{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:29:11Z","timestamp":1761182951964,"version":"build-2065373602"},"reference-count":10,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Daiichi Sankyo Co.,Ltd"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.jiac.2018.09.012","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T09:36:43Z","timestamp":1540287403000},"page":"322-324","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gene expression analysis in the potent bactericidal activity of sitafloxacin against Streptococcus pneumoniae"],"prefix":"10.1016","volume":"25","author":[{"given":"Intetsu","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumo","family":"Kanesaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Kanayama Katsuse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiac.2018.09.012_bib1","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1128\/AAC.41.11.2362","article-title":"Inhibitory activities of quinolones against DNA gyrase and topoisomerase IV purified from\u00a0Staphylococcus aureus","volume":"41","author":"Tanaka","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2018.09.012_bib2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/jac\/dkn136","article-title":"Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: contribution to reducing in\u00a0vitro emergence of quinolone-resistant Streptococcus pneumoniae","volume":"62","author":"Okumura","year":"2008","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2018.09.012_bib3","first-page":"25","article-title":"Bactericidal activity of sitafloxacin and other new quinolones against antimicrobial resistant Streptococcus pneumoniae","volume":"66","author":"Kobayashi","year":"2013","journal-title":"Jpn J Antibiot"},{"key":"10.1016\/j.jiac.2018.09.012_bib4","first-page":"136","article-title":"Bactericidal activity of sitafloxacin and other new quinolones against anaerobes and oral Streptococcus","volume":"32","author":"Kobayashi","year":"2013","journal-title":"Oral Ther Pharmacol"},{"key":"10.1016\/j.jiac.2018.09.012_bib5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1128\/AAC.01617-06","article-title":"Quinolone-mediated bacterial death","volume":"52","author":"Drlica","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2018.09.012_bib6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u22bf\u22bfCT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jiac.2018.09.012_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1128\/MMBR.00030-07","article-title":"Molecular control of bacterial death and lysis","volume":"72","author":"Rice","year":"2008","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.jiac.2018.09.012_bib8","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1046\/j.1469-0691.2002.00477.x","article-title":"Antibiotic tolerance in pneumococci","volume":"8","author":"Normark","year":"2002","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jiac.2018.09.012_bib9","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1073\/pnas.72.10.4162","article-title":"Mechanism of action of penicillin: triggering of the pneumococcal autolytic enzyme by inhibitors of cell wall synthesis","volume":"72","author":"Tomasz","year":"1975","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jiac.2018.09.012_bib10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1159\/000220828","article-title":"Quinolones with enhanced bactericidal activity induce autolysis in Streptococcus pneumoniae","volume":"55","author":"Okumura","year":"2009","journal-title":"Chemotherapy"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X18303520?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X18303520?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:58:18Z","timestamp":1761159498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X18303520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S1341321X18303520"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2018.09.012","relation":{},"ISSN":["1341-321X"],"issn-type":[{"type":"print","value":"1341-321X"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene expression analysis in the potent bactericidal activity of sitafloxacin against Streptococcus pneumoniae","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2018.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}