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Cases were patients with a diagnosis of Dupuytren\u2019s disease and, for each, two controls were individually matched by age, sex, and general practice. Our dataset included 821 cases and 1,642 controls. Five hundred and eighty-eight (72%) of the cases were men. The mean age at diagnosis was 62 (range 24\u201397) years. Diabetes was a significant risk factor for Dupuytren\u2019s disease (OR = 1.75) and there was an increased risk for medicinally treated diabetes (metformin \u2013 R = 3.56; sulphonylureas \u2013 OR = 1.75) and particularly insulin controlled (OR = 4.39) rather than diet-controlled diabetes. Epilepsy (OR = 1.12) and antiepileptic medications were not associated with Dupuytren\u2019s disease. Ascertainment bias in previous studies may explain the reported association with epilepsy.<\/jats:p>","DOI":"10.1016\/j.jhsb.2004.06.006","type":"journal-article","created":{"date-parts":[[2004,8,31]],"date-time":"2004-08-31T12:58:01Z","timestamp":1093957081000},"page":"423-426","source":"Crossref","is-referenced-by-count":127,"title":["Dupuytren\u2019s Disease Risk Factors"],"prefix":"10.1177","volume":"29","author":[{"given":"J.M.","family":"GEOGHEGAN","sequence":"first","affiliation":[{"name":"From the Department of Trauma and Orthopaedics, Derbyshire Royal Infirmary, UK, University of Nottingham Medical School, UK, Division of Respiratory Medicine, Nottingham City Hospital, UK, and Clinical Epidemiology & Respiratory Medicine, Nottingham City Hospital, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"FORBES","sequence":"additional","affiliation":[{"name":"From the Department of Trauma and Orthopaedics, Derbyshire Royal Infirmary, UK, University of 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