{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:00:45Z","timestamp":1787886045044,"version":"build-2784847793"},"reference-count":28,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jiac.2022.05.005","type":"journal-article","created":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T16:41:42Z","timestamp":1652546502000},"page":"1261-1265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["How do we reduce acyclovir overuse? Impact of FilmArray meningitis\/encephalitis panel tests for pediatric patients"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0084-9878","authenticated-orcid":false,"given":"Shogo","family":"Otake","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Oue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiac.2022.05.005_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1053\/j.spid.2004.09.007","article-title":"Herpes simplex: encephalitis children and adolescents","volume":"16","author":"Whitley","year":"2005","journal-title":"Semin Pediatr Infect Dis"},{"key":"10.1016\/j.jiac.2022.05.005_bib2","article-title":"Efficacy of acyclovir for herpes simplex encephalitis","volume":"98","author":"Wang","year":"2019","journal-title":"Medicine (Baltim)"},{"key":"10.1016\/j.jiac.2022.05.005_bib3","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.cmi.2017.06.011","article-title":"Is antimicrobial stewardship cost-effective? A narrative review of the evidence","volume":"23","author":"Naylor","year":"2017","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jiac.2022.05.005_bib4","doi-asserted-by":"crossref","first-page":"e651","DOI":"10.1542\/peds.2014-0294","article-title":"Herpes PCR testing and empiric acyclovir use beyond the neonatal period","volume":"134","author":"Gaensbauer","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.jiac.2022.05.005_bib5","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.jpeds.2015.01.023","article-title":"Intravenous acyclovir and renal dysfunction in children: a matched case control study","volume":"166","author":"Rao","year":"2015","journal-title":"J Pediatr"},{"key":"10.1016\/j.jiac.2022.05.005_bib6","doi-asserted-by":"crossref","first-page":"115085","DOI":"10.1016\/j.diagmicrobio.2020.115085","article-title":"Impact of FilmArray meningitis encephalitis panel on HSV testing and empiric acyclovir use in children beyond the neonatal period","volume":"97","author":"Messacar","year":"2020","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jiac.2022.05.005_bib7","doi-asserted-by":"crossref","first-page":"144","DOI":"10.7883\/yoken.JJID.2020.623","article-title":"Burden of pediatric central nervous system infection and cost-benefit simulation of multiplex polymerase chain reaction in Japan","volume":"74","author":"Kitano","year":"2021","journal-title":"Jpn J Infect Dis"},{"key":"10.1016\/j.jiac.2022.05.005_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1345\/aph.17135","article-title":"Acyclovir- and ganciclovir-induced neurotoxicity","volume":"32","author":"Ernst","year":"1998","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.jiac.2022.05.005_bib9","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1093\/clinids\/20.6.1557","article-title":"Acyclovir-induced neutropenia in an infant with herpes simplex encephalitis: case report","volume":"20","author":"Feder","year":"1995","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2022.05.005_bib10","first-page":"3417","article-title":"Acyclovir-induced immune thrombocytopenia: case report and review of the literature","volume":"4","author":"Fekete","year":"2020","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jiac.2022.05.005_bib11","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0190-9622(88)70025-0","article-title":"Adverse reactions to acyclovir: topical, oral, and intravenous","volume":"18","author":"Arndt","year":"1988","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jiac.2022.05.005_bib12","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1128\/JCM.00730-16","article-title":"Multicenter evaluation of biofire filmarray meningitis\/encephalitis panel for detection of bacteria, viruses, and yeast in cerebrospinal fluid specimens","volume":"54","author":"Leber","year":"2016","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jiac.2022.05.005_bib13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cmi.2019.11.016","article-title":"Diagnostic test accuracy of the BioFire\u00ae FilmArray\u00ae meningitis\/encephalitis panel: a systematic review and meta-analysis","volume":"26","author":"Tansarli","year":"2020","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jiac.2022.05.005_bib14","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1542\/hpeds.2019-0064","article-title":"Association of the FilmArray meningitis\/encephalitis panel with clinical management","volume":"9","author":"Nabower","year":"2019","journal-title":"Hosp Pediatr"},{"key":"10.1016\/j.jiac.2022.05.005_bib15","article-title":"Assessment of the FilmArray\u00ae multiplex PCR system and associated meningitis\/encephalitis panel in the diagnostic service of a tertiary hospital","volume":"2","author":"Mostyn","year":"2020","journal-title":"Infect Prev Pract"},{"key":"10.1016\/j.jiac.2022.05.005_bib16","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/PEC.0000000000002180","article-title":"Rapid diagnostic tests for meningitis and encephalitis - Biofire","volume":"36","author":"Fleischer","year":"2020","journal-title":"Pediatr Emerg Care"},{"key":"10.1016\/j.jiac.2022.05.005_bib17","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1007\/s10096-020-03986-6","article-title":"Impact of cerebrospinal fluid syndromic testing in the management of children with suspected central nervous system infection","volume":"39","author":"Posnakoglou","year":"2020","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jiac.2022.05.005_bib18","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1086\/339550","article-title":"Patients with suspected herpes simplex encephalitis: rethinking an initial negative polymerase chain reaction result","volume":"34","author":"Weil","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2022.05.005_bib20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1086\/589747","article-title":"The management of encephalitis: clinical practice guidelines by the Infectious Diseases Society of America","volume":"47","author":"Tunkel","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2022.05.005_bib21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.7861\/clinmedicine.18-2-155","article-title":"Acute encephalitis \u2013 diagnosis and management","volume":"18","author":"Ellul","year":"2018","journal-title":"Clin Med"},{"key":"10.1016\/j.jiac.2022.05.005_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ofid\/ofw245","article-title":"Delayed diagnosis of tuberculous meningitis misdiagnosed as herpes simplex virus-1 encephalitis with the film array syndromic polymerase chain reaction panel","volume":"4","author":"Gomez","year":"2017","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.jiac.2022.05.005_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ajic.2006.05.237","article-title":"Antimicrobial stewardship","volume":"34","author":"Fishman","year":"2006","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.jiac.2022.05.005_bib24","first-page":"819","article-title":"Antimicrobial resistance: an antimicrobial\/diagnostic stewardship and infection prevention approach","volume":"102","author":"Septimus","year":"2018","journal-title":"Med Clin"},{"key":"10.1016\/j.jiac.2022.05.005_bib25","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1093\/milmed\/usx025","article-title":"A tertiary care center's experience with novel molecular meningitis\/encephalitis diagnostics and implementation with antimicrobial stewardship","volume":"183","author":"Chang","year":"2018","journal-title":"Mil Med"},{"key":"10.1016\/j.jiac.2022.05.005_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.17161\/kjm.v12i1.11695","article-title":"Contribution of the BioFire\u00ae FilmArray\u00ae meningitis\/encephalitis panel: assessing antimicrobial duration and length of stay","volume":"12","author":"Dack","year":"2019","journal-title":"Kansas J Med"},{"key":"10.1016\/j.jiac.2022.05.005_bib27","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1007\/s00431-021-04043-w","article-title":"Early impact of school closure and social distancing for COVID-19 on the number of inpatients with childhood non-COVID-19 acute infections in Japan","volume":"180","author":"Kishimoto","year":"2021","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jiac.2022.05.005_bib28","first-page":"9","article-title":"COVID-19 and herpes simplex virus infection: a cross-sectional study","volume":"13","author":"Shanshal","year":"2021","journal-title":"Cureus"},{"key":"10.1016\/j.jiac.2022.05.005_bib29","first-page":"1","article-title":"Post COVID-19 HSV encephalitis: a review","author":"Gupta","year":"2022","journal-title":"QJM An Int J Med"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X22001544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X22001544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:04:37Z","timestamp":1761159877000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X22001544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S1341321X22001544"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2022.05.005","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"How do we reduce acyclovir overuse? Impact of FilmArray meningitis\/encephalitis panel tests for pediatric patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2022.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}