{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:01:37Z","timestamp":1790791297741,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca PLC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhandsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Hand Surgery"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jhsa.2025.01.028","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T07:29:19Z","timestamp":1741332559000},"page":"1528.e1-1528.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Development of an Amyloidosis Risk Score for Positive Tenosynovial Biopsy at Carpal Tunnel Release"],"prefix":"10.1016","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0155-8244","authenticated-orcid":false,"given":"Dafang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon E.","family":"Earp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyra A.","family":"Benavent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchiao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Cuddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George S.M.","family":"Dyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney H.","family":"Falk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey N.","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard N.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Robert F.","family":"Padera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Blazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jhsa.2025.01.028_bib1","first-page":"396","article-title":"Amyloidosis as a systemic disease in context","volume":"36","author":"Cuddy","year":"2020","journal-title":"Can J Cardiol"},{"issue":"10","key":"10.1016\/j.jhsa.2025.01.028_bib2","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.jhsa.2019.06.016","article-title":"Carpal tunnel syndrome: a potential early, red-flag sign of amyloidosis","volume":"44","author":"Donnelly","year":"2019","journal-title":"J Hand Surg Am"},{"issue":"3","key":"10.1016\/j.jhsa.2025.01.028_bib3","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002877","article-title":"Subtype-specific interactions and prognosis in cardiac amyloidosis","volume":"5","author":"Sperry","year":"2016","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"10.1016\/j.jhsa.2025.01.028_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1716153","article-title":"Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis","volume":"379","author":"Adams","year":"2018","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.jhsa.2025.01.028_bib5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1056\/NEJMoa1716793","article-title":"Inotersen treatment for patients with hereditary transthyretin amyloidosis","volume":"379","author":"Benson","year":"2018","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jhsa.2025.01.028_bib6","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1056\/NEJMoa2305434","article-title":"Efficacy and safety of acoramidis in transthyretin amyloid cardiomyopathy","volume":"390","author":"Gillmore","year":"2024","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.jhsa.2025.01.028_bib7","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1056\/NEJMoa1805689","article-title":"Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy","volume":"379","author":"Maurer","year":"2018","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jhsa.2025.01.028_bib8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cardfail.2017.12.005","article-title":"Time course of common clinical manifestations in patients with transthyretin cardiac amyloidosis: delay from symptom onset to diagnosis","volume":"24","author":"Papoutsidakis","year":"2018","journal-title":"J Card Fail"},{"issue":"14","key":"10.1016\/j.jhsa.2025.01.028_bib9","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.2106\/JBJS.20.02093","article-title":"Diagnosing systemic amyloidosis presenting as carpal tunnel syndrome: a risk nomogram to guide biopsy at time of carpal tunnel release","volume":"103","author":"Sood","year":"2021","journal-title":"J Bone Joint Surg Am"},{"issue":"5","key":"10.1016\/j.jhsa.2025.01.028_bib10","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/ajcp\/61.5.711","article-title":"Amyloidosis and the carpal tunnel syndrome","volume":"61","author":"Bastian","year":"1974","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.jhsa.2025.01.028_bib11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/PRS.0000000000005090","article-title":"Histopathologic evaluation of flexor tenosynovium in recurrent carpal tunnel syndrome","volume":"143","author":"Scott","year":"2019","journal-title":"Plast Reconstr Surg"},{"issue":"11","key":"10.1016\/j.jhsa.2025.01.028_bib12","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.humpath.2011.03.004","article-title":"High prevalence of wild-type transthyretin deposition in patients with idiopathic carpal tunnel syndrome: a common cause of carpal tunnel syndrome in the elderly","volume":"42","author":"Sekijima","year":"2011","journal-title":"Hum Pathol"},{"issue":"17","key":"10.1016\/j.jhsa.2025.01.028_bib13","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.jacc.2018.07.092","article-title":"Tenosynovial and cardiac amyloidosis in patients undergoing carpal tunnel release","volume":"72","author":"Sperry","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.jhsa.2025.01.028_bib14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jhsa.2024.01.002","article-title":"A comparison of amyloid deposition in endoscopic and open carpal tunnel release","volume":"49","author":"Ozdag","year":"2024","journal-title":"J Hand Surg Am"},{"issue":"10","key":"10.1016\/j.jhsa.2025.01.028_bib15","doi-asserted-by":"crossref","first-page":"e488","DOI":"10.5435\/JAAOS-D-20-01146","article-title":"Orthopaedic manifestations of amyloidosis","volume":"29","author":"Zhang","year":"2021","journal-title":"J Am Acad Orthop Surg"},{"issue":"4","key":"10.1016\/j.jhsa.2025.01.028_bib16","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/mus.22208","article-title":"Electrodiagnostic evaluation of carpal tunnel syndrome","volume":"44","author":"Werner","year":"2011","journal-title":"Muscle Nerve"},{"issue":"7","key":"10.1016\/j.jhsa.2025.01.028_bib17","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1001\/jama.1954.03690250015005","article-title":"Systemic disease and the carpal tunnel syndrome","volume":"155","author":"Grokoest","year":"1954","journal-title":"J Am Med Assoc"},{"issue":"9","key":"10.1016\/j.jhsa.2025.01.028_bib18","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.humpath.2010.11.017","article-title":"Wild-type transthyretin-derived amyloidosis in various ligaments and tendons","volume":"42","author":"Sueyoshi","year":"2011","journal-title":"Hum Pathol"},{"issue":"6","key":"10.1016\/j.jhsa.2025.01.028_bib19","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.jhsa.2022.02.013","article-title":"Prevalence and subtypes of tenosynovial amyloid in patients undergoing carpal tunnel release","volume":"47","author":"DiBenedetto","year":"2022","journal-title":"J Hand Surg Am"},{"issue":"7","key":"10.1016\/j.jhsa.2025.01.028_bib20","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jhsa.2022.09.005","article-title":"Results of implementation of amyloidosis screening for patients undergoing carpal tunnel release","volume":"49","author":"Gannon","year":"2024","journal-title":"J Hand Surg Am"},{"issue":"1","key":"10.1016\/j.jhsa.2025.01.028_bib21","doi-asserted-by":"crossref","first-page":"102.e1","DOI":"10.1016\/j.jhsa.2023.05.008","article-title":"Occult amyloid deposition in older patients presenting with bilateral carpal tunnel syndrome or multiple trigger digits","volume":"50","author":"Gray","year":"2025","journal-title":"J Hand Surg Am"},{"issue":"1","key":"10.1016\/j.jhsa.2025.01.028_bib22","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3109\/13506129.2015.1135792","article-title":"Carpal tunnel syndrome: a common initial symptom of systemic wild-type ATTR (ATTRwt) amyloidosis","volume":"23","author":"Nakagawa","year":"2016","journal-title":"Amyloid"},{"issue":"6","key":"10.1016\/j.jhsa.2025.01.028_bib23","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.jhsa.2022.01.022","article-title":"Risk of amyloidosis and heart failure among patients undergoing surgery for trigger digit or carpal tunnel syndrome: a nationwide cohort study with implications for screening","volume":"47","author":"Sood","year":"2022","journal-title":"J Hand Surg Am"},{"issue":"10","key":"10.1016\/j.jhsa.2025.01.028_bib24","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.jacc.2022.06.026","article-title":"Screening for cardiac amyloidosis 5 to 15 years after surgery for bilateral carpal tunnel syndrome","volume":"80","author":"Westin","year":"2022","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"10.1016\/j.jhsa.2025.01.028_bib25","doi-asserted-by":"crossref","first-page":"929.e1","DOI":"10.1016\/j.jhsa.2017.07.009","article-title":"Surgical demographics of carpal tunnel syndrome and cubital tunnel syndrome over 5 years at a single institution","volume":"42","author":"Zhang","year":"2017","journal-title":"J Hand Surg Am"},{"issue":"13","key":"10.1016\/j.jhsa.2025.01.028_bib26","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1001\/jama.2022.1820","article-title":"Collider bias","volume":"327","author":"Holmberg","year":"2022","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.jhsa.2025.01.028_bib27","first-page":"203","article-title":"Positive staining with Congo red in tissues with heat artifact due to cautery","volume":"50","author":"Fernandez-Flores","year":"2009","journal-title":"Rom J Morphol Embryol"},{"key":"10.1016\/j.jhsa.2025.01.028_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.949401","article-title":"The frequency of V122I transthyretin mutation in a cohort of african american individuals with bilateral carpal tunnel syndrome","volume":"13","author":"Shije","year":"2022","journal-title":"Front Neurol"}],"container-title":["The Journal of Hand Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0363502325000668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0363502325000668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T22:46:08Z","timestamp":1764629168000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0363502325000668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0363502325000668"],"URL":"https:\/\/doi.org\/10.1016\/j.jhsa.2025.01.028","relation":{},"ISSN":["0363-5023"],"issn-type":[{"value":"0363-5023","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of an Amyloidosis Risk Score for Positive Tenosynovial Biopsy at Carpal Tunnel Release","name":"articletitle","label":"Article Title"},{"value":"The Journal of Hand Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhsa.2025.01.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the American Society for Surgery of the Hand. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}