{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:01:57Z","timestamp":1774378917231,"version":"3.50.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jiac.2025.102798","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T16:29:30Z","timestamp":1755620970000},"page":"102798","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effectiveness of repeated vaccination for COVID-19 symptom resolution during the KP.3-dominant epidemic period in Japan: A retrospective multicenter study"],"prefix":"10.1016","volume":"31","author":[{"given":"Takuma","family":"Bando","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3548-4231","authenticated-orcid":false,"given":"Hideyuki","family":"Ikematsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keigo","family":"Shibao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Mizuguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokunao","family":"Amemiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Oribe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woon Joo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsunari","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinro","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-ichi","family":"Doniwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Asamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Sugawara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiac.2025.102798_bib3","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jiac.2025.102798_bib4","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa2035389","article-title":"Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine","volume":"384","author":"Baden","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jiac.2025.102798_bib5","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1056\/NEJMoa2105290","article-title":"Phase 3 safety and efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 vaccine","volume":"385","author":"Falsey","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jiac.2025.102798_bib6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1056\/NEJMoa2116185","article-title":"Efficacy and safety of NVX-CoV2373 in adults in the United States and Mexico","volume":"386","author":"Dunkle","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jiac.2025.102798_bib9","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41586-021-04385-3","article-title":"Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies","volume":"602","author":"Cao","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jiac.2025.102798_bib10","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41586-021-04389-z","article-title":"Considerable escape of SARS-CoV-2 omicron to antibody neutralization","volume":"602","author":"Planas","year":"2022","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.jiac.2025.102798_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/S1473-3099(24)00505-X","article-title":"Virological characteristics of the SARS-CoV-2 KP.3.1.1 variant","volume":"24","author":"Kaku","year":"2024","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jiac.2025.102798_bib12","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1001\/jama.2022.0470","article-title":"Association between 3 doses of mRNA COVID-19 vaccine and symptomatic infection caused by the SARS-CoV-2 omicron and Delta variants","volume":"15","author":"Accorsi","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.jiac.2025.102798_bib13","first-page":"400","article-title":"Observational study of the COVID-19 vaccine booster's effect on the incidence of infection and the development of fever during the sixth COVID-19 wave in Japan","volume":"37","author":"Bando","year":"2023","journal-title":"JJPA"},{"key":"10.1016\/j.jiac.2025.102798_bib14","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jinf.2023.08.009","article-title":"SARS-CoV-2 infection following booster vaccination: illness and symptom profile in a prospective, observational community-based case-control study","volume":"87","author":"Antonelli","year":"2023","journal-title":"J Infect"},{"key":"10.1016\/j.jiac.2025.102798_bib15","doi-asserted-by":"crossref","first-page":"521","DOI":"10.11150\/kansenshogakuzasshi.e24011","article-title":"Impact of the number of vaccinations on the duration of fever and symptoms in adult patients with mild COVID-19 during the period of spread of the omicron variant of SARS-CoV-2 in Japan","volume":"98","author":"Goto","year":"2024","journal-title":"Kansenshogaku Zasshi"},{"key":"10.1016\/j.jiac.2025.102798_bib16","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1056\/NEJMoa2118946","article-title":"Protection and waning of natural and hybrid immunity to SARS-CoV-2","volume":"386","author":"Goldberg","year":"2022","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.jiac.2025.102798_bib17","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.3370","article-title":"Analysis of previous infection, vaccinations, and anti-SARS-CoV-2 antibody titers and protection against infection with the SARS-CoV-2 omicron BA.5 variant","volume":"6","author":"Yamamoto","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jiac.2025.102798_bib18","first-page":"1066","article-title":"Pronounced antibody elevation after SARS-CoV-2 BNT162b2 mRNA booster vaccination in nursing home residents. Influenza other","volume":"16","author":"Chong","year":"2022","journal-title":"Respir Virus"},{"key":"10.1016\/j.jiac.2025.102798_bib19","doi-asserted-by":"crossref","first-page":"ofac493","DOI":"10.1093\/ofid\/ofac493","article-title":"Correlation of postvaccination fever with specific antibody response to severe acute respiratory syndrome coronavirus 2 BNT162b2 booster and no significant influence of antipyretic medication","volume":"9","author":"Tani","year":"2022","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.jiac.2025.102798_bib20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.chom.2024.01.014","article-title":"XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against XBB subvariants and JN.1","volume":"32","author":"Wang","year":"2024","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jiac.2025.102798_bib21","article-title":"Antiviral humoral immunity induced by JN.1 monovalent mRNA vaccines against SARS-CoV-2 omicron subvariants including JN.1, KP.3.1.1, and XEC","author":"Uriu","year":"2024","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jiac.2025.102798_bib22","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.3201\/eid3007.231723","article-title":"Prevalence of and risk factors for post-COVID-19 condition during the omicron BA.5\u2013dominant wave in Japan","volume":"30","author":"Iba","year":"2024","journal-title":"Emerg Infect Dis"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X25001953?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X25001953?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T11:38:19Z","timestamp":1772883499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X25001953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S1341321X25001953"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2025.102798","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effectiveness of repeated vaccination for COVID-19 symptom resolution during the KP.3-dominant epidemic period in Japan: A retrospective multicenter study","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2025.102798","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102798"}}