{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:08:47Z","timestamp":1790431727848,"version":"4.1.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["19fk0108081j0301"],"award-info":[{"award-number":["19fk0108081j0301"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20fk0108081j0802"],"award-info":[{"award-number":["20fk0108081j0802"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["21fk0108081j0803"],"award-info":[{"award-number":["21fk0108081j0803"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["21wm0325032j0201"],"award-info":[{"award-number":["21wm0325032j0201"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H02856"],"award-info":[{"award-number":["18H02856"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012000","name":"All Japan Coffee Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.jiac.2021.11.005","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T09:07:51Z","timestamp":1637226471000},"page":"373-376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["L-DOPA, a treatment for Parkinson's disease, and its enantiomer D-DOPA inhibit severe fever with thrombocytopenia syndrome virus infection in vitro"],"prefix":"10.1016","volume":"28","author":[{"given":"Motohiko","family":"Ogawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mana","family":"Murae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryutaro","family":"Gemba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Irie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Shimojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Saijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohji","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0702-0691","authenticated-orcid":false,"given":"Masayoshi","family":"Fukasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiac.2021.11.005_bib1","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1056\/NEJMoa1010095","article-title":"Fever with thrombocytopenia associated with a novel bunyavirus in China","volume":"364","author":"Yu","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jiac.2021.11.005_bib2","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/infdis\/jit603","article-title":"The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan","volume":"209","author":"Takahashi","year":"2014","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jiac.2021.11.005_bib3","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3390\/v13020204","article-title":"Pathological characteristics of a patient with severe fever with thrombocytopenia syndrome (SFTS) infected with SFTS virus through a sick cat's bite","volume":"13","author":"Tsuru","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.jiac.2021.11.005_bib4","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.3201\/eid2008.131857","article-title":"Severe fever with thrombocytopenia syndrome virus in ticks collected from humans, South Korea","volume":"20","author":"Yun","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jiac.2021.11.005_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165207","article-title":"Epidemiological and clinical features of severe fever with thrombocytopenia syndrome in Japan, 2013-2014","volume":"11","author":"Kato","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jiac.2021.11.005_bib6","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3201\/eid2604.191011","article-title":"Epidemiological study of severe fever with thrombocytopenia syndrome in Japan, 2013-2017","volume":"26","author":"Kobayashi","year":"2020","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"10.1016\/j.jiac.2021.11.005_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009103","article-title":"A multicenter non-randomized, uncontrolled single arm trial for evaluation of the efficacy and the safety of the treatment with favipiravir for patients with severe fever with thrombocytopenia syndrome","volume":"15","author":"Suemori","year":"2021","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.jiac.2021.11.005_bib8","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fmicb.2020.00150","article-title":"Antiviral drugs against severe fever with thrombocytopenia syndrome virus infection","volume":"11","author":"Takayama-Ito","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jiac.2021.11.005_bib9","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3390\/v13040627","article-title":"Vaccine development for severe fever with thrombocytopenia syndrome","volume":"13","author":"Yoshikawa","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.jiac.2021.11.005_bib10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.jiac.2018.03.005","article-title":"Caffeic acid, a coffee-related organic acid, inhibits infection by severe fever with thrombocytopenia syndrome virus in vitro","volume":"24","author":"Ogawa","year":"2018","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.jiac.2021.11.005_bib11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jiac.2020.10.015","article-title":"Structural basis of antiviral activity of caffeic acid against severe fever with thrombocytopenia syndrome virus","volume":"27","author":"Ogawa","year":"2021","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.jiac.2021.11.005_bib12","doi-asserted-by":"crossref","first-page":"234","DOI":"10.2174\/157488407781668802","article-title":"The pharmacokinetics and pharmacodynamics of levodopa in the treatment of Parkinson's disease","volume":"2","author":"Khor","year":"2007","journal-title":"Curr Clin Pharmacol"},{"key":"10.1016\/j.jiac.2021.11.005_bib13","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s12264-010-0302-z","article-title":"Treatment strategies for Parkinson's disease","volume":"26","author":"Yuan","year":"2010","journal-title":"Neurosci Bull"},{"key":"10.1016\/j.jiac.2021.11.005_bib14","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00061-15","article-title":"Efficacy of T-705 (favipiravir) in the treatment of infections with lethal severe fever with thrombocytopenia syndrome virus","volume":"1","author":"Tani","year":"2016","journal-title":"mSphere"},{"key":"10.1016\/j.jiac.2021.11.005_bib15","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/mds.20383","article-title":"Identification of motor and nonmotor wearing-off in Parkinson's disease: comparison of a patient questionnaire versus a clinician assessment","volume":"20","author":"Stacy","year":"2005","journal-title":"Mov Disord"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X2100310X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X2100310X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:02:56Z","timestamp":1761159776000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X2100310X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S1341321X2100310X"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2021.11.005","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"L-DOPA, a treatment for Parkinson's disease, and its enantiomer D-DOPA inhibit severe fever with thrombocytopenia syndrome virus infection in vitro","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2021.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}