{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:12:48Z","timestamp":1791443568057,"version":"4.3.3"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.jid.2016.10.003","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T13:56:45Z","timestamp":1476712605000},"page":"367-376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Allergy-Inducing Chromium Compounds Trigger Potent Innate Immune Stimulation Via ROS-Dependent Inflammasome Activation"],"prefix":"10.1016","volume":"137","author":[{"given":"Christian","family":"Adam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Wohlfarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"Hau\u00dfmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga","family":"Sennefelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Rodin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mareike","family":"Maler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan F.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Goebeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2016.10.003_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2340\/00015555179122","article-title":"Cement eczema. An epidemiological intervention study","volume":"179","author":"Avnstorp","year":"1992","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jid.2016.10.003_bib2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/cod.12436","article-title":"Chromium allergy and dermatitis: prevalence and main findings","volume":"73","author":"Bregnbak","year":"2015","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jid.2016.10.003_bib3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A\u00a0small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2016.10.003_bib4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.fct.2013.02.038","article-title":"Role of oxidative stress in chemical allergens induced skin cells activation","volume":"61","author":"Corsini","year":"2013","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jid.2016.10.003_bib5","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.celrep.2015.05.003","article-title":"Diverse activators of the NLRP3 inflammasome promote IL-1beta secretion by triggering necrosis","volume":"11","author":"Cullen","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.jid.2016.10.003_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4939-3335-8_1","article-title":"Toll-like receptors: ligands, cell-based models, and readouts for receptor action","volume":"1390","author":"Dowling","year":"2016","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jid.2016.10.003_bib7","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/nature06939","article-title":"Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants","volume":"453","author":"Eisenbarth","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jid.2016.10.003_bib8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/imr.12286","article-title":"Initiation and perpetuation of NLRP3 inflammasome activation and assembly","volume":"265","author":"Elliott","year":"2015","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jid.2016.10.003_bib9","doi-asserted-by":"crossref","first-page":"e41340","DOI":"10.1371\/journal.pone.0041340","article-title":"Contact sensitizers induce skin inflammation via ROS production and hyaluronic acid degradation","volume":"7","author":"Esser","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2016.10.003_bib10","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1600-0536.1992.tb03284.x","article-title":"Permeation of chromium salts through human skin in\u00a0vitro","volume":"27","author":"Gammelgaard","year":"1992","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jid.2016.10.003_bib11","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.0105-1873.2003.0230.x","article-title":"Chromium allergy: significance of both Cr(III) and Cr(VI)","volume":"49","author":"Hansen","year":"2003","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jid.2016.10.003_bib12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1034\/j.1600-0536.2002.470301.x","article-title":"Quantitative aspects of contact allergy to chromium and exposure to chrome-tanned leather","volume":"47","author":"Hansen","year":"2002","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jid.2016.10.003_bib13","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ni.1631","article-title":"Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization","volume":"9","author":"Hornung","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2016.10.003_bib14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.immuni.2013.08.001","article-title":"Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation","volume":"39","author":"Iyer","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2016.10.003_bib15","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1034\/j.1600-0536.2002.470608.x","article-title":"Role of different valence states of chromium in the elicitation of allergic contact dermatitis","volume":"47","author":"Iyer","year":"2002","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jid.2016.10.003_bib16","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nri3150","article-title":"Early immune events in the induction of allergic contact dermatitis","volume":"12","author":"Kaplan","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2016.10.003_bib17","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and functions of inflammasomes","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jid.2016.10.003_bib18","doi-asserted-by":"crossref","first-page":"e108317","DOI":"10.1371\/journal.pone.0108317","article-title":"N-acetylcysteine attenuates hexavalent chromium-induced hypersensitivity through inhibition of cell death, ROS-related signaling and cytokine expression","volume":"9","author":"Lee","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2016.10.003_bib19","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cmet.2012.07.007","article-title":"IRE1alpha induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress","volume":"16","author":"Lerner","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.jid.2016.10.003_bib20","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s10753-013-9759-z","article-title":"Nickel induces interleukin-1beta secretion via the NLRP3-ASC-caspase-1 pathway","volume":"37","author":"Li","year":"2014","journal-title":"Inflammation"},{"key":"10.1016\/j.jid.2016.10.003_bib21","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1074\/jbc.272.11.7223","article-title":"Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases","volume":"272","author":"Margolin","year":"1997","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2016.10.003_bib22","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature04515","article-title":"Cryopyrin activates the inflammasome in response to toxins and ATP","volume":"440","author":"Mariathasan","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jid.2016.10.003_bib23","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/j.1398-9995.2011.02652.x","article-title":"Mechanisms of chemical-induced innate immunity in allergic contact dermatitis","volume":"66","author":"Martin","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jid.2016.10.003_bib24","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol Cell"},{"key":"10.1016\/j.jid.2016.10.003_bib25","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1034\/j.1600-0536.2000.042003123.x","article-title":"Contact allergy, irritancy and 'danger'","volume":"42","author":"McFadden","year":"2000","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jid.2016.10.003_bib26","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.immuni.2013.05.016","article-title":"K(+) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter","volume":"38","author":"Munoz-Planillo","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2016.10.003_bib27","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1038\/sj.jid.5700802","article-title":"EC-SOD suppresses contact hypersensitivity in mouse skin by impairing Langerhans cell migration","volume":"127","author":"Na","year":"2007","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.10.003_bib28","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2016.10.003_bib29","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/oem.51.6.371","article-title":"A\u00a0study of chromium induced allergic contact dermatitis with 54 volunteers: implications for environmental risk assessment","volume":"51","author":"Nethercott","year":"1994","journal-title":"Occup Environ Med"},{"key":"10.1016\/j.jid.2016.10.003_bib30","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1038\/jid.2014.93","article-title":"Nonmetal haptens induce ATP release from keratinocytes through opening of pannexin hemichannels by reactive oxygen species","volume":"134","author":"Onami","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.10.003_bib31","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/sj.cdd.4402195","article-title":"Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration","volume":"14","author":"Petrilli","year":"2007","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jid.2016.10.003_bib32","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/embor.2012.155","article-title":"Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2","volume":"13","author":"Raghavan","year":"2012","journal-title":"EMBO Rep"},{"key":"10.1016\/j.jid.2016.10.003_bib33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1600-0536.1996.tb02111.x","article-title":"Addition of ferrous sulfate to cement and risk of chromium dermatitis among construction workers","volume":"34","author":"Roto","year":"1996","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jid.2016.10.003_bib34","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/jid.1962.3","article-title":"Inactivation of chromium ion in allergic eczematous dermatitis","volume":"38","author":"Samitz","year":"1962","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.10.003_bib35","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1365-2222.2007.02705.x","article-title":"Lipopolysaccharide promotes and augments metal allergies in mice, dependent on innate immunity and histidine decarboxylase","volume":"37","author":"Sato","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jid.2016.10.003_bib36","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s00109-011-0780-0","article-title":"Nickel allergies: paying the Toll for innate immunity","volume":"89","author":"Schmidt","year":"2011","journal-title":"J\u00a0Mol Med (Berl)"},{"key":"10.1016\/j.jid.2016.10.003_bib37","first-page":"653","article-title":"Immunology of metal allergies","volume":"13","author":"Schmidt","year":"2015","journal-title":"J\u00a0Dtsch Dermatol Ges"},{"key":"10.1016\/j.jid.2016.10.003_bib38","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/978-1-4939-3335-8_20","article-title":"Methods to investigate the role of Toll-like receptors in allergic contact dermatitis","volume":"1390","author":"Schmidt","year":"2016","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jid.2016.10.003_bib39","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/ni.1919","article-title":"Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel","volume":"11","author":"Schmidt","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2016.10.003_bib40","doi-asserted-by":"crossref","first-page":"e85983","DOI":"10.1371\/journal.pone.0085983","article-title":"Accumulation of metal-specific T cells in inflamed skin in a novel murine model of chromium-induced allergic contact dermatitis","volume":"9","author":"Shigematsu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2016.10.003_bib41","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2016.10.003_bib42","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1074\/jbc.M006781200","article-title":"Altered cytokine production in mice lacking P2X(7) receptors","volume":"276","author":"Solle","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2016.10.003_bib43","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.immuni.2006.02.004","article-title":"Critical role for NALP3\/CIAS1\/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1","volume":"24","author":"Sutterwala","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2016.10.003_bib44","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/356768a0","article-title":"A\u00a0novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes","volume":"356","author":"Thornberry","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.jid.2016.10.003_bib45","first-page":"1530","article-title":"Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester","volume":"42","author":"Tsuchiya","year":"1982","journal-title":"Cancer Res"},{"key":"10.1016\/j.jid.2016.10.003_bib46","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1038\/sj.jid.5700819","article-title":"Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity","volume":"127","author":"Watanabe","year":"2007","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.10.003_bib47","doi-asserted-by":"crossref","first-page":"5826","DOI":"10.4049\/jimmunol.180.9.5826","article-title":"Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization","volume":"180","author":"Watanabe","year":"2008","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2016.10.003_bib48","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1084\/jem.20092489","article-title":"Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivity","volume":"207","author":"Weber","year":"2010","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2016.10.003_bib49","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1600-0536.1996.tb02295.x","article-title":"Chromium allergy in consecutive patients in a country where ferrous sulfate has been added to cement since 1981","volume":"35","author":"Zachariae","year":"1996","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jid.2016.10.003_bib50","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A\u00a0role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X16324940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X16324940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T11:40:35Z","timestamp":1749642035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X16324940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S0022202X16324940"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2016.10.003","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Allergy-Inducing Chromium Compounds Trigger Potent Innate Immune Stimulation Via ROS-Dependent Inflammasome Activation","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2016.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}