{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:52:20Z","timestamp":1781272340024,"version":"3.54.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.jiac.2015.11.012","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T09:30:17Z","timestamp":1451295017000},"page":"331-334","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Successful treatment of methicillin-resistant Staphylococcus aureus osteomyelitis with combination therapy using linezolid and rifampicin under therapeutic drug monitoring"],"prefix":"10.1016","volume":"22","author":[{"given":"Nobuyuki","family":"Ashizawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koyomi","family":"Kawago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitsugu","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Nogami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Gejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munetoshi","family":"Narukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoatsu","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiac.2015.11.012_bib1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/cid\/ciq146","article-title":"Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children","volume":"52","author":"Liu","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2015.11.012_bib2","first-page":"59","article-title":"Linezolid: a review of safety and tolerability","volume":"59","author":"Vinh","year":"2009","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.jiac.2015.11.012_bib3","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s10156-010-0182-1","article-title":"Risk factors associated with the development of thrombocytopenia in patients who received linezolid therapy","volume":"17","author":"Takahashi","year":"2011","journal-title":"J\u00a0Infect Chemother"},{"key":"10.1016\/j.jiac.2015.11.012_bib4","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1093\/jac\/dks153","article-title":"Therapeutic drug monitoring may improve safety outcomes of long-term treatment with linezolid in adult patients","volume":"67","author":"Pea","year":"2012","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2015.11.012_bib5","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ijantimicag.2014.05.010","article-title":"Analysis of thrombocytopenic effects and population pharmacokinetics of linezolid: a dosage strategy according to the trough concentration target and renal function in adult patients","volume":"44","author":"Matsumoto","year":"2014","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jiac.2015.11.012_bib6","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1093\/jac\/dkh191","article-title":"Antibiotic treatment of gram-positive bone and joint infections","volume":"53","author":"Darley","year":"2004","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2015.11.012_bib7","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s00228-008-0531-5","article-title":"Pharmacokinetics and penetration of linezolid into inflamed soft tissue in diabetic foot infections","volume":"64","author":"Majcher-Peszynska","year":"2008","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.jiac.2015.11.012_bib8","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.berh.2006.08.014","article-title":"Infection and musculoskeletal conditions: osteomyelitis","volume":"20","author":"Sia","year":"2006","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.jiac.2015.11.012_bib9","first-page":"539","article-title":"Oral step-down therapy is comparable to intravenous therapy for Staphylococcus aureus osteomyelitis","volume":"54","author":"Daver","year":"2007","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.jiac.2015.11.012_bib10","first-page":"110","article-title":"Clinical failures of appropriately-treated methicillin-resistant Staphylococcus aureus infections","volume":"57","author":"Dombrowski","year":"2008","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.jiac.2015.11.012_bib11","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1128\/AAC.00177-10","article-title":"Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis","volume":"54","author":"Pea","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2015.11.012_bib12","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1128\/AAC.49.6.2260-2266.2005","article-title":"Linezolid versus vancomycin in treatment of complicated skin and soft tissue infections","volume":"49","author":"Weigelt","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2015.11.012_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/jac\/dkf066","article-title":"Penetration of linezolid into bone, fat, muscle and haematoma of patients undergoing routine hip replacement","volume":"50","author":"Lovering","year":"2002","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2015.11.012_bib14","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.ijid.2013.03.008","article-title":"Pharmacokinetics of linezolid in the mediastinum and pleural space","volume":"17","author":"Tsuji","year":"2013","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.jiac.2015.11.012_bib15","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1128\/AAC.45.6.1843-1846.2001","article-title":"Pharmacokinetics and tissue penetration of linezolid following multiple oral doses","volume":"45","author":"Gee","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2015.11.012_bib16","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1086\/338403","article-title":"Thrombocytopenia associated with linezolid therapy","volume":"34","author":"Attassi","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2015.11.012_bib17","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1093\/jac\/dkt133","article-title":"High plasma linezolid concentration and impaired renal function affect development of linezolid-induced thrombocytopenia","volume":"68","author":"Nukui","year":"2013","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2015.11.012_bib18","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1592\/phco.27.3.476","article-title":"Decreased serum linezolid levels in a critically ill patient receiving concomitant linezolid and rifampin","volume":"27","author":"Gebhart","year":"2007","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.jiac.2015.11.012_bib19","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/jac\/dkg160","article-title":"In\u00a0vitro activity of linezolid alone and in combination with gentamicin, vancomycin or rifampicin against methicillin-resistant Staphylococcus aureus by time-kill curve methods","volume":"51","author":"Jacqueline","year":"2003","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2015.11.012_bib20","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00228-009-0766-9","article-title":"Pharmacokinetics of linezolid in septic patients with and without extended dialysis","volume":"66","author":"Swoboda","year":"2010","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.jiac.2015.11.012_bib21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2169\/internalmedicine.54.2292","article-title":"Treatment of mediastinitis due to methicillin-resistant Staphylococcus aureus in a renal dysfunction patient undergoing adjustments to the linezolid dose","volume":"54","author":"Tsuji","year":"2015","journal-title":"Intern Med"},{"key":"10.1016\/j.jiac.2015.11.012_bib22","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1002\/jcph.133","article-title":"Population pharmacokinetic analysis of linezolid in low body weight patients with renal dysfunction","volume":"53","author":"Tsuji","year":"2013","journal-title":"J\u00a0Clin Pharmacol"},{"key":"10.1016\/j.jiac.2015.11.012_bib23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/bdd.255","article-title":"Linezolid absolute bioavailability and the effect of food on oral bioavailability","volume":"22","author":"Welshman","year":"2001","journal-title":"Biopharm Drug Dispos"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X15002846?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X15002846?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:55:49Z","timestamp":1761159349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X15002846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S1341321X15002846"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2015.11.012","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Successful treatment of methicillin-resistant Staphylococcus aureus osteomyelitis with combination therapy using linezolid and rifampicin under therapeutic drug monitoring","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2015.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}