{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:47:52Z","timestamp":1780919272615,"version":"3.54.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"am","delay-in-days":312,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","jiac-j.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jiac.2025.102633","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T17:26:14Z","timestamp":1737566774000},"page":"102633","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and microbiological characteristics of invasive diseases due to Haemophilus influenzae in the Minami Ibaraki Area, Japan"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6393-6180","authenticated-orcid":false,"given":"Naoya","family":"Sakamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigemi","family":"Hitomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiac.2025.102633_bib1","series-title":"Bennett's principles and practice of infectious diseases","first-page":"2743","article-title":"Haemophilus species, including H. influenzae and H. ducreyi (chancroid)","author":"Murphy","year":"2020"},{"key":"10.1016\/j.jiac.2025.102633_bib2","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S1473-3099(14)70734-0","article-title":"Non-typeable Haemophilus influenzae, an under-recognised pathogen","volume":"14","author":"Van Eldere","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jiac.2025.102633_bib3","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1128\/JCM.05476-11","article-title":"Haemophilus influenzae infections in the H. influenzae type b conjugate vaccine era","volume":"49","author":"Agrawal","year":"2011","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jiac.2025.102633_bib4","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1128\/CMR.13.2.302","article-title":"Worldwide Haemophilus influenzae type b disease at the beginning of the 21st century: global analysis of the disease burden 25 years after the use of the polysaccharide vaccine and a decade after the advent of conjugates","volume":"13","author":"Peltola","year":"2000","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jiac.2025.102633_bib5","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.3201\/eid2110.150004","article-title":"Invasive disease caused by nontypeable Haemophilus influenzae","volume":"21","author":"Langereis","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jiac.2025.102633_bib6","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1016\/j.vaccine.2018.09.060","article-title":"Increasing trend in invasive non-typeable Haemophilus influenzae disease and molecular characterization of the isolates, Italy, 2012-2016","volume":"36","author":"Giufr\u00e8","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.jiac.2025.102633_bib7","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1016\/j.vaccine.2014.06.022","article-title":"Recent progress and concerns regarding the Japanese immunization program: addressing the \"vaccine gap\"","volume":"32","author":"Saitoh","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.jiac.2025.102633_bib8","first-page":"229","article-title":"Invasive Haemophilus influenzae and Streptococcus pneumoniae infections, as of august 2014","volume":"35","year":"2014","journal-title":"Infect Agents Surveill Rep"},{"key":"10.1016\/j.jiac.2025.102633_bib9","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3201\/eid2303.161552","article-title":"Epidemiology of invasive Haemophilus influenzae disease, Europe, 2007\u20132014","volume":"23","author":"Whittaker","year":"2017","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jiac.2025.102633_bib10","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1093\/cid\/ciy187","article-title":"Current epidemiology and trends in invasive Haemophilus influenzae disease\u2014United States, 2009\u20132015","volume":"67","author":"Soeters","year":"2018","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2025.102633_bib11","first-page":"1568","article-title":"The incidence of pediatric Haemophilus influenzae systemic infections","volume":"111","author":"Ishiwada","year":"2007","journal-title":"J Jpn Pediatr Soc"},{"key":"10.1016\/j.jiac.2025.102633_bib12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s10156-006-0491-6","article-title":"Invasive Haemophilus influenzae infections in children in Kamikawa subprefecture, Hokkaido, Japan, 1996\u20132005, before the introduction of H. influenzae type b vaccination","volume":"13","author":"Sakata","year":"2007","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.jiac.2025.102633_bib13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10156-011-0323-1","article-title":"Genotyping of Haemophilus influenzae type b in pre-vaccination era","volume":"18","author":"Otsuka","year":"2012","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.jiac.2025.102633_bib14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s10156-012-0448-x","article-title":"Longitudinal surveillance of Haemophilus influenzae isolates from pediatric patients with meningitis throughout Japan, 2000-2011","volume":"19","author":"Ubukata","year":"2013","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.jiac.2025.102633_bib15","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1016\/j.vaccine.2014.07.100","article-title":"The incidence of pediatric invasive Haemophilus influenzae and pneumococcal disease in Chiba prefecture, Japan before and after the introduction of conjugate vaccines","volume":"32","author":"Ishiwada","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.jiac.2025.102633_bib16","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jiac.2014.04.007","article-title":"Recent trends in pediatric bacterial meningitis in Japan\u2014a country where Haemophilus influenzae type b and Streptococcus pneumoniae conjugated vaccines have just been introduced","volume":"20","author":"Shinjoh","year":"2014","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.jiac.2025.102633_bib17","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jiac.2017.02.014","article-title":"Pediatric bacterial meningitis in Japan, 2013-2015\u20143-5 years after the wide use of Haemophilus influenzae type b and Streptococcus pneumoniae conjugated vaccines","volume":"23","author":"Shinjoh","year":"2017","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.jiac.2025.102633_bib18","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jiac.2017.03.019","article-title":"Invasive Haemophilus influenzae infections in children in Kamikawa subprefecture, Hokkaido, Japan, 2006\u20132015: the effectiveness of H. influenzae type b vaccine","volume":"23","author":"Sakata","year":"2017","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.jiac.2025.102633_bib19","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.00141-18","article-title":"Clinical and bacteriologic analysis of nontypeable Haemophilus influenzae strains isolated from children with invasive diseases in Japan from 2008 to 2015","volume":"56","author":"Naito","year":"2018","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jiac.2025.102633_bib20","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1016\/j.vaccine.2018.08.029","article-title":"A nationwide population-based surveillance of invasive Haemophilus influenzae diseases in children after the introduction of the Haemophilus influenzae type b vaccine in Japan","volume":"36","author":"Suga","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.jiac.2025.102633_bib21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s15010-022-01885-w","article-title":"Invasive Haemophilus influenzae disease among adults in Japan during 2014\u20132018","volume":"51","author":"Hachisu","year":"2023","journal-title":"Infection"},{"key":"10.1016\/j.jiac.2025.102633_bib23","doi-asserted-by":"crossref","first-page":"791","DOI":"10.7326\/0003-4819-137-10-200211190-00007","article-title":"Health care-associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections","volume":"137","author":"Friedman","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jiac.2025.102633_bib24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s10156-011-0277-3","volume":"18","author":"Yamaguchi","year":"2012","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.jiac.2025.102633_bib25","series-title":"Performance standards for antimicrobial susceptibility testing","year":"2021"},{"key":"10.1016\/j.jiac.2025.102633_bib26","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/jac\/dki281","article-title":"Global distribution of TEM-1 and ROB-1 beta-lactamases in Haemophilus influenzae","volume":"56","author":"Farrell","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2025.102633_bib27","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1128\/JCM.41.4.1623-1636.2003","article-title":"Characterization of encapsulated and noncapsulated Haemophilus influenzae and determination of phylogenetic relationships by multilocus sequence typing","volume":"41","author":"Meats","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jiac.2025.102633_bib28","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1128\/JCM.43.6.2741-2749.2005","article-title":"Increase in genetic diversity of Haemophilus influenzae serotype b (Hib) strains after introduction of Hib vaccination in The Netherlands","volume":"43","author":"Schouls","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jiac.2025.102633_bib29","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jiac.2025.102633_bib30","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1001\/jama.283.23.3089","article-title":"Invasive Haemophilus influenzae disease in Alaskan residents aged 10 years and older before and after infant vaccination programs","volume":"283","author":"Perdue","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.jiac.2025.102633_bib31","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1086\/511861","article-title":"The changing epidemiology of invasive Haemophilus influenzae disease, especially in persons > or =65 years old","volume":"44","author":"Dworkin","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2025.102633_bib32","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1016\/j.vaccine.2010.03.075","article-title":"Changing epidemiology of invasive Haemophilus influenzae in Ontario, Canada: evidence for herd effects and strain replacement due to Hib vaccination","volume":"28","author":"Adam","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.jiac.2025.102633_bib33","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3201\/eid1603.090290","article-title":"Invasive Haemophilus influenzae disease, Europe, 1996\u20132006","volume":"16","author":"Ladhani","year":"2010","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jiac.2025.102633_bib34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/thoraxjnl-2018-211767","article-title":"Effect of childhood pneumococcal conjugate vaccination on invasive disease in older adults of 10 European countries: implications for adult vaccination","volume":"74","author":"Hanquet","year":"2019","journal-title":"Thorax"},{"key":"10.1016\/j.jiac.2025.102633_bib35","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ijid.2019.06.030","article-title":"Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults","volume":"86","author":"Ciruela","year":"2019","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.jiac.2025.102633_bib36","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S1473-3099(13)70170-1","article-title":"Haemophilus influenzae serotype a as a cause of serious invasive infections","volume":"14","author":"Ulanova","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jiac.2025.102633_bib37","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1093\/cid\/cix234","article-title":"Emergence of invasive Haemophilus influenzae type A disease in Italy","volume":"64","author":"Giufr\u00e8","year":"2017","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2025.102633_bib38","article-title":"Shoni to seijin no shinshusei haienkyukin kansensho no ekigaku joho","year":"2024","journal-title":"Shoni seijin no shinshusei infuruenzakin kansensho no ekigaku joho"},{"key":"10.1016\/j.jiac.2025.102633_bib39","doi-asserted-by":"crossref","DOI":"10.3402\/ijch.v75.29798","article-title":"Laboratory characterization of invasive Haemophilus influenzae isolates from Nunavut, Canada, 2000\u20132012","volume":"75","author":"Tsang","year":"2016","journal-title":"Int J Circumpolar Health"},{"key":"10.1016\/j.jiac.2025.102633_bib40","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1099\/jmm.0.000721","article-title":"Genotypic characterization of Haemophilus influenzae isolates from paediatric patients in Japan","volume":"67","author":"Adachi","year":"2018","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.jiac.2025.102633_bib41","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1016\/j.vaccine.2018.09.060","article-title":"Increasing trend in invasive non-typeable Haemophilus influenzae disease and molecular characterization of the isolates, Italy, 2012-2016","volume":"36","author":"Giufr\u00e8","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.jiac.2025.102633_bib42","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/s10096-020-03865-0","article-title":"Molecular epidemiology of invasive Haemophilus influenzae disease in Portugal: an update of the post-vaccine period, 2011-2018","volume":"39","author":"Heliodoro","year":"2020","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jiac.2025.102633_bib43","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1007\/s10096-020-03971-z","article-title":"Epidemiology of Haemophilus influenzae in the republic of Ireland, 2010\u20132018","volume":"39","author":"McElligot","year":"2020","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jiac.2025.102633_bib44","doi-asserted-by":"crossref","first-page":"209.e1","DOI":"10.1016\/j.cmi.2016.11.006","article-title":"The spread and clinical impact of ST14CC-PBP3 type IIb\/A, a clonal group of non-typeable Haemophilus influenzae with chromosomally mediated \u03b2-lactam resistance-a prospective observational study","volume":"23","author":"M\u00e5nsson","year":"2017","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jiac.2025.102633_bib45","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jiac.2019.03.019","article-title":"Genetic characteristics and antibiotic resistance of Haemophilus influenzae isolates from pediatric patients with acute otitis media after introduction of 13-valent pneumococcal conjugate vaccine in Japan","volume":"25","author":"Ubukata","year":"2019","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.jiac.2025.102633_bib46","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1128\/CMR.00040-06","article-title":"Antimicrobial resistance in Haemophilus influenzae","volume":"20","author":"Tristram","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jiac.2025.102633_bib47","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02579-21","article-title":"Antimicrobial susceptibility survey of invasive Haemophilus influenzae in the United States in 2016","volume":"10","author":"Potts","year":"2022","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.jiac.2025.102633_bib48","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3390\/microorganisms11020315","article-title":"Antibiotic susceptibility and molecular typing of invasive Haemophilus influenzae isolates, with emergence of ciprofloxacin resistance, 2017\u20132021, Italy","volume":"11","author":"Giufr\u00e8","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.jiac.2025.102633_bib49","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1093\/jac\/dkl142","article-title":"High prevalence of type b b-lactamase-non-producing ampicillin-resistant Haemophilus influenzae in meningitis: the situation in Japan where Hib vaccine has not been introduced","volume":"57","author":"Hasegawa","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2025.102633_bib50","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jiac.2019.02.010","article-title":"Cefotaxime-non-susceptibility of Haemophilus influenzae induced by additional amino acid substitutions of G555E and Y557H in altered penicillin-binding protein 3","volume":"25","author":"Mizoguchi","year":"2019","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.jiac.2025.102633_bib51","first-page":"1314","article-title":"Antibiotic susceptibility and molecular analysis of invasive Haemophilus influenzae in Canada, 2007 to 2014","volume":"72","author":"Tsang","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2025.102633_bib52","doi-asserted-by":"crossref","first-page":"29","DOI":"10.14442\/general.15.29","article-title":"Trends in the number and multiplicity of blood culture submissions in hospitals in the Minami-Ibaraki Area of Japan","volume":"15","author":"Osuka","year":"2014","journal-title":"Gen Med"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X25000297?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X25000297?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T16:42:45Z","timestamp":1747240965000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X25000297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S1341321X25000297"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2025.102633","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical and microbiological characteristics of invasive diseases due to Haemophilus influenzae in the Minami Ibaraki Area, Japan","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2025.102633","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102633"}}