{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:57:29Z","timestamp":1773921449174,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.jiac.2016.10.007","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T05:47:17Z","timestamp":1479880037000},"page":"80-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) levels in the cerebrospinal fluid of children with influenza-associated encephalopathy"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9790-9808","authenticated-orcid":false,"given":"Shinichiro","family":"Morichi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsumi","family":"Morishita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Oana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaku","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyo","family":"Kashiwagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiac.2016.10.007_bib1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1086\/341407","article-title":"Encephalitis and encephalopathy associated with influenza epidemic in Japan","volume":"35","author":"Morishima","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2016.10.007_bib2","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/jmv.23317","article-title":"National survey of pandemic influenza A (H1N1) 2009-associated encephalopathy in Japanese children","volume":"84","author":"Kawashima","year":"2012","journal-title":"J\u00a0Med Virol"},{"key":"10.1016\/j.jiac.2016.10.007_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/0036554021000026986","article-title":"Cerebrospinal fluid and serum levels of cytokines and soluble tumor necrosis factor receptor in influenza virus-associated encephalopathy","volume":"35","author":"Ichiyama","year":"2003","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.jiac.2016.10.007_bib4","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jns.2015.01.017","article-title":"Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy","volume":"15","author":"Sun","year":"2015","journal-title":"J\u00a0Neurol Sci"},{"key":"10.1016\/j.jiac.2016.10.007_bib5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cyto.2011.01.006","article-title":"Serum and cerebrospinal fluid cytokine profile of patients with 2009 pandemic H1N1 influenza virus-associated encephalopathy","volume":"54","author":"Hasegawa","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.jiac.2016.10.007_bib6","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1210\/edrv.18.1.0287","article-title":"The biology of vascular endothelial growth factor","volume":"18","author":"Ferrara","year":"1997","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jiac.2016.10.007_bib7","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1152\/physrev.1999.79.4.1283","article-title":"Mechanism of action and in\u00a0vivo role of platelet-derived growth factor","volume":"79","author":"Heldin","year":"1999","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jiac.2016.10.007_bib8","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1136\/adc.2009.180554","article-title":"Determinants of outcomes following acute child encephalopathy and encephalitis: pivotal effect of early and delayed cooling","volume":"96","author":"Kawano","year":"2011","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jiac.2016.10.007_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-0404.2007.00809.x","article-title":"Acute encephalopathy associated with influenza and other viral infections","volume":"115","author":"Mizuguchi","year":"2007","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.jiac.2016.10.007_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/cvr\/cvv216","article-title":"Endothelial G\u03b1q\/11 is required for VEGF-induced vascular permeability and angiogenesis","volume":"108","author":"Sivaraj","year":"2015","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jiac.2016.10.007_bib11","first-page":"104","article-title":"Systematic hypothesis for post-stroke depression caused inflammation and neurotransmission and resultant on possible treatments","volume":"35","author":"Li","year":"2014","journal-title":"Neuro Endocrinol Lett"},{"key":"10.1016\/j.jiac.2016.10.007_bib12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/03009742.2014.956140","article-title":"Acute pericardial effusion representing the TNF-\u03b1-mediated severe inflammation but not the coronary artery outcome of Kawasaki disease","volume":"44","author":"Okada","year":"2015","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.jiac.2016.10.007_bib13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/art.33316","article-title":"Disruption of vascular homeostasis in patients with Kawasaki disease: involvement of vascular endothelial growth factor and angiopoietins","volume":"64","author":"Breunis","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jiac.2016.10.007_bib14","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-2141.2009.07922.x","article-title":"Platelet vascular endothelial growth factor is a useful predictor for prognosis in Kawasaki syndrome","volume":"148","author":"Ueno","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jiac.2016.10.007_bib15","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrc1093","article-title":"Tumorigenesis and the angiogenic switch","volume":"3","author":"Bergers","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jiac.2016.10.007_bib16","first-page":"199","article-title":"VEGF expression in pancreatic cancer and other malignancies: a review of the literature","volume":"53","author":"Costache","year":"2015","journal-title":"Rom J Intern Med"},{"key":"10.1016\/j.jiac.2016.10.007_bib17","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3892\/or.2015.4528","article-title":"Targeted therapy for gastric cancer: current status and future directions","volume":"35","author":"Yuan","year":"2016","journal-title":"Oncol Rep"},{"key":"10.1016\/j.jiac.2016.10.007_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(13)61719-5","article-title":"Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial","volume":"383","author":"Fuchs","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jiac.2016.10.007_bib19","doi-asserted-by":"crossref","first-page":"e52215","DOI":"10.1371\/journal.pone.0052215","article-title":"Cytokine expression profile of dengue patients at different phases of illness","volume":"7","author":"Rathakrishnan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jiac.2016.10.007_bib20","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1161\/ATVBAHA.114.304864","article-title":"Genetic ablation of PDGF-dependent signaling pathways abolishes vascular remodeling and experimental pulmonary hypertension","volume":"35","author":"Ten Freyhaus","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jiac.2016.10.007_bib21","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1517\/14728222.2012.719500","article-title":"Targeting PDGF pathway in pulmonary arterial hypertension","volume":"16","author":"Antoniu","year":"2012","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.jiac.2016.10.007_bib22","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.2741\/3052","article-title":"Arterial remodeling in vascular disease: a key role for hyaluronan and versican","volume":"13","author":"Wight","year":"2008","journal-title":"Front Biosci"},{"key":"10.1016\/j.jiac.2016.10.007_bib23","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.brainres.2015.11.003","article-title":"Possible involvement of basic FGF in the upregulation of PDGFR\u03b2 in pericytes after ischemic stroke","volume":"1630","author":"Nakamura","year":"2016","journal-title":"Brain Res"},{"key":"10.1016\/j.jiac.2016.10.007_bib24","doi-asserted-by":"crossref","first-page":"19579","DOI":"10.1523\/JNEUROSCI.4318-13.2013","article-title":"Progranulin deficiency promotes post-ischemic blood-brain barrier disruption","volume":"33","author":"Jackman","year":"2013","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.jiac.2016.10.007_bib25","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.nbd.2010.03.008","article-title":"Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator","volume":"38","author":"Jin","year":"2010","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jiac.2016.10.007_bib26","first-page":"30028","article-title":"E2F1 transcription factor and its impact on growth factor and cytokine signaling","volume":"2","author":"Ertosun","year":"2016","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jiac.2016.10.007_bib27","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.molmed.2013.04.006","article-title":"PDGF-C: a new performer in the neurovascular interplay","volume":"19","author":"Lee","year":"2013","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jiac.2016.10.007_bib28","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Growth factors and cytokines in wound healing","volume":"16","author":"Barrientos","year":"2008","journal-title":"Wound Repair Regen"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X16302094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X16302094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:55:46Z","timestamp":1761159346000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X16302094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S1341321X16302094"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2016.10.007","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) levels in the cerebrospinal fluid of children with influenza-associated encephalopathy","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2016.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}