{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:19:49Z","timestamp":1790133589207,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.jid.2016.09.010","type":"journal-article","created":{"date-parts":[[2016,9,18]],"date-time":"2016-09-18T09:02:31Z","timestamp":1474189351000},"page":"71-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Increased Levels of the Bullous Pemphigoid BP180 Autoantibody Are Associated with\u00a0More Severe Dementia in Alzheimer\u2019s\u00a0Disease"],"prefix":"10.1016","volume":"137","author":[{"given":"Nina","family":"Kokkonen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanna-Kaisa","family":"Herukka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Huilaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merja","family":"Kokki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Koivisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"Hartikainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Remes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisa","family":"Tasanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2016.09.010_bib1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/jid.2010.301","article-title":"Risk factors for bullous pemphigoid in the elderly: a prospective case-control study","volume":"131","author":"Bastuji-Garin","year":"2011","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib2","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.jaad.2014.07.052","article-title":"A\u00a0population-based study of the association between bullous pemphigoid and neurologic disorders","volume":"71","author":"Brick","year":"2014","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib3","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1365-2133.2011.10386.x","article-title":"Comorbidity profiles among patients with bullous pemphigoid: a nationwide population-based study","volume":"165","author":"Chen","year":"2011","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib4","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/cne.20549","article-title":"Collagen XVII and BPAG1 expression in the retina: evidence for an anchoring complex in the central nervous system","volume":"487","author":"Claudepierre","year":"2005","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.jid.2016.09.010_bib5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000106574","article-title":"Neurological disorders in patients with bullous pemphigoid","volume":"215","author":"Cordel","year":"2007","journal-title":"Dermatology"},{"key":"10.1016\/j.jid.2016.09.010_bib6","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1365-2133.2012.11108.x","article-title":"Clinical presentation and diagnostic delay in bullous pemphigoid: a prospective nationwide cohort","volume":"167","author":"della Torre","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.clindermatol.2011.03.005","article-title":"Bullous pemphigoid: from the clinic to the bench","volume":"30","author":"Di Zenzo","year":"2012","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib8","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1038\/jid.2011.180","article-title":"Demonstration of epitope-spreading phenomena in bullous pemphigoid: results of a prospective multicenter study","volume":"131","author":"Di Zenzo","year":"2011","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib9","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/bjd.13189","article-title":"Increasing incidence of bullous pemphigoid in northern Finland: a retrospective database study in Oulu university hospital","volume":"171","author":"F\u00f6rsti","year":"2014","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib10","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0151-9638(06)70935-8","article-title":"Correlation between the presence of type-2 anti-pemphigoid antibodies and dementia in elderly subjects with no clinical signs of pemphigoid","volume":"133","author":"Foureur","year":"2006","journal-title":"Ann Dermatol Venereol"},{"key":"10.1016\/j.jid.2016.09.010_bib11","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1074\/jbc.R400034200","article-title":"Collagenous transmembrane proteins: recent insights into biology and pathology","volume":"280","author":"Franzke","year":"2005","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2016.09.010_bib12","doi-asserted-by":"crossref","first-page":"24521","DOI":"10.1074\/jbc.M308835200","article-title":"Shedding of collagen XVII\/BP180: structural motifs influence cleavage from cell surface","volume":"279","author":"Franzke","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2016.09.010_bib13","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1212\/01.WNL.0000156914.16988.56","article-title":"CSF Abeta42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment","volume":"64","author":"Herukka","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.jid.2016.09.010_bib14","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.matbio.2007.10.007","article-title":"Pemphigoid gestationis autoantigen, transmembrane collagen XVII, promotes the migration of cytotrophoblastic cells of placenta and is a structural component of fetal membranes","volume":"27","author":"Huilaja","year":"2008","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jid.2016.09.010_bib15","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/jid.2014.443","article-title":"Deletion of the major bullous pemphigoid epitope region of collagen XVII induces blistering, autoimmunization, and itching in mice","volume":"135","author":"Hurskainen","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00441-012-1368-x","article-title":"Transmembrane collagen XVII is a novel component of the glomerular filtration barrier","volume":"348","author":"Hurskainen","year":"2012","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jid.2016.09.010_bib17","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1038\/jid.2012.35","article-title":"Incidence and mortality of bullous pemphigoid in France","volume":"132","author":"Joly","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3109\/08916934.2011.606447","article-title":"Pemphigoid diseases: pathogenesis, diagnosis, and treatment","volume":"45","author":"Kasperkiewicz","year":"2012","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jid.2016.09.010_bib19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/exd.12877","article-title":"One gene but different proteins and diseases: the complexity of dystonin and bullous pemphigoid antigen 1","volume":"25","author":"Kunzli","year":"2016","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib20","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/jid.2010.357","article-title":"The relationship between neurological disease and bullous pemphigoid: a population-based case-control study","volume":"131","author":"Langan","year":"2011","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib21","doi-asserted-by":"crossref","first-page":"a180","DOI":"10.1136\/bmj.a180","article-title":"Bullous pemphigoid and pemphigus vulgaris\u2014incidence and mortality in the UK: population based cohort study","volume":"337","author":"Langan","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.jid.2016.09.010_bib22","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.jid.2016.09.010_bib23","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.jid.2015.12.005","article-title":"Autoantibodies to collagen XVII are present in Parkinson's disease and localize to tyrosine-hydroxylase positive neurons","volume":"136","author":"Messingham","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jdermsci.2013.12.001","article-title":"Update on the pathogenesis of bullous pemphigoid: an autoantibody-mediated blistering disease targeting collagen XVII","volume":"73","author":"Nishie","year":"2014","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2016.09.010_bib25","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.jaad.2013.06.033","article-title":"The relationship between motor neuron disease and bullous pemphigoid: an English cohort study","volume":"69","author":"Ong","year":"2013","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib26","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/j.1365-2230.2005.01937.x","article-title":"Collagen XVII\/BP180: a collagenous transmembrane protein and component of the dermoepidermal anchoring complex","volume":"30","author":"Powell","year":"2005","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13023-015-0278-x","article-title":"Prevalence of pemphigus and pemphigoid autoantibodies in the general population","volume":"10","author":"Prussmann","year":"2015","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jid.2016.09.010_bib28","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/bjd.14538","article-title":"Parkinson's disease and multiple sclerosis are not associated with autoantibodies against structural proteins of the dermal-epidermal junction","volume":"175","author":"Recke","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib29","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1365-2133.2004.06082.x","article-title":"Evaluation of a BP180-NC16a enzyme-linked immunosorbent assay in the initial diagnosis of bullous pemphigoid","volume":"151","author":"Sakuma-Oyama","year":"2004","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib30","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0140-6736(12)61140-4","article-title":"Pemphigoid diseases","volume":"381","author":"Schmidt","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2016.09.010_bib31","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/bjd.12936","article-title":"BP180- and BP230-specific IgG autoantibodies in pruritic disorders of the elderly: a preclinical stage of bullous pemphigoid?","volume":"171","author":"Schmidt","year":"2014","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib32","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0002-9440(10)64772-4","article-title":"The shed ectodomain of collagen XVII\/BP180 is targeted by autoantibodies in different blistering skin diseases","volume":"156","author":"Schumann","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2016.09.010_bib33","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3233\/JAD-2011-101911","article-title":"Longitudinal changes of CSF Biomarkers in Alzheimer\u2019s disease","volume":"25","author":"Sepp\u00e4l\u00e4","year":"2011","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.jid.2016.09.010_bib34","doi-asserted-by":"crossref","first-page":"240570","DOI":"10.1155\/2013\/240570","article-title":"Collagen XVII: a shared antigen in neurodermatological interactions?","volume":"2013","author":"Sepp\u00e4nen","year":"2013","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.jid.2016.09.010_bib35","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.matbio.2005.11.004","article-title":"Collagen XVII is expressed in human CNS neurons","volume":"25","author":"Sepp\u00e4nen","year":"2006","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jid.2016.09.010_bib36","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.brainres.2007.04.073","article-title":"Distribution of collagen XVII in the human brain","volume":"1158","author":"Sepp\u00e4nen","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.jid.2016.09.010_bib37","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1080\/00015550410024481","article-title":"A\u00a0retrospective epidemiological study on the association of bullous pemphigoid and neurological diseases","volume":"85","author":"Stinco","year":"2005","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jid.2016.09.010_bib38","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.autrev.2012.07.006","article-title":"Diagnostic accuracy of enzyme-linked immunosorbent assays (ELISA) to detect anti-skin autoantibodies in autoimmune blistering skin diseases: a systematic review and meta-analysis","volume":"12","author":"Tampoia","year":"2012","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jid.2016.09.010_bib39","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/archneurol.2008.596","article-title":"Cerebrospinal fluid beta-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain","volume":"66","author":"Tapiola","year":"2009","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jid.2016.09.010_bib40","first-page":"37","article-title":"BP180 (type XVII collagen) and its role in cutaneous biology and disease","volume":"19","author":"Van den Bergh","year":"2003","journal-title":"Adv Dermatol"},{"key":"10.1016\/j.jid.2016.09.010_bib41","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S1474-4422(16)00062-4","article-title":"Defeating Alzheimer's disease and other dementias: a priority for European science and society","volume":"15","author":"Winblad","year":"2016","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jid.2016.09.010_bib42","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/STROKEAHA.110.596361","article-title":"Increased risk of stroke in patients with bullous pemphigoid: a population-based follow-up study","volume":"42","author":"Yang","year":"2011","journal-title":"Stroke"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X16324514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X16324514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T07:27:15Z","timestamp":1543303635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X16324514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0022202X16324514"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2016.09.010","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased Levels of the Bullous Pemphigoid BP180 Autoantibody Are Associated with\u00a0More Severe Dementia in Alzheimer\u2019s\u00a0Disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2016.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}