{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:24:43Z","timestamp":1790691883977,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.jid.2016.10.040","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T09:47:01Z","timestamp":1478771221000},"page":"650-659","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["S100A12 Induced in the Epidermis by Reduced Hydration Activates Dermal Fibroblasts and Causes Dermal Fibrosis"],"prefix":"10.1016","volume":"137","author":[{"given":"Jingling","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily E.","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxian","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Galiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Mustoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok Jong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7380","key":"10.1016\/j.jid.2016.10.040_bib1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/bmj.326.7380.88","article-title":"Skin scarring","volume":"326","author":"Bayat","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.jid.2016.10.040_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.1737","article-title":"Epidermis promotes dermal fibrosis: role in the pathogenesis of hypertrophic scars","volume":"206","author":"Bellemare","year":"2005","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jid.2016.10.040_bib3","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1089\/ars.2012.4773","article-title":"New insights into the regulation of neutrophil NADPH oxidase activity in the phagosome: a focus on the role of lipid and Ca(2+) signaling","volume":"18","author":"Br\u00e9chard","year":"2013","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"10.1016\/j.jid.2016.10.040_bib4","doi-asserted-by":"crossref","first-page":"e0115828","DOI":"10.1371\/journal.pone.0115828","article-title":"S100A9 induced inflammatory responses are mediated by distinct damage associated molecular patterns (DAMP) receptors in\u00a0vitro and in\u00a0vivo","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2016.10.040_bib5","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1186\/1471-2164-11-471","article-title":"Positional differences in the wound transcriptome of skin and oral mucosa","volume":"11","author":"Chen","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jid.2016.10.040_bib6","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2174\/156652407783220688","article-title":"RAGE: a single receptor for several ligands and different cellular responses: the case of certain S100 proteins","volume":"7","author":"Donato","year":"2007","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.jid.2016.10.040_bib7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.0022-202X.2004.22719.x","article-title":"S100 proteins in the epidermis","volume":"123","author":"Eckert","year":"2004","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.10.040_bib8","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1034\/j.1600-0625.2002.110503.x","article-title":"Evidence for local control of gene expression in the epidermal differentiation complex","volume":"11","author":"Elder","year":"2002","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2016.10.040_bib9","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1093\/rheumatology\/keg385","article-title":"Expression of the pro-inflammatory protein S100A12 (EN-RAGE) in rheumatoid and psoriatic arthritis","volume":"42","author":"Foell","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jid.2016.10.040_bib10","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1164\/rccm.201209-1602OC","article-title":"Proinflammatory S100A12 can activate human monocytes via Toll-like receptor 4","volume":"187","author":"Foell","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jid.2016.10.040_bib11","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1189\/jlb.0306170","article-title":"S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules","volume":"81","author":"Foell","year":"2007","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.jid.2016.10.040_bib12","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/jid.2010.420","article-title":"Epithelial regulation of mesenchymal tissue behavior","volume":"131","author":"Gallant-Behm","year":"2011","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.10.040_bib13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1524-475X.2010.00575.x","article-title":"Occlusion regulates epidermal cytokine production and inhibits scar formation","volume":"18","author":"Gallant-Behm","year":"2010","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jid.2016.10.040_bib14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2119\/molmed.2009.00153","article-title":"Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies","volume":"17","author":"Gauglitz","year":"2011","journal-title":"Mol Med"},{"key":"10.1016\/j.jid.2016.10.040_bib15","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.biocel.2007.10.024","article-title":"Metalloproteinases and their inhibitors: regulators of wound healing","volume":"40","author":"Gill","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jid.2016.10.040_bib16","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00726-010-0528-0","article-title":"Inflammation-associated S100 proteins: new mechanisms that regulate function","volume":"41","author":"Goyette","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.jid.2016.10.040_bib17","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2353\/ajpath.2007.070112","article-title":"The myofibroblast: one function, multiple origins","volume":"170","author":"Hinz","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2016.10.040_bib18","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0092-8674(00)80801-6","article-title":"RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100\/calgranulin polypeptides","volume":"97","author":"Hofmann","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.jid.2016.10.040_bib19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/imm.12352","article-title":"S100A8, S100A9 and S100A12 activate airway epithelial cells to produce MUC5AC via extracellular signal-regulated kinase and nuclear factor-kappaB pathways","volume":"144","author":"Kang","year":"2015","journal-title":"Immunology"},{"key":"10.1016\/j.jid.2016.10.040_bib20","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/jid.2012.359","article-title":"Gene profiling of narrowband UVB-induced skin injury defines cellular and molecular innate immune responses","volume":"133","author":"Kennedy Crispin","year":"2013","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.10.040_bib21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.5414\/CNP66315","article-title":"Increased serum levels of S100A12 in patients with MPO-ANCA-associated glomerulonephritis","volume":"66","author":"Komatsuda","year":"2006","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.jid.2016.10.040_bib22","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jamcollsurg.2007.03.001","article-title":"Temporal expression of the transforming growth factor-Beta pathway in the rabbit ear model of wound healing and scarring","volume":"205","author":"Kryger","year":"2007","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.jid.2016.10.040_bib23","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/BCR.0b013e3182374452","article-title":"Epidemiology and impact of scarring after burn injury: a systematic review of the literature","volume":"33","author":"Lawrence","year":"2012","journal-title":"J\u00a0Burn Care Res"},{"key":"10.1016\/j.jid.2016.10.040_bib24","first-page":"1232","article-title":"The importance of Ca2+\/Zn2+ signaling S100 proteins and RAGE in translational medicine","volume":"3","author":"Leclerc","year":"2011","journal-title":"Front Biosci (Schol Ed)"},{"key":"10.1016\/j.jid.2016.10.040_bib25","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1016\/j.bbagen.2015.09.015","article-title":"The S100 proteins in epidermis: topology and function","volume":"1850","author":"Lesniak","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jid.2016.10.040_bib26","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jdermsci.2009.09.005","article-title":"Scarless healing of oral mucosa is characterized by faster resolution of inflammation and control of myofibroblast action compared to skin\u00a0wounds in the red Duroc pig model","volume":"56","author":"Mak","year":"2009","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2016.10.040_bib27","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.bbrc.2004.07.096","article-title":"S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)","volume":"322","author":"Marenholz","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jid.2016.10.040_bib28","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1046\/j.1523-1747.2000.00005-2.x","article-title":"Calgranulin C is overexpressed in lesional psoriasis","volume":"114","author":"Mirmohammadsadegh","year":"2000","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.10.040_bib29","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/1523-1747.ep12338501","article-title":"Genes encoding structural proteins of epidermal cornification and S100 calcium-binding proteins form a gene complex (\u201cepidermal differentiation complex\u201d) on human chromosome 1q21","volume":"106","author":"Mischke","year":"1996","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.10.040_bib30","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/jemt.10300","article-title":"Multiple structural states of S100A12: A key to its functional diversity","volume":"60","author":"Moroz","year":"2003","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.jid.2016.10.040_bib31","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/00006534-200208000-00031","article-title":"International clinical recommendations on scar management","volume":"110","author":"Mustoe","year":"2002","journal-title":"Plast Reconstr Surg"},{"issue":"Suppl. 1","key":"10.1016\/j.jid.2016.10.040_bib32","doi-asserted-by":"crossref","first-page":"s16","DOI":"10.1111\/j.1524-475X.2011.00709.x","article-title":"The role of the epidermis and the mechanism of action of occlusive dressings in scarring","volume":"19","author":"Mustoe","year":"2011","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jid.2016.10.040_bib33","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/path.853","article-title":"Keratinocyte-derived growth factors play a role in the formation of hypertrophic scars","volume":"194","author":"Niessen","year":"2001","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jid.2016.10.040_bib34","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/wrr.12381","article-title":"Exacerbated and prolonged inflammation impairs wound healing and increases scarring","volume":"24","author":"Qian","year":"2016","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jid.2016.10.040_bib35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.matbio.2015.03.002","article-title":"Matrix remodeling by MMPs during wound repair","volume":"44\u201346","author":"Rohani","year":"2015","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jid.2016.10.040_bib36","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1067\/maj.2002.123023","article-title":"Silicone occlusive treatment of hypertrophic scar in the rabbit model","volume":"22","author":"Saulis","year":"2002","journal-title":"Aesthet Surg J"},{"issue":"4\u20135","key":"10.1016\/j.jid.2016.10.040_bib37","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s00439-002-0812-5","article-title":"Evidence for differential S100 gene over-expression in psoriatic patients from genetically heterogeneous pedigrees","volume":"111","author":"Semprini","year":"2002","journal-title":"Hum Genet"},{"key":"10.1016\/j.jid.2016.10.040_bib38","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1524-475X.2008.00416.x","article-title":"Antisense inhibition of connective tissue growth factor (CTGF\/CCN2) mRNA limits hypertrophic scarring without affecting wound healing in\u00a0vivo","volume":"16","author":"Sisco","year":"2008","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jid.2016.10.040_bib39","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1046\/j.1523-1747.1999.00613.x","article-title":"Human epidermal differentiation complex in a single 2.5 Mbp long continuum of overlapping DNA cloned in bacteria integrating physical and transcript maps","volume":"112","author":"South","year":"1999","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.10.040_bib40","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1001\/archderm.1996.03890360039008","article-title":"Functional analyses of the stratum corneum in scars. Sequential studies after injury and comparison among keloids, hypertrophic scars, and atrophic scars","volume":"132","author":"Suetake","year":"1996","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jid.2016.10.040_bib41","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1177\/154405910308200810","article-title":"Differential injury responses in oral mucosal and cutaneous wounds","volume":"82","author":"Szpaderska","year":"2003","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.jid.2016.10.040_bib42","first-page":"62","article-title":"S100A12: a noninvasive marker of inflammation in inflammatory bowel disease","volume":"14","author":"van de Logt","year":"2013","journal-title":"J\u00a0Dig Dis"},{"key":"10.1016\/j.jid.2016.10.040_bib43","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0143-4160(96)90087-1","article-title":"Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21","volume":"20","author":"Wicki","year":"1996","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jid.2016.10.040_bib44","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1172\/JCI31487","article-title":"Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases","volume":"117","author":"Wynn","year":"2007","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2016.10.040_bib45","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/jid.2014.477","article-title":"Hydration status regulates sodium flux and inflammatory pathways through epithelial sodium channel (ENaC) in the skin","volume":"135","author":"Xu","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"issue":"312","key":"10.1016\/j.jid.2016.10.040_bib46","doi-asserted-by":"crossref","first-page":"312ra177","DOI":"10.1126\/scitranslmed.aad0286","article-title":"Sodium channel Nax is a regulator in epithelial sodium homeostasis","volume":"7","author":"Xu","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2016.10.040_bib47","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/jid.2013.425","article-title":"The expression of proinflammatory genes in epidermal keratinocytes is regulated by hydration status","volume":"134","author":"Xu","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.10.040_bib48","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/labinvest.2011.184","article-title":"Application of a partial-thickness human ex\u00a0vivo skin culture model in cutaneous wound healing study","volume":"92","author":"Xu","year":"2012","journal-title":"Lab Invest"},{"key":"10.1016\/j.jid.2016.10.040_bib49","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jaci.2006.08.021","article-title":"S100A12 provokes mast cell activation: a potential amplification pathway in asthma and innate immunity","volume":"119","author":"Yang","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2016.10.040_bib50","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ajpath.2015.09.005","article-title":"S100A8 and S100A9 are induced by decreased hydration in the epidermis and promote fibroblast activation and fibrosis in the dermis","volume":"186","author":"Zhong","year":"2016","journal-title":"Am J Pathol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X16326380?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X16326380?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T12:33:19Z","timestamp":1543321999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X16326380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0022202X16326380"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2016.10.040","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"S100A12 Induced in the Epidermis by Reduced Hydration Activates Dermal Fibroblasts and Causes Dermal Fibrosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2016.10.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}