{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T04:15:26Z","timestamp":1771042526764,"version":"3.50.1"},"reference-count":14,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jiac.2015.09.008","type":"journal-article","created":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T07:32:20Z","timestamp":1446363140000},"page":"27-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Oral administration and younger age decrease plasma concentrations of voriconazole in pediatric patients"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9181-2500","authenticated-orcid":false,"given":"Karin","family":"Kato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasufumi","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunji","family":"Takakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ichiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiac.2015.09.008_bib1","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1093\/cid\/cis599","article-title":"The effect of therapeutic drug monitoring on safety and efficacy of voriconazole in invasive fungal infections: a randomized controlled trial","volume":"55","author":"Park","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2015.09.008_bib2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/FTD.0b013e31823f3516","article-title":"Therapeutic drug monitoring of voriconazole in children","volume":"34","author":"Chen","year":"2012","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.jiac.2015.09.008_bib3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1128\/AAC.01540-12","article-title":"Highly variable plasma concentrations of voriconazole in pediatric hematopoietic stem cell transplantation patients","volume":"57","author":"Bartelink","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2015.09.008_bib4","first-page":"722","article-title":"Voriconazole for invasive aspergillosis in oncohematological patients: a single-center pediatric experience","volume":"11","author":"Cesaro","year":"2003","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.jiac.2015.09.008_bib5","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/pbc.24262","article-title":"Importance of voriconazole therapeutic drug monitoring in pediatric cancer patients with invasive aspergillosis","volume":"60","author":"Choi","year":"2013","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jiac.2015.09.008_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1086\/648679","article-title":"Voriconazole pharmacokinetics and pharmacodynamics in children","volume":"50","author":"Neely","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2015.09.008_bib7","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1086\/588660","volume":"46","author":"De Pauw","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2015.09.008_bib8","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/jac\/dkr517","article-title":"Voriconazole drug monitoring in the management of invasive fungal infection in immunocompromised children: a prospective study","volume":"67","author":"Soler-Palacin","year":"2012","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2015.09.008_bib9","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1086\/656293","article-title":"Oral voriconazole dose in children: one size does not fit all","volume":"51","author":"Goutelle","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2015.09.008_bib10","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1128\/AAC.46.8.2546-2553.2002","article-title":"Pharmacokinetics and safety of voriconazole following intravenous- to oral-dose escalation regimens","volume":"46","author":"Purkins","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2015.09.008_bib11","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1128\/AAC.04993-14","article-title":"Population pharmacokinetic analysis of voriconazole from a pharmacokinetic study with immunocompromised Japanese pediatric subjects","volume":"59","author":"Muto","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2015.09.008_bib12","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1128\/AAC.05761-11","article-title":"Integrated population pharmacokinetic analysis of voriconazole in children, adolescents, and adults","volume":"56","author":"Friberg","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2015.09.008_bib13","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1128\/AAC.00032-15","article-title":"Achieving target voriconazole concentrations more accurately in children and adolescents","volume":"59","author":"Neely","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2015.09.008_bib14","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1093\/jac\/dks258","article-title":"Monitoring of voriconazole plasma concentrations in immunocompromised pediatric patients","volume":"67","author":"Pieper","year":"2012","journal-title":"J\u00a0Antimicrob Chemother"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X15002330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X15002330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:54:44Z","timestamp":1761159284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X15002330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S1341321X15002330"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2015.09.008","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral administration and younger age decrease plasma concentrations of voriconazole in pediatric patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2015.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}