{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:00:14Z","timestamp":1787792414506,"version":"build-2784847793"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jiac-j.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Chemotherapy"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jiac.2026.102952","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:19:33Z","timestamp":1774311573000},"page":"102952","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prophylactic effect of cefotiam against postoperative infection: Systematic review and meta-analysis"],"prefix":"10.1016","volume":"32","author":[{"given":"Takeru","family":"Tsuruta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0693-1896","authenticated-orcid":false,"given":"Kazutaka","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4606-7150","authenticated-orcid":false,"given":"Yuki","family":"Hanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8993-4333","authenticated-orcid":false,"given":"Tomoyuki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Jono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jiac.2026.102952_bib1","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1001\/jamasurg.2017.0904","article-title":"Centers for Disease Control and Prevention Guideline for the prevention of surgical site infection, 2017","volume":"152","author":"Berr\u00edos-Torres","year":"2017","journal-title":"JAMA Surg"},{"issue":"5","key":"10.1016\/j.jiac.2026.102952_bib2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ajic.2008.12.010","article-title":"Surgical site infection: incidence and impact on hospital utilization and treatment costs","volume":"37","author":"de Lissovoy","year":"2009","journal-title":"Am J Infect Control"},{"issue":"12","key":"10.1016\/j.jiac.2026.102952_bib3","doi-asserted-by":"crossref","first-page":"e276","DOI":"10.1016\/S1473-3099(16)30398-X","article-title":"New WHO recommendations on preoperative measures for surgical site infection prevention: an evidence-based global perspective","volume":"16","author":"Allegranzi","year":"2016","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"10.1016\/j.jiac.2026.102952_bib4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1089\/sur.2013.9999","article-title":"Clinical practice guidelines for antimicrobial prophylaxis in surgery","volume":"14","author":"Bratzler","year":"2013","journal-title":"Surg Infect"},{"issue":"2","key":"10.1016\/j.jiac.2026.102952_bib5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1248\/yakushi.22-00185","article-title":"[Shortages of Prescription Drugs Due to Compliance and Quality Issues in Japan]","volume":"143","author":"Izutsu","year":"2023","journal-title":"Yakugaku Zasshi"},{"issue":"9","key":"10.1016\/j.jiac.2026.102952_bib8","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1111\/jgh.14769","article-title":"Prophylactic use of antibiotics in endoscopic injection of tissue adhesive for the elective treatment of gastric varices: a randomized controlled study","volume":"34","author":"Liu","year":"2019","journal-title":"J Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.jiac.2026.102952_bib13","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s10156-007-0544-5","article-title":"Randomized prospective comparison of fosfomycin and cefotiam for prevention of postoperative infection following urological surgery","volume":"13","author":"Ishizaka","year":"2007","journal-title":"J Infect Chemother"},{"issue":"3","key":"10.1016\/j.jiac.2026.102952_bib14","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000007282","article-title":"Prospective randomized study of antibiotic prophylaxis for nonlaparotomy surgery in benign conditions","volume":"46","author":"Hayashi","year":"2000","journal-title":"Chemotherapy"},{"issue":"4","key":"10.1016\/j.jiac.2026.102952_bib35","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2957\/kanzo.45.186","article-title":"Antimicrobial prophylaxis for percutaneous liver biopsy","volume":"45","author":"Kakizaki","year":"2004","journal-title":"Kanzo\/Acta Hepatol Jpn"},{"key":"10.1016\/j.jiac.2026.102952_bib20","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s100960000365","article-title":"Randomized trial of cefotiam prophylaxis in the prevention of postoperative infectious morbidity after elective cesarean section","volume":"20","author":"Kolben","year":"2001","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"3","key":"10.1016\/j.jiac.2026.102952_bib15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF00383721","article-title":"Antibiotic prophylaxis in cerebrospinal fluid shunting: a prospective randomized trial in 129 patients","volume":"18","author":"Zentner","year":"1995","journal-title":"Neurosurg Rev"},{"issue":"2","key":"10.1016\/j.jiac.2026.102952_bib31","first-page":"90","article-title":"Prospective study of sulbactam\/ampicillin and cefotiam for antibiotic prophylaxis against surgical site infection after gastric cancer surgery","volume":"46","author":"Sakaguchi","year":"1998","journal-title":"Jpn J Chemother"},{"key":"10.1016\/j.jiac.2026.102952_bib21","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1023\/A:1018819316633","article-title":"Risk factors and prevention of early infection after implantation or revision of transjugular intrahepatic portosystemic shunts: results of a randomized study","volume":"43","author":"Deibert","year":"1998","journal-title":"Dig Dis Sci"},{"issue":"4","key":"10.1016\/j.jiac.2026.102952_bib32","first-page":"137","article-title":"Perioperative antibiotic prophylaxis in reconstructive vascular surgery","volume":"25","author":"Harnoss","year":"1996","journal-title":"Klinikarzt"},{"issue":"5","key":"10.1016\/j.jiac.2026.102952_bib22","first-page":"279","article-title":"Perioperative antibiotic prophylaxis in breast surgery: Cefotiam versus clindamycin","volume":"118","author":"Bier","year":"1996","journal-title":"Zentralbl Gynakol"},{"key":"10.1016\/j.jiac.2026.102952_bib16","series-title":"Cochrane handbook for systematic reviews of interventions","author":"Sterne","year":"2019"},{"issue":"3","key":"10.1016\/j.jiac.2026.102952_bib33","first-page":"351","article-title":"Prophylactic antibiotics for patients undergoing biliary tract surgery: a prospective randomized study of cefotiam and cefuzonam","volume":"42","author":"Ito","year":"1994","journal-title":"Chemotherapy"},{"issue":"12","key":"10.1016\/j.jiac.2026.102952_bib23","first-page":"1145","article-title":"Antibiotic prophylaxis for transurethral resection of the prostate--comparison of oral administration therapy with intravenous administration therapy","volume":"39","author":"Tsuji","year":"1993","journal-title":"Hinyokika Kiyo"},{"issue":"1","key":"10.1016\/j.jiac.2026.102952_bib24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2106\/00004623-199301000-00009","article-title":"Antibiotic prophylaxis with two doses of cephalosporin in patients managed with internal fixation for a fracture of the hip","volume":"75","author":"Bodoky","year":"1993","journal-title":"J Bone Joint Surg Am"},{"issue":"2","key":"10.1016\/j.jiac.2026.102952_bib25","first-page":"162","article-title":"Identification and antibiotic prophylaxis of high-risk patients in biliary tract surgery","volume":"93","author":"Shinagawa","year":"1992","journal-title":"Nihon Geka Gakkai Zasshi"},{"issue":"10 Spec No","key":"10.1016\/j.jiac.2026.102952_bib26","first-page":"467","article-title":"Prevention of postoperative infections with cefotiam (Pansporine) in orthopedic surgery","volume":"32","author":"Frajman","year":"1991","journal-title":"Agressologie"},{"issue":"3-4","key":"10.1016\/j.jiac.2026.102952_bib27","first-page":"103","article-title":"Intra-operative antibiotic prophylaxis in neurosurgery. A prospective, randomized, controlled study on cefotiam. Acta Neurochir (Wien)","volume":"113","author":"Gaillard","year":"1991"},{"issue":"5 Pt 2","key":"10.1016\/j.jiac.2026.102952_bib28","first-page":"564","article-title":"Comparative study of two protocols of antibiotic prophylaxis in endoscopic urologic surgery","volume":"38","author":"Lepage","year":"1990","journal-title":"Pathol Biol"},{"issue":"4","key":"10.1016\/j.jiac.2026.102952_bib34","first-page":"440","article-title":"Prophylactic antibiotics for patients undergoing biliary tract surgery: a prospective randomized study of cefotiam and cefpiramide","volume":"37","author":"Muramoto","year":"1989","journal-title":"Chemotherapy"},{"issue":"5 Pt 2","key":"10.1016\/j.jiac.2026.102952_bib29","first-page":"857","article-title":"Prevention of postoperative infections in non-endoscopic urologic surgery by a single dose of cefotiam","volume":"35","author":"Charton","year":"1987","journal-title":"Pathol Biol"},{"key":"10.1016\/j.jiac.2026.102952_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02470577","article-title":"Prophylactic antibiotics for patients undergoing elective biliary tract surgery: a prospective randomized study of cefotiam and cefoperazone","volume":"17","author":"Shinagawa","year":"1987","journal-title":"Jpn J Surg"},{"issue":"Suppl 1","key":"10.1016\/j.jiac.2026.102952_bib6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2106\/JBJS.24.01123","article-title":"Outcomes associated with choice of prophylactic antibiotics in open fractures","volume":"107","author":"Lin","year":"2025","journal-title":"J Bone Joint Surg Am"},{"issue":"3","key":"10.1016\/j.jiac.2026.102952_bib7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2165\/00003088-198917030-00003","article-title":"Clinical pharmacokinetics of cefotiam","volume":"17","author":"Brogard","year":"1989","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.jiac.2026.102952_bib9","series-title":"Global guidelines for the prevention of surgical site infection","year":"2018"},{"key":"10.1016\/j.jiac.2026.102952_bib10","doi-asserted-by":"crossref","DOI":"10.1186\/s13643-024-02639-5","article-title":"Antibiotic prophylaxis for the prevention of surgical site infections following colorectal surgery: protocol for network meta-analysis of randomized trials","author":"Motaghi","year":"2024","journal-title":"Syst Rev"},{"key":"10.1016\/j.jiac.2026.102952_bib11","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.jiac.2026.102952_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0196-6553(91)90157-8","article-title":"National nosocomial infections surveillance system (NNIS): description of surveillance methods","volume":"19","author":"Emori","year":"1991","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.jiac.2026.102952_bib17","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"issue":"9","key":"10.1016\/j.jiac.2026.102952_bib18","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/sim.1761","article-title":"What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data","volume":"23","author":"Sweeting","year":"2004","journal-title":"Stat Med"},{"issue":"1","key":"10.1016\/j.jiac.2026.102952_bib19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s10156-008-0660-X","article-title":"Systemic use of antibiotics does not prevent postoperative infection in elective colorectal surgery: a randomized controlled trial","volume":"15","author":"Sato","year":"2009","journal-title":"J Infect Chemother"},{"issue":"11","key":"10.1016\/j.jiac.2026.102952_bib37","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.3390\/antibiotics11111543","article-title":"Meta-analysis of clinical trials comparing cefazolin to cefuroxime, ceftriaxone, and cefamandole for surgical site infection prevention","volume":"11","author":"Ahmed","year":"2022","journal-title":"Antibiotics (Basel)"},{"issue":"3","key":"10.1016\/j.jiac.2026.102952_bib38","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2146\/ajhp120568","article-title":"Clinical practice guidelines for antimicrobial prophylaxis in surgery","volume":"70","author":"Bratzler","year":"2013","journal-title":"Am J Health Syst Pharm"},{"issue":"2","key":"10.1016\/j.jiac.2026.102952_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtcvs.2015.09.090","article-title":"Antibiotic prophylaxis and risk of Clostridium difficile infection after coronary artery bypass graft surgery","volume":"151","author":"Poeran","year":"2016","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["Journal of Infection and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X26000504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1341321X26000504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:42:33Z","timestamp":1776771753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1341321X26000504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S1341321X26000504"],"URL":"https:\/\/doi.org\/10.1016\/j.jiac.2026.102952","relation":{},"ISSN":["1341-321X"],"issn-type":[{"value":"1341-321X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prophylactic effect of cefotiam against postoperative infection: Systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Chemotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiac.2026.102952","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102952"}}