obliterans syndrome","volume":"175","author":"Daud","year":"2007","journal-title":"Am\u00a0J\u00a0Respir\u00a0Crit\u00a0Care Med"},{"key":"10.1016\/j.jhlto.2025.100445_bib30","doi-asserted-by":"crossref","DOI":"10.1111\/tid.12964","article-title":"University of Alberta Cardiothoracic Transplant Group. Impact of donor and recipient cytomegalovirus serology on long-term survival of lung transplant recipients","volume":"20","author":"Mabilangan","year":"2018","journal-title":"Transpl Infect Dis"}],"container-title":["JHLT Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950133425002447?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950133425002447?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T20:34:24Z","timestamp":1776976464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950133425002447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":30,"alternative-id":["S2950133425002447"],"URL":"https:\/\/doi.org\/10.1016\/j.jhlto.2025.100445","relation":{},"ISSN":["2950-1334"],"issn-type":[{"value":"2950-1334","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic impact of restrictive ventilatory defects in chronic lung allograft dysfunction without restrictive allograft syndrome-like opacities: Stratification of emerging undefined and unclassified phenotypes","name":"articletitle","label":"Article Title"},{"value":"JHLT Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhlto.2025.100445","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of International Society for Heart and Lung Transplantation.","name":"copyright","label":"Copyright"}],"article-number":"100445"}}