{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:15:55Z","timestamp":1772774155709,"version":"3.50.1"},"reference-count":13,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H04309"],"award-info":[{"award-number":["22H04309"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H05299"],"award-info":[{"award-number":["23H05299"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","jiac-j.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jiac.2025.102686","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T20:40:57Z","timestamp":1742935257000},"page":"102686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Optimizing cytomegalovirus treatment through therapeutic drug monitoring in a ganciclovir-unresponsive lung transplant recipient"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1963-2510","authenticated-orcid":false,"given":"Keisuke","family":"Umemura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0803-8823","authenticated-orcid":false,"given":"Yoshiki","family":"Katada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3003-3238","authenticated-orcid":false,"given":"Yurie","family":"Katsube","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Hira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Tsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsaku","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiaki","family":"Shima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5882-8594","authenticated-orcid":false,"given":"Akira","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2847-9653","authenticated-orcid":false,"given":"Akihiro","family":"Ohsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7262-6000","authenticated-orcid":false,"given":"Hiroshi","family":"Date","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8886-6145","authenticated-orcid":false,"given":"Miki","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-9753","authenticated-orcid":false,"given":"Tomohiro","family":"Terada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiac.2025.102686_bib1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/ctr.12686","article-title":"Cytomegalovirus disease is associated with higher all-cause mortality after lung transplantation despite extended antiviral prophylaxis","volume":"30","author":"Beam","year":"2016","journal-title":"Clin Transplant"},{"key":"10.1016\/j.jiac.2025.102686_bib2","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1097\/TP.0000000000002191","article-title":"The third international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation","volume":"102","author":"Kotton","year":"2018","journal-title":"Transplantation"},{"key":"10.1016\/j.jiac.2025.102686_bib3","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.healun.2019.09.005","article-title":"Drug-resistant cytomegalovirus infection after lung transplantation: incidence, characteristics, and clinical outcomes","volume":"38","author":"Heli\u00f6vaara","year":"2019","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jiac.2025.102686_bib4","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/FTD.0000000000000925","article-title":"Therapeutic drug monitoring of ganciclovir: where are we?","volume":"44","author":"M\u00e4rtson","year":"2022","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.jiac.2025.102686_bib5","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1093\/jac\/dkab195","article-title":"Ganciclovir therapeutic drug monitoring in transplant recipients","volume":"76","author":"M\u00e4rtson","year":"2021","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jiac.2025.102686_bib6","doi-asserted-by":"crossref","DOI":"10.1111\/tid.14141","article-title":"Trough ganciclovir concentration as predictor of leukopenia in lung transplant recipients receiving valganciclovir prophylaxis","volume":"25","author":"Katada","year":"2023","journal-title":"Transpl Infect Dis"},{"key":"10.1016\/j.jiac.2025.102686_bib7","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1086\/650463","article-title":"Cytomegalovirus resistance testing: pitfalls and problems for the clinician","volume":"50","author":"Drew","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jiac.2025.102686_bib8","doi-asserted-by":"crossref","DOI":"10.1128\/jcm.01302-23","article-title":"Next-generation sequencing for cytomegalovirus genotypic antiviral resistance testing","volume":"61","author":"Mostafa","year":"2023","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jiac.2025.102686_bib9","article-title":"Treatment of cytomegalovirus infection with cidofovir and CMV immune globulin in a lung transplant recipient","volume":"2016","author":"Wilkens","year":"2016","journal-title":"Case Rep Transplant"},{"key":"10.1016\/j.jiac.2025.102686_bib10","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1097\/TP.0000000000001418","article-title":"Outcomes in transplant recipients treated with foscarnet for ganciclovir-resistant or refractory cytomegalovirus infection","volume":"100","author":"Avery","year":"2016","journal-title":"Transplantation"},{"key":"10.1016\/j.jiac.2025.102686_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.healun.2021.01.2067","article-title":"Use of maribavir and letermovir for ganciclovir-resistant cytomegalovirus infection in lung transplant recipients","volume":"40","author":"Underwood","year":"2021","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jiac.2025.102686_bib12","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1111\/ajt.16718","article-title":"Letermovir in lung transplant recipients with cytomegalovirus infection: a retrospective observational study","volume":"21","author":"Veit","year":"2021","journal-title":"Am J Transplant"},{"key":"10.1016\/j.jiac.2025.102686_bib13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1517\/17425255.2015.988139","article-title":"Clinical pharmacokinetics and pharmacodynamics of ganciclovir and valganciclovir in children with cytomegalovirus infection","volume":"11","author":"Stockmann","year":"2015","journal-title":"Expet Opin Drug Metabol Toxicol"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X25000832?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X25000832?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T02:17:04Z","timestamp":1744424224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X25000832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S1341321X25000832"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2025.102686","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimizing cytomegalovirus treatment through therapeutic drug monitoring in a ganciclovir-unresponsive lung transplant recipient","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2025.102686","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102686"}}