{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T14:17:26Z","timestamp":1776176246327,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.jiac.2013.07.010","type":"journal-article","created":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T01:30:53Z","timestamp":1386725453000},"page":"20-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical efficacy of roxithromycin in men with chronic prostatitis\/chronic pelvic pain syndrome in comparison with ciprofloxacin and aceclofenac: A prospective, randomized, multicenter pilot trial"],"prefix":"10.1016","volume":"20","author":[{"given":"Hyun-Sop","family":"Choe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Ju","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Hee","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bong Suk","family":"Shim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Hyun","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl.\u00a01","key":"10.1016\/j.jiac.2013.07.010_bib1","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1016\/j.ijantimicag.2007.08.028","article-title":"Epidemiology of prostatitis","volume":"31","author":"Krieger","year":"2008","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jiac.2013.07.010_bib2","first-page":"842","article-title":"Prevalence of prostatitis-like symptoms in a population based study using the National Institutes of Health chronic prostatitis symptom index","volume":"165","author":"Nickel","year":"2001","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.jiac.2013.07.010_bib3","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0090-4295(98)00034-X","article-title":"Prevalence of a physician-assigned diagnosis of prostatitis: the Olmsted County study of urinary symptoms and health status among men","volume":"51","author":"Roberts","year":"1998","journal-title":"Urology"},{"key":"10.1016\/j.jiac.2013.07.010_bib4","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s002400100172","article-title":"The prevalence of chronic prostatitis-like symptoms in young men: a community-based survey","volume":"29","author":"Ku","year":"2001","journal-title":"Urol Res"},{"key":"10.1016\/j.jiac.2013.07.010_bib5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1586\/14737175.7.3.301","article-title":"Prostatitis and chronic prostatitis\/chronic pelvic pain syndrome","volume":"7","author":"Bergman","year":"2007","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.jiac.2013.07.010_bib6","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.urology.2011.02.065","article-title":"Long-term fluoroquinolone use before the prostate biopsy may increase the risk of sepsis caused by resistant microorganisms","volume":"78","author":"Akduman","year":"2011","journal-title":"Urology"},{"key":"10.1016\/j.jiac.2013.07.010_bib7","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1469-0691.2012.03807.x","article-title":"Relentless increase of resistance to fluoroquinolones and expanded-spectrum cephalosporins in Escherichia coli: 20 years of surveillance in resource-limited settings from Latin America","volume":"19","author":"Bartoloni","year":"2013","journal-title":"Clin Microbiol Infect"},{"issue":"Suppl.\u00a0B","key":"10.1016\/j.jiac.2013.07.010_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/41.suppl_2.1","article-title":"Roxithromycin: review of its antimicrobial activity","volume":"41","author":"Bryskier","year":"1998","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2013.07.010_bib9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/jac\/dkh519","article-title":"Anti-inflammatory effects of macrolides\u2013an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions?","volume":"55","author":"Amsden","year":"2005","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2013.07.010_bib10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00228-011-1161-x","article-title":"Macrolides: from in\u00a0vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases","volume":"68","author":"Zarogoulidis","year":"2012","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.jiac.2013.07.010_bib11","first-page":"337","article-title":"Inhibitory action of roxithromycin on histamine release and prostaglandin D2 production from beta-defensin 2-stimulated mast cells","volume":"23","author":"Kase","year":"2009","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jiac.2013.07.010_bib12","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/ppul.1076","article-title":"Anti-inflammatory effects of macrolides in lung disease","volume":"31","author":"Jaffe","year":"2001","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jiac.2013.07.010_bib13","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1001\/jama.282.3.236","article-title":"NIH consensus definition and classification of prostatitis","volume":"282","author":"Krieger","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.jiac.2013.07.010_bib14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11136-005-1317-1","article-title":"Responsiveness of the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI)","volume":"15","author":"Propert","year":"2006","journal-title":"Qual Life Res"},{"key":"10.1016\/j.jiac.2013.07.010_bib15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2165\/00003495-200969010-00005","article-title":"Chronic prostatitis: management strategies","volume":"69","author":"Murphy","year":"2009","journal-title":"Drugs"},{"key":"10.1016\/j.jiac.2013.07.010_bib16","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.2165\/00002512-200320150-00004","article-title":"Chronic prostatitis\/chronic pelvic pain syndrome in elderly men: toward better understanding and treatment","volume":"20","author":"Pontari","year":"2003","journal-title":"Drugs Aging"},{"key":"10.1016\/j.jiac.2013.07.010_bib17","first-page":"273","article-title":"The use of triacetyloleandomycin in chronic infectious asthma","volume":"6","author":"Kaplan","year":"1958","journal-title":"Antibiot Annu"},{"key":"10.1016\/j.jiac.2013.07.010_bib18","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1136\/thx.49.6.531","article-title":"Diffuse panbronchiolitis and cystic fibrosis: East meets West","volume":"49","author":"Hoiby","year":"1994","journal-title":"Thorax"},{"key":"10.1016\/j.jiac.2013.07.010_bib19","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1136\/thx.51.10.1065","article-title":"Diffuse panbronchiolitis in an Asian immigrant","volume":"51","author":"Brugiere","year":"1996","journal-title":"Thorax"},{"key":"10.1016\/j.jiac.2013.07.010_bib20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000195915","article-title":"Long-term low-dose administration of erythromycin to patients with diffuse panbronchiolitis","volume":"58","author":"Nagai","year":"1991","journal-title":"Respiration"},{"key":"10.1016\/j.jiac.2013.07.010_bib21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000196514","article-title":"Interleukin 1 beta, tumor necrosis factor alpha, and interleukin 8 in bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis: a potential mechanism of macrolide therapy","volume":"63","author":"Sakito","year":"1996","journal-title":"Respiration"},{"key":"10.1016\/j.jiac.2013.07.010_bib22","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0954-6111(93)90099-L","article-title":"Diffuse panbronchiolitis: efficacy of low-dose erythromycin","volume":"87","author":"Tredaniel","year":"1993","journal-title":"Respir Med"},{"key":"10.1016\/j.jiac.2013.07.010_bib23","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1001\/jama.2010.1913","article-title":"Management of chronic prostatitis\/chronic pelvic pain syndrome: a systematic review and network meta-analysis","volume":"305","author":"Anothaisintawee","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.jiac.2013.07.010_bib24","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s00120-002-0262-7","article-title":"European Association of Urology guidelines on urinary and male genital tract infections","volume":"42","author":"Schneede","year":"2003","journal-title":"Urologe A"},{"key":"10.1016\/j.jiac.2013.07.010_bib25","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0094-0143(05)70056-2","article-title":"Effective office management of chronic prostatitis","volume":"25","author":"Nickel","year":"1998","journal-title":"Urol Clin North Am"},{"key":"10.1016\/j.jiac.2013.07.010_bib26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1159\/000019784","article-title":"The role of antibiotics in the treatment of chronic prostatitis: a consensus statement","volume":"34","author":"Bjerklund Johansen","year":"1998","journal-title":"Eur Urol"},{"key":"10.1016\/j.jiac.2013.07.010_bib27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ucl.2007.09.008","article-title":"Bacterial prostatitis","volume":"35","author":"Benway","year":"2008","journal-title":"Urol Clin North Am"},{"key":"10.1016\/j.jiac.2013.07.010_bib28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0924-8579(98)00059-4","article-title":"Classification of fluoroquinolones","volume":"10","author":"Naber","year":"1998","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jiac.2013.07.010_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0090-4295(02)01979-9","article-title":"Overview summary statement. Diagnosis and management of chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS)","volume":"60","author":"Schaeffer","year":"2002","journal-title":"Urology"},{"key":"10.1016\/j.jiac.2013.07.010_bib30","first-page":"1265","article-title":"Pharmacology of the potent new non-steroidal anti-inflammatory agent aceclofenac","volume":"41","author":"Grau","year":"1991","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.jiac.2013.07.010_bib31","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1517\/14656566.5.6.1347","article-title":"Aceclofenac in the management of inflammatory pain","volume":"5","author":"Legrand","year":"2004","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.jiac.2013.07.010_bib32","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0014-2999(97)89179-0","article-title":"Aceclofenac blocks prostaglandin E2 production following its intracellular conversion into cyclooxygenase inhibitors","volume":"329","author":"Yamazaki","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jiac.2013.07.010_bib33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00345-005-0039-x","article-title":"Preliminary experience with a terpene mixture versus ibuprofen for treatment of category III chronic prostatitis\/chronic pelvic pain syndrome","volume":"24","author":"Lee","year":"2006","journal-title":"World J Urol"},{"key":"10.1016\/j.jiac.2013.07.010_bib34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000089730","article-title":"Can the effect of antibiotherapy and anti-inflammatory therapy on serum PSA levels discriminate between benign and malign prostatic pathologies?","volume":"76","author":"Erol","year":"2006","journal-title":"Urol Int"},{"key":"10.1016\/j.jiac.2013.07.010_bib35","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.eururo.2006.09.036","article-title":"A\u00a0placebo-controlled comparison of the efficiency of triple- and monotherapy in category III B chronic pelvic pain syndrome (CPPS)","volume":"51","author":"Tugcu","year":"2007","journal-title":"Eur Urol"},{"key":"10.1016\/j.jiac.2013.07.010_bib36","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/j.1476-5381.1994.tb17093.x","article-title":"Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone","volume":"113","author":"Mitchell","year":"1994","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jiac.2013.07.010_bib37","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/PL00000261","article-title":"In\u00a0vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators","volume":"50","author":"Henrotin","year":"2001","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jiac.2013.07.010_bib38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10067-003-0710-9","article-title":"A\u00a0double-blind, multicentre, randomised clinical trial comparing the efficacy and tolerability of aceclofenac with diclofenac resinate in patients with acute low back pain","volume":"22","author":"Schattenkirchner","year":"2003","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.jiac.2013.07.010_bib39","first-page":"2574","article-title":"Bacteria in the chronic prostatitis-chronic pelvic pain syndrome: molecular approaches to critical research questions","volume":"167","author":"Krieger","year":"2002","journal-title":"J\u00a0Urol"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.jiac.2013.07.010_bib40","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1016\/j.ijantimicag.2007.07.028","article-title":"Treatment of chronic prostatitis\/chronic pelvic pain syndrome","volume":"31","author":"Nickel","year":"2008","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jiac.2013.07.010_bib41","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1111\/j.1464-410X.2012.11088.x","article-title":"Alpha-blockers, antibiotics and anti-inflammatories have a role in the management of chronic prostatitis\/chronic pelvic pain syndrome","volume":"110","author":"Thakkinstian","year":"2012","journal-title":"BJU Int"},{"key":"10.1016\/j.jiac.2013.07.010_bib42","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s11934-008-0055-7","article-title":"Category III chronic prostatitis\/chronic pelvic pain syndrome: insights from the National Institutes of Health Chronic Prostatitis Collaborative Research Network studies","volume":"9","author":"Nickel","year":"2008","journal-title":"Curr Urol Rep"},{"key":"10.1016\/j.jiac.2013.07.010_bib43","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1439-0272.2009.01033.x","article-title":"Eradication of Chlamydia trachomatis parallels symptom regression in chronic bacterial prostatitis patients treated with a fluoroquinolone-macrolide combination","volume":"42","author":"Magri","year":"2010","journal-title":"Andrologia"},{"key":"10.1016\/j.jiac.2013.07.010_bib44","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4111\/kju.2011.52.3.194","article-title":"Detection of nanobacteria in patients with chronic prostatitis and vaginitis by reverse transcriptase polymerase chain reaction","volume":"52","author":"Kim","year":"2011","journal-title":"Korean J Urol"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X13000160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X13000160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:50:00Z","timestamp":1761159000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X13000160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S1341321X13000160"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2013.07.010","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical efficacy of roxithromycin in men with chronic prostatitis\/chronic pelvic pain syndrome in comparison with ciprofloxacin and aceclofenac: A prospective, randomized, multicenter pilot trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2013.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}