{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:44:24Z","timestamp":1790685864196,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.jid.2016.09.008","type":"journal-article","created":{"date-parts":[[2016,9,17]],"date-time":"2016-09-17T14:45:37Z","timestamp":1474123537000},"page":"115-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":135,"title":["Lupus Skin Is Primed for IL-6 Inflammatory Responses through a Keratinocyte-Mediated Autocrine Type\u00a0I\u00a0Interferon Loop"],"prefix":"10.1016","volume":"137","author":[{"given":"Jasmine N.","family":"Stannard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamra J.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrinal K.","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianying","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann E.","family":"Gudjonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-8945","authenticated-orcid":false,"given":"J. Michelle","family":"Kahlenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2016.09.008_bib1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1177\/0961203313483377","article-title":"High mobility group box1 (HMGB1) in relation to cutaneous inflammation in systemic lupus erythematosus (SLE)","volume":"22","author":"Abdulahad","year":"2013","journal-title":"Lupus"},{"key":"10.1016\/j.jid.2016.09.008_bib2","doi-asserted-by":"crossref","first-page":"e1003678","DOI":"10.1371\/journal.pgen.1003678","article-title":"Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations","volume":"9","author":"Absher","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jid.2016.09.008_bib3","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1073\/pnas.0337679100","article-title":"Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus","volume":"100","author":"Baechler","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2016.09.008_bib4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3899\/jrheum.090194","article-title":"Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus","volume":"37","author":"Cash","year":"2010","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.jid.2016.09.008_bib5","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10875-007-9104-0","article-title":"Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus","volume":"27","author":"Chun","year":"2007","journal-title":"J\u00a0Clin Immunol"},{"key":"10.1016\/j.jid.2016.09.008_bib6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/00000372-199806000-00002","article-title":"Apoptosis in the pathogenesis of cutaneous lupus erythematosus","volume":"20","author":"Chung","year":"1998","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.jid.2016.09.008_bib7","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jaut.2013.04.003","article-title":"Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus patients","volume":"43","author":"Coit","year":"2013","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jid.2016.09.008_bib8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaut.2015.01.004","article-title":"Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils","volume":"58","author":"Coit","year":"2015","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jid.2016.09.008_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/43.1.7822763","article-title":"Expression of MxA protein in inflammatory dermatoses","volume":"43","author":"Fah","year":"1995","journal-title":"J\u00a0Hisotchem Cytochem"},{"key":"10.1016\/j.jid.2016.09.008_bib10","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jaad.2013.03.015","article-title":"Characterization of clinical photosensitivity in cutaneous lupus erythematosus","volume":"69","author":"Foering","year":"2013","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2016.09.008_bib11","doi-asserted-by":"crossref","unstructured":"Furie R, Merrill JT, Werth VP, Khamashta M, Kalunian K, Brohawn P, Illei G, et\u00a0al. Anifrolumab, an anti-interferon alpha receptor monoclonal antibody, in moderate to severe systemic lupus erythematosus (SLE) [abstract]. American College of Rheumatology Annual Meeting, San Franscisco, CA;\u00a02015.","DOI":"10.1136\/annrheumdis-2016-eular.3919"},{"key":"10.1016\/j.jid.2016.09.008_bib12","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.4049\/jimmunol.0901194","article-title":"Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells","volume":"184","author":"Gill","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.09.008_bib13","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/706825","article-title":"The role of genetic variation near interferon-kappa in systemic lupus erythematosus","author":"Harley","year":"2010","journal-title":"J\u00a0Biomed Biotechnol"},{"key":"10.1016\/j.jid.2016.09.008_bib14","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/art.27221","article-title":"Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study","volume":"62","author":"Illei","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2016.09.008_bib15","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0198-8859(02)00751-6","article-title":"Natural type I interferon-producing cells as a link between innate and adaptive immunity","volume":"63","author":"Kadowaki","year":"2002","journal-title":"Human Immunol"},{"key":"10.1016\/j.jid.2016.09.008_bib16","doi-asserted-by":"crossref","first-page":"6143","DOI":"10.4049\/jimmunol.1101284","article-title":"Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus","volume":"187","author":"Kahlenberg","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.09.008_bib17","first-page":"1","article-title":"Sifalimumab, an anti-interferon-alpha monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study","volume":"0","author":"Khamashta","year":"2016","journal-title":"Ann Rheumatic Dis"},{"key":"10.1016\/j.jid.2016.09.008_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1546-0096-11-9","article-title":"Surface expression and genotypes of Toll-like receptors 2 and 4 in patients with juvenile idiopathic arthritis and systemic lupus erythematosus","volume":"11","author":"Kirchner","year":"2013","journal-title":"Pediatr Rheumatol Online"},{"key":"10.1016\/j.jid.2016.09.008_bib19","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1084\/jem.172.6.1609","article-title":"Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light","volume":"172","author":"Kock","year":"1990","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2016.09.008_bib20","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1365-2249.2008.03646.x","article-title":"Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus","volume":"152","author":"Komatsuda","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jid.2016.09.008_bib21","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/art.21658","article-title":"Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation","volume":"54","author":"Kuhn","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2016.09.008_bib22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1067\/mjd.2001.114589","article-title":"Phototesting in lupus erythematosus: a 15-year experience","volume":"45","author":"Kuhn","year":"2001","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2016.09.008_bib23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000131451","article-title":"Cutaneous lupus erythematosus: molecular and cellular basis of clinical findings","volume":"10","author":"Kuhn","year":"2008","journal-title":"Curr Dir Autoimmun"},{"key":"10.1016\/j.jid.2016.09.008_bib24","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s12016-013-8403-x","article-title":"Photosensitivity, apoptosis, and cytokines in the pathogenesis of lupus erythematosus: a critical review","volume":"47","author":"Kuhn","year":"2014","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jid.2016.09.008_bib25","doi-asserted-by":"crossref","first-page":"39765","DOI":"10.1074\/jbc.M102502200","article-title":"Interferon-kappa, a novel type I interferon expressed in human keratinocytes","volume":"76","author":"LaFleur","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2016.09.008_bib26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s12016-013-8402-y","article-title":"TLR2 and TLR4 in autoimmune diseases: a comprehensive review","volume":"47","author":"Liu","year":"2014","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jid.2016.09.008_bib27","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1002\/art.38716","article-title":"Interleukin-6 deficiency corrects nephritis, lymphocyte abnormalities, and secondary Sjogren's syndrome features in lupus-prone Sle1.Yaa mice","volume":"66","author":"Maier-Moore","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jid.2016.09.008_bib28","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/RHU.0b013e31823ecd73","article-title":"Successful use of interleukin 6 antagonist tocilizumab in a patient with refractory cutaneous lupus and urticarial vasculitis","volume":"18","author":"Makol","year":"2012","journal-title":"J\u00a0Clin Rheumatol"},{"key":"10.1016\/j.jid.2016.09.008_bib29","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/cyto.b.20468","article-title":"Monocytes and T lymphocytes contribute to a predominance of interleukin 6 and interleukin 10 in systemic lupus erythematosus","volume":"76","author":"Mellor-Pita","year":"2009","journal-title":"Cytometry B Clin Cytom"},{"key":"10.1016\/j.jid.2016.09.008_bib30","doi-asserted-by":"crossref","first-page":"7367","DOI":"10.4049\/jimmunol.181.10.7367","article-title":"Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice","volume":"181","author":"Menke","year":"2008","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.09.008_bib31","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/j.1751-1097.1997.tb01905.x","article-title":"The influence of ultraviolet light on immunological cytotoxicity in the skin","volume":"65","author":"Norris","year":"1997","journal-title":"Photochem photobiol"},{"key":"10.1016\/j.jid.2016.09.008_bib32","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/art.37824","article-title":"Sifalimumab, a human anti-interferon-alpha monoclonal antibody, in systemic lupus erythematosus: a phase I randomized, controlled, dose-escalation study","volume":"65","author":"Petri","year":"2013","journal-title":"Arthritis Rhem"},{"key":"10.1016\/j.jid.2016.09.008_bib33","doi-asserted-by":"crossref","first-page":"20423","DOI":"10.1073\/pnas.0910371106","article-title":"Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling","volume":"106","author":"Pflegerl","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2016.09.008_bib34","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/intimm\/dxg068","article-title":"Expression and function of Toll-like receptors 2 and 4 in human keratinocytes","volume":"15","author":"Pivarcsi","year":"2003","journal-title":"Int Immunol"},{"key":"10.1016\/j.jid.2016.09.008_bib35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/ard.2007.070359","article-title":"Type I interferons are involved in the development of ultraviolet B-induced inflammatory skin lesions in systemic lupus erythaematosus patients","volume":"67","author":"Reefman","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jid.2016.09.008_bib36","doi-asserted-by":"crossref","first-page":"11372","DOI":"10.1128\/JVI.05279-11","article-title":"High-risk human papillomaviruses repress constitutive kappa interferon transcription via E6 to prevent pathogen recognition receptor and antiviral-gene expression","volume":"85","author":"Reiser","year":"2011","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jid.2016.09.008_bib37","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.cyto.2015.01.031","article-title":"The role of cytokines in the pathogenesis of cutaneous lupus erythematosus","volume":"73","author":"Robinson","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.jid.2016.09.008_bib38","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1002\/art.39722","article-title":"A\u00a0multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of treatment with sirukumab (CNTO 136) in patients with active lupus nephritis","volume":"68","author":"Rovin","year":"2016","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2016.09.008_bib39","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1002\/art.22571","article-title":"Protection against autoimmune nephritis in MyD88-deficient MRL\/lpr mice","volume":"56","author":"Sadanaga","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2016.09.008_bib40","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1002\/art.38091","article-title":"Phase I, randomized, double-blind, placebo-controlled, multiple intravenous, dose-ascending study of sirukumab in cutaneous or systemic lupus erythematosus","volume":"65","author":"Szepietowski","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2016.09.008_bib41","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1751-1097.1996.tb03054.x","article-title":"Impact of UVB radiation on the epidermal cytokine network","volume":"63","author":"Takashima","year":"1996","journal-title":"Photochemistry and photobiology"},{"key":"10.1016\/j.jid.2016.09.008_bib42","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/1523-1747.ep12874666","article-title":"Ultraviolet light induces increased circulating interleukin-6 in humans","volume":"94","author":"Urbanski","year":"1990","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.09.008_bib43","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/art.39441","article-title":"Elimination of granulocytic myeloid-derived suppressor cells in lupus-prone mice linked to reactive cxygen species-dependent extracellular trap formation","volume":"68","author":"Vlachou","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jid.2016.09.008_bib44","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/j.1365-2133.2005.06784.x","article-title":"Scarring skin lesions of discoid lupus erythematosus are characterized by high numbers of skin-homing cytotoxic lymphocytes associated with strong expression of the type I interferon-induced protein MxA","volume":"153","author":"Wenzel","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2016.09.008_bib45","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/path.1721","article-title":"Enhanced type I interferon signalling promotes Th1-biased inflammation in cutaneous lupus erythematosus","volume":"205","author":"Wenzel","year":"2005","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jid.2016.09.008_bib46","first-page":"1124","article-title":"The influence of antimalarial treatment on IL-1beta, IL-6 and TNF-alpha mRNA expression on UVB-irradiated skin in systemic lupus erythematosus","volume":"159","author":"Wozniacka","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2016.09.008_bib47","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/art.38298","article-title":"Epicutaneous application of toll-like receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic Lupus erythematosus","volume":"66","author":"Yokogawa","year":"2014","journal-title":"Arthritis Rheumatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X16323806?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X16323806?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T15:42:29Z","timestamp":1749570149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X16323806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0022202X16323806"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2016.09.008","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726760175.793557803","asserted-by":"object"}]},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lupus Skin Is Primed for IL-6 Inflammatory Responses through a Keratinocyte-Mediated Autocrine Type\u00a0I\u00a0Interferon Loop","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2016.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}