{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:36:34Z","timestamp":1791412594713,"version":"4.3.3"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jiac.2020.09.033","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T01:48:14Z","timestamp":1602899294000},"page":"256-261","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["A meta-analysis of the target trough concentration of gentamicin and amikacin for reducing the risk of nephrotoxicity"],"prefix":"10.1016","volume":"27","author":[{"given":"Tomoyuki","family":"Yamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akari","family":"Shigemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Takesue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiac.2020.09.033_bib1","series-title":"Therapeutic drug monitoring newer drugs and biomarkers","author":"Dasgupta","year":"2012"},{"key":"10.1016\/j.jiac.2020.09.033_bib2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s13054-016-1320-7","article-title":"Antibiotic strategies in the era of multidrug resistance","volume":"20","author":"Karam","year":"2016","journal-title":"Crit Care"},{"key":"10.1016\/j.jiac.2020.09.033_bib3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fpubh.2019.00151","article-title":"The \"Old\" and the \"New\" antibiotics for MDR gram-negative pathogens: for whom, when, and how","volume":"7","author":"Karaiskos","year":"2019","journal-title":"Front Publ Health"},{"key":"10.1016\/j.jiac.2020.09.033_bib4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000440867","article-title":"Acute kidney injury and renal recovery with the use of aminoglycosides: a large retrospective study","volume":"131","author":"Paquette","year":"2015","journal-title":"Nephron"},{"key":"10.1016\/j.jiac.2020.09.033_bib5","first-page":"387","article-title":"Practice guidelines for therapeutic drug monitoring of antimicrobial drugs rivised edition","volume":"64","author":"Takesue","year":"2016","journal-title":"Jpn J Chemother"},{"key":"10.1016\/j.jiac.2020.09.033_bib6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1128\/AAC.8.1.58","article-title":"Gentamicin blood levels: a guide to nephrotoxicity","volume":"8","author":"Dahlgren","year":"1975","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2020.09.033_bib7","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0002-9343(77)90669-6","article-title":"Comparative efficacy and toxicity of amikacin\/carbenicillin versus gentamicin\/carbenicillin in leukopenic patients: a randomized prospective trail","volume":"62","author":"Lau","year":"1977","journal-title":"Am J Med"},{"key":"10.1016\/j.jiac.2020.09.033_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.jiac.2020.09.033_bib10","first-page":"85","article-title":"Nephrotoxicity induced by gentamicin and amikacin","volume":"142","author":"Smith","year":"1978","journal-title":"Johns Hopkins Med J"},{"key":"10.1016\/j.jiac.2020.09.033_bib11","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/qjmed\/hcp143","article-title":"Gentamicin-associated acute kidney injury","volume":"102","author":"Selby","year":"2009","journal-title":"QJM"},{"key":"10.1016\/j.jiac.2020.09.033_bib12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/qjmed\/95.5.291","article-title":"Risk factors for nephrotoxicity in elderly patients receiving once-daily aminoglycosides","volume":"95","author":"Raveh","year":"2002","journal-title":"QJM"},{"key":"10.1016\/j.jiac.2020.09.033_bib13","first-page":"CD003344","article-title":"Beta lactam antibiotic monotherapy versus beta lactam-aminoglycoside antibiotic combination therapy for sepsis","author":"Paul","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jiac.2020.09.033_bib14","series-title":"Applied pharmacokinetics & pharmacodynamics principles of therapeutic drug monitoring","author":"Burton","year":"2006"},{"key":"10.1016\/j.jiac.2020.09.033_bib15","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1128\/AAC.23.1.74","article-title":"Aminoglycoside accumulation kinetics in rat renal parenchyma","volume":"23","author":"Aronoff","year":"1983","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2020.09.033_bib16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0002-9343(86)90488-2","article-title":"Choice of drug and dosage regimen. Two important risk factors for aminoglycoside nephrotoxicity","volume":"80","author":"De Broe","year":"1986","journal-title":"Am J Med"},{"key":"10.1016\/j.jiac.2020.09.033_bib17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2133\/dmpk.19.159","article-title":"Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity","volume":"19","author":"Nagai","year":"2004","journal-title":"Drug Metabol Pharmacokinet"},{"key":"10.1016\/j.jiac.2020.09.033_bib18","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1128\/AAC.31.4.570","article-title":"Correlation between renal membrane binding and nephrotoxicity of aminoglycosides","volume":"31","author":"Williams","year":"1987","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl 2","key":"10.1016\/j.jiac.2020.09.033_bib19","first-page":"1","article-title":"KDIGO clinical practice guideline for acute kidney injury","author":"Kidney disease Improving Global Outcomes","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.jiac.2020.09.033_bib20","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1592\/phco.19.16.1252.30876","article-title":"Pharmacodynamic characterization of nephrotoxicity associated with once-daily aminoglycoside","volume":"19","author":"Murry","year":"1999","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.jiac.2020.09.033_bib21","first-page":"CD002009","article-title":"Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis","volume":"9","author":"Bhatt","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jiac.2020.09.033_bib22","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1136\/bmj.312.7027.338","article-title":"Single or multiple daily doses of aminoglycosides: a meta-analysis","volume":"312","author":"Barza","year":"1996","journal-title":"BMJ"},{"key":"10.1016\/j.jiac.2020.09.033_bib23","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/ajhp\/53.10.1141","article-title":"Effectiveness and safety of once-daily aminoglycosides: a meta-analysis","volume":"53","author":"Ferriols-Lisart","year":"1996","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/j.jiac.2020.09.033_bib24","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/j.1875-9114.1996.tb03038.x","article-title":"Mega-analysis of meta-analysis: an examination of meta-analysis with an emphasis on once-daily aminoglycoside comparative trials","volume":"16","author":"Freeman","year":"1996","journal-title":"Pharmacotherapy"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X20303536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X20303536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:01:26Z","timestamp":1761159686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X20303536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S1341321X20303536"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2020.09.033","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A meta-analysis of the target trough concentration of gentamicin and amikacin for reducing the risk of nephrotoxicity","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2020.09.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}