{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:06:43Z","timestamp":1778249203326,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"am","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhandsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Hand Surgery"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jhsa.2023.11.023","type":"journal-article","created":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T06:55:29Z","timestamp":1704092129000},"page":"237-246","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Effect of Local Purified Exosome Product, Stem Cells, and Tacrolimus on Neurite Extension"],"prefix":"10.1016","volume":"49","author":[{"given":"Daan J.","family":"Rademakers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Saffari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiam M.","family":"Saffari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Pulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander Y.","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jhsa.2023.11.023_bib1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1529-8027.2010.00260.x","article-title":"Traumatic peripheral nerve injuries: epidemiological findings, neuropathic pain and quality of life in 158 patients","volume":"15","author":"Ciaramitaro","year":"2010","journal-title":"J\u00a0Peripher Nerv Syst"},{"issue":"4","key":"10.1016\/j.jhsa.2023.11.023_bib2","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/micr.1920140403","article-title":"Forty-two years of peripheral nerve surgery","volume":"14","author":"Millesi","year":"1993","journal-title":"Microsurgery"},{"issue":"2","key":"10.1016\/j.jhsa.2023.11.023_bib3","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/00006534-197508000-00008","article-title":"The nerve gap: suture under tension vs. graft","volume":"56","author":"Terzis","year":"1975","journal-title":"Plast Reconstr Surg"},{"issue":"1","key":"10.1016\/j.jhsa.2023.11.023_bib4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.expneurol.2009.03.031","article-title":"Management of nerve gaps: autografts, allografts, nerve transfers, and end-to-side neurorrhaphy","volume":"223","author":"Ray","year":"2010","journal-title":"Exp Neurol"},{"issue":"3","key":"10.1016\/j.jhsa.2023.11.023_bib5","doi-asserted-by":"crossref","first-page":"E4","DOI":"10.3171\/2017.1.FOCUS16462","article-title":"Optimizing decellularization techniques to create a new nerve allograft: an in\u00a0vitro study using rodent nerve segments","volume":"42","author":"Hundepool","year":"2017","journal-title":"Neurosurg Focus"},{"issue":"2","key":"10.1016\/j.jhsa.2023.11.023_bib6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.hcl.2015.12.012","article-title":"Autograft substitutes: conduits and processed nerve allografts","volume":"32","author":"Safa","year":"2016","journal-title":"Hand Clin"},{"issue":"5","key":"10.1016\/j.jhsa.2023.11.023_bib7","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jhsa.2017.02.017","article-title":"The role of nerve graft substitutes in motor and mixed motor\/sensory peripheral nerve injuries","volume":"42","author":"Rbia","year":"2017","journal-title":"J\u00a0Hand Surg Am"},{"issue":"3","key":"10.1016\/j.jhsa.2023.11.023_bib8","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3109\/21691401.2015.1129620","article-title":"Implications of mesenchymal stem cells in regenerative medicine","volume":"44","author":"Kariminekoo","year":"2016","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"8","key":"10.1016\/j.jhsa.2023.11.023_bib9","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.4103\/1673-5374.303009","article-title":"The interaction of stem cells and vascularity in peripheral nerve regeneration","volume":"16","author":"Saffari","year":"2021","journal-title":"Neural Regen Res"},{"issue":"2","key":"10.1016\/j.jhsa.2023.11.023_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1089\/scd.2018.0205","article-title":"Characterization and therapeutic uses of exosomes: a new potential tool in orthopedics","volume":"28","author":"Vitha","year":"2019","journal-title":"Stem Cells Dev"},{"issue":"6","key":"10.1016\/j.jhsa.2023.11.023_bib11","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/mus.26862","article-title":"Magnetic resonance imaging of enhanced nerve repair with mesenchymal stem cells combined with microenvironment immunomodulation in neurotmesis","volume":"61","author":"Yang","year":"2020","journal-title":"Muscle Nerve"},{"issue":"1","key":"10.1016\/j.jhsa.2023.11.023_bib12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/nyas.13469","article-title":"Exosomes: biology, therapeutic potential, and emerging role in musculoskeletal repair and regeneration","volume":"1410","author":"Cobelli","year":"2017","journal-title":"Ann N Y Acad Sci"},{"issue":"7","key":"10.1016\/j.jhsa.2023.11.023_bib13","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3390\/cells8070727","article-title":"Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis","volume":"8","author":"Doyle","year":"2019","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.jhsa.2023.11.023_bib14","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1177\/1545968318798955","article-title":"Exosomes and their microRNA cargo: new players in peripheral nerve regeneration","volume":"32","author":"Qing","year":"2018","journal-title":"Neurorehabil Neural Repair"},{"key":"10.1016\/j.jhsa.2023.11.023_bib15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.actbio.2019.05.058","article-title":"Local delivery of FK506 to injured peripheral nerve enhances axon regeneration after surgical nerve repair in rats","volume":"96","author":"Tajdaran","year":"2019","journal-title":"Acta Biomater"},{"issue":"2","key":"10.1016\/j.jhsa.2023.11.023_bib16","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/bit.26853","article-title":"Local FK506 dose-dependent study using a novel three-dimensional organotypic assay","volume":"116","author":"Tajdaran","year":"2019","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.jhsa.2023.11.023_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113680","article-title":"Local FK506 drug delivery enhances nerve regeneration through fresh, unprocessed peripheral nerve allografts","volume":"341","author":"Zuo","year":"2021","journal-title":"Exp Neurol"},{"issue":"11","key":"10.1016\/j.jhsa.2023.11.023_bib18","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1002\/bit.27916","article-title":"Mesenchymal stem cells and local tacrolimus delivery synergistically enhance neurite extension","volume":"118","author":"Saffari","year":"2021","journal-title":"Biotechnol Bioeng"},{"issue":"11","key":"10.1016\/j.jhsa.2023.11.023_bib19","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1080\/17512433.2019.1675507","article-title":"Exploring the neuroregenerative potential of tacrolimus","volume":"12","author":"Saffari","year":"2019","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"3-4","key":"10.1016\/j.jhsa.2023.11.023_bib20","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/BF00434555","article-title":"Revascularisation of bone allografts following vascular bundle implantation: an experimental study in rats","volume":"115","author":"Kumta","year":"1996","journal-title":"Arch Orthop Trauma Surg"},{"issue":"11-12","key":"10.1016\/j.jhsa.2023.11.023_bib21","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1089\/ten.2004.10.1641","article-title":"Optimized acellular nerve graft is immunologically tolerated and supports regeneration","volume":"10","author":"Hudson","year":"2004","journal-title":"Tissue Eng"},{"issue":"2","key":"10.1016\/j.jhsa.2023.11.023_bib22","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.expneurol.2007.06.029","article-title":"Adipose-derived stem cells differentiate into a Schwann cell phenotype and promote neurite outgrowth in\u00a0vitro","volume":"207","author":"Kingham","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jhsa.2023.11.023_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2019.144151","article-title":"Gene expression profiles of differentiated and undifferentiated adipose derived mesenchymal stem cells dynamically seeded onto a processed nerve allograft","volume":"724","author":"Mathot","year":"2020","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.jhsa.2023.11.023_bib24","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/PRS.0000000000004614","article-title":"A\u00a0simple dynamic strategy to deliver stem cells to decellularized nerve allografts","volume":"142","author":"Rbia","year":"2018","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.jhsa.2023.11.023_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121019","article-title":"Effects of purified exosome product on rotator cuff tendon-bone healing in\u00a0vitro and in\u00a0vivo","volume":"276","author":"Ren","year":"2021","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.jhsa.2023.11.023_bib26","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1002\/jor.24587","article-title":"Characterization of a purified exosome product and its effects on canine flexor tenocyte biology","volume":"38","author":"Qi","year":"2020","journal-title":"J\u00a0Orthop Res"},{"issue":"6","key":"10.1016\/j.jhsa.2023.11.023_bib27","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1111\/j.1582-4934.2011.01391.x","article-title":"Mesenchymal stem cells promote the sustained expression of CD69 on activated T lymphocytes: roles of canonical and non-canonical NF-\u03baB signalling","volume":"16","author":"Saldanha-Araujo","year":"2012","journal-title":"J\u00a0Cell Mol Med"},{"issue":"12","key":"10.1016\/j.jhsa.2023.11.023_bib28","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.2174\/1570159X19666210203161559","article-title":"Exosomes as a promising therapeutic strategy for peripheral nerve injury","volume":"19","author":"Yu","year":"2021","journal-title":"Curr Neuropharmacol"},{"issue":"2","key":"10.1016\/j.jhsa.2023.11.023_bib29","doi-asserted-by":"crossref","first-page":"200e","DOI":"10.1097\/PRS.0000000000008202","article-title":"Administration of purified exosome product in a rat sciatic serve reverse autograft model","volume":"148","author":"Ikumi","year":"2021","journal-title":"Plast Reconstr Surg"},{"issue":"6","key":"10.1016\/j.jhsa.2023.11.023_bib30","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1097\/PRS.0000000000010389","article-title":"Enhancing functional recovery after segmental nerve defect using nerve allograft treated with plasma-derived exosome","volume":"152","author":"Wang","year":"2023","journal-title":"Plast Reconstr Surg"},{"issue":"3","key":"10.1016\/j.jhsa.2023.11.023_bib31","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.3390\/ijms15034142","article-title":"Exosomes derived from mesenchymal stem cells","volume":"15","author":"Yu","year":"2014","journal-title":"Int J Mol Sci"},{"issue":"16","key":"10.1016\/j.jhsa.2023.11.023_bib32","doi-asserted-by":"crossref","first-page":"8545","DOI":"10.3390\/ijms22168545","article-title":"Enhanced nerve regeneration by exosomes secreted by adipose-derived stem cells with or without FK506 stimulation","volume":"22","author":"Rau","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhsa.2023.11.023_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6458237","article-title":"MSC-derived exosomes-based therapy for peripheral nerve injury: a novel therapeutic strategy","author":"Dong","year":"2019","journal-title":"BioMed Res Int"},{"issue":"11","key":"10.1016\/j.jhsa.2023.11.023_bib34","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1002\/bit.28520","article-title":"Dose-response analysis after administration of a human platelet-derived exosome product on neurite outgrowth in\u00a0vitro","volume":"120","author":"Saffari","year":"2023","journal-title":"Biotechnol Bioeng"},{"issue":"5","key":"10.1016\/j.jhsa.2023.11.023_bib35","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/mus.26656","article-title":"Local FK506 delivery at the direct nerve repair site improves nerve regeneration","volume":"60","author":"Davis","year":"2019","journal-title":"Muscle Nerve"},{"issue":"7","key":"10.1016\/j.jhsa.2023.11.023_bib36","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1002\/bit.27799","article-title":"Combined local delivery of tacrolimus and stem cells in hydrogel for enhancing peripheral nerve regeneration","volume":"118","author":"Saffari","year":"2021","journal-title":"Biotechnol Bioeng"},{"issue":"1","key":"10.1016\/j.jhsa.2023.11.023_bib37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40902-022-00339-5","article-title":"The effect of FK506 (tacrolimus) loaded with collagen membrane and fibrin glue on promotion of nerve regeneration in a rat sciatic nerve traction injury model","volume":"44","author":"Kim","year":"2022","journal-title":"Maxillofac Plast Reconstr Surg"},{"issue":"2","key":"10.1016\/j.jhsa.2023.11.023_bib38","first-page":"207","article-title":"Effect of tacrolimus and cyclosporine immunosuppressants on peripheral nerve regeneration: systematic review and meta-analysis","volume":"57","author":"Seixas","year":"2022","journal-title":"Rev Bras Ortop"},{"issue":"12","key":"10.1016\/j.jhsa.2023.11.023_bib39","doi-asserted-by":"crossref","DOI":"10.1177\/23259671211062929","article-title":"Intrinsic tendon regeneration after application of purified exosome product: an in\u00a0vivo study","volume":"9","author":"Wellings","year":"2021","journal-title":"Orthop J Sports Med"},{"issue":"1","key":"10.1016\/j.jhsa.2023.11.023_bib40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2217\/rme-2022-0132","article-title":"Purified exosome product enhances chondrocyte survival and regeneration by modulating inflammation and promoting chondrogenesis","volume":"18","author":"Shi","year":"2023","journal-title":"Regen Med"},{"issue":"13","key":"10.1016\/j.jhsa.2023.11.023_bib41","doi-asserted-by":"crossref","first-page":"6616","DOI":"10.7150\/thno.57701","article-title":"TGF-\u03b2 loaded exosome enhances ischemic wound healing in\u00a0vitro and in\u00a0vivo","volume":"11","author":"Shi","year":"2021","journal-title":"Theranostics"},{"issue":"10","key":"10.1016\/j.jhsa.2023.11.023_bib42","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1097\/SPV.0000000000001005","article-title":"Exosome-induced vaginal tissue regeneration in a porcine mesh exposure model","volume":"27","author":"Kisby","year":"2021","journal-title":"Female Pelvic Med Reconstr Surg"},{"issue":"1","key":"10.1016\/j.jhsa.2023.11.023_bib43","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neuron.2017.09.008","article-title":"The wound microenvironment reprograms schwann cells to invasive mesenchymal-like cells to drive peripheral nerve regeneration","volume":"96","author":"Clements","year":"2017","journal-title":"Neuron"},{"issue":"8","key":"10.1016\/j.jhsa.2023.11.023_bib44","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.3390\/biomedicines11082099","article-title":"Advancements and insights in exosome-based therapies for wound healing: a comprehensive systematic review (2018-June 2023)","volume":"11","author":"Sousa","year":"2023","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.jhsa.2023.11.023_bib45","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1007\/s12035-018-1172-z","article-title":"Effect of exosomes from rat adipose-derived mesenchymal stem cells on neurite outgrowth and sciatic nerve regeneration after crush injury","volume":"56","author":"Bucan","year":"2019","journal-title":"Mol Neurobiol"}],"container-title":["The Journal of Hand Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0363502323006421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0363502323006421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T23:08:41Z","timestamp":1759792121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0363502323006421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S0363502323006421"],"URL":"https:\/\/doi.org\/10.1016\/j.jhsa.2023.11.023","relation":{},"ISSN":["0363-5023"],"issn-type":[{"value":"0363-5023","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Effect of Local Purified Exosome Product, Stem Cells, and Tacrolimus on Neurite Extension","name":"articletitle","label":"Article Title"},{"value":"The Journal of Hand Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhsa.2023.11.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the American Society for Surgery of the Hand. All rights reserved.","name":"copyright","label":"Copyright"}]}}