{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:57:43Z","timestamp":1779213463647,"version":"3.51.4"},"reference-count":15,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012319","name":"National Center for Global Health and Medicine","doi-asserted-by":"publisher","award":["20A2010"],"award-info":[{"award-number":["20A2010"]}],"id":[{"id":"10.13039\/100012319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19fk018163"],"award-info":[{"award-number":["JP19fk018163"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20fk0108104"],"award-info":[{"award-number":["JP20fk0108104"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20fk108262"],"award-info":[{"award-number":["JP20fk108262"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.jiac.2022.02.006","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T22:49:57Z","timestamp":1644446997000},"page":"971-974","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prolonged SARS-CoV-2 infection associated with long-term corticosteroid use in a patient with impaired B-cell immunity"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6357-9465","authenticated-orcid":false,"given":"Momoko","family":"Morishita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8515-6466","authenticated-orcid":false,"given":"Manabu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9405-2009","authenticated-orcid":false,"given":"Akihiro","family":"Matsunaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keishi","family":"Ishizhima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yudai","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5151-3012","authenticated-orcid":false,"given":"Takayuki","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshie","family":"Tsujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akane","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Takasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Go","family":"Naka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoyasu","family":"Iikura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6384-5022","authenticated-orcid":false,"given":"Shinyu","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3820-9542","authenticated-orcid":false,"given":"Tadaki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3488-5439","authenticated-orcid":false,"given":"Ken","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihito","family":"Ishizaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9595-9657","authenticated-orcid":false,"given":"Masayuki","family":"Hojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhito","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiac.2022.02.006_bib1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41586-020-2196-x","article-title":"Virological assessment of hospitalized patients with COVID-2019","volume":"581","author":"W\u00f6lfel","year":"2020","journal-title":"Nature"},{"issue":"22","key":"10.1016\/j.jiac.2022.02.006_bib2","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1001\/jama.2020.8259","article-title":"Interpreting diagnostic tests for SARS-CoV-2","volume":"323","author":"Sethuraman","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.jiac.2022.02.006_bib3","doi-asserted-by":"crossref","unstructured":"Madewell ZJ, Yang Y, Longini IM, Halloran ME, Dean NE. Household Transmission of SARS-CoV-2: A Systematic Review and Meta-analysis. JAMA Netw Open 3, e2031756\u2013e2031756. https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.31756.","DOI":"10.1001\/jamanetworkopen.2020.31756"},{"key":"10.1016\/j.jiac.2022.02.006_bib4","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhin.2021.02.014","article-title":"Duration of isolation and precautions in immunocompromised patients with COVID-19","volume":"111","author":"Taramasso","year":"2021","journal-title":"J Hosp Infect"},{"key":"10.1016\/j.jiac.2022.02.006_bib5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ijid.2020.12.050","article-title":"Persistent replication of SARS-CoV-2 in a severely immunocompromised patient treated with several courses of remdesivir","volume":"104","author":"Camprub\u00ed","year":"2021","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.jiac.2022.02.006_bib6","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/s41375-021-01175-8","article-title":"Severe clinical relapse in an immunocompromised host with persistent SARS-CoV-2 infection","volume":"35","author":"Reuken","year":"2021","journal-title":"Leukemia"},{"key":"10.1016\/j.jiac.2022.02.006_bib7","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1093\/infdis\/jiaa446","article-title":"Persistent COVID-19 in an immunocompromised patient temporarily responsive to two courses of remdesivir therapy","volume":"222","author":"Helleberg","year":"2020","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jiac.2022.02.006_bib8","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1001\/jama.2021.7212","article-title":"Researchers tie severe immunosuppression to chronic COVID-19 and virus variants","volume":"325","author":"Abbasi","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.jiac.2022.02.006_bib9","doi-asserted-by":"crossref","first-page":"e815","DOI":"10.1093\/cid\/ciab072","article-title":"Intractable coronavirus Disease 2019 (COVID-19) and prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in a chimeric antigen receptor-modified T-cell therapy recipient: a case study","volume":"73","author":"Hensley","year":"2021","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2022.02.006_bib10","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1093\/infdis\/jiab075","article-title":"Long-term severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectiousness among three immunocompromised patients: from prolonged viral shedding to SARS-CoV-2 superinfection","volume":"223","author":"Tarhini","year":"2021","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jiac.2022.02.006_bib11","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.cell.2020.09.038","article-title":"Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity","volume":"183","author":"Rydyznski Moderbacher","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jiac.2022.02.006_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103230","article-title":"SARS-CoV-2 persistence is associated with antigen-specific CD8 T-cell responses","volume":"64","author":"Vibholm","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jiac.2022.02.006_bib13","doi-asserted-by":"crossref","unstructured":"Matthew JO, Yuri K, Angelique B, Foo C, Jinguo C, Rongye S, Huizhi Z, Ena W, John ST, Robert N, CHI Consortium, et al. Effects of Systemically Administered Hydrocortisone on the Human Immunome. Sci Rep 2016:6:23002. https:\/\/doi.org\/10.1038\/srep23002.","DOI":"10.1038\/srep25215"},{"key":"10.1016\/j.jiac.2022.02.006_bib14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1056\/NEJMoa2021436","article-title":"Dexamethasone in hospitalized patients with Covid-19","volume":"384","author":"Horby","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jiac.2022.02.006_bib15","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000512063","article-title":"Early use of corticosteroid may prolong SARS-CoV-2 shedding in non-intensive care unit patients with COVID-19 pneumonia: a multicenter, single-blind, randomized control trial","volume":"100","author":"Tang","year":"2021","journal-title":"Respiration"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X22000460?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X22000460?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:05:08Z","timestamp":1761159908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X22000460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S1341321X22000460"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2022.02.006","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prolonged SARS-CoV-2 infection associated with long-term corticosteroid use in a patient with impaired B-cell immunity","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2022.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}