{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:31:52Z","timestamp":1761183112355,"version":"build-2065373602"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jiac.2021.10.005","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T20:44:40Z","timestamp":1635453880000},"page":"187-191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Molecular characterisation of carbapenem- and tigecycline-resistant Klebsiella pneumoniae strains isolated from blood and bile samples"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9506-707X","authenticated-orcid":false,"given":"Takeaki","family":"Wajima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sugawara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Umeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuya","family":"Hagimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2889-8257","authenticated-orcid":false,"given":"Hidemasa","family":"Nakaminami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2019","series-title":"Antibiotic resistance threats in the United States, 2019","key":"10.1016\/j.jiac.2021.10.005_bib1"},{"year":"2017","series-title":"Guidelines for the prevention and control of carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa in health care facilities","author":"Who","key":"10.1016\/j.jiac.2021.10.005_bib2"},{"key":"10.1016\/j.jiac.2021.10.005_bib3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/joim.13007","article-title":"Hypervirulent Klebsiella pneumoniae - clinical and molecular perspectives","volume":"287","author":"Choby","year":"2020","journal-title":"J Intern Med"},{"key":"10.1016\/j.jiac.2021.10.005_bib4","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1084\/jem.20030857","article-title":"A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications","volume":"199","author":"Fang","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.jiac.2021.10.005_bib5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/QCO.0000000000000464","article-title":"Getting hypervirulent Klebsiella pneumoniae on the radar screen","volume":"31","author":"Sellick","year":"2018","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.jiac.2021.10.005_bib6","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00174-20","article-title":"Molecular and clinical characterization of multidrug-resistant and hypervirulent Klebsiella pneumoniae strains from liver abscess in Taiwan","volume":"64","author":"Lin","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2021.10.005_bib7","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S1473-3099(13)70190-7","article-title":"Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases","volume":"13","author":"Munoz-Price","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jiac.2021.10.005_bib8","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1128\/AAC.01019-15","article-title":"Carbapenemase-producing Klebsiella pneumoniae, a key pathogen set for global nosocomial dominance","volume":"59","author":"Pitout","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2021.10.005_bib9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/jac\/dkz450","article-title":"Tigecycline-non-susceptible hypervirulent Klebsiella pneumoniae strains in Taiwan","volume":"75","author":"Cheng","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2021.10.005_bib10","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00391-17","article-title":"Roles of ramR and tet(A) mutations in conferring tigecycline resistance in carbapenem-resistant Klebsiella pneumoniae clinical isolates","volume":"61","author":"Chiu","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2021.10.005_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23506","article-title":"Molecular epidemiology and mechanisms of tigecycline resistance in carbapenem-resistant Klebsiella pneumoniae isolates","volume":"34","author":"Park","year":"2020","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.jiac.2021.10.005_bib12","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/cid\/ciw805","article-title":"Bonomo RA, van Duin D and Antibacterial Resistance Leadership G. Colistin resistance in carbapenem-resistant Klebsiella pneumoniae: Laboratory detection and impact on mortality","volume":"64","author":"Rojas","year":"2017","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2021.10.005_bib13","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.00776-18","article-title":"Identification of biomarkers for differentiation of hypervirulent Klebsiella pneumoniae from classical K. pneumoniae","volume":"56","author":"Russo","year":"2018","journal-title":"J Clin Microbiol"},{"year":"2019","series-title":"Performance standards for antimicrobial susceptibility testing","key":"10.1016\/j.jiac.2021.10.005_bib14"},{"key":"10.1016\/j.jiac.2021.10.005_bib15","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1093\/jac\/dky293","article-title":"Impact of OqxR loss of function on the envelope proteome of Klebsiella pneumoniae and susceptibility to antimicrobials","volume":"73","author":"Wan Nur Ismah","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2021.10.005_bib16","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1128\/JCM.36.5.1357-1360.1998","article-title":"Nosocomial outbreak of Klebsiella pneumoniae producing SHV-5 extended-spectrum beta-lactamase, originating from a contaminated ultrasonography coupling gel","volume":"36","author":"Gaillot","year":"1998","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jiac.2021.10.005_bib17","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software 'EZR' for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jiac.2021.10.005_bib18","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1128\/AAC.00085-10","article-title":"ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline","volume":"54","author":"Hentschke","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2021.10.005_bib19","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1128\/AAC.00285-06","article-title":"High-level carbapenem resistance in a Klebsiella pneumoniae clinical isolate is due to the combination of blaACT-1 beta-lactamase production, porin OmpK35\/36 insertional inactivation, and down-regulation of the phosphate transport porin PhoE","volume":"50","author":"Kaczmarek","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2021.10.005_bib20","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1099\/jmm.0.012575-0","article-title":"Contribution of OmpK36 to carbapenem susceptibility in KPC-producing Klebsiella pneumoniae","volume":"58","author":"Landman","year":"2009","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.jiac.2021.10.005_bib21","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jgar.2020.01.012","article-title":"Effect of ramr loss-of-function insertion on tigecycline resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae","volume":"21","author":"Mao","year":"2020","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.jiac.2021.10.005_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1128\/AAC.00715-09","article-title":"Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence","volume":"54","author":"Padilla","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiac.2021.10.005_bib23","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.diagmicrobio.2009.08.010","article-title":"In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment","volume":"65","author":"Song","year":"2009","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jiac.2021.10.005_bib24","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/MEG.0b013e3282f1c985","article-title":"Effects of biliary obstruction on the penetration of ciprofloxacin and cefotaxime","volume":"20","author":"Dhalluin-Venier","year":"2008","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.jiac.2021.10.005_bib25","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S0016-5107(94)70115-6","article-title":"Antibiotics, biliary sepsis, and bile duct stones","volume":"40","author":"Leung","year":"1994","journal-title":"Gastrointest Endosc"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X21002749?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X21002749?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:03:19Z","timestamp":1761159799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X21002749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S1341321X21002749"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2021.10.005","relation":{},"ISSN":["1341-321X"],"issn-type":[{"type":"print","value":"1341-321X"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular characterisation of carbapenem- and tigecycline-resistant Klebsiella pneumoniae strains isolated from blood and bile samples","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2021.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}