{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:46:17Z","timestamp":1790520377442,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.jid.2016.08.023","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T18:50:03Z","timestamp":1473706203000},"page":"106-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Down-Regulation of CD62L Shedding in\u00a0T\u00a0Cells by CD39+ Regulatory T Cells Leads\u00a0to Defective Sensitization in Contact\u00a0Hypersensitivity Reactions"],"prefix":"10.1016","volume":"137","author":[{"given":"Karsten","family":"Mahnke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgina","family":"Useliene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Ring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Kage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Jendrossek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon C.","family":"Robson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilda","family":"Bylaite-Bucinskiene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Steinbrink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander H.","family":"Enk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2016.08.023_bib1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11302-005-6322-x","article-title":"P2X7 receptor: death or life?","volume":"1","author":"Adinolfi","year":"2005","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.jid.2016.08.023_bib2","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/nrc3613","article-title":"Immunity, inflammation and cancer: a leading role for adenosine","volume":"13","author":"Antonioli","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jid.2016.08.023_bib3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1046\/j.1365-2567.1997.00336.x","article-title":"L-selectin activates JNK via src-like tyrosine kinases and the small G-protein Rac","volume":"92","author":"Brenner","year":"1997","journal-title":"Immunology"},{"key":"10.1016\/j.jid.2016.08.023_bib4","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/jid.2011.344","article-title":"Purinergic signaling in healthy and diseased skin","volume":"132","author":"Burnstock","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.08.023_bib5","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/imm.12053","article-title":"Adenosine and cAMP signalling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8(+) T-cell priming capacity","volume":"138","author":"Challier","year":"2013","journal-title":"Immunology"},{"key":"10.1016\/j.jid.2016.08.023_bib6","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1002\/eji.200737221","article-title":"c-Abl is required for the signaling transduction induced by L-selectin ligation","volume":"37","author":"Chen","year":"2007","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jid.2016.08.023_bib7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0008-8749(86)90427-2","article-title":"Alterations in lymphocyte recirculation within ultraviolet light-irradiated mice: efferent blockade of lymphocyte egress from peripheral lymph nodes","volume":"102","author":"Chung","year":"1986","journal-title":"Cell Immunol"},{"key":"10.1016\/j.jid.2016.08.023_bib8","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1084\/jem.20062512","article-title":"Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression","volume":"204","author":"Deaglio","year":"2007","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2016.08.023_bib9","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1091\/mbc.01-11-0561","article-title":"Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding","volume":"13","author":"D\u00edaz-Rodr\u00edguez","year":"2002","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jid.2016.08.023_bib10","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.tips.2007.07.002","article-title":"Liaisons dangereuses: P2X(7) and the inflammasome","volume":"28","author":"Di Virgilio","year":"2007","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.jid.2016.08.023_bib11","doi-asserted-by":"crossref","first-page":"6962","DOI":"10.1093\/emboj\/18.24.6962","article-title":"Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades","volume":"18","author":"Fan","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.jid.2016.08.023_bib12","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.4049\/jimmunol.1201510","article-title":"Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naive human CD4+ T lymphocytes","volume":"190","author":"Foster","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.08.023_bib13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jdermsci.2009.10.001","article-title":"L-selectin: role in regulating homeostasis and cutaneous inflammation","volume":"56","author":"Grailer","year":"2009","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2016.08.023_bib14","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1182\/blood.V92.3.946","article-title":"Adenosine triphosphate-induced shedding of CD23 and L-selectin (CD62L) from lymphocytes is mediated by the same receptor but different metalloproteases","volume":"92","author":"Gu","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.jid.2016.08.023_bib15","doi-asserted-by":"crossref","first-page":"5751","DOI":"10.4049\/jimmunol.1001878","article-title":"Memory T cells are enriched in lymph nodes of selectin-ligand-deficient mice","volume":"185","author":"Harp","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.08.023_bib16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/jid.2012.284","article-title":"Update of immune events in the murine contact hypersensitivity model: toward the understanding of allergic contact dermatitis","volume":"133","author":"Honda","year":"2013","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.08.023_bib17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nri3150","article-title":"Early immune events in the induction of allergic contact dermatitis","volume":"12","author":"Kaplan","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2016.08.023_bib18","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1182\/blood-2006-02-005827","article-title":"ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding","volume":"108","author":"Li","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jid.2016.08.023_bib19","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1161\/ATVBAHA.111.226837","article-title":"Regulation of lymphocyte function by adenosine","volume":"32","author":"Linden","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jid.2016.08.023_bib20","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.4049\/jimmunol.178.6.3437","article-title":"Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3","volume":"178","author":"Maeda","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.08.023_bib21","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nm0402-358","article-title":"CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness","volume":"8","author":"Mizumoto","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2016.08.023_bib22","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1046\/j.1523-1747.2003.12558.x","article-title":"Keratinocyte ATP release assay for testing skin-irritating potentials of structurally diverse chemicals","volume":"121","author":"Mizumoto","year":"2003","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.08.023_bib23","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1165\/rcmb.2010-0466OC","article-title":"Inducible costimulator controls migration of T cells to the lungs via down-regulation of CCR7 and CD62L","volume":"45","author":"Moore","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jid.2016.08.023_bib24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jdermsci.2010.02.007","article-title":"Gene expression profiling defines the role of ATP-exposed keratinocytes in skin inflammation","volume":"58","author":"Ohara","year":"2010","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2016.08.023_bib25","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1346-8138.2002.tb00206.x","article-title":"Initial recruitment of interferon-gamma-producing CD8+ effector cells, followed by infiltration of CD4+ cells in 2,4,6-trinitro-1-chlorobenzene (TNCB)-induced murine contact hypersensitivity reactions","volume":"29","author":"Okazaki","year":"2002","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.jid.2016.08.023_bib26","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1038\/jid.2014.93","article-title":"Nonmetal haptens induce ATP release from keratinocytes through opening of pannexin hemichannels by reactive oxygen species","volume":"134","author":"Onami","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.08.023_bib27","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/jid.2011.50","article-title":"Regulatory T cells from IL-10-deficient mice fail to suppress contact hypersensitivity reactions due to lack of adenosine production","volume":"131","author":"Ring","year":"2011","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.08.023_bib28","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.4049\/jimmunol.0901751","article-title":"ATP activates regulatory T Cells in\u00a0vivo during contact hypersensitivity reactions","volume":"184","author":"Ring","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.08.023_bib29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jaci.2009.10.025","article-title":"Gap junctions between regulatory T cells and dendritic cells prevent sensitization of CD8(+) T cells","volume":"125","author":"Ring","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2016.08.023_bib30","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.jaci.2009.03.022","article-title":"CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions through a CD39, adenosine-dependent mechanism","volume":"123","author":"Ring","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2016.08.023_bib31","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1002\/1521-4141(2002010)32:10<2905::AID-IMMU2905>3.0.CO;2-6","article-title":"Inhibition of TCR-mediated shedding of L-selectin (CD62L) on human and mouse CD4+ T cells by metalloproteinase inhibition: analysis of the regulation of Th1\/Th2 function","volume":"32","author":"Savage","year":"2002","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jid.2016.08.023_bib32","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.4049\/jimmunol.0801711","article-title":"NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells","volume":"182","author":"Scheuplein","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.08.023_bib33","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1189\/jlb.0212079","article-title":"Exogenous application of hydrogen sulfide donor attenuates inflammatory reactions through the L-selectin-involved pathway in the cutaneous reverse passive Arthus reaction","volume":"93","author":"Shimizu","year":"2013","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.jid.2016.08.023_bib34","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature04606","article-title":"CD69 acts downstream of interferon-alpha\/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs","volume":"440","author":"Shiow","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jid.2016.08.023_bib35","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.4049\/jimmunol.1101032","article-title":"Signaling through L-selectin mediates enhanced chemotaxis of lymphocyte subsets to secondary lymphoid tissue chemokine","volume":"188","author":"Subramanian","year":"2012","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.08.023_bib36","doi-asserted-by":"crossref","first-page":"6030","DOI":"10.1038\/srep06030","article-title":"Tracking and quantification of dendritic cell migration and antigen trafficking between the skin and lymph nodes","volume":"4","author":"Tomura","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2016.08.023_bib37","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1074-7613(03)00295-4","article-title":"Leukocyte migration is regulated by L-selectin endoproteolytic release","volume":"19","author":"Venturi","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2016.08.023_bib38","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nri2343","article-title":"How regulatory T cells work","volume":"8","author":"Vignali","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2016.08.023_bib39","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1084\/jem.20092489","article-title":"Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivity","volume":"207","author":"Weber","year":"2010","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2016.08.023_bib40","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1084\/jem.183.3.1001","volume":"183","author":"Xu","year":"1996","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2016.08.023_bib41","doi-asserted-by":"crossref","first-page":"e22560","DOI":"10.1371\/journal.pone.0022560","article-title":"The shedding of CD62L (L-selectin) regulates the acquisition of lytic activity in human tumor reactive T lymphocytes","volume":"6","author":"Yang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2016.08.023_bib42","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1096\/fj.08-126458","article-title":"Autocrine regulation of T-cell activation by ATP release and P2X7 receptors","volume":"23","author":"Yip","year":"2009","journal-title":"FASEB J"},{"key":"10.1016\/j.jid.2016.08.023_bib43","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.4049\/jimmunol.1100670","article-title":"FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus","volume":"187","author":"Zhi","year":"2011","journal-title":"J\u00a0Immunol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X16323673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X16323673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T19:49:20Z","timestamp":1601063360000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X16323673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0022202X16323673"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2016.08.023","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726734209.793547213","asserted-by":"object"}]},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Down-Regulation of CD62L Shedding in\u00a0T\u00a0Cells by CD39+ Regulatory T Cells Leads\u00a0to Defective Sensitization in Contact\u00a0Hypersensitivity Reactions","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2016.08.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}