{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:10:36Z","timestamp":1786727436397,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hideya Kato","award":["No.17K16747"],"award-info":[{"award-number":["No.17K16747"]}]},{"name":"Masaru Shimizu","award":["No. 17H07015"],"award-info":[{"award-number":["No. 17H07015"]}]},{"name":"Teiji Sawa","award":["No. 24390403"],"award-info":[{"award-number":["No. 24390403"]}]},{"name":"Teiji Sawa","award":["No. 26670791"],"award-info":[{"award-number":["No. 26670791"]}]},{"name":"Teiji Sawa","award":["No. 15H05008"],"award-info":[{"award-number":["No. 15H05008"]}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.jiac.2018.03.008","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T18:07:04Z","timestamp":1522951624000},"page":"615-622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["An outbreak of fluoroquinolone-resistant Pseudomonas aeruginosa ST357 harboring the exoU gene"],"prefix":"10.1016","volume":"24","author":[{"given":"Atsushi","family":"Kainuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Momiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Naito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideya","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Shime","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohisa","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9558-9011","authenticated-orcid":false,"given":"Teiji","family":"Sawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiac.2018.03.008_bib1","series-title":"Review on antimicrobial resistance","first-page":"p.1","article-title":"Antimicrobial resistance: tackling a crisis for the health and wealth of nations","author":"The Wellcome Trust and the UK Department of Health","year":"2014"},{"key":"10.1016\/j.jiac.2018.03.008_bib2","first-page":"824","article-title":"Pseudomonas aeruginosa: acute lung injury or ventilator-associated pneumonia?","volume":"76","author":"Berra","year":"2010","journal-title":"Minerva Anestesiol"},{"key":"10.1016\/j.jiac.2018.03.008_bib3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.drup.2015.08.002","article-title":"The increasing threat of Pseudomonas aeruginosa high-risk clones","volume":"21\u201322","author":"Oliver","year":"2015","journal-title":"Drug Resist Updates"},{"issue":"150","key":"10.1016\/j.jiac.2018.03.008_bib4","first-page":"1","article-title":"Pseudomonas aeruginosa genomic structure and diversity","volume":"2","author":"Klockgether","year":"2011","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jiac.2018.03.008_bib5","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1128\/MMBR.00027-10","article-title":"The accessory genome of Pseudomonas aeruginosa","volume":"74","author":"Kung","year":"2010","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.jiac.2018.03.008_bib6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2052-0492-2-10","article-title":"The molecular mechanism of acute lung injury caused by Pseudomonas aeruginosa: from bacterial pathogenesis to host response","volume":"2","author":"Sawa","year":"2014","journal-title":"J\u00a0Intensive Care"},{"key":"10.1016\/j.jiac.2018.03.008_bib7","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1128\/iai.65.2.579-586.1997","article-title":"Pseudomonas aeruginosa-mediated cytotoxicity and invasion correlate with distinct genotypes at the loci encoding exoenzyme S","volume":"65","author":"Fleiszig","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/j.jiac.2018.03.008_bib8","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1046\/j.1365-2958.1997.4891851.x","article-title":"ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury","volume":"25","author":"Finck-Barbancon","year":"1997","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.jiac.2018.03.008_bib9","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1073\/pnas.0304622101","article-title":"The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes","volume":"101","author":"He","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jiac.2018.03.008_bib10","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1097\/01.CCM.0000145588.79063.07","article-title":"Pseudomonas aeruginosa causes acute lung injury via the catalytic activity of the patatin-like phospholipase domain of ExoU","volume":"32","author":"Pankhaniya","year":"2004","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jiac.2018.03.008_bib11","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1093\/emboj\/cdg290","article-title":"The mechanism of action of the Pseudomonas aeruginosa-encoded type III cytotoxin, ExoU","volume":"22","author":"Sato","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.jiac.2018.03.008_bib12","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00032-13","article-title":"Type III secretion of ExoU is critical during early Pseudomonas aeruginosa pneumonia","volume":"4","author":"Howell","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.jiac.2018.03.008_bib13","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1086\/320737","article-title":"Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections","volume":"183","author":"Roy-Burman","year":"2001","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.jiac.2018.03.008_bib14","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.3389\/fmicb.2016.01591","article-title":"Fitness cost of fluoroquinolone resistance in clinical isolates of Pseudomonas aeruginosa differs by type III secretion genotype","volume":"7","author":"Agnello","year":"2016","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jiac.2018.03.008_bib15","doi-asserted-by":"crossref","first-page":"e42973","DOI":"10.1371\/journal.pone.0042973","article-title":"Differentiation in quinolone resistance by virulence genotype in Pseudomonas aeruginosa","volume":"7","author":"Agnello","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jiac.2018.03.008_bib16","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1469-0691.2007.01939.x","article-title":"Comparison of type III secretion system virulence among fluoroquinolone-susceptible and -resistant clinical isolates of Pseudomonas aeruginosa","volume":"14","author":"Wong-Beringer","year":"2008","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jiac.2018.03.008_bib17","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1186\/s13054-014-0668-9","article-title":"Association between Pseudomonas aeruginosa type III secretion, antibiotic resistance, and clinical outcome: a review","volume":"18","author":"Sawa","year":"2014","journal-title":"Crit Care"},{"key":"10.1016\/j.jiac.2018.03.008_bib18","series-title":"Performance standards for antimicrobial susceptibility testing -twenty-fifth informational supplement M100-S25","first-page":"62","author":"Patel","year":"2016"},{"key":"10.1016\/j.jiac.2018.03.008_bib19","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jiac.2018.03.008_bib20","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1128\/JCM.38.1.40-43.2000","article-title":"Convenient test for screening metallo-\u03b2-producing gram negative bacteria by using thiol compounds","volume":"38","author":"Arakawa","year":"2000","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.jiac.2018.03.008_bib21","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1128\/JCM.41.8.3526-3531.2003","article-title":"Single-nucleotide-polymorphism mapping of the Pseudomonas aeruginosa type III secretion toxins for development of a diagnostic multiplex PCR system","volume":"41","author":"Ajayi","year":"2003","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.jiac.2018.03.008_bib22","doi-asserted-by":"crossref","first-page":"5644","DOI":"10.1128\/JCM.42.12.5644-5649.2004","article-title":"Development of a multilocus sequence typing scheme for the opportunistic pathogen Pseudomonas aeruginosa","volume":"42","author":"Curran","year":"2004","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.jiac.2018.03.008_bib23","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1186\/1471-2105-11-595","article-title":"Bigsdb: scalable analysis of bacterial genome variation at the population level","volume":"11","author":"Jolley","year":"2010","journal-title":"BMC Bioinf"},{"key":"10.1016\/j.jiac.2018.03.008_bib24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1128\/AAC.39.1.185","article-title":"PCR mapping of integrons reveals several novel combinations of resistance genes","volume":"39","author":"Levesque","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2018.03.008_bib25","doi-asserted-by":"crossref","first-page":"5407","DOI":"10.1128\/JCM.41.12.5407-5413.2003","article-title":"PCR typing of genetic determinants for metallo-\u03b2-lactamases and integrases carried by gram-negative bacteria isolated in Japan, with focus on the class 3 integron","volume":"41","author":"Shibata","year":"2003","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.jiac.2018.03.008_bib26","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1128\/JB.186.5.1518-1530.2004","article-title":"eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data","volume":"186","author":"Feil","year":"2004","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.jiac.2018.03.008_bib27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.femsle.2004.11.015","article-title":"Displaying the relatedness among isolates of bacterial species \u2013 the eBurst approach","volume":"241","author":"Spratt","year":"2004","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.jiac.2018.03.008_bib28","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.bbrc.2004.02.050","article-title":"Lysophospholipase A activity of Pseudomonas aeruginosa type III secretory toxin ExoU","volume":"316","author":"Tamura","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jiac.2018.03.008_bib29","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1099\/00221287-147-10-2659","article-title":"Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa","volume":"147","author":"Feltman","year":"2001","journal-title":"Microbiol"},{"key":"10.1016\/j.jiac.2018.03.008_bib30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jiac.2017.08.018","article-title":"Association of the ExoU genotype with a\u00a0multidrug non-susceptible phenotype and mRNA expressions of resistance genes in Pseudomonas aeruginosa","volume":"24","author":"Takata","year":"2018","journal-title":"J\u00a0Infect Chemother"},{"key":"10.1016\/j.jiac.2018.03.008_bib31","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/CCM.0b013e318298a86f","article-title":"Risk of developing pneumonia is enhanced by the combined traits of fluoroquinolone resistance and type III secretion virulence in respiratory isolates of Pseudomonas aeruginosa","volume":"42","author":"Sullivan","year":"2014","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jiac.2018.03.008_bib32","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3343\/alm.2014.34.4.286","article-title":"Correlation between virulence genotype and fluoroquinolone resistance in carbapenem-resistant Pseudomonas aeruginosa","volume":"34","author":"Cho","year":"2014","journal-title":"Ann Lab Med"},{"key":"10.1016\/j.jiac.2018.03.008_bib33","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1128\/JCM.01905-09","article-title":"Multilocus sequence types of carbapenem-resistant Pseudomonas aeruginosa in Singapore carrying metallo-\u03b2-lactamase genes, including the novel bla(IMP-26) gene","volume":"48","author":"Koh","year":"2010","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.jiac.2018.03.008_bib34","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.resmic.2010.02.002","article-title":"Multidrug-resistant epidemic clones among bloodstream isolates of Pseudomonas aeruginosa in the Czech republic","volume":"161","author":"Nemec","year":"2010","journal-title":"Res Microbiol"},{"key":"10.1016\/j.jiac.2018.03.008_bib35","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1128\/JCM.00684-10","article-title":"Regional spread of Pseudomonas aeruginosa ST357 producing IMP-7 metallo-\u03b2-lactamase in Central Europe","volume":"49","author":"Hrabak","year":"2011","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.jiac.2018.03.008_bib36","first-page":"3250","article-title":"Genetic environment of metallo-\u03b2-lactamase genes in Pseudomonas aeruginosa isolates from the UK","volume":"70","author":"Wright","year":"2015","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2018.03.008_bib37","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/jac\/dku339","article-title":"Dominance of international 'high-risk clones' among metallo-\u03b2-lactamase-producing Pseudomonas aeruginosa in the UK","volume":"70","author":"Wright","year":"2015","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2018.03.008_bib38","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ijantimicag.2014.11.002","article-title":"Characterisation of an IMP-7-producing ST357 Pseudomonas aeruginosa isolate detected in Denmark using whole genome sequencing","volume":"45","author":"Hammerum","year":"2015","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jiac.2018.03.008_bib39","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01811-17","article-title":"Molecular characterization of carbapenemase-producing Pseudomonas aeruginosa of Czech origin and evidence for clonal spread of extensively resistant sequence type 357 expressing IMP-7 metallo-\u03b2-lactamase","volume":"61","author":"Papagiannitsis","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2018.03.008_bib40","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.01092-16","article-title":"Draft genome sequence of extremely drug-resistant Pseudomonas aeruginosa (ST357) strain CMC_VB_PA_b22862 isolated from a community-acquired bloodstream infection","volume":"4","author":"Pragasam","year":"2016","journal-title":"Genome Announc"},{"key":"10.1016\/j.jiac.2018.03.008_bib41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12866-015-0378-8","article-title":"Molecular analysis of the integrons of metallo-\u03b2-lactamase-producing Pseudomonas aeruginosa isolates collected by nationwide surveillance programs across Japan","volume":"15","author":"Mano","year":"2015","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jiac.2018.03.008_bib42","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.cmi.2017.06.018","article-title":"Global emergence of the widespread Pseudomonas aeruginosa ST235 clone","volume":"24","author":"Treepong","year":"2018","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jiac.2018.03.008_bib43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/jac\/dkx337","article-title":"Unravelling the genome of a Pseudomonas aeruginosa isolate belonging to the high-risk clone ST235 reveals an integrative conjugative element housing a blaGES-6 carbapenemase","volume":"73","author":"Botelho","year":"2017","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2018.03.008_bib44","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3201\/eid0702.010239","article-title":"Emerging mechanisms of fluoroquinolone resistance","volume":"7","author":"Hooper","year":"2001","journal-title":"Emerg Infect Dis"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X18300862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X18300862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:57:32Z","timestamp":1761159452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X18300862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S1341321X18300862"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2018.03.008","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An outbreak of fluoroquinolone-resistant Pseudomonas aeruginosa ST357 harboring the exoU gene","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2018.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}