{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:44:11Z","timestamp":1792205051473,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.jid.2016.02.002","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T23:15:16Z","timestamp":1455750916000},"page":"1116-1123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Collagen VII Half-Life at the Dermal-Epidermal Junction Zone: Implications for Mechanisms and Therapy of Genodermatoses"],"prefix":"10.1016","volume":"136","author":[{"given":"Tobias","family":"K\u00fchl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Mezger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Hausser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin T.","family":"Guey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert","family":"Handgretinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Bruckner-Tuderman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Nystr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2016.02.002_bib1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3109\/14653249.2010.518609","article-title":"Gene expression signatures of mouse bone marrow-derived mesenchymal stem cells in the cutaneous environment and therapeutic implications for blistering skin disorder","volume":"13","author":"Alexeev","year":"2011","journal-title":"Cytotherapy"},{"issue":"Suppl. 2","key":"10.1016\/j.jid.2016.02.002_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1365-2133.2005.06968.x","article-title":"Protective effect of matrix metalloproteinase inhibitors against epidermal basement membrane damage: skin equivalents partially mimic photoageing process","volume":"153","author":"Amano","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2016.02.002_bib3","doi-asserted-by":"crossref","first-page":"18700","DOI":"10.1074\/jbc.M111.336073","article-title":"The epidermal basement membrane is a composite of separate laminin- or collagen IV-containing networks connected by aggregated perlecan, but not by nidogens","volume":"287","author":"Behrens","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2016.02.002_bib4","doi-asserted-by":"crossref","first-page":"13004","DOI":"10.1073\/pnas.0605420103","article-title":"Quantification of protein half-lives in the budding yeast proteome","volume":"103","author":"Belle","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2016.02.002_bib5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1432-1033.1987.tb11483.x","article-title":"Tissue form type VII collagen from human skin and dermal fibroblasts in culture","volume":"165","author":"Bruckner-Tuderman","year":"1987","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jid.2016.02.002_bib6","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.1021\/pr101183k","article-title":"Systems-wide proteomic analysis in mammalian cells reveals conserved, functional protein turnover","volume":"10","author":"Cambridge","year":"2011","journal-title":"J\u00a0Proteome Res"},{"key":"10.1016\/j.jid.2016.02.002_bib7","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2217\/rme.13.33","article-title":"The long and winding road that leads to a cure for epidermolysis bullosa","volume":"8","author":"Carulli","year":"2013","journal-title":"Regen Med"},{"key":"10.1016\/j.jid.2016.02.002_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.det.2009.10.011","article-title":"Type VII collagen: the anchoring fibril protein at fault in dystrophic epidermolysis bullosa","volume":"28","author":"Chung","year":"2010","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.jid.2016.02.002_bib9","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1055\/s-2008-1063444","article-title":"Current concepts in pediatric burn care: the biology of cultured epithelial autografts: an eight-year study in pediatric burn patients","volume":"2","author":"Compton","year":"1992","journal-title":"Eur J Pediatr Surg"},{"key":"10.1016\/j.jid.2016.02.002_bib10","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jaad.2008.09.035","article-title":"Epidermolysis bullosa and the risk of life-threatening cancers: The National EB Registry experience, 1986-2006","volume":"60","author":"Fine","year":"2009","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2016.02.002_bib11","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1172\/JCI34292","article-title":"A\u00a0hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy","volume":"118","author":"Fritsch","year":"2008","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2016.02.002_bib12","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/JID.2015.364","article-title":"Lentiviral engineered fibroblasts expressing codon optimized COL7A1 restore anchoring fibrils in RDEB","volume":"136","author":"Georgiadis","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.02.002_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev-genom-090413-025540","article-title":"The genetics of skin fragility","volume":"15","author":"Has","year":"2014","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"10.1016\/j.jid.2016.02.002_bib14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1161\/01.HYP.25.3.399","article-title":"Decreased glomerular basement membrane heparan sulfate proteoglycan in essential hypertension","volume":"25","author":"Heintz","year":"1995","journal-title":"Hypertension"},{"key":"10.1016\/j.jid.2016.02.002_bib15","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/DAD.0b013e31821e8744","article-title":"Matrix metalloproteinases in health and disease: insights from dermatopathology","volume":"34","author":"Hern\u00e1ndez-P\u00e9rez","year":"2012","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.jid.2016.02.002_bib16","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1038\/jid.2015.291","article-title":"Intravenously administered recombinant human type VII collagen derived from Chinese hamster ovary cells reverses the disease phenotype in recessive dystrophic epidermolysis bullosa mice","volume":"135","author":"Hou","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.02.002_bib17","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/j.1600-0625.2011.01347.x","article-title":"Key role of heparan sulfate chains in assembly of anchoring complex at the dermal-epidermal junction","volume":"20","author":"Iriyama","year":"2011","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2016.02.002_bib18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1034\/j.1600-0625.2003.120201.x","article-title":"Matrix metalloproteinases in tumor progression: focus on basal and squamous cell skin cancer","volume":"12","author":"Kerkel\u00e4","year":"2003","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2016.02.002_bib19","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1038\/mt.2009.144","article-title":"Mechanisms of fibroblast cell therapy for dystrophic epidermolysis bullosa: high stability of collagen VII favors long-term skin integrity","volume":"17","author":"Kern","year":"2009","journal-title":"Mol Ther"},{"key":"10.1016\/j.jid.2016.02.002_bib20","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1038\/mt.2015.58","article-title":"High local concentrations of intradermal MSCs restore skin integrity and facilitate wound healing in dystrophic epidermolysis bullosa","volume":"23","author":"Kuhl","year":"2015","journal-title":"Mol Ther"},{"key":"10.1016\/j.jid.2016.02.002_bib21","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1093\/hmg\/ddu013","article-title":"Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice","volume":"23","author":"Muir","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jid.2016.02.002_bib22","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.15252\/emmm.201505061","article-title":"Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms","volume":"7","author":"Nystrom","year":"2015","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jid.2016.02.002_bib23","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1172\/JCI68127","article-title":"Collagen VII plays a dual role in wound healing","volume":"123","author":"Nystrom","year":"2013","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2016.02.002_bib24","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1038\/jid.2015.158","article-title":"Potential of systemic allogeneic mesenchymal stromal cell therapy for children with recessive dystrophic epidermolysis bullosa","volume":"135","author":"Petrof","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.02.002_bib25","doi-asserted-by":"crossref","first-page":"8597","DOI":"10.1016\/S0021-9258(19)75262-4","article-title":"Studies on the metabolism of the renal glomerular basement membrane. Turnover measurements in the rat with the use of radiolabeled amino acids","volume":"252","author":"Price","year":"1977","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2016.02.002_bib26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.matbio.2015.01.010","article-title":"Meprin \u03b1 and meprin \u03b2: procollagen proteinases in health and disease","volume":"44-46","author":"Prox","year":"2015","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jid.2016.02.002_bib27","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1172\/JCI118901","article-title":"Cross-linking of the dermo-epidermal junction of skin regenerating from keratinocyte autografts. Anchoring fibrils are a target for tissue transglutaminase","volume":"98","author":"Raghunath","year":"1996","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2016.02.002_bib28","doi-asserted-by":"crossref","first-page":"26372","DOI":"10.1074\/jbc.M203247200","article-title":"Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen","volume":"277","author":"Rattenholl","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2016.02.002_bib29","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/mt.2008.234","article-title":"Injection of recombinant human type VII collagen corrects the disease phenotype in a murine model of dystrophic epidermolysis bullosa","volume":"17","author":"Remington","year":"2009","journal-title":"Mol Ther"},{"key":"10.1016\/j.jid.2016.02.002_bib30","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"Schwanh\u00e4usser","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jid.2016.02.002_bib31","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/bjd.13945","article-title":"A\u00a0COL7A1 variant leading to in-frame skipping of exon 15 attenuates disease severity in recessive dystrophic epidermolysis bullosa","volume":"173","author":"Schwieger-Briel","year":"2015","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2016.02.002_bib32","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1242\/jcs.080911","article-title":"Lung-specific loss of the laminin \u03b13 subunit confers resistance to mechanical injury","volume":"124","author":"Urich","year":"2011","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.jid.2016.02.002_bib33","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.matbio.2015.02.006","article-title":"BMP-1\/tolloid-like proteinases synchronize matrix assembly with growth factor activation to promote morphogenesis and tissue remodeling","volume":"44-46","author":"Vadon-Le Goff","year":"2015","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jid.2016.02.002_bib34","doi-asserted-by":"crossref","first-page":"35","DOI":"10.12703\/P6-35","article-title":"Advances in understanding and treating dystrophic epidermolysis bullosa","volume":"6","author":"Vanden Oever","year":"2014","journal-title":"F1000Prime Rep"},{"key":"10.1016\/j.jid.2016.02.002_bib35","doi-asserted-by":"crossref","first-page":"39027","DOI":"10.1074\/jbc.M006700200","article-title":"Effect of collagen turnover on the accumulation of advanced glycation end products","volume":"275","author":"Verzijl","year":"2000","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2016.02.002_bib36","doi-asserted-by":"crossref","first-page":"24506","DOI":"10.1074\/jbc.M802415200","article-title":"Supramolecular interactions in the dermo-epidermal junction zone: anchoring fibril-collagen VII tightly binds to banded collagen fibrils","volume":"283","author":"Villone","year":"2008","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2016.02.002_bib37","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1113\/expphysiol.1984.sp002829","article-title":"Protein turnover with special reference to man","volume":"69","author":"Waterlow","year":"1984","journal-title":"Q\u00a0J Exp Physiol Camb Engl"},{"key":"10.1016\/j.jid.2016.02.002_bib38","doi-asserted-by":"crossref","first-page":"e0137639","DOI":"10.1371\/journal.pone.0137639","article-title":"Lysyl hydroxylase 3 localizes to epidermal basement membrane and is reduced in patients with recessive dystrophic epidermolysis bullosa","volume":"10","author":"Watt","year":"2015","journal-title":"PLoS One"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X16004838?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X16004838?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T08:22:20Z","timestamp":1654330940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X16004838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0022202X16004838"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2016.02.002","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Collagen VII Half-Life at the Dermal-Epidermal Junction Zone: Implications for Mechanisms and Therapy of Genodermatoses","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2016.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}