{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:38:13Z","timestamp":1790001493996,"version":"4.0.1"},"reference-count":74,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.jid.2016.06.619","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T02:22:11Z","timestamp":1467685331000},"page":"2211-2220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["PDE4 Inhibition as Potential Treatment of\u00a0Epidermolysis Bullosa Acquisita"],"prefix":"10.1016","volume":"136","author":[{"given":"Hiroshi","family":"Koga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Recke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gestur","family":"Vidarsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendri H.","family":"Pas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel F.","family":"Jonkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Kasprick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeedeh","family":"Ghorbanalipoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Tenor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Zillikens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf J.","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2016.06.619_bib1","doi-asserted-by":"crossref","first-page":"898","DOI":"10.4049\/jimmunol.169.2.898","article-title":"Inhibition of the spontaneous apoptosis of neutrophil granulocytes by the intracellular parasite Leishmania major","volume":"169","author":"Aga","year":"2002","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.06.619_bib2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/0091270006294529","article-title":"Dose-proportional intraindividual single- and repeated-dose pharmacokinetics of roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor","volume":"47","author":"Bethke","year":"2007","journal-title":"J\u00a0Clin Pharmacol"},{"key":"10.1016\/j.jid.2016.06.619_bib3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/00004836-200110000-00006","article-title":"Side effects of corticosteroid therapy","volume":"33","author":"Buchman","year":"2001","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.jid.2016.06.619_bib4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1365-2133.2011.10346.x","article-title":"The many faces of epidermolysis bullosa acquisita after serration pattern analysis by direct immunofluorescence microscopy","volume":"165","author":"Buijsrogge","year":"2011","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2016.06.619_bib5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/path.2157","article-title":"NADPH oxidase is required for neutrophil-dependent autoantibody-induced tissue damage","volume":"212","author":"Chiriac","year":"2007","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jid.2016.06.619_bib6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1046\/j.1523-1747.1998.00114.x","article-title":"Cyclic nucleotide phosphodiesterase 4 subtypes are differentially expressed by primary keratinocytes and human epidermoid cell lines","volume":"110","author":"Chujor","year":"1998","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.06.619_bib7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1189\/jlb.0113040","article-title":"Technical advance: autofluorescence-based sorting: rapid and nonperturbing isolation of ultrapure neutrophils to determine cytokine production","volume":"94","author":"Dorward","year":"2013","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.jid.2016.06.619_bib8","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.micinf.2003.09.008","article-title":"Neutrophil granules and secretory vesicles in inflammation","volume":"5","author":"Faurschou","year":"2003","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jid.2016.06.619_bib9","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.intimp.2013.06.034","article-title":"Neutrophil cell surface receptors and their intracellular signal transduction pathways","volume":"17","author":"Futosi","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jid.2016.06.619_bib10","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/1523-1747.ep12470317","article-title":"Increased frequency of HLA-DR2 in patients with autoantibodies to epidermolysis bullosa acquisita antigen: evidence that the expression of autoimmunity to type VII collagen is HLA class II allele associated","volume":"91","author":"Gammon","year":"1988","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.06.619_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/exd.12265","article-title":"Jakpot! New small molecules in autoimmune and inflammatory diseases","volume":"23","author":"Ghoreschi","year":"2014","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2016.06.619_bib12","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1136\/thx.2006.075937","article-title":"Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD","volume":"62","author":"Grootendorst","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.jid.2016.06.619_bib13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.clindermatol.2011.03.011","article-title":"Epidermolysis bullosa acquisita","volume":"30","author":"Gupta","year":"2012","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.jid.2016.06.619_bib14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.pupt.2010.03.011","article-title":"The preclinical pharmacology of roflumilast\u2014a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease","volume":"23","author":"Hatzelmann","year":"2010","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.jid.2016.06.619_bib15","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1038\/jid.2013.91","article-title":"Methylprednisolone blocks autoantibody-induced tissue damage in experimental models of bullous pemphigoid and epidermolysis bullosa acquisita through inhibition of neutrophil activation","volume":"133","author":"Hellberg","year":"2013","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.06.619_bib16","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/jid.2014.453","article-title":"Effects of intravenous immunoglobulins on mice with experimental epidermolysis bullosa acquisita","volume":"135","author":"Hirose","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.06.619_bib17","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/path.2857","article-title":"Autoantibody-induced intestinal inflammation and weight loss in experimental epidermolysis bullosa acquisita","volume":"224","author":"Ishii","year":"2011","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jid.2016.06.619_bib18","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.2174\/1381612821666150316122502","article-title":"Animal models to investigate pathomechanisms and evaluate novel treatments for autoimmune bullous dermatoses","volume":"21","author":"Iwata","year":"2015","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jid.2016.06.619_bib19","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.4049\/jimmunol.1300310","article-title":"B\u00a0cells, dendritic cells, and macrophages are required to induce an autoreactive CD4 helper T cell response in experimental epidermolysis bullosa acquisita","volume":"191","author":"Iwata","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.06.619_bib20","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/jid.2014.451","article-title":"Recombinant soluble CD32 suppresses disease progression in experimental epidermolysis bullosa acquisita","volume":"135","author":"Iwata","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.06.619_bib21","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.4049\/jimmunol.1501003","article-title":"Radiosensitive hematopoietic cells determine the extent of skin inflammation in experimental epidermolysis bullosa acquisita","volume":"195","author":"Iwata","year":"2015","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.06.619_bib22","doi-asserted-by":"crossref","first-page":"D412","DOI":"10.1093\/nar\/gkn760","article-title":"STRING 8\u2014a global view on proteins and their functional interactions in 630 organisms","volume":"37","author":"Jensen","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2016.06.619_bib23","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0022-3565(24)29287-9","article-title":"Phosphodiesterase 4 inhibitors prevent cytokine secretion by T lymphocytes by inhibiting nuclear factor-kappaB and nuclear factor of activated T cells activation","volume":"299","author":"Jimenez","year":"2001","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.jid.2016.06.619_bib24","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1038\/jid.2008.412","article-title":"A\u00a0comparison of two regimens of topical corticosteroids in the treatment of patients with bullous pemphigoid: a multicenter randomized study","volume":"129","author":"Joly","year":"2009","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.06.619_bib25","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1056\/NEJMoa011592","article-title":"A\u00a0comparison of oral and topical corticosteroids in patients with bullous pemphigoid","volume":"346","author":"Joly","year":"2002","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jid.2016.06.619_bib26","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1182\/blood-2010-10-314609","article-title":"Heat-shock protein 90 inhibition in autoimmunity to type VII collagen: evidence that nonmalignant plasma cells are not therapeutic targets","volume":"117","author":"Kasperkiewicz","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jid.2016.06.619_bib27","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/path.4023","article-title":"Genetic identification and functional validation of FcgammaRIV as key molecule in autoantibody-induced tissue injury","volume":"228","author":"Kasperkiewicz","year":"2012","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jid.2016.06.619_bib28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/JID.2015.356","article-title":"Epidermolysis bullosa acquisita: from pathophysiology to novel therapeutic options","volume":"136","author":"Kasperkiewicz","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.06.619_bib29","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1111\/jdv.12096","article-title":"Epidermolysis bullosa acquisita","volume":"27","author":"Kim","year":"2013","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2016.06.619_bib30","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2340\/00015555-1065","article-title":"Epidermolysis bullosa acquisita: a retrospective clinical analysis of 30 cases","volume":"91","author":"Kim","year":"2011","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jid.2016.06.619_bib31","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/jid.2012.457","article-title":"Topically applied flightless I neutralizing antibodies improve healing of blistered skin in a murine model of epidermolysis bullosa acquisita","volume":"133","author":"Kopecki","year":"2013","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.06.619_bib32","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1084\/jem.20132496","article-title":"The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in\u00a0vivo inflammatory environment without a direct role in leukocyte recruitment","volume":"211","author":"Kovacs","year":"2014","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2016.06.619_bib33","doi-asserted-by":"crossref","first-page":"ra23","DOI":"10.1126\/scisignal.2001617","article-title":"PI3Kbeta plays a critical role in neutrophil activation by immune complexes","volume":"4","author":"Kulkarni","year":"2011","journal-title":"Sci Signal"},{"key":"10.1016\/j.jid.2016.06.619_bib34","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1741-7015-11-96","article-title":"Phosphodiesterase 4-targeted treatments for autoimmune diseases","volume":"11","author":"Kumar","year":"2013","journal-title":"BMC Med"},{"key":"10.1016\/j.jid.2016.06.619_bib35","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1124\/jpet.105.092056","article-title":"Roflumilast inhibits lipopolysaccharide-induced inflammatory mediators via suppression of nuclear factor-kappaB, p38 mitogen-activated protein kinase, and c-Jun NH2-terminal kinase activation","volume":"315","author":"Kwak","year":"2005","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.jid.2016.06.619_bib36","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1128\/IAI.70.2.826-835.2002","article-title":"Intracellular survival of Leishmania major in neutrophil granulocytes after uptake in the absence of heat-labile serum factors","volume":"70","author":"Laufs","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.jid.2016.06.619_bib37","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.febslet.2011.04.071","article-title":"Insight into interactions of the von-Willebrand-factor-A-like domain 2 with the FNIII-like domain 9 of collagen VII by NMR and SPR","volume":"585","author":"Leineweber","year":"2011","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jid.2016.06.619_bib38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0140-6736(05)17708-3","article-title":"Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease","volume":"365","author":"Lipworth","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2016.06.619_bib39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1046\/j.1365-2567.2000.00082.x","article-title":"Calcitonin gene-related peptide inhibits lipopolysaccharide-induced interleukin-12 release from mouse peritoneal macrophages, mediated by the cAMP pathway","volume":"101","author":"Liu","year":"2000","journal-title":"Immunology"},{"key":"10.1016\/j.jid.2016.06.619_bib40","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1189\/jlb.0803360","article-title":"Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2","volume":"75","author":"Lotz","year":"2004","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.jid.2016.06.619_bib41","doi-asserted-by":"crossref","first-page":"812029","DOI":"10.1155\/2013\/812029","article-title":"Clinical presentation, pathogenesis, diagnosis, and treatment of epidermolysis bullosa acquisita","volume":"2013","author":"Ludwig","year":"2013","journal-title":"ISRN Dermatol"},{"key":"10.1016\/j.jid.2016.06.619_bib42","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.molmed.2013.06.003","article-title":"Emerging treatments for pemphigoid diseases","volume":"19","author":"Ludwig","year":"2013","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jid.2016.06.619_bib43","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/jid.2011.466","article-title":"Identification of quantitative trait loci in experimental epidermolysis bullosa acquisita","volume":"132","author":"Ludwig","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.06.619_bib44","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jaci.2014.02.001","article-title":"Roflumilast N-oxide reverses corticosteroid resistance in neutrophils from patients with chronic obstructive pulmonary disease","volume":"134","author":"Milara","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2016.06.619_bib45","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1021\/jm900210d","article-title":"Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor","volume":"52","author":"Man","year":"2009","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.jid.2016.06.619_bib46","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/JID.2015.361","article-title":"Dimethylfumarate impairs neutrophil functions","volume":"136","author":"Muller","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.06.619_bib47","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.immuni.2005.05.010","article-title":"FcgammaRIV: a novel FcR with distinct IgG subclass specificity","volume":"23","author":"Nimmerjahn","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2016.06.619_bib48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri2206","article-title":"Fcgamma receptors as regulators of immune responses","volume":"8","author":"Nimmerjahn","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2016.06.619_bib49","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1182\/blood.V99.9.3390","article-title":"Inhibition of PDE4 phosphodiesterase activity induces growth suppression, apoptosis, glucocorticoid sensitivity, p53, and p21(WAF1\/CIP1) proteins in human acute lymphoblastic leukemia cells","volume":"99","author":"Ogawa","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.jid.2016.06.619_bib50","doi-asserted-by":"crossref","first-page":"8082","DOI":"10.4049\/jimmunol.174.12.8082","article-title":"Evidence for a role of phosphodiesterase 4 in lipopolysaccharide-stimulated prostaglandin E2 production and matrix metalloproteinase-9 activity in human amniochorionic membranes","volume":"174","author":"Oger","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.06.619_bib51","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S0140-6736(12)60642-4","article-title":"Efficacy of apremilast in the treatment of moderate to severe psoriasis: a randomised controlled trial","volume":"380","author":"Papp","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2016.06.619_bib52","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jaad.2015.03.049","article-title":"Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: Results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)","volume":"73","author":"Papp","year":"2015","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2016.06.619_bib53","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1476-5381.2011.01218.x","article-title":"Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease","volume":"163","author":"Rabe","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jid.2016.06.619_bib54","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.4049\/jimmunol.1400160","article-title":"Recombinant human IgA1 and IgA2 autoantibodies to type VII collagen induce subepidermal blistering ex\u00a0vivo","volume":"193","author":"Recke","year":"2014","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.06.619_bib55","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jaut.2015.05.004","article-title":"Allelic and copy-number variations of FcgammaRs affect granulocyte function and susceptibility for autoimmune blistering diseases","volume":"61","author":"Recke","year":"2015","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jid.2016.06.619_bib56","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/path.4556","article-title":"The retinoid-related orphan receptor alpha is essential for the end-stage effector phase of experimental epidermolysis bullosa acquisita","volume":"237","author":"Sadeghi","year":"2015","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jid.2016.06.619_bib57","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.4049\/jimmunol.1402688","article-title":"Caspase-1-independent IL-1 release mediates blister formation in autoantibody-induced tissue injury through modulation of endothelial adhesion molecules","volume":"194","author":"Sadeghi","year":"2015","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.06.619_bib58","doi-asserted-by":"crossref","first-page":"559","DOI":"10.4049\/jimmunol.1301556","article-title":"GM-CSF modulates autoantibody production and skin blistering in experimental epidermolysis bullosa acquisita","volume":"192","author":"Samavedam","year":"2014","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.06.619_bib59","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jaut.2012.08.002","article-title":"Recombinant IL-6 treatment protects mice from organ specific autoimmune disease by IL-6 classical signalling-dependent IL-1ra induction","volume":"40","author":"Samavedam","year":"2013","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jid.2016.06.619_bib60","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0140-6736(12)61140-4","article-title":"Pemphigoid diseases","volume":"381","author":"Schmidt","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2016.06.619_bib61","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1007\/BF00174752","article-title":"Influence of selective phosphodiesterase inhibitors on human neutrophil functions and levels of cAMP and Cai","volume":"344","author":"Schudt","year":"1991","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jid.2016.06.619_bib62","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s00109-008-0366-7","article-title":"Neonatal Fc receptor deficiency protects from tissue injury in experimental epidermolysis bullosa acquisita","volume":"86","author":"Sesarman","year":"2008","journal-title":"J\u00a0Mol Med"},{"key":"10.1016\/j.jid.2016.06.619_bib63","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1096\/fj.03-1367fje","article-title":"Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells","volume":"18","author":"Sheibanie","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.jid.2016.06.619_bib64","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0002-9440(10)64182-X","article-title":"Autoantibodies to type VII collagen mediate Fcgamma-dependent neutrophil activation and induce dermal-epidermal separation in cryosections of human skin","volume":"161","author":"Sitaru","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2016.06.619_bib65","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1172\/JCI200521386","article-title":"Induction of dermal-epidermal separation in mice by passive transfer of antibodies specific to type VII collagen","volume":"115","author":"Sitaru","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2016.06.619_bib66","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1046\/j.1523-1747.2002.01720.x","article-title":"Autoantibodies to bullous pemphigoid antigen 180 induce dermal-epidermal separation in cryosections of human skin","volume":"118","author":"Sitaru","year":"2002","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.06.619_bib67","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1189\/jlb.0809540","article-title":"PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K\/Akt-dependent and NF-kappaB-independent manner","volume":"87","author":"Sousa","year":"2010","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.jid.2016.06.619_bib68","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1517\/14656566.2013.837159","article-title":"Roflumilast: the new orally active, selective phophodiesterase-4 inhibitor, for the treatment of COPD","volume":"15","author":"Tashkin","year":"2014","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.jid.2016.06.619_bib69","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-3-642-17969-3_3","article-title":"Pharmacology, clinical efficacy, and tolerability of phosphodiesterase-4 inhibitors: impact of human pharmacokinetics","volume":"204","author":"Tenor","year":"2011","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.jid.2016.06.619_bib70","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1164\/ajrccm.157.2.9708012","article-title":"Phosphodiesterase isozymes: molecular targets for novel antiasthma agents","volume":"157","author":"Torphy","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jid.2016.06.619_bib71","doi-asserted-by":"crossref","first-page":"e85243","DOI":"10.1371\/journal.pone.0085243","article-title":"Roflumilast N-oxide prevents cytokine secretion induced by cigarette smoke combined with LPS through JAK\/STAT and ERK1\/2 inhibition in airway epithelial cells","volume":"9","author":"Victoni","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2016.06.619_bib72","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1172\/JCI113373","article-title":"Epidermolysis bullosa acquisita antigen is the globular carboxyl terminus of type VII procollagen","volume":"81","author":"Woodley","year":"1988","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2016.06.619_bib73","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1038\/jid.2010.230","article-title":"FcgammaRIIA and FcgammaRIIIB are required for autoantibody-induced tissue damage in experimental human models of bullous pemphigoid","volume":"130","author":"Yu","year":"2010","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.06.619_bib74","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1038\/jid.2011.231","article-title":"Black patients of African descent and HLA-DRB1*15:03 frequency overrepresented in epidermolysis bullosa acquisita","volume":"131","author":"Zumelzu","year":"2011","journal-title":"J\u00a0Invest Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X16320954?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X16320954?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T23:49:11Z","timestamp":1748994551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X16320954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":74,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0022202X16320954"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2016.06.619","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PDE4 Inhibition as Potential Treatment of\u00a0Epidermolysis Bullosa Acquisita","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2016.06.619","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}