{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:51:17Z","timestamp":1784220677330,"version":"3.55.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hand Surgery"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:p>5-Fluorouracil reduces proliferation rates of fibroblasts, myofibroblast differentiation and contractility of ocular fibroblasts in vitro. This double-blind randomized clinical trial assesses whether intra-operative topical treatment with 5-fluorouracil reduces the recurrence rate after limited excision of Dupuytren\u2019s tissue. Patients with two-digit disease were randomized to having 5-fluorouracil (25 mg\/ml) treatment for 5 minutes on one digit and placebo on the other.<\/jats:p>\n                  <jats:p>Fifteen patients were enrolled with 18 months follow-up. There were no peri-operative complications. Wound healing was not delayed and there was no deterioration in the flexion deformity of the 5-fluorouracil treated digits. Patients were subsequently assessed by joint angle measurement at 3, 6, 12 and 18 months. There was no significant difference between control and 5-fluorouracil treated digits.<\/jats:p>","DOI":"10.1016\/j.jhsb.2003.08.002","type":"journal-article","created":{"date-parts":[[2004,1,15]],"date-time":"2004-01-15T05:21:22Z","timestamp":1074144082000},"page":"18-21","source":"Crossref","is-referenced-by-count":34,"title":["A Prospective Randomised Clinical Trial of the Intra-Operative Use of 5-Fluorouracil on the Outcome of Dupuytren\u2019s Disease"],"prefix":"10.1177","volume":"29","author":[{"given":"N. 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