{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T13:14:24Z","timestamp":1772370864945,"version":"3.50.1"},"reference-count":10,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Hand Surgery"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.jhsa.2014.02.015","type":"journal-article","created":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T03:17:29Z","timestamp":1395458249000},"page":"1646-1648","source":"Crossref","is-referenced-by-count":8,"title":["Holt\u2013Oram Syndrome"],"prefix":"10.1016","volume":"39","author":[{"given":"Charles A.","family":"Goldfarb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindley B.","family":"Wall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhsa.2014.02.015_bib1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1136\/hrt.22.2.236","article-title":"Familial heart disease with skeletal malformations","volume":"22","author":"Holt","year":"1960","journal-title":"Br Heart J"},{"issue":"7","key":"10.1016\/j.jhsa.2014.02.015_bib2","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.jhsa.2006.05.012","article-title":"Radial longitudinal deficiency: the incidence of associated medical and musculoskeletal conditions","volume":"31","author":"Goldfarb","year":"2006","journal-title":"J\u00a0Hand Surg Am"},{"issue":"1","key":"10.1016\/j.jhsa.2014.02.015_bib3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/ng0197-30","article-title":"Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome","volume":"15","author":"Basson","year":"1997","journal-title":"Nat Genet"},{"issue":"suppl 4","key":"10.1016\/j.jhsa.2014.02.015_bib4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2106\/JBJS.I.00073","article-title":"Genetics of radial deficiencies","volume":"91","author":"de Graaff","year":"2009","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"1","key":"10.1016\/j.jhsa.2014.02.015_bib5","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1086\/376436","article-title":"Expressivity of Holt-Oram syndrome is not predicted by TBX5 genotype","volume":"73","author":"Brassington","year":"2003","journal-title":"Am J Hum Genet"},{"issue":"11","key":"10.1016\/j.jhsa.2014.02.015_bib6","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/j.jhsa.2013.08.091","article-title":"The utility\u00a0of prenatal ultrasound as a screening tool for upper extremity\u00a0congenital anomalies","volume":"38","author":"Gray","year":"2013","journal-title":"J\u00a0Hand Surg Am"},{"issue":"1","key":"10.1016\/j.jhsa.2014.02.015_bib7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1148\/10.1148\/94.1.45","article-title":"Skeletal manifestations of the Holt-Oram syndrome","volume":"94","author":"Poznanski","year":"1970","journal-title":"Radiology"},{"issue":"9","key":"10.1016\/j.jhsa.2014.02.015_bib8","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/ajmg.a.32170","article-title":"Holt-Oram syndrome associated with anomalies of the feet","volume":"146","author":"Garavelli","year":"2008","journal-title":"Am J Med Genet A"},{"issue":"4","key":"10.1016\/j.jhsa.2014.02.015_bib9","first-page":"277","article-title":"Holt-Oram syndrome: postaxial and central polydactyly as variable manifestations in a four generations family","volume":"4","author":"Moens","year":"1993","journal-title":"Genet Couns"},{"issue":"4","key":"10.1016\/j.jhsa.2014.02.015_bib10","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/jmg.33.4.300","article-title":"Holt-Oram syndrome: a clinical genetic study","volume":"33","author":"Newbury-Ecob","year":"1996","journal-title":"J\u00a0Med Genet"}],"container-title":["The Journal of Hand Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0363502314002603?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0363502314002603?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T21:20:35Z","timestamp":1538774435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0363502314002603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0363502314002603"],"URL":"https:\/\/doi.org\/10.1016\/j.jhsa.2014.02.015","relation":{},"ISSN":["0363-5023"],"issn-type":[{"value":"0363-5023","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]}}}