{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:39:08Z","timestamp":1790674748567,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Okinawa Communicable Disease Research Hub Formation Promotion Project"},{"name":"Okinawa Prefectural Government Commissioned Projects"},{"name":"Agency for Medical Research and DevelopmentAgency for Medical Research and Development (AMED)","award":["18fk0108061, Japan"],"award-info":[{"award-number":["18fk0108061, Japan"]}]},{"name":"JSPS KAKENHI","award":["16K19133, Japan"],"award-info":[{"award-number":["16K19133, Japan"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.jiac.2018.09.004","type":"journal-article","created":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T18:11:08Z","timestamp":1538244668000},"page":"285-288","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Emergence of a carbapenem-resistant and colistin-heteroresistant Enterobacter cloacae clinical isolate in Japan"],"prefix":"10.1016","volume":"25","author":[{"given":"Kohei","family":"Uechi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Tada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayo","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isamu","family":"Nakasone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6954-6875","authenticated-orcid":false,"given":"Teruo","family":"Kirikae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiac.2018.09.004_bib1","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1001\/jama.2008.896","article-title":"Carbapenem-resistant Enterobacteriaceae: a potential threat","volume":"300","author":"Schwaber","year":"2008","journal-title":"J\u00a0Am Med Assoc"},{"key":"10.1016\/j.jiac.2018.09.004_bib2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/infdis\/jiw282","article-title":"The epidemiology of carbapenem-resistant Enterobacteriaceae: the impact and evolution of a global menace","volume":"215","author":"Logan","year":"2017","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.jiac.2018.09.004_bib3","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1128\/AAC.00103-06","article-title":"Heteroresistance to colistin in multidrug-resistant Acinetobacter baumannii","volume":"50","author":"Li","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2018.09.004_bib4","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1128\/AAC.01406-06","article-title":"Comparative evaluation of the VITEK 2, disk diffusion, Etest, broth microdilution, and agar dilution susceptibility testing methods for colistin in clinical isolates, including heteroresistant Enterobacter cloacae and Acinetobacter baumannii strains","volume":"51","author":"Lo-Ten-Foe","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2018.09.004_bib5","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.diagmicrobio.2009.05.019","article-title":"Selection of colistin-resistant Acinetobacter baumannii isolates in postneurosurgical meningitis in an intensive care unit with high presence of heteroresistance to colistin","volume":"65","author":"Hernan","year":"2009","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jiac.2018.09.004_bib6","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/jac\/dkr007","article-title":"Colistin heteroresistance in carbapenemase-producing Klebsiella pneumoniae","volume":"66","author":"Meletis","year":"2011","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2018.09.004_bib7","doi-asserted-by":"crossref","DOI":"10.5812\/jjm.12287","article-title":"Post neurosurgical meningitis due to colistin heteroresistant Acinetobacter baumannii","volume":"7","author":"Moosavian","year":"2014","journal-title":"Jundishapur J Microbiol"},{"key":"10.1016\/j.jiac.2018.09.004_bib8","doi-asserted-by":"crossref","first-page":"5594","DOI":"10.1128\/AAC.02432-14","article-title":"Colistin heteroresistance in Enterobacter cloacae is associated with cross-resistance to the host antimicrobial lysozyme","volume":"58","author":"Napier","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2018.09.004_bib9","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1128\/AAC.05055-14","article-title":"Heteroresistance to colistin in Klebsiella pneumoniae associated with alterations in the PhoPQ regulatory system alterations in the PhoPQ regulatory system","volume":"59","author":"Jayol","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2018.09.004_bib10","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftw036","article-title":"Heteroresistance to colistin in Klebsiella pneumoniae is triggered by small colony variants sub-populations within biofilms","volume":"74","author":"Silva","year":"2016","journal-title":"Pathog Dis"},{"key":"10.1016\/j.jiac.2018.09.004_bib11","series-title":"Performance standards for antimicrobial susceptibility testing","year":"2017"},{"key":"10.1016\/j.jiac.2018.09.004_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0066358","article-title":"Multilocus sequence typing (MLST) for characterization of Enterobacter cloacae","volume":"8","author":"Miyoshi-Akiyama","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jiac.2018.09.004_bib13","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jiac.2018.09.004_bib14","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.3389\/fmicb.2016.02054","article-title":"Altered outer membrane transcriptome balance with AmpC overexpression in carbapenem-resistant Enterobacter cloacae","volume":"7","author":"Majewski","year":"2016","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jiac.2018.09.004_bib15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/nyas.12830","article-title":"Mechanisms of drug resistance: quinolone resistance","volume":"1354","author":"Hooper","year":"2015","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jiac.2018.09.004_bib16","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3389\/fmicb.2014.00643","article-title":"Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria","volume":"5","author":"Olaitan","year":"2014","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jiac.2018.09.004_bib17","first-page":"281","article-title":"Molecular mechanisms of carbapenem resistance in Enterobacter cloacae clinical isolates from Korea and clinical outcome","volume":"42","author":"Lee","year":"2012","journal-title":"Ann Clin Lab Sci"},{"key":"10.1016\/j.jiac.2018.09.004_bib18","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1128\/AAC.00285-06","article-title":"High-level carbapenem resistance in a Klebsiella pneumoniae clinical isolate is due to the combination of blaACT-1\u202f\u03b2-lactamase production, porin OmpK35\/36 insertional inactivation, and down-regulation of the phosphate transport porin PhoE","volume":"50","author":"Kaczmarek","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2018.09.004_bib19","doi-asserted-by":"crossref","first-page":"5521","DOI":"10.1128\/AAC.01480-13","article-title":"In\u00a0vivo emergence of colistin resistance in Klebsiella pneumoniae producing KPC-type carbapenemases mediated by insertional inactivation of the PhoQ\/PhoP mgrB regulator","volume":"57","author":"Cannatelli","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2018.09.004_bib20","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.1128\/AAC.00084-14","article-title":"Resistance to colistin associated with a single amino acid change in protein PmrB among Klebsiella pneumoniae isolates of worldwide origin","volume":"58","author":"Jayol","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2018.09.004_bib21","doi-asserted-by":"crossref","first-page":"16053","DOI":"10.1038\/nmicrobiol.2016.53","article-title":"Antibiotic failure mediated by a resistant subpopulation in Enterobacter cloacae","volume":"1","author":"Band","year":"2016","journal-title":"Nat Microbiol"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X18303052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X18303052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:58:33Z","timestamp":1761159513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X18303052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S1341321X18303052"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2018.09.004","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emergence of a carbapenem-resistant and colistin-heteroresistant Enterobacter cloacae clinical isolate in Japan","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2018.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}