{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T00:32:13Z","timestamp":1794097933629,"version":"4.8.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhandsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Hand Surgery"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.jhsa.2022.08.011","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T03:21:10Z","timestamp":1666063270000},"page":"263-272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Role of Intravenous Heparin Following Digital Replantation: A Retrospective Cohort Study on 1,155 Digits"],"prefix":"10.1016","volume":"48","author":[{"given":"Linda M.","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aslan","family":"Baradaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Thibaudeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Mastropasqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Supp 1","key":"10.1016\/j.jhsa.2022.08.011_bib1","doi-asserted-by":"crossref","first-page":"i115","DOI":"10.1136\/injuryprev-2019-043495","article-title":"Global trends of hand and wrist trauma: a systematic analysis of fracture and digit amputation using the Global Burden of Disease 2017 Study","volume":"26","author":"Crowe","year":"2020","journal-title":"Inj Prev"},{"issue":"2","key":"10.1016\/j.jhsa.2022.08.011_bib2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.hcl.2019.01.003","article-title":"Postoperative management and rehabilitation of the replanted or revascularized digit","volume":"35","author":"Prsic","year":"2019","journal-title":"Hand Clin"},{"issue":"3","key":"10.1016\/j.jhsa.2022.08.011_bib3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11552-012-9427-z","article-title":"Complete digital amputations undergoing replantation surgery: a 10-year retrospective study","volume":"7","author":"Neinstein","year":"2012","journal-title":"Hand (N Y)"},{"issue":"3","key":"10.1016\/j.jhsa.2022.08.011_bib4","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1097\/PRS.0000000000003087","article-title":"Annual hospital volume and success of digital replantation","volume":"139","author":"Brown","year":"2017","journal-title":"Plast Reconstr Surg"},{"issue":"3","key":"10.1016\/j.jhsa.2022.08.011_bib5","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/SAP.0b013e3182321b81","article-title":"Fingertip replantation without venous anastomosis","volume":"70","author":"Chen","year":"2013","journal-title":"Ann Plast Surg"},{"issue":"2","key":"10.1016\/j.jhsa.2022.08.011_bib6","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/PRS.0000000000005195","article-title":"The effect of increasing age on outcomes of digital revascularization or replantation","volume":"143","author":"Retrouvey","year":"2019","journal-title":"Plast Reconstr Surg"},{"issue":"23","key":"10.1016\/j.jhsa.2022.08.011_bib7","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.2106\/JBJS.L.01219","article-title":"Digit replantation: experience of two U.S. academic level-I trauma centers","volume":"95","author":"Fufa","year":"2013","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"4","key":"10.1016\/j.jhsa.2022.08.011_bib8","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jhsa.2006.12.006","article-title":"Current practice of microsurgery by members of the American Society for\u00a0Surgery of the Hand","volume":"32","author":"Payatakes","year":"2007","journal-title":"J\u00a0Hand Surg Am"},{"issue":"1","key":"10.1016\/j.jhsa.2022.08.011_bib9","first-page":"35","article-title":"Trends in digital replantation: 10 years of experience at a large Canadian tertiary care center","volume":"23","author":"Solaja","year":"2022","journal-title":"Plast Surg"},{"issue":"8","key":"10.1016\/j.jhsa.2022.08.011_bib10","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jhsa.2021.03.018","article-title":"Hand trauma network in the United States: ASSH member perspective over the last decade","volume":"46","author":"Eberlin","year":"2021","journal-title":"J\u00a0Hand Surg Am"},{"issue":"10","key":"10.1016\/j.jhsa.2022.08.011_bib11","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.jhsa.2018.07.021","article-title":"Finger Replantation Optimization Study (FRONT): update on national trends","volume":"43","author":"Cho","year":"2018","journal-title":"J\u00a0Hand Surg Am"},{"issue":"1","key":"10.1016\/j.jhsa.2022.08.011_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jhsa.2016.10.016","article-title":"A\u00a0population-based study of replantation after traumatic thumb amputation, 2007-2012","volume":"42","author":"Mahmoudi","year":"2017","journal-title":"J\u00a0Hand Surg Am"},{"issue":"9","key":"10.1016\/j.jhsa.2022.08.011_bib13","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s00402-009-1021-7","article-title":"Digit and hand replantation","volume":"130","author":"Beris","year":"2010","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.jhsa.2022.08.011_bib14","article-title":"Digital replantation\/revascularization: predictive factors to microsurgery success-a single-center study","author":"Tejedor Navarro","year":"2019","journal-title":"Eur J Trauma Emerg Surg"},{"issue":"7","key":"10.1016\/j.jhsa.2022.08.011_bib15","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1177\/1753193415624663","article-title":"Replantation of digits: a review of predictive factors for survival","volume":"41","author":"Breahna","year":"2016","journal-title":"J\u00a0Hand Surg Eur Vol"},{"issue":"8","key":"10.1016\/j.jhsa.2022.08.011_bib16","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.jhsa.2008.08.009","article-title":"Clinical use of anticoagulants following replantation surgery","volume":"33","author":"Levin","year":"2008","journal-title":"J\u00a0Hand Surg Am"},{"key":"10.1016\/j.jhsa.2022.08.011_bib17","article-title":"Salvaging digital replantation and revascularisation: efficiency of heparin solution subcutaneous injection","volume":"2018","author":"Alfeky","year":"2018","journal-title":"Surg Res Pract"},{"issue":"3","key":"10.1016\/j.jhsa.2022.08.011_bib18","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1097\/PRS.0b013e318180ed61","article-title":"Fingertip replantation: Determinants of survival","volume":"122","author":"Li","year":"2008","journal-title":"Plast Reconstr Surg"},{"issue":"7","key":"10.1016\/j.jhsa.2022.08.011_bib19","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/0007-1226(91)90009-9","article-title":"Continuous local intra-arterial infusion of antithrombotic agents for replantation (comparison with intravenous infusion). Comparative study","volume":"44","author":"Maeda","year":"1991","journal-title":"Br J Plast Surg"},{"issue":"4","key":"10.1016\/j.jhsa.2022.08.011_bib20","first-page":"CD009894","article-title":"Low molecular weight heparin for prevention of microvascular occlusion in digital replantation","author":"Lin","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"10.1016\/j.jhsa.2022.08.011_bib21","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/hq0701.093686","article-title":"Mechanism of action and pharmacology of unfractionated heparin","volume":"21","author":"Hirsh","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"10.1016\/j.jhsa.2022.08.011_bib22","article-title":"Complications of anticoagulation with heparin","volume":"7","author":"Krishnamurthy","year":"2005","journal-title":"Virtual Mentor"},{"issue":"8","key":"10.1016\/j.jhsa.2022.08.011_bib23","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.jhsa.2011.03.019","article-title":"Anticoagulation following digital replantation","volume":"36","author":"Buckley","year":"2011","journal-title":"J\u00a0Hand Surg Am"},{"issue":"1","key":"10.1016\/j.jhsa.2022.08.011_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1142\/S2424835519500012","article-title":"Is antithrombotic therapy necessary following replantation of an amputated digit?","volume":"24","author":"Matsusue","year":"2019","journal-title":"J\u00a0Hand Surg Asian Pac Vol"},{"issue":"5","key":"10.1016\/j.jhsa.2022.08.011_bib25","article-title":"Perioperative thromboprophylaxis in digital replantation: a systematic review","volume":"8","author":"Reissis","year":"2020","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"5","key":"10.1016\/j.jhsa.2022.08.011_bib26","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/SAP.0000000000001848","article-title":"Role of postoperative anticoagulation in predicting digit replantation and revascularization failure: a propensity-matched cohort study","volume":"83","author":"Retrouvey","year":"2019","journal-title":"Ann Plast Surg"},{"issue":"4","key":"10.1016\/j.jhsa.2022.08.011_bib27","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s11552-011-9353-5","article-title":"Upper extremity and digital replantation","volume":"6","author":"Maricevich","year":"2011","journal-title":"Hand (N Y)"},{"issue":"3","key":"10.1016\/j.jhsa.2022.08.011_bib28","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.cps.2019.03.002","article-title":"Efficiency in digital and hand replantation","volume":"46","author":"Ono","year":"2019","journal-title":"Clin Plast Surg"},{"key":"10.1016\/j.jhsa.2022.08.011_bib29","series-title":"Param\u00e8tres relatifs \u00e0 l\u2019offre de service de r\u00e9adaptation pour les personnes victimes d\u2019amputation traumatique ou n\u00e9cessitant une revascularisation microchirurgicale d\u2019urgence","year":"2019"},{"issue":"3","key":"10.1016\/j.jhsa.2022.08.011_bib30","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/micr.30194","article-title":"Duration and cessation characteristics of heparinization after finger replantation: A retrospective analysis of outcomes","volume":"38","author":"Efanov","year":"2018","journal-title":"Microsurgery"},{"issue":"5","key":"10.1016\/j.jhsa.2022.08.011_bib31","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.main.2010.03.007","article-title":"[Addition of antithrombosis in situ in the case of digital replantation: preliminary prospective study of 13 cases]","volume":"29","author":"Loisel","year":"2010","journal-title":"Chir Main"},{"issue":"1","key":"10.1016\/j.jhsa.2022.08.011_bib32","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000127639","article-title":"Anticoagulation in microvascular surgery","volume":"5","author":"Kolar","year":"1973","journal-title":"Eur Surg Res"},{"issue":"5","key":"10.1016\/j.jhsa.2022.08.011_bib33","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0363-5023(78)80133-6","article-title":"Pharmacological alterations in the clotting mechanism: use in microvascular surgery","volume":"3","author":"Ketchum","year":"1978","journal-title":"J\u00a0Hand Surg Am"},{"issue":"6","key":"10.1016\/j.jhsa.2022.08.011_bib34","doi-asserted-by":"crossref","first-page":"1224e","DOI":"10.1097\/PRS.0000000000005665","article-title":"Appropriate use of intravenous unfractionated heparin after digital replantation: a randomized controlled trial involving three groups","volume":"143","author":"Nishijima","year":"2019","journal-title":"Plast Reconstr Surg"},{"issue":"26","key":"10.1016\/j.jhsa.2022.08.011_bib35","doi-asserted-by":"crossref","first-page":"e3979","DOI":"10.1097\/MD.0000000000003979","article-title":"Controlled continuous systemic heparinization increases success rate of artery-only anastomosis replantation in single distal digit amputation","volume":"95","author":"Lee","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"10.1016\/j.jhsa.2022.08.011_bib36","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1055\/s-0038-1626689","article-title":"Predictors of digit survival following replantation: quantitative review and meta-Analysis","volume":"10","author":"Shaterian","year":"2018","journal-title":"J\u00a0Hand Microsurg"},{"issue":"3","key":"10.1016\/j.jhsa.2022.08.011_bib37","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/01.bth.0000225005.64605.17","article-title":"A\u00a0meta-analysis of success rates for digit replantation","volume":"10","author":"Dec","year":"2006","journal-title":"Tech Hand Up Extrem Surg"},{"issue":"1","key":"10.1016\/j.jhsa.2022.08.011_bib38","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0020-1383(99)00196-5","article-title":"Results of 1018 digital replantations in 552 patients","volume":"31","author":"Waikakul","year":"2000","journal-title":"Injury"},{"issue":"5","key":"10.1016\/j.jhsa.2022.08.011_bib39","first-page":"766","article-title":"Thrombus formation in microvascular surgery: an experimental study of the effects of surgical trauma","volume":"73","author":"Acland","year":"1973","journal-title":"Surgery"},{"issue":"4","key":"10.1016\/j.jhsa.2022.08.011_bib40","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/micr.10146","article-title":"Microvascular repair following crush-avulsion type injury with vein grafts: effect of direct inhibitors of thrombin on patency rate","volume":"23","author":"Gravvanis","year":"2003","journal-title":"Microsurgery"},{"issue":"6","key":"10.1016\/j.jhsa.2022.08.011_bib41","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/micr.20900","article-title":"Intravenous heparin use in digital replantation and revascularization: The Quebec Provincial Replantation program experience","volume":"31","author":"Nikolis","year":"2011","journal-title":"Microsurgery"}],"container-title":["The Journal of Hand Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0363502322004713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0363502322004713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T23:05:18Z","timestamp":1759791918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0363502322004713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0363502322004713"],"URL":"https:\/\/doi.org\/10.1016\/j.jhsa.2022.08.011","relation":{},"ISSN":["0363-5023"],"issn-type":[{"value":"0363-5023","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Role of Intravenous Heparin Following Digital Replantation: A Retrospective Cohort Study on 1,155 Digits","name":"articletitle","label":"Article Title"},{"value":"The Journal of Hand Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhsa.2022.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the American Society for Surgery of the Hand. All rights reserved.","name":"copyright","label":"Copyright"}]}}