{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:14:25Z","timestamp":1791944065623,"version":"4.3.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T00:00:00Z","timestamp":1476921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.jid.2016.07.039","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T02:28:53Z","timestamp":1472610533000},"page":"85-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Spread of Psoriasiform Inflammation to Remote Tissues Is Restricted by the Atypical Chemokine Receptor ACKR2"],"prefix":"10.1016","volume":"137","author":[{"given":"Kave","family":"Shams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian J.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen H.","family":"van den Bogaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Le Brocq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Schalkwijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. David","family":"Burden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive S.","family":"McKimmie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard J.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2016.07.039_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.113.007724","article-title":"International Union of Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors","volume":"66","author":"Bachelerie","year":"2014","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jid.2016.07.039_bib2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/ni.2812","article-title":"New nomenclature for atypical chemokine receptors","volume":"15","author":"Bachelerie","year":"2014","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2016.07.039_bib3","doi-asserted-by":"crossref","first-page":"36473","DOI":"10.1074\/jbc.M113.491563","article-title":"Microarray analyses demonstrate the involvement of Type I Interferons in psoriasiform pathology development in D6 deficient mice","volume":"288","author":"Baldwin","year":"2013","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2016.07.039_bib4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1378\/chest.11-3220","article-title":"Expression of the atypical chemokine receptor D6 in human alveolar macrophages in chronic obstructive pulmonary disease","volume":"143","author":"Bazzan","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.jid.2016.07.039_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2003627","article-title":"Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6","author":"Borroni","year":"2013","journal-title":"Sci Signal"},{"key":"10.1016\/j.jid.2016.07.039_bib6","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/anr.1780320805","article-title":"Double-blind trial of recombinant gamma-interferon versus placebo in the treatment of rheumatoid-arthritis","volume":"32","author":"Cannon","year":"1989","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2016.07.039_bib7","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1161\/ATVBAHA.112.254409","article-title":"The chemokine decoy receptor D6 prevents excessive inflammation and adverse ventricular remodeling after myocardial infarction","volume":"32","author":"Cochain","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jid.2016.07.039_bib8","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1136\/ard.2010.137349","article-title":"An investigation of the inflammatory cytokine and chemokine network in systemic sclerosis","volume":"70","author":"Codullo","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jid.2016.07.039_bib9","doi-asserted-by":"crossref","first-page":"11514","DOI":"10.1038\/ncomms11514","article-title":"Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation","volume":"7","author":"Collins","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2016.07.039_bib10","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nm1605","article-title":"alpha(1)beta(1) integrin is crucial for accumulation of epidermal T cells and the development of psoriasis","volume":"13","author":"Conrad","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2016.07.039_bib11","doi-asserted-by":"crossref","first-page":"S138","DOI":"10.1111\/1523-1747.ep12875040","article-title":"Treatment of psoriasis and psoritic-arthirits with interferon-gamma","volume":"95","author":"Fierlbeck","year":"1990","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.07.039_bib12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1001\/archderm.1990.01670270083013","article-title":"Psoriasis induced at the injection site of recombinant interferon-gamma\u2014results of immunologic investigations","volume":"126","author":"Fierlbeck","year":"1990","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jid.2016.07.039_bib13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1046\/j.1365-2133.1998.02027.x","article-title":"RANTES expression in psoriatic skin, and regulation of RANTES and IL-8 production in cultured epidermal keratinocytes by active vitamin D3 (tacalcitol)","volume":"138","author":"Fukuoka","year":"1998","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2016.07.039_bib14","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/path.4123","article-title":"Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6","volume":"229","author":"Graham","year":"2013","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jid.2016.07.039_bib15","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.imlet.2012.04.004","article-title":"The biochemistry and biology of the atypical chemokine receptors","volume":"145","author":"Graham","year":"2012","journal-title":"Immunol Lett"},{"key":"10.1016\/j.jid.2016.07.039_bib16","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-producing CD4(+) effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2016.07.039_bib17","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/ni1182","article-title":"The chemokine receptor D6 limits the inflammatory response in\u00a0vivo","volume":"6","author":"Jamieson","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2016.07.039_bib18","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/jid.2011.458","article-title":"A\u00a0single intradermal injection of IFN-[gamma] induces an inflammatory state in both non-lesional psoriatic and healthy skin","volume":"132","author":"Johnson-Huang","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.07.039_bib20","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-immunol-032713-120225","article-title":"Immunology of psoriasis","volume":"32","author":"Lowes","year":"2014","journal-title":"Ann Rev Immunol"},{"key":"10.1016\/j.jid.2016.07.039_bib21","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.4049\/jimmunol.0902118","article-title":"Chemokine scavenger D6 is expressed by trophoblasts and aids the survival of mouse embryos transferred into allogeneic recipients","volume":"184","author":"Madigan","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.07.039_bib22","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1006\/clim.2001.5178","article-title":"Impaired T cell function in RANTES-deficient mice","volume":"102","author":"Makino","year":"2002","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jid.2016.07.039_bib25","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1001\/archderm.1987.01660360061013","article-title":"Use of recombinant interferon gamma administered intramuscularly for the treatment of psoraisis","volume":"123","author":"Morhenn","year":"1987","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jid.2016.07.039_bib26","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1172\/JCI30068","article-title":"The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors","volume":"117","author":"Nibbs","year":"2007","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2016.07.039_bib27","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nri3544","article-title":"Immune regulation by atypical chemokine receptors","volume":"13","author":"Nibbs","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2016.07.039_bib28","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni1261","article-title":"A\u00a0distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17","volume":"6","author":"Park","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2016.07.039_bib29","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1146\/annurev.immunol.22.012703.104543","article-title":"Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells","volume":"22","author":"Rot","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jid.2016.07.039_bib30","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.ajpath.2012.06.042","article-title":"Elevated expression of the chemokine-scavenging receptor D6 is associated with impaired lesion development in psoriasis","volume":"181","author":"Singh","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2016.07.039_bib31","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1001\/archderm.134.7.799","article-title":"Long-term effectiveness and safety of recombinant human interferon gamma therapy for atopic dermatitis despite unchanged serum IgE levels","volume":"134","author":"Stevens","year":"1998","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jid.2016.07.039_bib32","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/jid.2013.417","article-title":"Crosstalk between keratinocytes and T cells in a 3D microenvironment: a model to study inflammatory skin diseases","volume":"134","author":"van den Bogaard","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.07.039_bib33","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 axis","volume":"182","author":"van der Fits","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.07.039_bib34","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/art.1780400110","article-title":"A\u00a0randomized, double-blind study comparing twenty-four-week treatment with recombinant interferon-gamma versus placebo in the treatment of rheumatoid arthritis","volume":"40","author":"Veys","year":"1997","journal-title":"Arthrits Rheum"},{"key":"10.1016\/j.jid.2016.07.039_bib35","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1091\/mbc.e03-09-0634","article-title":"The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokines","volume":"15","author":"Weber","year":"2004","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jid.2016.07.039_bib36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1074-7613(00)80165-X","article-title":"Chemokines: a new classification system and their role in immunity","volume":"12","author":"Zlotnik","year":"2000","journal-title":"Immunity"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X16322746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X16322746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T07:24:21Z","timestamp":1543303461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X16322746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0022202X16322746"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2016.07.039","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spread of Psoriasiform Inflammation to Remote Tissues Is Restricted by the Atypical Chemokine Receptor ACKR2","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2016.07.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}