{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:19:55Z","timestamp":1777594795820,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.jiac.2014.10.009","type":"journal-article","created":{"date-parts":[[2014,11,16]],"date-time":"2014-11-16T19:56:38Z","timestamp":1416167798000},"page":"114-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["In\u00a0vitro activity of potential old and new drugs against multidrug-resistant gram-negatives"],"prefix":"10.1016","volume":"21","author":[{"given":"Camila","family":"Rizek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Rosa","family":"Ferraz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inneke Marie","family":"van der Heijden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Giudice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Karina","family":"Mostachio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Paez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Carrilho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Sara","family":"Levin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia F.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiac.2014.10.009_bib1","doi-asserted-by":"crossref","first-page":"i29","DOI":"10.1093\/jac\/dkp255","article-title":"Has the era of untreatable infections arrived?","volume":"64","author":"Livermore","year":"2009","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2014.10.009_bib2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ijantimicag.2012.04.010","article-title":"Old agent, new experience: colistin use in the paediatric intensive care unit\u2013a multicentre study","volume":"40","author":"Paksu","year":"2012","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jiac.2014.10.009_bib3","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1021\/cb300063v","article-title":"Api88 is a novel antibacterial designer peptide to treat systemic infections with multidrug-resistant gram-negative pathogens","volume":"20","author":"Czihal","year":"2012","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.jiac.2014.10.009_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s15010-011-0192-7","article-title":"Use of parenteral colistin for the treatment of multiresistant gram-negative organisms in major burn patients in South Korea","volume":"40","author":"Cho","year":"2012","journal-title":"Infection"},{"key":"10.1016\/j.jiac.2014.10.009_bib5","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.ajic.2011.12.014","article-title":"Retrospective evaluation of colistin versus tigecycline for the treatment of Acinetobacter baumannii and\/or carbapenem-resistant Enterobacteriaceae infections","volume":"40","author":"Ku","year":"2012","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.jiac.2014.10.009_bib6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1128\/CMR.00019-11","article-title":"Stenotrophomonas maltophilia: an emerging global opportunistic pathogen","volume":"25","author":"Brooke","year":"2012","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jiac.2014.10.009_bib7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ijantimicag.2010.10.025","article-title":"Stenotrophomonas maltophilia resistance to trimethoprim\/sulfamethoxazole mediated by acquisition of sul and dfrA genes in a plasmid-mediated class 1 integron","volume":"37","author":"Hu","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jiac.2014.10.009_bib8","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2217\/fmb.12.40","article-title":"Comparison of antibiotic susceptibility of old and current Serratia","volume":"7","author":"Fust\u00e9","year":"2012","journal-title":"Future Microbiol"},{"key":"10.1016\/j.jiac.2014.10.009_bib9","series-title":"Performance standards for antimicrobial susceptibility testing: 23rd informational supplement (M100\u2013S23) CLSI","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2013"},{"key":"10.1016\/j.jiac.2014.10.009_bib10","series-title":"Breakpoint tables for interpretation of MICs and zone diameters. Version 3.0 (2013)","author":"EUCAST","year":"2013"},{"key":"10.1016\/j.jiac.2014.10.009_bib11","unstructured":"FDA. U.S. Food and Drug Administration. Tygacil (tigecycline) for injection. http:\/\/www.fda.gov\/Safety\/MedWatch\/SafetyInformation\/ucm228387.htm [accessed 18.04.12]."},{"key":"10.1016\/j.jiac.2014.10.009_bib12","unstructured":"FDA. U.S. Food and Drug Administration. Tygacil (tigecycline) iv injection label. http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2010\/021821s021lbl.pdf [accessed 18.04.12]."},{"key":"10.1016\/j.jiac.2014.10.009_bib13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijantimicag.2008.06.027","article-title":"Distribution of the multidrug efflux pump genes, adeABC, adeDE and adeIJK, and class 1 integron genes in multiple-antimicrobial-resistant clinical isolates of Acinetobacter baumannii-Acinetobacter calcoaceticus complex","volume":"33","author":"Lin","year":"2009","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jiac.2014.10.009_bib14","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ijantimicag.2006.01.004","article-title":"Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp","volume":"27","author":"Woodford","year":"2006","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jiac.2014.10.009_bib15","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/jac\/dkr082","article-title":"Emergence of NDM-1-producing Acinetobacter baumannii in China","volume":"66","author":"Chen","year":"2011","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2014.10.009_bib16","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.1128\/AAC.00856-09","article-title":"OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii","volume":"53","author":"Higgins","year":"2009","journal-title":"Antimicrobial Agents Chemother"},{"key":"10.1016\/j.jiac.2014.10.009_bib17","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1128\/JCM.01728-06","article-title":"Rapid detection and identification of metallo-beta-lactamase-encoding genes by multiplex real-time PCR assay and melt curve analysis","volume":"45","author":"Mendes","year":"2007","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.jiac.2014.10.009_bib18","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ijantimicag.2012.01.021","article-title":"High prevalence of OXA-143 and alteration of outer membrane proteins in carbapenem-resistant Acinetobacter spp. isolates in Brazil","volume":"39","author":"Mostachio","year":"2012","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jiac.2014.10.009_bib19","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1128\/MMBR.00048-05","article-title":"ISCR elements: novel gene-capturing systems of the 21st century?","volume":"70","author":"Toleman","year":"2006","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.jiac.2014.10.009_bib20","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/1471-2180-8-148","article-title":"Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of QNR determinants","volume":"8","author":"S\u00e1nchez","year":"2008","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jiac.2014.10.009_bib21","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1093\/jac\/dkr239","article-title":"Contemporary activity of colistin and polymyxin B against a worldwide collection of gram-negative pathogens: results from the SENTRY antimicrobial surveillance program (2006\u201309)","volume":"66","author":"Gales","year":"2011","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2014.10.009_bib22","doi-asserted-by":"crossref","first-page":"e18485","DOI":"10.1371\/journal.pone.0018485","article-title":"In-vitro activity of polymyxin B, rifampicin, tigecycline alone and in combination against carbapenem-resistant Acinetobacter baumannii in Singapore","volume":"6","author":"Lim","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jiac.2014.10.009_bib23","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/jac\/dkh128","article-title":"In\u00a0vitro susceptibility of Stenotrophomonas maltophilia isolates: comparison of disc diffusion, Etest and agar dilution methods","volume":"53","author":"Nicodemo","year":"2004","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2014.10.009_bib24","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ijantimicag.2011.01.012","article-title":"What remains against carbapenem-resistant Enterobacteriaceae? Evaluation of chloramphenicol, ciprofloxacin, colistin, fosfomycin, minocycline, nitrofurantoin, temocillin and tigecycline","volume":"37","author":"Livermore","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jiac.2014.10.009_bib25","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/1756-0500-5-215","article-title":"In\u00a0vitro activity of tigecycline against clinical isolates of carbapenem resistant Acinetobacter baumannii complex in Pretoria, South Africa","volume":"3","author":"Ahmed","year":"2012","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.jiac.2014.10.009_bib26","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0924-8579(08)70027-X","article-title":"In-vitro activity of tigecycline against clinical isolates of Acinetobacter baumannii in Taiwan determined by the broth microdilution and disk diffusion methods","volume":"32","author":"Liao","year":"2008","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jiac.2014.10.009_bib27","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.1128\/AAC.00730-13","article-title":"Contribution of efflux pumps, porins, and \u03b2-lactamases to multidrug resistance in clinical isolates of Acinetobacter baumannii","volume":"57","author":"Rumbo","year":"2013","journal-title":"Antimicrobial Agents Chemother"},{"key":"10.1016\/j.jiac.2014.10.009_bib28","first-page":"446","article-title":"Tigecycline susceptibility report from an Indian tertiary care hospital","volume":"129","author":"Behera","year":"2009","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.jiac.2014.10.009_bib29","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/jac\/dkr466","article-title":"Fosfomycin: evaluation of the published evidence on the emergence of antimicrobial resistance in gram-negative pathogens","volume":"67","author":"Karageorgopoulos","year":"2012","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2014.10.009_bib30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1473-3099(09)70325-1","article-title":"Fosfomycin for the treatment of multidrug-resistant, including extended-spectrum beta-lactamase producing, Enterobacteriaceae infections: a systematic review","volume":"10","author":"Falagas","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jiac.2014.10.009_bib31","article-title":"Susceptibility to fosfomycin of multiresistant gram-negative bacteria and performance of different susceptibility testing methods: preparing for clinical use","volume":"57","author":"Perdig\u00e3o-Neto","year":"2013","journal-title":"Antimicrobial Agents Chemother"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X14003626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X14003626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:53:29Z","timestamp":1761159209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X14003626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S1341321X14003626"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2014.10.009","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In\u00a0vitro activity of potential old and new drugs against multidrug-resistant gram-negatives","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2014.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}