{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:50:14Z","timestamp":1786992614854,"version":"build-2736575974"},"reference-count":57,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"am","delay-in-days":325,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["JPMH23HA2011"],"award-info":[{"award-number":["JPMH23HA2011"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["JPMH21HA2011"],"award-info":[{"award-number":["JPMH21HA2011"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["JPMH24HA2015"],"award-info":[{"award-number":["JPMH24HA2015"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["JPMH25HA2005"],"award-info":[{"award-number":["JPMH25HA2005"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jiac.2025.102708","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T08:35:32Z","timestamp":1744878932000},"page":"102708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long-term functional prognosis with tocilizumab in severe COVID-19 infection: A multicenter prospective observational study on mechanically ventilated ICU patients in the COVID-19 recovery study II"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2290-6965","authenticated-orcid":false,"given":"Junji","family":"Hatakeyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8481-0294","authenticated-orcid":false,"given":"Kensuke","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Kanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2934-3333","authenticated-orcid":false,"given":"Akira","family":"Kawauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Fujitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3868-8272","authenticated-orcid":false,"given":"Taku","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7853-5721","authenticated-orcid":false,"given":"Hideaki","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Ota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7292-1157","authenticated-orcid":false,"given":"Hiroshi","family":"Kamijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Asahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6358-0801","authenticated-orcid":false,"given":"Yoko","family":"Muto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4796-1805","authenticated-orcid":false,"given":"Miyuki","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arisa","family":"Iba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Hosozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyasu","family":"Iso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiac.2025.102708_bib1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/CCM.0b013e318232da75","article-title":"Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference","volume":"40","author":"Needham","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jiac.2025.102708_bib2","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1056\/NEJMra1209390","article-title":"ICU-acquired weakness and recovery from critical illness","volume":"370","author":"Kress","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jiac.2025.102708_bib3","doi-asserted-by":"crossref","first-page":"5758","DOI":"10.3390\/jcm11195758","article-title":"Prevalence and risk factor analysis of post-intensive care syndrome in patients with COVID-19 requiring mechanical ventilation: a multicenter prospective observational study","volume":"11","author":"Hatakeyama","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.jiac.2025.102708_bib4","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1097\/CCM.0000000000005014","article-title":"Postintensive care syndrome in survivors of critical illness related to coronavirus disease 2019: cohort study from a New York city critical care recovery clinic","volume":"49","author":"Martillo","year":"2021","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jiac.2025.102708_bib5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13613-021-00910-9","article-title":"Post-intensive care syndrome after a critical COVID-19: cohort study from a Belgian follow-up clinic","volume":"11","author":"Rousseau","year":"2021","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.jiac.2025.102708_bib6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41579-022-00846-2","article-title":"Long COVID: major findings, mechanisms and recommendations","volume":"21","author":"Davis","year":"2023","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jiac.2025.102708_bib7","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3389\/fimmu.2020.01446","article-title":"The COVID-19 cytokine storm; what we know so far","volume":"11","author":"Ragab","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jiac.2025.102708_bib8","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1056\/NEJMoa2100433","article-title":"Interleukin-6 receptor antagonists in critically ill patients with covid-19","volume":"384","author":"Investigators","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jiac.2025.102708_bib9","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1056\/NEJMoa2028700","article-title":"Tocilizumab in hospitalized patients with severe covid-19 pneumonia","volume":"384","author":"Rosas","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jiac.2025.102708_bib10","article-title":"Japanese rapid\/living recommendations on drug management for COVID-19","volume":"8","author":"Yamakawa","year":"2021","journal-title":"Acute Med Surg"},{"key":"10.1016\/j.jiac.2025.102708_bib11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3390\/neurolint13010010","article-title":"Acute and post-acute neurological complications of COVID-19","volume":"13","author":"Al-Ramadan","year":"2021","journal-title":"Neurol Int"},{"key":"10.1016\/j.jiac.2025.102708_bib12","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S1474-4422(20)30221-0","article-title":"Neurological associations of COVID-19","volume":"19","author":"Ellul","year":"2020","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jiac.2025.102708_bib13","first-page":"1426","article-title":"Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I\/II clinical study","volume":"30","author":"Nishimoto","year":"2003","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jiac.2025.102708_bib14","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/S0140-6736(21)00676-0","article-title":"Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial","volume":"397","author":"Group","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jiac.2025.102708_bib15","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/physrev.00028.2014","article-title":"The sick and the weak: neuropathies\/myopathies in the critically ill","volume":"95","author":"Friedrich","year":"2015","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jiac.2025.102708_bib16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cmet.2007.11.011","article-title":"Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy","volume":"7","author":"Serrano","year":"2008","journal-title":"Cell Metab"},{"key":"10.1016\/j.jiac.2025.102708_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017392","article-title":"IL-6 induced STAT3 signalling is associated with the proliferation of human muscle satellite cells following acute muscle damage","volume":"6","author":"Toth","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jiac.2025.102708_bib18","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/jcsm.12589","article-title":"COVID-19: a major cause of cachexia and sarcopenia?","volume":"11","author":"Morley","year":"2020","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jiac.2025.102708_bib19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.14336\/AD.2017.0315","article-title":"Acute sarcopenia secondary to hospitalisation - an emerging condition affecting older adults","volume":"9","author":"Welch","year":"2018","journal-title":"Aging Dis"},{"key":"10.1016\/j.jiac.2025.102708_bib20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"10.1016\/j.jiac.2025.102708_bib21","unstructured":"ISARIC. ISARIC COVID-19 follow-up study. Available: https:\/\/isaric.org\/research\/covid-19-clinical-research-resources\/covid-19-long-term-follow-up-study-old\/. (Accessed 2024 21 June)."},{"key":"10.1016\/j.jiac.2025.102708_bib22","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.4187\/respcare.08889","article-title":"Modified medical research Council and COPD assessment test cutoff points","volume":"66","author":"Munari","year":"2021","journal-title":"Respir Care"},{"key":"10.1016\/j.jiac.2025.102708_bib23","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.jiac.2025.102708_bib24","doi-asserted-by":"crossref","DOI":"10.1080\/20008198.2017.1364119","article-title":"A new short version of the Posttraumatic Diagnostic Scale: validity among Japanese adults with and without PTSD","volume":"8","author":"Itoh","year":"2017","journal-title":"Eur J Psychotraumatol"},{"key":"10.1016\/j.jiac.2025.102708_bib25","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40359-019-0285-0","article-title":"Development of the Japanese version of the three-item loneliness scale","volume":"7","author":"Igarashi","year":"2019","journal-title":"BMC Psychol"},{"key":"10.1016\/j.jiac.2025.102708_bib26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0168-8510(96)00822-6","article-title":"The current state of play","volume":"37","author":"EuroQol","year":"1996","journal-title":"Health Policy"},{"key":"10.1016\/j.jiac.2025.102708_bib27","doi-asserted-by":"crossref","DOI":"10.2188\/jea.JE20240179","article-title":"Post COVID-19 condition in hospitalized survivors after one year of infection during the Alpha- and Delta-variant dominant waves in Japan: COVID-19 Recovery Study II","author":"Muto","year":"2025","journal-title":"J Epidemiol."},{"key":"10.1016\/j.jiac.2025.102708_bib28","unstructured":"Organization Wh. Post COVID-19 condition (Long COVID). Available: https:\/\/www.who.int\/europe\/news-room\/fact-sheets\/item\/post-covid-19-condition. (Accessed 21 June 2024)."},{"key":"10.1016\/j.jiac.2025.102708_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2021.114318","article-title":"Loneliness in Japan during the COVID-19 pandemic: prevalence, correlates and association with mental health","volume":"307","author":"Stickley","year":"2022","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.jiac.2025.102708_bib30","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1111\/jgs.12001","article-title":"Presepsis depressive symptoms are associated with incident cognitive impairment in survivors of severe sepsis: a prospective cohort study of older Americans","volume":"60","author":"Davydow","year":"2012","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.jiac.2025.102708_bib31","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1093\/infdis\/jiac136","article-title":"Global prevalence of post-coronavirus disease 2019 (COVID-19) condition or long COVID: a meta-analysis and systematic review","volume":"226","author":"Chen","year":"2022","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jiac.2025.102708_bib32","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/ane.12964","article-title":"Risk factors for intensive care unit-acquired weakness: a systematic review and meta-analysis","volume":"138","author":"Yang","year":"2018","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.jiac.2025.102708_bib33","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cmi.2022.01.014","article-title":"Prevalence of post-acute COVID-19 syndrome symptoms at different follow-up periods: a systematic review and meta-analysis","volume":"28","author":"Alkodaymi","year":"2022","journal-title":"Clin Microbiol Infection"},{"key":"10.1016\/j.jiac.2025.102708_bib34","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/oby.23111","article-title":"BMI and outcomes of SARS-CoV-2 among US veterans","volume":"29","author":"Eastment","year":"2021","journal-title":"Obesity"},{"key":"10.1016\/j.jiac.2025.102708_bib35","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nrd4467","article-title":"Muscle wasting in disease: molecular mechanisms and promising therapies","volume":"14","author":"Cohen","year":"2015","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jiac.2025.102708_bib36","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1152\/physrev.90100.2007","article-title":"Muscle as an endocrine organ: focus on muscle-derived interleukin-6","volume":"88","author":"Pedersen","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jiac.2025.102708_bib37","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/eci.12781","article-title":"Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease","volume":"47","author":"Pedersen","year":"2017","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jiac.2025.102708_bib38","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1172\/JCI115767","article-title":"Evidence for the involvement of interleukin 6 in experimental cancer cachexia","volume":"89","author":"Strassmann","year":"1992","journal-title":"J Clin Investig"},{"key":"10.1016\/j.jiac.2025.102708_bib39","doi-asserted-by":"crossref","first-page":"R393","DOI":"10.1152\/ajpregu.00716.2007","article-title":"Interleukin-6 and cachexia in ApcMin\/+ mice","volume":"294","author":"Baltgalvis","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jiac.2025.102708_bib40","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1111\/febs.12338","article-title":"Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?","volume":"280","author":"Munoz-Canoves","year":"2013","journal-title":"FEBS J"},{"key":"10.1016\/j.jiac.2025.102708_bib41","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bone.2015.03.015","article-title":"Inflammation induced loss of skeletal muscle","volume":"80","author":"Londhe","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.jiac.2025.102708_bib42","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/jcsm.12189","article-title":"Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis","volume":"8","author":"Tournadre","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jiac.2025.102708_bib43","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s13075-022-02858-y","article-title":"The effect of disease-modifying anti-rheumatic drugs on skeletal muscle mass in rheumatoid arthritis patients: a systematic review with meta-analysis","volume":"24","author":"Hein","year":"2022","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jiac.2025.102708_bib44","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1164\/rccm.202005-1885OC","article-title":"Uncontrolled innate and impaired adaptive immune responses in patients with COVID-19 acute respiratory distress syndrome","volume":"202","author":"Hue","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jiac.2025.102708_bib45","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1001\/jamainternmed.2020.3313","article-title":"Is a \"cytokine storm\" relevant to COVID-19?","volume":"180","author":"Sinha","year":"2020","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.jiac.2025.102708_bib46","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jiac.2025.102708_bib47","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13054-022-04253-0","article-title":"The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis","volume":"27","author":"Fazzini","year":"2023","journal-title":"Crit Care"},{"key":"10.1016\/j.jiac.2025.102708_bib48","doi-asserted-by":"crossref","first-page":"S299","DOI":"10.1097\/CCM.0b013e3181b6ef67","article-title":"A framework for diagnosing and classifying intensive care unit-acquired weakness","volume":"37","author":"Stevens","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jiac.2025.102708_bib49","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1182\/blood-2008-05-155846","article-title":"Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease","volume":"112","author":"Nishimoto","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jiac.2025.102708_bib50","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1002\/jmv.26149","article-title":"Higher levels of IL-6 early after tocilizumab distinguish survivors from nonsurvivors in COVID-19 pneumonia: a possible indication for deeper targeting of IL-6","volume":"92","author":"Quartuccio","year":"2020","journal-title":"J Med Virol"},{"key":"10.1016\/j.jiac.2025.102708_bib51","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jad.2011.08.003","article-title":"Interleukin (IL)-6, tumour necrosis factor alpha (TNF-alpha) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression","volume":"139","author":"Liu","year":"2012","journal-title":"J Affect Disord"},{"key":"10.1016\/j.jiac.2025.102708_bib52","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/mp.2016.167","article-title":"Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions","volume":"23","author":"Kappelmann","year":"2018","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jiac.2025.102708_bib53","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41398-021-01349-z","article-title":"Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease","volume":"11","author":"Lyra","year":"2021","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.jiac.2025.102708_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-62505-1","article-title":"Tocilizumab is associated with reduced delirium and coma in critically ill patients with COVID-19","volume":"14","author":"Alkhateeb","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jiac.2025.102708_bib55","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/npp.2011.205","article-title":"Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior","volume":"37","author":"Haroon","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jiac.2025.102708_bib56","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.pharmthera.2011.01.014","article-title":"Immune system to brain signaling: neuropsychopharmacological implications","volume":"130","author":"Capuron","year":"2011","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jiac.2025.102708_bib57","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4103\/0972-6748.62274","article-title":"Hypothesis testing, type I and type II errors","volume":"18","author":"Banerjee","year":"2009","journal-title":"Ind Psychiatry J"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X25001059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X25001059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:56:00Z","timestamp":1778594160000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X25001059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S1341321X25001059"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2025.102708","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term functional prognosis with tocilizumab in severe COVID-19 infection: A multicenter prospective observational study on mechanically ventilated ICU patients in the COVID-19 recovery study II","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2025.102708","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102708"}}