{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:03:37Z","timestamp":1787241817689,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003968","name":"Iran National Science Foundation","doi-asserted-by":"publisher","award":["96006039"],"award-info":[{"award-number":["96006039"]}],"id":[{"id":"10.13039\/501100003968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.jiac.2021.02.011","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T17:42:58Z","timestamp":1614102178000},"page":"984-990","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy of amiodarone and voriconazole combination therapy in cutaneous leishmaniasis in the mice experimentally infected with Leishmania major"],"prefix":"10.1016","volume":"27","author":[{"given":"S.","family":"Bahrami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Oryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bemani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiac.2021.02.011_bib1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1586\/eri.10.19","article-title":"Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis","volume":"8","author":"Goto","year":"2010","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.jiac.2021.02.011_bib2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.actatropica.2017.04.029","article-title":"Application of nanotechnology in treatment of leishmaniasis: a Review","volume":"172","author":"Akbari","year":"2017","journal-title":"Acta Trop"},{"key":"10.1016\/j.jiac.2021.02.011_bib3","first-page":"1","article-title":"Plant-derived compounds in treatment of leishmaniasis","volume":"16","author":"Oryan","year":"2015","journal-title":"Iran J Vet Res"},{"key":"10.1016\/j.jiac.2021.02.011_bib4","doi-asserted-by":"crossref","first-page":"562","DOI":"10.4103\/1995-7645.244516","article-title":"Efficacy of voriconazole on leishmaniasis by Leishmania major: an in\u00a0vitro and in\u00a0vivo study","volume":"11","author":"Oryan","year":"2018","journal-title":"Asian Pac J Trop Med"},{"issue":"3","key":"10.1016\/j.jiac.2021.02.011_bib5","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1021\/jm050691f","article-title":"Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole","volume":"49","author":"Benaim","year":"2006","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.jiac.2021.02.011_bib6","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1128\/AAC.01215-08","article-title":"Amiodarone destabilizes intracellular Ca2+ homeostasis and biosynthesis of sterols in Leishmania mexicana","volume":"53","author":"Serrano-Mart\u00edn","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2021.02.011_bib7","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1128\/AAC.00505-09","article-title":"Amiodarone and miltefosine act synergistically against Leishmania mexicana and can induce parasitological cure in a murine model of cutaneous leishmaniasis","volume":"53","author":"Serrano-Mart\u00edn","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2021.02.011_bib8","first-page":"876021","article-title":"Antiproliferative, ultrastructural, and physiological effects of amiodarone on promastigote and amastigote forms of Leishmania amazonensis","volume":"2011","author":"de Macedo-Silva","year":"2011","journal-title":"Mol Biol Int"},{"key":"10.1016\/j.jiac.2021.02.011_bib9","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/20477724.2016.1220732","article-title":"Amiodarone triggers induction of apoptosis in cutaneous leishmaniasis agents","volume":"110","author":"Bahrami","year":"2016","journal-title":"Pathog Glob Health"},{"key":"10.1016\/j.jiac.2021.02.011_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003588","article-title":"Targeting ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase","volume":"9","author":"McCall","year":"2015","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.jiac.2021.02.011_bib11","doi-asserted-by":"crossref","DOI":"10.5812\/jjhs.57990","article-title":"Isobologram curve of leishmanicidal effects of amiodarone and ketoconazole","volume":"9","author":"Bahrami","year":"2017","journal-title":"Jundishapur J Health Sci"},{"key":"10.1016\/j.jiac.2021.02.011_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083247","article-title":"In\u00a0vitro activity of the antifungal azoles itraconazole and posaconazole against Leishmania amazonensis","volume":"8","author":"de Macedo-Silva","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jiac.2021.02.011_bib13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s40506-015-0038-4","article-title":"Cutaneous leishmaniasis: current treatment practices in the USA for returning travelers","volume":"7","author":"Eiras","year":"2015","journal-title":"Curr Treat Options Infect Dis"},{"key":"10.1016\/j.jiac.2021.02.011_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186117","article-title":"Efficacy of azole therapy for tegumentary leishmaniasis: a systematic review and meta-analysis","volume":"12","author":"Galv\u00e3o","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.jiac.2021.02.011_bib15","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.jaad.2010.04.014","article-title":"Superior efficacy of oral fluconazole 400 mg daily versus oral fluconazole 200 mg daily in the treatment of cutaneous leishmania major infection: a randomized clinical trial","volume":"64","author":"Emad","year":"2011","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jiac.2021.02.011_bib16","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/cid\/cir496","article-title":"High-dose oral fluconazole therapy effective for cutaneous leishmaniasis due to Leishmania (Vianna) braziliensis","volume":"53","author":"Sousa","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2021.02.011_bib17","doi-asserted-by":"crossref","first-page":"107747","DOI":"10.1016\/j.exppara.2019.107747","article-title":"Effectiveness of amiodarone in treatment of cutaneous leishmaniasis caused by Leishmania major","volume":"205","author":"Bemani","year":"2019","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.jiac.2021.02.011_bib18","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/BF02977761","article-title":"Production of cytokine and NO by RAW 264.7 macrophages and PBMC in\u00a0vitro incubation with flavonoids","volume":"28","author":"Lyu","year":"2005","journal-title":"Arch Pharm Res (Seoul)"},{"key":"10.1016\/j.jiac.2021.02.011_bib19","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1128\/AAC.22.5.743","article-title":"Synergism between aminoglycosides and cephalosporins with antipseudomonal activity: interaction index and killing curve method","volume":"22","author":"Hallander","year":"1982","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2021.02.011_bib20","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1590\/S0074-02762011000800022","article-title":"Investigation into in\u00a0vitro anti-leishmanial combinations of calcium channel blockers and current anti-leishmanial drugs","volume":"106","author":"Reim\u00e3o","year":"2011","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.jiac.2021.02.011_bib21","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.1007\/s00436-015-4707-5","article-title":"Potential application of nanochitosan film as a therapeutic agent against cutaneous leishmaniasis caused by L.\u00a0major","volume":"114","author":"Bahrami","year":"2015","journal-title":"Parasitol Res"},{"key":"10.1016\/j.jiac.2021.02.011_bib22","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Paglia","year":"1967","journal-title":"J\u00a0Lab Clin Med"},{"key":"10.1016\/j.jiac.2021.02.011_bib23","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1996.0292","article-title":"The ferric reducing ability of plasma (FRAP) as a measure of \u201cantioxidant power\u201d: the FRAP assay","volume":"239","author":"Benzie","year":"1996","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jiac.2021.02.011_bib24","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0003-2697(66)90167-9","article-title":"Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems","volume":"16","author":"Placer","year":"1966","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jiac.2021.02.011_bib25","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1007\/s00436-013-3274-x","article-title":"Voriconazole suppresses the growth of Leishmania species in\u00a0vitro","volume":"112","author":"Kulkarni","year":"2013","journal-title":"Parasitol Res"},{"key":"10.1016\/j.jiac.2021.02.011_bib26","doi-asserted-by":"crossref","first-page":"562","DOI":"10.4103\/1995-7645.244516","article-title":"Efficacy of voriconazole on leishmaniasis by Leishmania major: an in\u00a0vitro and in\u00a0vivo study","volume":"11","author":"Oryan","year":"2018","journal-title":"Asian Pac J Trop Med"},{"key":"10.1016\/j.jiac.2021.02.011_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1020804916733","article-title":"Antioxidant status during cutaneous wound healing in immunocompromised rats","volume":"24","author":"Gupta","year":"2002","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jiac.2021.02.011_bib28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.phrs.2008.06.004","article-title":"Oxidative stress in normal and impaired wound repair","volume":"58","author":"Sch\u00e4fer","year":"2008","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jiac.2021.02.011_bib29","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1086\/340261","article-title":"Epidemiologic and immunologic findings for the subclinical form of Leishmania braziliensis infection","volume":"34","author":"Follador","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2021.02.011_bib30","first-page":"1","article-title":"The role of inflammatory, anti-inflammatory, and regulatory cytokines in patients infected with cutaneous leishmaniasis in Amazonas state, Brazil","volume":"2014","author":"Espir","year":"2014","journal-title":"J\u00a0Immunol Res"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X21000428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X21000428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:02:40Z","timestamp":1761159760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X21000428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S1341321X21000428"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2021.02.011","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of amiodarone and voriconazole combination therapy in cutaneous leishmaniasis in the mice experimentally infected with Leishmania major","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2021.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}